Shanghai Yangpu District Central Hospital

Shanghai, China

Shanghai Yangpu District Central Hospital

Shanghai, China
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Kuang X.,Shanghai Yangpu District Central Hospital | Xu X.,University of Florida | Kan H.,Fudan University
Environmental Pollution | Year: 2014

Few prior cohort studies exist in developing countries examining the association of ambient particulate matter (PM) with mortality. We examined the association of particulate air pollution with mortality in a prospective cohort study of 71,431 middle-aged Chinese men. Baseline data were obtained during 1990-1991. The follow-up evaluation was completed in January, 2006. Annual average PM exposure between 1990 and 2005, including TSP and PM10, were estimated by linking fixed-site monitoring data with residential communities. We found significant associations between PM10 and mortality from cardiopulmonary diseases; each 10 μg/m3 PM 10 was associated with a 1.6% (95%CI: 0.7%, 2.6%), 1.8% (95%CI: 0.8%, 2.9%) and 1.7% (95%CI: 0.3%, 3.2%) increased risk of total, cardiovascular and respiratory mortality, respectively. For TSP, we observed significant associations only for cardiovascular morality. These data contribute to the scientific literature on long-term effects of particulate air pollution for high exposure settings typical in developing countries. © 2013 Elsevier Ltd. All rights reserved.

Yu Q.,Shanghai JiaoTong University | Chen H.,Shanghai Yangpu District Central Hospital | Sheng L.,Shanghai JiaoTong University | Liang Y.,Shanghai JiaoTong University | Li Q.,Shanghai JiaoTong University
International Immunopharmacology | Year: 2014

Acute rejection is a major problem for allograft transplantation in the clinic. Classic immunosuppressive drug therapy is accompanied by a variety of side effects. Therefore, safe and effective immunosuppressive drugs remain in demand. In this study, the effect of sodium tanshinone IIA sulfonate (STS) on prolonging the allogeneic skin graft survival was determined using a rat skin transplantation model. Rat recipients were divided into four groups that received different treatments: physiological saline, STS, CsA, or STS + CsA. The results indicated that the administration of STS alone, CsA alone or combined STS and CsA all significantly promoted skin allograft survival as demonstrated by a longer mean survival time (MST) compared with the control group. This effect was due to the reductions in the infiltration of inflammatory cells into allograft and the percentages of CD4 + T cells and CD8 + T cells in the peripheral blood of rat recipients. The injection of STS could also downregulate the expression of RANTES, IP-10 as well as IL-2, IFN-γ and TNF-α in allograft tissue. STS markedly inhibited the proliferation of mouse spleen T lymphocytes stimulated by mitogen and alloantigen in vitro. Taken together, these results suggest that STS is a widely applicable drug with few complications that may serve as a new therapeutic alternative for allograft rejection or even other Th1 cell-dominated immune diseases. © 2014 Elsevier B.V.

Wang C.,Fudan University | Chen R.,Fudan University | Kuang X.,Shanghai Yangpu District Central Hospital | Duan X.,Chinese Research Academy of Environmental Sciences | Kan H.,Fudan University
Science of the Total Environment | Year: 2014

The evidence concerning the association between ambient temperature and mortality is limited in developing countries, especially in China. We assessed the effects of temperature on daily mortality between 2005 and 2008 in Suzhou, China. A Poisson regression model combined with a distributed-lag nonlinear model was used to examine the association between temperature and daily mortality. We investigated effect modification by individual characteristics, including gender, age and educational attainment. We found significant non-linear effects of temperature on total and cardiovascular mortality. Heat effects were immediate and lasted for 1-2. days, whereas cold effects persisted for 10. days. The relative risk of total morality associated with extreme cold temperature (1st percentile of temperature, -. 0.3. °C) over lags 0-14. days was 1.75 [95% confidence interval (CI): 1.43, 2.14)], compared with the minimum mortality temperature (26. °C). The relative risk associated with extremely hot temperature (99th percentile of temperature, 32.6. °C) over lags 0-3. days was 1.43 (95% CI: 1.31, 1.56). We did not observe significant modifying effect by gender, age or educational level. This study showed that exposure to both hot and cold temperatures was associated with increased mortality in Suzhou. Our findings may have implications for developing intervention strategies for extreme cold and hot temperatures. © 2013 Elsevier B.V.

Wang C.,Fudan University | Zhou X.,Fudan University | Chen R.,Fudan University | Duan X.,Chinese Research Academy of Environmental Sciences | And 2 more authors.
Atmospheric Environment | Year: 2013

The air quality in China's cities has improved in recent years, but its impact on public health has rarely been investigated. This study was aimed at estimating the potential effects of air quality on life expectancy between 2003 and 2010 in China. We collected annual average concentrations of particulate matter less than 10 microns in aerodynamic diameter (PM10) in 113 key cities, covering all provinces in China, along with the national average age-specific mortality from 2003 to 2010. We constructed a cause-eliminated life table after excluding premature deaths attributable to PM10. The annual average PM10 levels in these cities decreased from 125.3μgm-3 in 2003 to 88.3μgm-3 in 2010. As the result, life expectancy loss due to PM10 decreased from 2.13 years in 2003 to 1.30 years in 2010. The estimated life expectancy increase due to PM10 mitigation accounted for 34% of the total increase in life expectancy in the same period. Our results suggested that air quality might have contributed substantially to life expectancy in China. © 2013 Elsevier Ltd.

Zhao A.,Fudan University | Chen R.,Fudan University | Kuang X.,Shanghai Yangpu District Central Hospital | Kan H.,Fudan University
Journal of Epidemiology | Year: 2014

Cardiac arrhythmias are cardiac rhythm disorders that comprise an important public health problem. Few prior studies have examined the association between ambient air pollution and arrhythmias in general populations in mainland China. We performed a time-series analysis to investigate the short-term association between air pollution (particulate matter with an aerodynamic diameter less than 10μm [PM10], sulfur dioxide [SO2], and nitrogen dioxide [NO2]) and outpatient visits for arrhythmia in Shanghai, China. We applied the over-dispersed Poisson generalized additive model to analyze the associations after control for seasonality, day of the week, and weather conditions. We then stratified the analyses by age, gender, and season. Results: We identified a total of 56 940 outpatient visits for cardiac arrhythmia. A 10-μg/m3 increase in the presentday concentrations of PM10, SO2, and NO2 corresponded to increases of 0.56% (95% CI 0.42%, 0.70%), 2.07% (95% CI 1.49%, 2.64%), and 2.90% (95% CI 2.53%, 3.27%), respectively, in outpatient arrhythmia visits. The associations were stronger in older people (aged ≥65 years) and in females. This study provides the first evidence that ambient air pollution is significantly associated with increased risk of cardiac arrhythmia in mainland China. Our analyses provide evidence that the current air pollution levels have an adverse effect on cardiovascular health and strengthened the rationale for further limiting air pollution levels in the city. © 2014 Ang Zhao et al.

Liu B.,Tongji University | Che W.,Tongji University | Yan H.,Tongji University | Zhu W.,Tongji University | Wang H.,Shanghai Yangpu District Central Hospital
Internal Medicine | Year: 2013

Objective Statins prevent cardiovascular events in patients with coronary artery disease (CAD). However, there is little information regarding the vascular effects of statins on arterial wall stiffness in CAD patients. Methods A total of 36 patients were randomly assigned to receive rosuvastatin (10 mg per day) or simvastatin/ezetimibe (10/10 mg per day) for eight weeks. The aim of the present study was to determine the effects of rosuvastatin or simvastatin/ezetimibe on arterial wall stiffness measured according to the brachial and ankle pulse wave velocity (baPWV) in CAD patients. Results Both treatments significantly improved the levels of total cholesterol (TC), triglycerides (TGs), low-density lipoprotein cholesterol (LDL-C) and high-sensitivity C-reactive protein (hs-CRP) (p<0.05). The ROCK activity and baPWV were significantly improved in the rosuvastatin group compared with that ob-served in the simvastatin/ezetimibe group (p<0.05). The changes in baPWV were significantly correlated with the changes in the ROCK activity (r=0.488, p<0.01), but not with the changes in the lipid profile or the hs-CRP level. Conclusion Compared with simvastatin/ezetimibe (10/10 mg), rosuvastatin (10 mg) appears to more effectively improve arterial wall stiffness that may be mediated by modulation of the ROCK activity. © 2013 The Japanese Society of Internal Medicine.

Weng W.,Tongji University | Wang M.,Shanghai Putuo District Central Hospital | Xie S.,Shanghai Yangpu District Central Hospital | Long Y.,Shanghai Yangpu District Central Hospital | And 4 more authors.
Oncology Reports | Year: 2014

Renal cell carcinoma (RCC) is a common urological malignancy. It remains unclear, however, whether Yin Yang 1 (YY1) plays a functional role in the development of human RCC. In the present study, we demonstrated that levels of YY1 were significantly increased in primary RCC tissues when compared to these levels in the matched healthy tissues. YY1 knockdown inhibited cell growth, migration and invasion of RCC cells. Additionally, we highlighted a positive feedback-loop pathway resulting in YY1 upregulation. We observed that overexpression of YY1 caused repression of C/EBPα and the inhibition of C/EBPα led to the suppression of miR-34a. Since YY1 is a direct target of miR-34a, the low level of miR-34a increased the expression of YY1, promoting the aggressiveness of RCC cells. Furthermore, this feedforward mechanism was found in RCC tissues. We observed that miR-34a was downregulated in the pools of cancer tissues when compared to that of the normal tissues. The expression of miR-34a displayed an inverse correlation with YY1, but a positive correlation with C/EBPα. In conclusion, our study highlights the importance of a novel regulatory circuitry for YY1 activation in maintaining the aggressive phenotypes of RCC.

Xue H.,Shanghai YangPu District Central Hospital | Tu Y.,Shanghai YangPu District Central Hospital | Cai M.,Shanghai YangPu District Central Hospital
Spine Journal | Year: 2012

Background context: Transforaminal lumbar interbody fusion (TLIF) has become a well-established technique that is traditionally performed with bilateral pedicle screw (PS) fixation. There are only a small number of case reports of unilateral instrumented TLIF. To our knowledge, there have been few well-designed studies comparing unilateral versus bilateral instrumentation with TLIF. Purpose: To compare clinical and radiographic outcomes in a selected series of patients treated with unilateral versus bilateral PS instrumented TLIF. Study design: Prospective randomized study in one unit. Patient sample: A total of 80 patients were enrolled in this study. Thirty-seven patients (17 men and 20 women; average age 57.1 years) were randomized to the unilateral PS group and 43 patients (18 men and 25 women; average age 58.2 years) to the bilateral PS group. Outcome measures: The demographic data collected from both groups were gender, age, preoperative index diagnosis, degenerated segment, and single/double level of fusion. Operative time, blood loss, hospital time, and implant costs were also evaluated. Postsurgical pain and functional results were analyzed by the visual analog scale (VAS), modified Prolo (mProlo) scores, and Oswestry Disability Index (ODI). Radiographic examinations were carried out to assess total fusion rates, screw failure, and general complications. Methods: Patients were randomized into the unilateral or bilateral PS instrumented TLIF group based on a computer-generated number list. Patients were asked to return to hospital for follow-up at 4 weeks, 3 months, 6 months, 12 months, and thereafter once a year after surgery. Results: The mean follow-up was 25.3 months, with a range of 18 to 32 months. There were no significant differences between the two groups in terms of demographic data. The unilateral PS group had a significantly shorter operative time, less blood loss, and reduced implant costs compared with the bilateral PS group, although hospital time was the same for double-level cases. The average postoperative VAS, mProlo, and ODI scores improved significantly in both groups, with no significant difference between groups. The total fusion rate, screw failure, and general complication rate were not significantly different. Conclusions: Unilateral PS instrumented TLIF is a viable treatment option generating better results, especially in terms of operative time, blood loss, and hospital time for single-level disease and implant costs. No decrease in the fusion rate or increase in the complication rate was observed in this group. Further improved study design and a longer period of follow-up are needed to confirm this effect. © 2012 Elsevier Inc. All rights reserved.

Kuang X.Y.,Shanghai Yangpu District Central Hospital
Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases | Year: 2011

To investigate the clinical manifestation of patients with renal injury induced by chronic mercury intoxication and the application of the diagnostic criteria of occupational mercury poisoning. The clinical data of 8 patients with chronic occupational mercury intoxication were analysed and evaluated. All the observed clinical signs of chronic mercury intoxication correspond with the items of the diagnostic criteria of occupational mercury poisoning. The increasing beta2-MG was one of the clinical manifestations of renal injury induced by chronical mercury intoxication. The renal injury obviously was dose-dependent and reversible. The national diagnostic criteria of occupational mercury poisoning is practically valuable. The renal injury induced by chronic mercury intoxication should not be neglected.

Lu H.Y.,Shanghai Yangpu District Central Hospital
Zhongguo shi yan xue ye xue za zhi / Zhongguo bing li sheng li xue hui = Journal of experimental hematology / Chinese Association of Pathophysiology | Year: 2013

The aim of this study was to investigate the tissue factor (TF) expression of platelets and leukocytes in patients with acute coronary syndrome (ACS), patients with stable angina (SA) and healthy subjects (as controls). 26 patients with ACS, 29 patients with SA, and 25 controls were enrolled in this study. The peripheral blood samples of above-mentioned subjects were collected and isolated to obtain the monocytes and platelet-rich plasma, the TF-mRNA expression of monocytes, and platelets among 3 groups was detected by RT-PCR, the TF expression ratio of platelets, platelet-leukocyte aggregates (PLA) and platelet-monocyte aggregates (PMP) was detected by flow cytometry among 3 groups. The results showed that the TF mRNA expression level of platelets in ACS group were significantly higher (3.11 ± 0.51 relative expression) as compared with SA and control groups (1.88 ± 0.78 and 0.7 ± 0.1, respectively) (P = 0.03). Expression of TF mRNA of monocytes was higher in ACS group (P = 0.05 versus controls) too. ACS group had a significantly higher amount of TF-positive platelets (8.8 ± 2.6) than SA (2.6 ± 0.5, P = 0.02) or control groups (2.5 ± 0.4, P = 0.02). A significantly greater number of TF positive platelet-leukocyte aggregates and platelet-monocyte aggregates were also found by flow cytometry in blood of ACS patients than in either SA patients or controls. It is concluded that the high TF expression of platelets and leukocytes in ACS patients strengthens the platelet activation, blood coagulation, and thrombus formation and may further contribute to the hypercoagulability associated with the disease. The present study further extends the proinflammatory/prothrombotic phenotype of ACS patients showing that new players on the scene.

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