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Chang J.,University of Sichuan | Dong S.-J.,University of Sichuan | She B.,University of Sichuan | Zhang R.-M.,University of Sichuan | And 5 more authors.
Evidence-based Complementary and Alternative Medicine

This study was designed to determine the therapeutic efficacy and safety of the Shi-cha capsule, a Chinese herbal formula, in the treatment of patients with wind-cold type common cold. In our multi-center, prospective, double-blind, randomized, placebo-controlled, dose-escalation trial, patients with wind-cold type common cold received 0.6 g of Shi-cha capsule plus 0.6 g placebo (group A), 1.2 g of Shi-cha capsule (group B), or 1.2 g placebo (group C), three times daily for 3 days and followed up to 10 days. The primary end point was all symptom duration. The secondary end points were main symptom duration, minor symptom duration, the changes in cumulative symptom score, main symptom score, and minor symptom score 4 days after the treatment, as well as adverse events. A total of 377 patients were recruited and 360 met the inclusive criteria; 120 patients constituted each treatment group. Compared with patients in group C, patients in groups A and B had significant improvement in the all symptom duration, main symptom duration, minor symptom duration, as well as change from baseline of cumulative symptom score, main symptom score, and minor symptom score at day 4. The symptom durations and scores showed slight superiority of group B over group A, although these differences were not statistically significant. There were no differences in adverse events. The Shi-cha capsule is efficacious and safe for the treatment of patients with wind-cold type common cold. Larger trials are required to fully assess the benefits and safety of this treatment for common cold. © 2012 Jing Chang et al. Source

Yan M.,Shanghai Punan Hospital | Ye F.,Shanghai University of Traditional Chinese Medicine | Zhang Y.,Shanghai University of Traditional Chinese Medicine | Cai X.,Shanghai Traditional Chinese Medicine Hospital | And 2 more authors.
Journal of Traditional Chinese Medicine

OBJECTIVE: To investigate the potential rules and knowledge of Traditional Chinese Medicine (TCM) and Western Medicine (WM) treatment on chronic urticaria (CU) based on data-mining methods. METHODS: Sixty patients with chronic urticaria, treated with TCM and WM, were selected. Gray correlation analyses were adopted to determine therapeutic efficacy. Association algorithms were utilized to ascertain the correlation between the disease course and treatment results. A genetic algorithm was applied to discover the optimization model in the TCM and WM treatment on CU. RESULTS: The total symptom scores after 4 weeks and 8 weeks of treatment in the TCM spleenstrengthening group correlated highly with the pretreatment total symptom score. The duration of treatment showed the greatest impact on the total symptom score. A quartic equation was established (y=-1.6403×10-6x4 + 0.00025576x3+0.0012819 x2-1.024x+79.5879, and x=106.9518, y=83.0036) using the genetic algorithm. CONCLUSION: TCM treatment had a better effect in the later stage, whereas WM was better in the early stage. The duration of disease course had an impact on the effects of treatment. If the average total symptom score before treatment was ≤ 83.0036, TCM or WM treatment could achieve better efficacy. © 2013 JTCM. All rights reserved. Source

Shen X.,Shanghai Shenkang Hospital Management Center | Zhang T.,Shanghai Traditional Chinese Medicine Hospital | Chen B.,Shanghai Shenkang Hospital Management Center | Chen M.,Shanghai Shenkang Hospital Management Center
Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences

OBJECTIVE: To construct a satisfaction evaluation indicator system based on patients' experiences of medical services.METHODS: A questionnaire was designed by expert interview and literature review and 400 copies were randomly handed out to inpatients and outpatients from five 3A-public hospitals in Shanghai. The patient's evaluation of importance of various factors in medical services was analyzed and the mean and weight of indicators in terms of recognition, importance and evaluation were determined to establish a satisfaction evaluation indicator system.RESULTS: A total of 396 valid questionnaires were retrieved, with an effective response rate of 99%. By analyzing survey data, the patient satisfaction evaluation indicator system was constructed with 5 primary indicators (hospital environment, medical procedures, attitude, and quality of care and patient rights) and 25 secondary indicators (convenient hospital environment, auxiliary facilities, reasonable arrangement, clearly mark, convenient appointment, simple procedures, short time, the attitude of medical staff, solutions of medical dispute, medical technology, treatment, medical equipment, medical expenses, respect, patient privacy, etc.).CONCLUSION: A patient satisfaction evaluation indicator system has been established based on patients' experience of medical services in the study, which may be applicable to measure patients' satisfaction and to improve medical services in hospitals. Source

Wang X.-Y.,Shanghai Traditional Chinese Medicine Hospital | Zhu L.-Y.,Shanghai Traditional Chinese Medicine Hospital
World Chinese Journal of Digestology

Gastroesophageal reflux disease (GERD) is one of the most common digestive system diseases. Although the disease is benign, its symptoms can seriously affect the patient's daily life. The etiology and pathogenesis of GERD are complex. Currently, great progress has been made in the diagnosis of GERD; however, its treatment is still confined to the inhibition of gastric acid secretion, with the use of proton pump inhibitors (PPIs) being the main means of treatment. However, long-term use or discontinued use of PPIs has many disadvantages and limitations. Traditional Chinese medicine based on disease differentiation treatment combined with syndrome differentiation treatment is a comprehensive treatment and has certain advantages in the treatment of GERD. © 2014 Baishideng Publishing Group Co., Limited. All rights reserved. Source

Li Y.,Ningxia Medical University | Zhang J.-J.,Shanghai Traditional Chinese Medicine Hospital | Zhang L.-C.,Ningxia Medical University | Zhu Q.-G.,Shanghai University of Traditional Chinese Medicine | And 2 more authors.
Academic Journal of Second Military Medical University

Objective To evaluate the role of modified microneedle roller in promoting permeation of triamcinolone acetonide across human hyperplastic scar skin. Methods The morphology of human hyperplastic scar skin was visualized by methylene blue staining and H-E staining after the insertion by microneedles of different lengths. The content of triamcinolone acetonide was determined by high performance liquid chromatography (HPLC). The in vivo absorption characteristics across human hyperplastic scar skin were investigated by elution method and the homogenization method at 1 h and 12 h after drug application. Skin irritation was assessed by transepidermal water-loss (TEWL) measurement and laser Doppler flowmetry. Results The preferred microneedle length of 500 µm effectively penetrated through the stratum corneum,and the distribution of the microchannels was homogeneous. It was found that 27. 42% and 60. 64% of the drug administered entered the skin at 1 h and 12 h, respectively. The drug accumulation in the skin at 12 h decreased to 45. 98% of that at 1 h after intracutaneous injection, while the accumulation increased to 2. 73-fold and 4. 18-fold in the microneedle group and direct application of triamcinolone acetonide cream group,respectively,with the content of microneedle group being 3. 56-fold that of the direct cream application group (P<0. 05). Triamcinolone acetonide distribution was not homogeneous at 12 h after intracutaneous injection, with the level being (4. 83 ± 5. 51) µg, while the distribution in the microneedle group was homogenous, with the level being (0.93 ± 0. 14) µg. TEWL results showed no significant difference in skin irritation between microneedle and intracutaneous injection group; however, laser Doppler flowmetry showed that the skin irritation of intracutaneous injection group was 8. 40- fold that of microneedle treatment group. Conclusion Modified microneedle roller treatment followed by cream application, compared with intracutaneous injection, can yield more homogeneous distribution and less skin irritation in human hyperplastic scar skin, but its efficacy for scar treatment remains to be further verified. © 2015, Second Military Medical University Press. All rights reserved. Source

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