Wang Y.,148th Hospital |
Wang Y.,Zhengzhou University |
Yin H.,148th Hospital |
Wang L.,Shangqiu Medical College |
And 5 more authors.
American Journal of Chinese Medicine | Year: 2013
Curcumin, an agent traditionally utilized for its preventative action against tumorigenesis, oxidation, inflammation, apoptosis and hyperlipemia, has also been used in the treatment of Alzheimer's disease (AD). Recent advances in the study of AD have revealed astrocytes (AS) as being key factors in the early pathophysiological changes in AD. Glial fibrillary acidic protein (GFAP), a marker specific to AS, is markedly more manifest during morphological modifications and neural degeneration signature during the onset of AD. Several studies investigating the functionality of curcumin have shown that it not only inhibits amyloid sedimentation but also accelerates the disaggregation of amyloid plaque. Thus, we are interested in the relationship between curcumin and spatial memory in AD. In this study, we intend to investigate the effects of curcumin in amyloid-β (Aβ1-40) induced AD rat models on both the behavioral and molecular levels, that is to say, on their spatial memory and on the expression of GFAP in their hippocampi. Our results were statistically significant, showing that the spatial memory of AD rats improved following curcumin treatment (p < 0.05), and that the expression of GFAP mRNA and the number of GFAP positive cells in the curcumin treated rats was decreased relative to the AD group rats (p < 0.05). Furthermore, the expression level of GFAP mRNA in hippocampal AS in the AD rats significantly increased when compared with that in the sham control (p < 0.05). Taken together, these results suggest that curcumin improves the spatial memory disorders (such disorders being symptomatic of AD) in Aβ1-40- induced rats by down regulating GFAP expression and suppressing AS activity. © 2013 World Scientific Publishing Company.
Wang N.,Shangqiu Medical College |
Qiu X.Y.,Shangqiu Normal University
Russian Journal of Coordination Chemistry/Koordinatsionnaya Khimiya | Year: 2015
A new dinuclear zinc(II) complex, [Zn2Br2L2] (I), was prepared from 4-methyl-2-[(2-methylaminoethyl-imino)methyl]phenol (HL) with zinc bromide in methanol. Self-assembly of I with ammonium thiocyanate in methanol afforded the mononuclear complex [Zn(L)(HL)]2[Zn(NCS)4] (II). Structures of complexes I, II have been characterized by elemental analysis, IR spectra and single crystal X-ray diffraction (CIF files CCDC nos. 1046617 (I), 1046618 (II)). Complex I possesses a crystallographic two-fold rotation axis symmetry, with Zn···Zn separation of 3.106(1) Å. Complex II contains two mononuclear zinc(II) complex cations and one [Zn(NCS)4] complex anion. The Zn(1) atom in I is in a tetrahedral coordination. The Zn(2) atom in I and the Zn atoms in II are in octahedral coordination. Crystals of I, II complexes are stabilized by hydrogen bonds. © 2015 Pleiades Publishing, Ltd.
Hua Y.X.,Shangqiu Medical College
Advanced Materials Research | Year: 2011
Decision support systems provide the field of query optimization with increasing challenges in the traditional questions of selectivity estimation that can exploit transformations without exploding search space. The aims of this paper are to understand what the data warehouse and protect the sensitive information stored elsewhere in data warehouse. In the system, management level of system can review all records of historical data for monthly or yearly as user desired item for each dimension. This system is developed to easy access for frequently needed data, to improve end-user respond time. The paper results in accumulation of growing amounts of data in operational databases. The system can help to retrieve complex query analysis report. In this paper, we analyze personnel information by using Data Warehouse and OLAP tools. © (2011) Trans Tech Publications, Switzerland.
Liu G.L.,Shangqiu Medical College
Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology | Year: 2010
To explore effects of total glucosides of paeonia (TGP)on the NF-κB/p65 protein expression in paws of rheumatoid arthritis (RA) rats, and the contents of serum TNF-α, IL-1β and IL-10 in RA rats serum. Type II collagen-induced arthritis model in SD rats was established. The expression of NF-κB/p65 proteins in rat, s paw tissues was detected by immunohistochemical staining. The contents of serum TNF-α, IL-1β and IL-10 in RA rats were detected by ELISA. TGP could down-regulate the expression of NF-κB/ p65 protein and contents of TNF-α, IL-1β and IL-10 in RA rats. The inhibitory effect of TGP on anti-inflammation maybe related to decreasing the expression of NF-κB/p65 protein and suppressing the production of TNF-α and IL-1β in RA rats.
Wang Y.-Y.,Zhejiang Agriculture And forestry University |
Li J.-T.,Shangqiu Medical College |
Dai C.-Q.,Zhejiang Agriculture And forestry University |
Zhang J.-F.,Zhejiang University of Media and Communications
Physics Letters, Section A: General, Atomic and Solid State Physics | Year: 2013
In this Letter, we discuss the electron acoustic (EA) waves in plasmas, which consist of nonthermal hot electrons featuring the Tsallis distribution, and obtain the corresponding governing equation, that is, a nonlinear Schrödinger (NLS) equation. By means of Modulation Instability (MI) analysis of the EA waves, it is found that both electron acoustic solitary wave and rogue wave can exist in such plasmas. Basing on the Darboux transformation method, we derive the analytical expressions of nonlinear solutions of NLS equations, such as single/double solitary wave solutions and single/double rogue wave solutions. The existential regions and amplitude of solitary wave solutions and the rogue wave solutions are influenced by the nonextensive parameter q and nonthermal parameter α. Moreover, the interaction of solitary wave and how to postpone the excitation of rogue wave are also studied. © 2013 Elsevier B.V. All rights reserved.