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Huang T.,Shanghai Eighth Peoples Hospital | Hong J.,Shanghai Putuo District Center Hospital | Lin W.,Shanghai Zhabei District Shibei Hospital | Yang Q.,Shanghai Zhabei District Shibei Hospital | And 3 more authors.
PLoS ONE | Year: 2013

Genome-wide association studies have identified 2q35-rs13387042 as a new breast cancer (BC) susceptibility locus in populations of European descent. Since then, the relationship between 2q35-rs13387042 and breast cancer has been reported in various ethnic groups; however, these studies have yielded inconsistent results. To investigate this inconsistency, we performed a meta-analysis of 26 studies involving a total of 101,529 cases and 167,363 controls for 2q35-rs13387042 polymorphism to evaluate its effect on genetic susceptibility for breast cancer. An overall random effects odds ratio of 1.14 (95% CI: 1.11-1.16, P<10-5) was found for rs13387042-A variant. Significant results were also observed using dominant (OR = 1.14, 95% CI: 1.12-1.17, P<10-5), recessive (OR = 1.17, 95% CI: 1.13-1.21, P<10-5) and co-dominant genetic model (heterozygous: OR = 1.15, 95% CI: 1.12-1.19, P<10-5; homozygous: OR = 1.20, 95% CI: 1.15-1.24, P<10-5). There was strong evidence of heterogeneity, which largely disappeared after stratification by ethnicity. Significant associations were found in East Asians, and White populations when stratified by ethnicity; while no significant associations were observed in Africans and other ethnic populations. An association was observed for both ER-positive (OR = 1.17, 95% 1.15-1.19; P<10-5) and ER-negative disease (OR = 1.08, 95% CI: 1.04-1.13; P<10-4) and both progesterone receptor (PR)-positive (OR = 1.18, 95% CI: 1.15-1.21; P<10-5) and PR-negative disease (OR = 1.10, 95% CI: 1.05-1.15; P<10-4). In conclusion, this meta-analysis demonstrated that the A allele of 2q35-rs13387042 is a risk factor associated with increased breast cancer susceptibility. © 2013 Huang et al.

Hong J.,Shanghai Putuo District Center Hospital | Sun J.,Shanghai Zhabei District Shibei Hospital | Huang T.,Shanghai Eighth Peoples Hospital
BioMed Research International | Year: 2013

Aim. To detect the expression pattern of tricho-rhino-phalangeal syndrome-1 (TRPS1) in human colon cancer and to analyze its correlation with prognosis of patients with this disease. Methods. The expressions of TRPS1 in human colon cancer and its corresponding noncancerous colon tissues were detected at both mRNA and protein levels. Results. The mRNA and protein expression levels of TRPS1 were both significantly higher in colon cancer than in corresponding noncancerous colon tissues (both P<0.001). The protein level of TRPS1 in colon cancer tissues was significantly correlated with the mRNA level (r=0.9, P<0.001). Additionally, immunohistochemistry analysis also found increased TRPS1 expression in 63.0% (63/100) of colon cancer tissues. High TRPS1 expression was significantly associated with positive lymph node metastasis (P=0.006) and higher pathological stage (P=0.008) of patients with colon cancer. Multivariate Cox regression analysis further suggested that the increased expression of TRPS1 was an independent poor prognostic factor for this disease. Conclusion. Our data offer the convincing evidence for the first time that the increased expression of TRPS1 may be involved in the pathogenesis and progression of colon cancer. TRPS1 might be a potential marker to predict the prognosis in colon cancer. © 2013 Jun Hong et al.

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