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Yan Z.-Y.,Fudan University | Gu M.-J.,Fudan University | Zhong B.-L.,Huazhong University of Science and Technology | Wang C.,Fudan University | And 4 more authors.
Journal of Psychosomatic Research | Year: 2013

Objective: To investigate the prevalence, risk factors and recognition rates of depressive disorders among inpatients of tertiary general hospitals in Shanghai, China. Methods: A total of 784 inpatients were randomly selected from three tertiary general hospitals and evaluated with a Chinese version of the Mini International Neuropsychiatric Interview 5.0 by ten trained psychiatrists. A questionnaire, containing socio-demographic and clinical data, and a social support scale were also administered to subjects during the course of the clinical interview. Logistic regression was used to identify factors that were associated with depression. Results: The current prevalence rates (95% confidence intervals) of any depressive disorder and major depressive disorder (MDD) were found to be 13.1% (10.7%-15.5%) and 6.9% (5.1%-8.7%), respectively. The risk factors for depression included poor marital status, living alone or with others, lack of medical insurance, poor or very poor self-rated physical health, hospitalization in the internal medicine department, and a subjective support score ≤ 23. Only 18.5% of the patients with current MDD were detected. Conclusion: Depression, especially MDD, has been a major mental health problem for Chinese tertiary general hospitals. There is an urgent need for the development of efficacious hospital-based consultation-liaison psychiatry programs aimed at improving Chinese physicians' recognition and ability to manage inpatient depression. © 2013.

Xu J.,Soochow University of China | Park K.-W.,Korea University | Kang Q.-L.,Shanghai Sixth Peoples Hospital | Jung Y.-J.,Korea University | Song H.-R.,Korea University
Clinical Orthopaedics and Related Research | Year: 2013

Background: Radiographic measurements are typically used in achondroplasia (ACH) during correction of lower limb alignment. However, reliabilities for the measurements on weightbearing radiographs of the foot and ankle in patients with ACH have not been described, and the differences between the ACH population and subjects without ACH likewise have not been well characterized; these issues limit the use of studies on this subject. Questions/purposes: We proposed (1) to measure the inter- and intraobserver reliability of a number of radiographic measures of ankle and foot alignment in an achondroplastic cohort of patients; and (2) to compare our radiographic measurement values with age-matched literature-based normative values. Methods: Ten radiographic measurements were applied to foot and ankle radiographs of 20 children (40 feet) with ACH (mean age, 10 years; range, 8-16 years). Interobserver and intraobserver reliabilities of these radiographic measurement methods were obtained and expressed by intraclass correlation coefficients (ICCs). The mean values were calculated and compared with the literature-based values. Results: The interobserver reliability was excellent for eight measurements with ICCs ranging from 0.801 to 0.962, except for lateral talo-first metatarsal angle and mediolateral column ratio, which were much lower. The intraobserver reliability was excellent for all 10 radiographic measurements with ICCs ranging from 0.812 to 0.998. Compared with existing literature-based values, all 10 measurements had a significant difference (p < 0.01). Conclusions: We suggest tibiotalar angle, calcaneal pitch angle, tibiocalcaneal angle, talocalcaneal angle, naviculocuboid overlap, talonavicular coverage angle, metatarsal stacking angle, and AP talo-first metatarsal angle with excellent interobserver and intraobserver reliabilities should be considered preferentially in analysis of foot and ankle alignment in children with ACH. Level of Evidence: Level II, diagnostic study. See Guidelines for Authors for a complete description of levels of evidence. © 2013 The Association of Bone and Joint Surgeons®.

Hu J.-D.,Soochow University of China | Tang H.-Q.,Chinese Academy of Sciences | Zhang Q.,Shanghai JiaoTong University | Fan J.,Shanghai JiaoTong University | And 3 more authors.
World Journal of Gastroenterology | Year: 2011

AIM: To gain new insights into tumor metabolism and to identify possible biomarkers with potential diagnostic values to predict tumor metastasis. METHODS: Human gastric cancer SGC-7901 cells were implanted into 24 severe combined immune deficiency (SCID) mice, which were randomly divided into metastasis group (n = 8), non-metastasis group (n = 8), and normal group (n = 8). Urinary metabolomic information was obtained by gas chromatography/mass spectrometry (GC/MS). RESULTS: There were significant metabolic differences among the three groups (t test, P < 0.05). Ten selected metabolites were different between normal and cancer groups (non-metastasis and metastasis groups), and seven metabolites were also different between non-metastasis and metastasis groups. Two diagnostic models for gastric cancer and metastasis were constructed respectively by the principal component analysis (PCA). These PCA models were confirmed by corresponding receiver operating characteristic analysis (area under the curve = 1.00). CONCLUSION: The urinary metabolomic profile is different, and the selected metabolites might be instructive to clinical diagnosis or screening metastasis for gastric cancer. © 2011 Baishideng. All rights reserved.

Chen J.,Zhejiang Hospital | Chen Y.,Shanghai Sixth Peoples Hospital | Luo Y.,Zhejiang Hospital | Gui D.,Shanghai Sixth Peoples Hospital | And 2 more authors.
European Journal of Pharmacology | Year: 2014

Podocyte loss and dysfunction play key role during the development of diabetic nephropathy (DN). The aim of this study was to observe the protective effects of astragaloside IV on podocyte in diabetic rats and explore its mechanisms preliminary. Healthy male Sprague-Dawley (SD) rats were randomized into normal control group, diabetic nephropathy group and diabetic nephropathy with AS-IV treatment group. DN was induced by intraperitoneal injection of streptozotocin (STZ). AS-IV treatment started 2 weeks before STZ injection and lasted 14 weeks. 24 h Urinary proteins were measured 4, 8 and 12 weeks after STZ injection. Body weight, blood glucose, blood urea nitrogen (BUN), creatinine (Cr), alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were measured 12 weeks after STZ injection. Renal pathology, podocyte morphological changes, podocyte density, protein and mRNA expression of integrin α3, integrin β1 and integrin-linked kinase (ILK) were detected by histopathology, electron microscopy, immunohistochemistry, western blot and real-time PCR, respectively. Hyperglycemia, proteinuria, mesangial expansion and podocyte loss, increased protein expression of ILK and decreased protein expression of integrin α3 and integrin β1 were detected in diabetic rats. AS-IV treatment ameliorated podocyte loss, renal histopathology and podocyte foot process effacement, decreased proteinuria, partially restored protein expression of integrin α3, integrin β1 and ILK. These findings suggested that AS-IV may protect podocyte and ameliorate diabetic nephropathy by inhibiting the expression of ILK and restoring the expression of integrin α3β1 in diabetic rats. © 2014 Elsevier B.V.

Liu W.,Shanghai Sixth Peoples Hospital | Zhou D.,Shandong University | Liu F.,Massachusetts General Hospital | Weaver M.J.,Brigham and Womens Hospital
Journal of Trauma and Acute Care Surgery | Year: 2013

BACKGROUND: The Trochanteric Fixation Nail System (TFN) was designed with a helical blade to improve resistance to cutout. We evaluated the incidence, modes, and predictors of failure for intertrochanteric hip fractures treated with this device. METHODS: A retrospective review of 341 intertrochanteric hip fractures treated with the TFN was conducted. Fractures were classified from the injury films using the Arbeitsgemeinschaft für Osteosynthesefragen/ Orthopedic Trauma Association (AO/OTA) classification, and quality of reduction and hardware placement was evaluated on the initial postoperative films. RESULTS: Two hundred twenty-three patients met inclusion criteria. The overall rate of mechanical complications was 20.5%. Twenty-one patients (9.4%) had excessive lateral migration of the helical blade (≥10 mm). Fifteen patients (6.7%) had blade migration in the head, including 7 patients (3.1%) with typical cutout and 8 patients (3.6%) with medial perforation without loss of reduction. Three patients (1.3%) sustained a femoral shaft fracture at the tip of the nail. The quality of calcar reduction was significantly predictive of all modes of failure (p < 0.05), except femoral shaft fracture at the nail tip. CONCLUSION: The most common mechanical complication was lateral migration of the helical blade; however, this rarely led to a clinical problem. Medial migration of the blade in the head without loss of reduction was the second most frequent complication. We have identified a new complication associated with the TFN, that is, medial perforation without loss of reduction. Blade migration in the head was less frequent when blades were placed inferiorly with a tip-apex distance of at least 15 mm. LEVEL OF EVIDENCE: Therapeutic study, level IV. Copyright © 2013 Lippincott Williams & Wilkins.

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