Time filter

Source Type

Wang X.-L.,Shanghai Skin Diseases and STD Hospital | Wang H.-W.,Shanghai Skin Diseases and STD Hospital | Yuan K.-H.,General Hospital of Guangzhou Military Command | Li F.-L.,Shanghai University of Traditional Chinese Medicine | And 4 more authors.
Photochemical and Photobiological Sciences | Year: 2011

In dermatology, photodynamic therapy (PDT) has become a well established treatment modality which has been shown to be effective and safe for many skin and mucosal disorders. Pre-clinical and clinical studies demonstrate that, in addition to the direct local cytotoxicity and vascular effects, PDT can induce various host immune responses. Recent clinical data also show that improved clinical outcomes can be obtained through the sequential use of PDT and immunomodulation. This article will provide an update on the current status of such a combination in dermatological applications. © 2011 The Royal Society of Chemistry and Owner Societies.


Ma L.,Fudan University | Xiang L.-H.,Fudan University | Yu B.,Peking University | Yin R.,Chongqing Medical University | And 12 more authors.
Photodiagnosis and Photodynamic Therapy | Year: 2013

Objectives: To investigate the efficacy and safety of low-concentration 5-aminolevulinic acid photodynamic therapy (ALA-PDT) in the treatment of different severity of acne vulgaris and optimize the treatment regimen. Methods: A self-controlled multicenter clinical trial was carried out in 15 centers throughout China. A total of 397 acne patients of grade II-IV received 3- or 4-session PDT treatment. 5% ALA gel was applied topically to acne lesions for 1h incubation. The lesions were irradiated by a LED light of 633nm at dose levels of 96-120J/cm2. Clinical assessment was conducted before and after every treatment up to 8 weeks. Results: The effective rate overall and of grade II, III and IV are 82.1%, 71.6%, 79.6% and 88.2%, respectively. The effective rate rises significantly proportionally to the severity of acne (P<. 0.01). No significant differences are found in the efficacy between patients received 3-session and 4-session PDT treatments (P>. 0.05). The count of inflammatory and non-inflammatory acne lesions gradually decrease after each treatment (P<. 0.01) and during the 8-week follow up (P<. 0.01 or P<. 0.05). Maximum efficacy is obtained at 8 weeks after the treatment completion. Conclusions: A low-dose topical ALA-PDT regimen using 5% ALA, 1. h incubation and red light source of 3 treatment sessions is suggested as optimal scheme for the treatment of different severity of acne vulgaris in Chinese patients. Superior efficacy is found in severe cystic acne of grade IV with mild side effects. © 2013 Elsevier B.V..


PubMed | Shanghai Skin Diseases and STD Hospital, Inner Mongolia Medical College, Jining No 1 Peoples Hospital, Dalian Medical University and 15 more.
Type: | Journal: Nature communications | Year: 2015

Genome-wide association studies (GWASs) have reproducibly associated 40 susceptibility loci with psoriasis. However, the missing heritability is evident and the contributions of coding variants have not yet been systematically evaluated. Here, we present a large-scale whole-exome array analysis for psoriasis consisting of 42,760 individuals. We discover 16 SNPs within 15 new genes/loci associated with psoriasis, including C1orf141, ZNF683, TMC6, AIM2, IL1RL1, CASR, SON, ZFYVE16, MTHFR, CCDC129, ZNF143, AP5B1, SYNE2, IFNGR2 and 3q26.2-q27 (P<5.00 10(-08)). In addition, we also replicate four known susceptibility loci TNIP1, NFKBIA, IL12B and LCE3D-LCE3E. These susceptibility variants identified in the current study collectively account for 1.9% of the psoriasis heritability. The variant within AIM2 is predicted to impact protein structure. Our findings increase the number of genetic risk factors for psoriasis and highlight new and plausible biological pathways in psoriasis.


Gong Z.,Sun Yat Sen University | Lai W.,Sun Yat Sen University | Zhao G.,General Hospital of the Air Force | Wang X.,Shanghai Skin Diseases and STD Hospital | And 6 more authors.
Clinical Drug Investigation | Year: 2015

Background and Objectives: This study aimed to determine the efficacy and safety of fluocinolone acetonide, hydroquinone, and tretinoin (FAHT) cream for the treatment of moderate and severe facial melasma. The primary objective was assessment of clinical efficacy, instrumental measured efficacy, and integral therapeutic efficacy at the end of weeks 4 and 8. Methods: A total of 233 subjects were randomly allocated (1:1 ratio) to receive topically administered FAHT cream (n = 117) or placebo (n = 116) once nightly for 8 weeks. Observed side effects were documented throughout. Results: In the per protocol set (PPS; those subjects who met all requirements of the protocol), the integral therapeutic efficacy rate of FAHT cream on moderate and severe melasma was 68.57 % (vs. placebo, 0.94 %), the clinical effective rate of FAHT cream was 74.29 % (vs. placebo, 0.94 %), and the instrumental measure efficacy of FAHT cream was 71.43 % (vs. placebo, 6.60 %). The difference in efficacy between the two groups was statistically significant (p < 0.001). In the full analysis set (FAS; the PPS and those subjects who were lost to follow-up but received at least one study treatment), the integral therapeutic efficacy rate of FAHT cream was 64.60 % (vs. placebo, 0.88 %), the clinical effective rate of FAHT cream was 69.91 % (vs. placebo, 0.88 %), and the instrumental measure efficacy of FAHT cream was 69.03 % (vs. placebo, 7.08 %). The difference in efficacy between the two groups was statistically significant (p < 0.001). Of 113 subjects in the FAHT group, 34 (30.1 %) reported adverse effects. Most of the pathological adverse effects were mild and resolved with either continuous treatment or discontinuation. Of 113 subjects in the placebo group, three (2.6 %) reported mild adverse effects. No severe adverse effects or other abnormal clinical results were associated with the study treatment. Conclusion: FAHT cream is efficacious, well tolerated, and has a high margin of safety for the treatment of moderate and severe melasma in the Chinese population. © 2015, Springer International Publishing Switzerland.


Liu W.,Air Force General Hospital | Wang X.,Shanghai Skin Diseases and STD Hospital | Lai W.,Sun Yat Sen University | Yan T.,Air Force General Hospital | And 4 more authors.
Photodermatology Photoimmunology and Photomedicine | Year: 2012

Background: Sunscreens are an important component of healthy sun-protection behavior. To achieve satisfactory protection, sunscreens must be applied consistently, evenly and correctly. Consumers do not apply sunscreen properly and, therefore, do not achieve the protection indicated by the label 'sun protection factor' (SPF). The objective of the present study was to determine the actual sun(burn) protection given by a range of sunscreen application thickness levels for both low and high SPF formulas. Subjects and Methods: Forty study subjects were recruited from each of three geographical regions in China. Sunscreens with label SPFs of 4, 15, 30, and 55 were tested at application levels of 0.5, 1.0, 1.5, and 2.0mg/cm 2 in three laboratories using a standard SPF protocol. Results: Sunscreens with lower SPFs (4 and 15) showed a linear dose-response relationship with application level, but higher SPF (30 and 55) product protection was exponentially related to application thickness. Conclusion: Sunscreen protection is not related in one uniform way to the amount of product applied to human skin. Consumers may achieve an even lower than expected sunburn protection from high SPF products than from low SPF sunscreens. © 2012 John Wiley & Sons A/S.


Glazner G.F.,University of Colorado at Denver | Lei T.C.,University of Colorado at Denver | Scherrer L.,University of Colorado at Denver | Pendyala S.,University of Colorado at Denver | And 5 more authors.
Progress in Biomedical Optics and Imaging - Proceedings of SPIE | Year: 2010

We report on some of the optical properties of hematoporphyrin monomethyl ether (HMME), a relatively new photosensitizer that has been in clinical trials in China since the early 1990s. We characterized the photosensitizer on the basis of one photon absorption and emission. In addition, the effects of photobleaching were probed to characterize its decay kinetics. © 2010 Copyright SPIE - The International Society for Optical Engineering.


Chen J.,Shanghai Skin Diseases and STD Hospital | Song X.,Shanghai Skin Diseases and STD Hospital | Song N.-J.,Shanghai Skin Diseases and STD Hospital | Zhang C.-G.,Shanghai Skin Diseases and STD Hospital | And 2 more authors.
Journal of Clinical Dermatology | Year: 2013

A case of adult Spitz nevus is reported. A 21-year-old male presented with a nodule on the left leg for 2 months. The histopathologic examination showed a symmetrical eosinophil clusters in the dermis. Nests of epithelioid and spindle cells without pigment extended focally into the epidermis, with Kamino bodies along the dermo-epidermal junction. Vascular proliferation was evident between cell masses in upper dermis. Cells had regular shape. Immunohistochemical staining confirmed the melanocytic origin of nevus. The diagnosis of Spitz nevus was made.


Wang X.-L.,Shanghai Skin Diseases and STD Hospital | Wang H.-W.,Shanghai Skin Diseases and STD Hospital | Zhang L.-L.,Shanghai Skin Diseases and STD Hospital | Guo M.-X.,Shanghai Skin Diseases and STD Hospital | Huang Z.,Shanghai Skin Diseases and STD Hospital
Photodiagnosis and Photodynamic Therapy | Year: 2010

Objectives: To evaluate the effectiveness of topical 5-aminolevulinic acid (ALA)-medicated photodynamic therapy (PDT) for the treatment of severe acne vulgaris. Methods: A total of 78 Chinese patients with Grade 4 severe facial acne were treated with 1-3 courses of ALA PDT. ALA cream (10%) was applied topically to acne lesions for 3 h. The lesions were irradiated by a LED light of 633 nm at dose levels of 50-70 J/cm2 at 66 mW/cm2. Clinical assessment was conducted before and after treatment up to 6 months. Results: 22% of patients showed excellent improvement after one-course treatment and another 34% showed excellent improvement after two-course. The rest (44%) required three-course treatment to further reduce the number and size of residual lesions. Adverse effects were minimal. The symptoms and signs in recurrent cases (14%) were much milder and responded well to conventional topical medication. Conclusions: ALA PDT is a simple, safe and effective therapeutic option for the treatment of severe acne. Further studies to fully understand its mechanisms and optimize its effectiveness are needed. © 2010 Elsevier B.V. All rights reserved.


PubMed | Shanghai Skin Diseases and STD Hospital
Type: Clinical Trial | Journal: Photodiagnosis and photodynamic therapy | Year: 2010

To evaluate the effectiveness of topical 5-aminolevulinic acid (ALA)-medicated photodynamic therapy (PDT) for the treatment of severe acne vulgaris.A total of 78 Chinese patients with Grade 4 severe facial acne were treated with 1-3 courses of ALA PDT. ALA cream (10%) was applied topically to acne lesions for 3 h. The lesions were irradiated by a LED light of 633 nm at dose levels of 50-70 J/cm(2) at 66 mW/cm(2). Clinical assessment was conducted before and after treatment up to 6 months.22% of patients showed excellent improvement after one-course treatment and another 34% showed excellent improvement after two-course. The rest (44%) required three-course treatment to further reduce the number and size of residual lesions. Adverse effects were minimal. The symptoms and signs in recurrent cases (14%) were much milder and responded well to conventional topical medication.ALA PDT is a simple, safe and effective therapeutic option for the treatment of severe acne. Further studies to fully understand its mechanisms and optimize its effectiveness are needed.


PubMed | Shanghai Skin Diseases and STD Hospital
Type: Journal Article | Journal: Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology | Year: 2011

In dermatology, photodynamic therapy (PDT) has become a well established treatment modality which has been shown to be effective and safe for many skin and mucosal disorders. Pre-clinical and clinical studies demonstrate that, in addition to the direct local cytotoxicity and vascular effects, PDT can induce various host immune responses. Recent clinical data also show that improved clinical outcomes can be obtained through the sequential use of PDT and immunomodulation. This article will provide an update on the current status of such a combination in dermatological applications.

Loading Shanghai Skin Diseases and STD Hospital collaborators
Loading Shanghai Skin Diseases and STD Hospital collaborators