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Zeng R.-M.,Shantou University | Wu S.-R.,Shantou Chaonan Minsheng Hospital | Lin S.-B.,Shantou Chaonan Minsheng Hospital
Chinese Journal of Tissue Engineering Research | Year: 2013

Background: Studies have shown the knee secondary osteoarthritis may occur after the treatment of tibial plateau fractures with open reduction and internal fixation, but the researches on the middle- and long-term effect of arthroscopic assisted tibial plateau fracture fixation are still rare. Objective: To evaluate the outcomes of lateral tibial plateau fractures after treated with arthroscopic assisted percutaneous bone grafting and screw fixation for 1 and 4 years through clinical and radiological assessment. Methods: Between March 2007 and March 2009, with the information of the patients with lateral tibial plateau fractures undergoing arthroscopic assisted percutaneous bone grafting and screw fixation were enrolled. The data of the type of fractures in the Schatzker classification, the accompanying lesions of the cartilage defect on the lateral tibial plateau, the cartilage damage on the femoral condyle, intra-articular soft tissue lesions and insufficient reduction of the fracture, as well as postoperative subsidence in the lateral tibial plateau were collected. The Lysholm score, Ahlback osteoarthritis classification, Rasmussen function score and radiological score were assessed at 1 and 4 years after treated with percutaneous bone grafting and screw fixation. Results and Conclusion: Twenty-three patients finished the follow-up. At 1 and 4 years after percutaneous bone grafting and screw fixation, the mean Lysholm score was 90 and 87 points respectively (P=0.23), and the mean Rasmussen function score was 26 and 24 points respectively (P=0.30). At 4 years after surgery, 11 cases (47.8%) presented osteoarthritis and the Rasmussen radiological score was decreased from early postoperative 17.4 points to 4-year postoperatively 13.6 points (P=0.01). No correlation could be observed between the various types of fractures and their prognosis. The elder cases, cartilage damage and/or defect, intra-articular soft tissue lesions and postoperative subsidence in the lateral tibial plateau were correlated with function and radiological middle outcomes after surgery. However, the cartilage defects on tibial plateau had minor effect on knee osteoarthritis when compared with cartilage damage on the femoral condyle. Early radiological outcomes do not completely consistent with that of the 4 years after surgery, but the medium-term clinical and functional follow-up outcomes are still satisfied. Age, cartilage damage or defect, intra-articular soft tissue lesions and postoperative subsidence in lateral tibial plateau appears as prognostic factors for osteoarthritis after treatment. The prognostic effect of cartilage defects on tibial plateau for osteoarthritis is lower than that of cartilage damage on the femoral condyle which may be attributed to integrated function of lateral meniscus.

Chen Q.-C.,Shantou Chaonan Minsheng Hospital | Xu W.,Shantou University
International Eye Science | Year: 2014

AIM: To observe the efficacy, complications and ocular surface tear dynamics of the treatment for pterygium combined with conjunctivochalasis by inferior limbal-stem-cell transplantation. METHODS: All 30 patients (46 eyes) diagnosed as pterygium combined with conjunctivochalasis in our hospital from December, 2010 to December, 2012 with a mean age of 61.2y (SD 7.2, range 49-75) were subjected to observation. After excision of nasal pterygium, an equivalent size of conjunctival flap linked with corneal limbal stem cell from inferior limbus was transplanted to the exposed sclera. Afterwards, the inferior bulbar conjunctiva was trimmed and fixed onto surface of sclera and inferior corneal limbus. After one-year follow-up, the comparisons regarding vision acuity between pre-operation and post-operation (1mo later) as well as ocular-surface tear dynamics changes including several indexes like altitude and integrity of tear meniscus, break-up time (BUT), corneal fluorescein staining and chloramphenicol gestation test before and 3mo after surgery were made. The operative complications and the recurrence rates 1y after operations were recorded. RESULTS: Median visual acuity was 0.2 (0.04-0.6) before the operation and median visual acuity was 0.4 (0.04-1.0) 1mo after the operation. Of total 46 eyes in 21 eyes (45.7%), visual acuity improved. No vision changes were found in other 25 eyes (54.3%). Significant difference (P<0.01) of vision acuity before and after surgery was found. In addition, break-up time (BUT), corneal fluorescein staining and chloramphenicol gestation test and altitude and integrity of tear meniscus show better results 3mo after surgery than that of pre-operation, which showed statistically significant (P<0.05). After 1y follow-up, 33 eyes (71.7%) healed while problems in 11 eyes (23%) were relieved. The total efficacy rate was 95.6%. Nonetheless, invalid surgeries were noticed in two eyes (4.4%) that affected by recurrence of pterygium. The 33 eyes (71.7%) affected by conjunctivochalasis was cured in terms of subjective evaluation and improved in 9 eyes (19.6 %), but 4 eyes (8.7%) exhibited no evident improvement in terms of subjective complains. Total efficacy was 91.3%. The 41 eyes (89.1%) were reported to be normal while 5 eyes (10.9%) were revealed to be abnormal in terms of objective therapeutic evaluation. And this condition was so-call conjunctivochalasis recurrence with a recurrence rate of 10.9%. No proliferation of granulation, narrowing inferior fornix and malfunction of eye movements was found. CONCLUSION: Inferior-limbal-stem-cell transplantation to treat pterygium combined with conjunctivochalasis obtains better results. It proves to eradicate or relieve symptoms of patients effectively and ameliorate ocular-surface tear dynamics.

Qiu S.-M.,Shantou University | Chen X.-P.,Shantou University | Zheng D.-Z.,Shantou University | Lin Y.-B.,Shantou University | And 3 more authors.
Chinese Journal of Tissue Engineering Research | Year: 2014

Background: Preoperative walking ability and activities are good predictors of functional recovery of patients after hip replacement. But these objective assessment tools are invalid to predict postoperative function of patients with no preoperative walking ability. Objective: To assess the effect of preoperative subjective physical activity questionnaire to predict the 6-month postoperative physical functioning outcomes in elder patients receiving hip arthroplasty, and to determine which aspects of patient's characteristics influence 6-month postoperative physical activity. Methods: A two-center prospective audit was carried out in elder patients who underwent hip arthroplasty between November 2010 and February 2013. These patients were divided into three groups, including the group of total hip arthroplasty for fractures of the femoral neck, the group of total hip arthroplasty for osteoarthritis and the group of hemiarthroplasty for fractures of the femoral neck. All patients had fulfilled Longitudinal Aging Study Amsterdam-Physical Activity Questionnaire (LAPAQ) and Short Form 36 (SF-36) recalling their physical activity at 2 weeks before the fall accident (for fractures of the femoral neck) or admission (for hip osteoarthritis). Preoperative demographic data were also collected. Postoperative assessment regarding subjective physical activity assessment including LAPAQ and SF-36, and objective physical activity assessment including timed up and go test and six-minute walk test were evaluated at the time of 6-month postoperation. Results And Conclusion: Totally 115 patients finished the study. Both preoperative LAPAQ and SF-36 can play a predictor to probe 6-month postoperative function of objective and subjective activity in patients with femoral neck fractures or hip osteoarthritis undergoing hip arthroplasty. Preoperative LAPAQ seems better than preoperative SF-36 to predict postoperative physical activity. For hip fracture patients, because preoperative objective function cannot be assessed, preoperative LAPAQ can play an effective and subjective index to predict postoperative function of objective activity, and physical functions can recover 70%-80% at 6 months postoperatively. For hip osteoarthritis patients, postoperative physical function can be increased by approximately 27% compared with before hip arthroplasty. Patient's characteristics also affect the postoperative physical activity, and the occurrence of preoperative complications is a most important factor.

Hu H.,Shantou Chaonan Minsheng Hospital | Jing X.-B.,Shantou University | Cai X.-B.,Shantou University | Wang Q.-J.,Shantou University
Chinese Journal of Cancer Prevention and Treatment | Year: 2010

OBJECTIVE: To investigate the curcumin induced apoptosis of esophageal cancer cell line Ec-109 cells by damaged mitochondria and explore the mechanism. METHODS: Ec-109 cells were treated with 80 μmol/ml curcumin in different time, and apoptotic Sub-G1 peak and mitochondrial membrane potential were detected by flow cytometry; the expressions of cytochrome C and Caspase-9 were detected by Western-blot. RESULTS: When Ec-109 cells treated with curcumin for 12, 24 and 48 h, the apoptotic Sub-G1 peas were about (15.89±2.12)%, (26.80±1.87)% and (36.97±1.80)% respectively. Compared with the control group [(3.23±0.24)%], there was a statistically significant difference (F = 6.75, P<0.01). The mitochondrial membrane potential was damaged obviously after 3, 6 and 12 h, which was 84.78%, 67.03% and 63.16% respectively, and there was a statistically significant difference too (F=5.12, P<0.05). And the difference between 6 h and 12 h was not significant (P=0.062). The expressions of cytochrome C and Caspase-9 appeared a kind of tendency of time-dependent up-regulation after treatment with curcumin for 12 h and 24 h respectively. CONCLUSION: Curcumin can damage mitochondria, from which cytochrome C is released and then Caspase-9 is activated, time-dependently inducuing EC-109 cells apoptosis.

Li C.-Y.,Shantou Chaonan Minsheng Hospital | Li C.-Y.,Shantou University | Ma S.-H.,Shantou Chaonan Minsheng Hospital | Ma S.-H.,Shantou University | And 2 more authors.
Chinese Journal of Medical Imaging Technology | Year: 2010

Function magnetic resonance imaging (fMRI) has been widely used in brain function research. At present, many soft wares are applied to the fMRI data processing and analysis, in which SPM and AFNI are widely used. The application and difference of SPM and AFNI in the fMRI were reviewed in this paper.

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