Wu Y.B.,Tongji University |
Zang W.D.,Shanghai JiaoTong University |
Yao W.Z.,Shanghai Zhongye Hospital |
Luo Y.,Tongji University |
And 3 more authors.
Genetics and Molecular Research | Year: 2013
The aim of this study was to identify differentially expressed genes (DEGs) in renal medullary hypertension and reveal their pathogenic mechanisms. We downloaded the gene expression profile of GSE28360 from the Gene Expression Omnibus database. The profile included 14 samples (5 normal and 9 hypertension). The DEGs in normal and disease samples were distinguished with a false-discovery rate threshold of <0.05 and a fold-change value of >2 or <-2. We put the selected genes into the online program String 8.3 to obtain the protein-protein interaction network and selected the hub proteins. These hub proteins were then placed in the PANTHER database to determine hub protein-related pathways and explain their functions. Finally, we cleared up the single-nucleotide polymorphisms (SNPs) of the hub genes via combing with the National Center for Biotechnology SNP database. A total of 13 genes were identified as DEGs between normal and disease samples. Five selected hub proteins, B-cell translocation gene 2 (BTG2), FBJ murine osteosarcoma viral oncogene homolog (FOS), nuclear receptor subfamily 4, group A, member 1 (NR4A1), NR4A member 2 (NR4A2), and NR4A member 3 (NR4A3), were mainly related to angiogenesis and B-cell activation. After SNP analysis, 103, 103, 595, 150, and 493 SNPs were found to correspond to BTG2, FOS, NR4A1, NR4A2, and NR4A3, respectively. Our results suggest that pathways of angiogenesis and B-cell activation may involve in the progression of renal medulla hypertension. © FUNPEC-RP.
Wang S.-C.,Shanghai Zhongye Hospital |
Liu X.-F.,Shanghai Zhongye Hospital |
Yang G.-Q.,Shanghai Zhongye Hospital |
Zhang Y.-Z.,Shanghai Zhongye Hospital |
And 4 more authors.
Chinese Journal of Tissue Engineering Research | Year: 2014
BACKGROUND: At present, the methods of treating unstable comminuted radial head fractures contain open reduction and internal fixation and metal prosthesis replacement. There were success cases treated by the two methods, but some shortcomings simultaneously existed. OBJECTIVE: To compare the clinical therapeutic effects of replacement of the radial head with metal prosthesis with open reduction and internal fixation for the treatment of unstable comminuted radial head fractures. METHODS: A prospective randomized controlled analysis was performed in 45 cases of unstable comminuted radial head fractures. These cases received open reduction and internal fixation and metal prosthesis replacement. This study compared the Broberg and Morrey elbow joint function score and the incidence of complications after fixation, and performed statistical analysis. RESULTS AND CONCLUSION: The subjects were followed up for 1-5 years, averagely 2.8 years. According to Broberg and Morrey scores, the average score was 90.1 and the incidence of complications was 13.6% in the prosthesis replacement group. The average score was 76.8 and the incidence of complications was 47.9% in the open reduction. Significant differences were visible between the two groups(P < 0.01). Compared with the open reduction group, prosthesis replacement for unstable comminuted radial head fractures obtained better joint function and lower incidence of complications. © 2014, Journal of Clinical Rehabilitative Tissue Engineering Research. All rights reserved.
Liu X.-F.,Shanghai Zhongye Hospital |
Fang Y.,Shanghai Zhongye Hospital |
Cao Z.-H.,Shanghai Zhongye Hospital |
Li G.-F.,Shanghai Zhongye Hospital |
Yang G.-Q.,Shanghai Zhongye Hospital
International Journal of Clinical and Experimental Medicine | Year: 2015
Objective: The objective of this study was to investigate the clinical curative effect of stage I repair of acute injuries of the lateral ligament complex of the ankle by the application of suture anchors. Methods: We retrospectively analyzed 18 cases of III degree acute injuries of the lateral ligament complex of the ankle. Results: There were statistically significant differences in preoperative and last follow-up VAS pain scores and AOFAS ankle hind-foot function scores. The X-ray talus displacement values in the anterior drawer test and pressure anteroposterior X-ray talar tilt in the ankle talar tilt test also showed statistically significant differences. Complications occurred in 2 patients, incision surface infection in one, and postoperative lateral dorsal skin numbness in one. All these cases were cured after symptomatic treatment. At the last follow-up all patients’ ankle joint activity recovered to their preinjury function levels. Conclusion: The application of suture anchors for small incision stage I repair of the lateral collateral ligament of ankle joint degree III injury, can effectively restored the stability of ankle joint, and prevent the occurrence of chronic ankle instability complications. It is effective and feasible for the treatment of ankle joint lateral collateral ligament injuries. © 2015, E-Century Publishing Corporation. All rights reserved.