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Yang R.,Shanghai University of Sport | Yang R.,Research Station of Sport Science | Shen X.,Shanghai Research Institute of Sport Science | Wang Y.,Shanghai University of Sport | And 8 more authors.
Journal of Strength and Conditioning Research | Year: 2017

Yang, R, Shen, X, Wang, Y, Voisin, S, Cai, G, Fu, Y, Xu, W, Eynon, N, Bishop, DJ, and Yan, X. ACTN3 R577X gene variant is associated with muscle-related phenotypes in elite Chinese sprint/power athletes. J Strength Cond Res 31(4): 1107-1115, 2017 - The ACTN3 R577X polymorphism (rs1815739) has been shown to influence athletic performance. The aim of this study was to investigate the prevalence of this polymorphism in elite Chinese track and field athletes, and to explore its effects on athletes' level of competition and lower-extremity power. We compared the ACTN3 R577X genotypes and allele frequencies in 59 elite sprint/power athletes, 44 elite endurance athletes, and 50 healthy controls from Chinese Han origin. We then subcategorized the athletes into international level and national level and investigated the effects of ACTN3 genotype on lower-extremity power. Genotype distribution of the sprint/power athletes was significantly different from endurance athletes (p = 0.001) and controls (p < 0.001). The frequency of the RR genotype was significantly higher in international-level than that in the national-level sprint/power athletes (p = 0.004), with no international-level sprint/power athletes with XX genotype. The best standing long jump and standing vertical jump results of sprint/power athletes were better in the RR than those in the RX + XX genotypes (p = 0.004 and p = 0.001, respectively). In conclusion, the ACTN3 R577X polymorphism influences the level of competition and lower-extremity power of elite Chinese sprint/power athletes. Including relevant phenotypes such as muscle performance in future studies is important to further understand the effects of gene variants on elite athletic performance. © 2017 National Strength and Conditioning Association.

Yang R.-Y.,Shanghai University of Sport | Yang R.-Y.,Research Station of Sports Science | Wang Y.-B.,Shanghai University of Sport | Wang Y.-B.,Shanghai East Hospital | And 2 more authors.
Chinese Journal of Tissue Engineering Research | Year: 2014

Background: Human has a high level heritability in physical performance. With the development of technology and test method in molecular biology, the researchers of sport science are concerned with the influence of gene variation on the elite athlete performance. They begin to know the important value of gene on predicting the physical performance. Objective: To review the research results in the field of gene polymorphisms and elite athlete performance and to expatiate the problems in these researches, thereby offering some proposals. Methods: A computer-based online research of PubMed and CNKI databases was performed to collect articles published from 1998 to 2013 with the key words "elite athlete performance, gene polymorphisms, endurance, power, training response" in Chinese and English. There were 150 articles after the initial survey. A total of 80 articles were included according inclusion and exclusion criteria. Results and Conclusion: The researches of this field are mainly focused on the three aspects: elite endurance performance, elite power performance, and training response, which are associated with gene polymorphisms. The main genes related to elite endurance performance are ACE, mtDNA, PPAR, ADR, GNB3, NRF2, etc. The main genes related to elite power performance are ACTN3, ACE, GDF-8, IL-6, HIF-1, etc. The main genes related to training response are HBB, TFAM, NRF2, AR, FECH, etc. Several gaps in the current researches have been identified including small sample size of most athletic cohorts, lack of corroboration with replication cohorts of different ethnic backgrounds. The numerous research findings can be applied to the gene selection of athletes by creating some kinds of algorithms and models.

Yang R.,Shanghai University of Sport | Shen X.,Shanghai Research Institute of Sport Science | Wang Y.,Shanghai University of Sport | Wang Y.,Shanghai East Hospital | And 3 more authors.
Medicina dello Sport | Year: 2016

BACKGROUND: The ACTN3 gene polymorphism (rs1815739) has been identiied as one of the most important genetic variations in physical performance, especially in power performance. The main aim of the present study was to investigate the genotype distribution and the allele frequencies of the ACTN3 R577X polymorphism in Chinese elite athletes and to study the inluence of ACTN3 R577X variation on the same subjects. METHODS: Our study involved 102 elite athletes, and 150 healthy controls of Chinese Han nationality. Genomic DNA was extracted from the mouth mucosa of participants and genotyping was conducted by multiplex SNaPshot technology. RESULTS: The genotype distribution and the allele frequencies of elite athletes were found to be signiicantly different from the group of controls. Furthermore, the elite athletes were divided into power and endurance athletes according to the characteristic of the sport. The genotype distribution of power athletes was signiicantly different from endurance athletes and controls. The allele frequencies of power athletes were signiicantly different from that of endurance athletes and controls. CONCLUSIONS: The present study shows that the XX genotype is disadvantageous for power performance and the ACTN3 R577X polymorphism is associated with the elite athletic status, especially with power performance in Chinese athletes.

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