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Liu J.-X.,Shanghai Ruijin Hospital Group | Yin X.-F.,Shanghai Ruijin Hospital Group | Xu J.,Shanghai Ruijin Hospital Group
Journal of Shanghai Jiaotong University (Medical Science) | Year: 2010

Objective: To investigate die clinical application of minimally invasive fixation of complex proximal tibia fractures by uniaxial and polyaxial locking plates. Methods: The clinical data of 38 patients with minimally invasive fixation of complex proximal tibia fractures by uniaxial (n = 21) and polyaxial (n = 17) locking plates from January 2008 to June 2009 were retrospectively analysed, and the union rates and function recovery were compared between groups. Results: All patients were followed up for 3 to 20 months, with an average of 12 months. All patients had bone union. The time of fracture union for fixation by uniaxial locking plates was 10 to 20 weeks, with an average of 14 weeks; and that for fixation by polyaxial locking plates was 11 to 18 weeks, with an average of 13 weeks. Evaluated by Johner-Wruhs method, there were 14 "excellent" cases, 5 "better" cases, 2 "good" cases and 0 "poor" case for fixation by uniaxial locking plates (rate of "excellent and better", 90.4%), and there were 11 "excellent" cases, 5 "better" cases, 1 "good" case and 0 "poor" case for fixation by polyaxial locking plates (rate of "excellent and better", 94.1%). Conclusion: Minimally invasive fixation of complex proximal tibia fractures by uniaxial and polyaxial locking plates is stable, has less effects on bone blood supply, high bone union rate and favourable function recovery, and is an effective way in the treatment of complex proximal tibia fractures. Fixation by uniaxial locking plate has a better mechanical intensity, while fixation by polyaxial locking plate can adjust the screw angle according to fracture situation, which can be clinically applied accordingly. Source


Deng X.,Shanghai Ruijin Hospital Group | Zhang Z.,Shanghai Ruijin Hospital Group | Gu W.,Shanghai Ruijin Hospital Group | Li Y.,Shanghai Ruijin Hospital Group | Liu M.,Shanghai Ruijin Hospital Group
Experimental Lung Research | Year: 2012

Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory disorder of the lung, and is the fifth leading cause of morbidity worldwide. A novel proinflammatory factor, interleukine-32 (IL-32), is suggested as a risk factor of COPD. Budesonide is widely used for COPD treatment as anti-inflammatory drug. However, the inflammatory inhibition mechanism of budesonide is not fully understood. In this study, we used a rat model with COPD to investigate the effect of budesonide on IL-32 expression in lung tissue. We found that cigarette smoking (CS) strongly induced IL-32 expression in lung tissue, seriously weakened lung function, and damaged pulmonary tissue. Budesonide inhibited the expression of IL-32 in lung tissue. In budesonide-treated rats, we observed no repair of damaged lung tissue but the pulmonary function was partly recovered. To our knowledge, this is the first report that budesonide inhibits the expression of IL-32 in lung tissues, which is strongly induced by CS. © Informa Healthcare USA, Inc. Source


Xinsheng Z.,Shanghai Ruijin Hospital Group | Zhang Y.,Shanghai Ruijin Hospital Group | He J.,Shanghai Ruijin Hospital Group | Wang H.,Shanghai Ruijin Hospital Group | And 2 more authors.
Chinese Journal of Andrology | Year: 2010

Objective: To study the expression of Trp-p8 protein in prostate tissues of PC patients with PSA value in "gray district" and explore its role in early diagnosis of prostate cancer. Methods: The expression of Trp-p8 was detected in prostate tissues of 28 PC patients, including 14 prostate cancers and 14 benign prostatic hyperplasias, with PSA value in "gray district" by Immunohistochemistry. The difference of expression level was judged and analyzed. Results: The expression of Trp-p8 was weak or negative in prostate tissues of the benign prostatic hyperplasia group, whereas it appeared much more positive in prostate cancer group. There was a significant difference in the expression of Trp-p8 between these two groups. Conclusion: The expression of Trp-p8 in prostate tissues of PC patients with PSA in "gray district" was higher than that in benign prostatic hyperplasia patients. It implied that Trp-p8 might become a potential biomarker in early diagnosis of prostate cancer. Source

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