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Liao C.,Kunming Medical University | Zheng R.,Kunming Medical University | Wei C.,Shanghai Qisheng Biological Preparation Co. | Yan J.,Kunming Medical University | And 4 more authors.
Magnetic Resonance Imaging | Year: 2016

Purpose: To observe the longitudinal changes in peripheral nerve repaired with chitosan conduits in a rat model of radiation-induced neuropathy. Materials and methods: Four months after 40 Gy radiation to the right lower limbs, forty-two rats were divided randomly into three groups. Chitosan conduits were implanted with (group A, n=12) or without (group B, n=12) mesenchymal stem cells (MSCs), and untreated controls (group C, n=12). Following sciatic nerve MR imaging (including T2WI and Gd-DTPA enhanced T1WI), functional evaluation and electrophysiological exam were performed two-monthly, final histological assessments were done at the end of one year. The differences among the experimental and control groups were statistically analysed with Fisher's PLSD or t-test. Results: The compound muscle action potentials (CMAPs) and sciatic function index (SFI) had declined since 4 months after radiation injury. The focal nerve enlargement and hyperintensity, the perineurium and connecting muscle enhancement were demonstrated by MR neurography images. After chitosan tube implantation, the normalized signal intensities (SIs) in group A were declined more rapidly than SIs in other groups. The histological assessments indicated that group A had better remyelination, combined with higher CMAPs amplitude and SFI score than other groups. Conclusion: A single fraction dose of 40 Gy can be used to establish a rat model of sciatic nerve injury. Longitudinal electrophysiological examination and MR neurography are useful to evaluate the post-irradiation sciatic neuropathy. The rats with tissue-engineered conduits implantation showed some improvement of lower limb function, accompanied by a normalization of (T1W/T2W) MR signal. © 2015 Elsevier Inc. Source


Jiang L.,Shanghai Qisheng Biological Preparation Co.
Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery | Year: 2013

To verify the technics of inactivating/removing virus in collagen sponge derived from bovine Achilles tendon. Possible pathogen species were determined according to the raw material of bovine Achilles tendon used in production, then vesicular stomatitis virus (VSV), theiler's mouse encephalomyelitis virus (TEMV), pseudorabies virus (PRV), and simian vacuolating virus 40 (SV40) were selected as indicator virus. Virus suspension was prepared in accordance with Technical Standard for Disinfection. 60Co radiation 25 kGy of collagen sponge was determined as inactivating/removing virus process according to the analysis of the manufacture process, the virus inactivation/removal effect was verified by the measurement of median tissue culture infective dose (TCID50) and showed by virus reduction factor (sample average values of numerical difference before and after processing). Reduction factors of VSV, TEMV, PRV, and SV40 after 60Co radiation 25 kGy were 5.646, 4.792, 5.042, and 5.292 logTCID50/0.1 mL (logs), respectively. Reduction factor of each indicator virus was greater than 4 logs, showing that 60Co irradiation 25 kGy can effectively inactivate and remove viruses. 60Co radiation 25 kGy of collagen sponge derived from bovine Achilles tendon can be used as the technics of inactivating/removing virus during the preparation process of collagen sponge to guarantee the safety of the product. Source


Trademark
Shanghai Qisheng Biological PreparationCo. Ltd and Shanghai Qisheng Biological Preparation; Co. | Date: 2013-02-12

Medicines for human purposes for the treatment of diseases of eyes, namely, cataracts, glaucoma and myopia; preparations for the treatment of callouses; mineral salts for medical purposes; pastilles for pharmaceutical purposes for the treatment of diseases of eyes, namely, cataracts, glaucoma and myopia; biological preparations for medical purposes for the treatment of diseases of eyes, namely, cataracts, glaucoma and myopia; medical preparations in the form of tablets for the treatment of diseases of eyes, namely, cataracts, glaucoma and myopia; eye-wash; lotions for pharmaceutical purposes for the treatment of diseases of eyes, namely, cataracts, glaucoma and myopia; medicated bath preparations; sterilising preparations. Nursing appliances, namely, tonometers and eye flushers as surgical aid in ophthalmic anterior and posterior segment surgical procedure to create and maintain the anterior chamber; fluid injectors for medical purposes; medical apparatus and instruments, namely, ophthalmic viscoelastic device used in ophthalmic anterior and posterior segment surgical procedure; ophthalmometers; opthalmoscopes; balling guns for veterinary purposes; apparatus for use in medical analysis, namely, apparatus for intraocular pressure; ophthalmic instruments for use in surgery; artificial eyes; lenses for surgical implantation.


Trademark
Shanghai Qisheng; Biological Preparation Co. | Date: 2014-09-26

Nursing appliances; syringes for medical purposes; medical apparatus and instruments; ophthalmometers; ophthalmoscopes; balling guns; apparatus for use in medical analysis; ophthalmic apparatus; artificial eyes; lenses intraocular prostheses for surgical implantation.


Zhu B.,Donghua University | Zhu B.,Shanghai Qisheng Biological Preparation Co. | Wei C.,Shanghai Qisheng Biological Preparation Co. | Hou C.,Shanghai University | And 2 more authors.
E-Polymers | Year: 2010

The insolubility in neutral condition is a major problem that confronts the further development of processing and uses of chitosan. Special emphasis has been put on the chemical modification of chitosan to explore its full potential. Studies on these methods are also encouraging and many kinds of water-soluble and alcohol-soluble derivatives have been prepared. In this article, hydroxybutyl chitosan, a new type of thermosensitive polymer, was prepared through the chemical modification of 1,2-epoxybutane. According to the FT-IR spectra, hydroxybutyl chitosan has the same basic structure as chitosan, and hydroxylbutyl group has been linked in the main chain. XRD shows that the solubility of hydroxybutyl chitosan has been improved. Hydroxybutyl chitosan solution underwent sol/gel phase transition at a certain temperature lower than 20 °C, however, at high temperature, hydroxybutyl chitosan can form hydrogel with a certain mechanical strength. Hydroxybutyl chitosan could be an ideal thermosensitive material which can be applied in drug delivery system. Source

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