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Sun J.,Pudong District Gongli Hospital | Yang W.,Shanghai JiaoTong University | Zhu Y.,Shanghai City Second Peoples Hospital | Liu X.,Shanghai Putuo District Peoples Hospital | And 4 more authors.
Journal of Clinical Hypertension | Year: 2014

To study the relationship between nocturnal blood pressure (BP) variation and spontaneous intracerebral hemorrhage (ICH) among Chinese hypertensive patients and its clinical significance, the authors retrospectively screened 371 patients with primary hypertension (189 patients with ICH, 182 patients without ICH) in Shanghai and analyzed their demographics, clinical information, nocturnal blood pressure variability and medication. Compared with the control group, the levels of blood glucose, triglycerides, and creatinine were significantly increased in the ICH group, along with a marked reduction in nocturnal BP drop (P<.05). Multivariate logistic regression indicated that blood glucose, creatinine, and nocturnal mean arterial pressure were risk factors for ICH, and the magnitude of nocturnal BP drop was negatively related to the risk for ICH. There was no significant difference in the prevalence of reverse dippers between the large hematoma volume group and the small hematoma volume group (χ2=2.529, P=.112), nor among the patients taking angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, or calcium channel blockers (χ2=1.981, P=.371). Reverse dipping is associated with the risk for ICH, suggesting that appropriate antihypertensive drug and chronotherapy might be effective to normalize the rhythm of abnormal circadian variation in hypertensive patients. © 2014 Wiley Periodicals, Inc. Source


Guo L.,East China Normal University | Wang Y.,East China Normal University | Zheng Y.,East China Normal University | Huang Z.,East China Normal University | And 4 more authors.
Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences | Year: 2016

A capillary electrophoresis approach with capacitively coupled contactless conductivity detection method has been developed for the determination of inorganic metabolites (thiocyanate, nitrite and nitrate) in human saliva. Field amplified sample injection, as a simple sample stacking technique, was used in conjunction for online preconcentration of above inorganic anions. A selective separation for the target anions from other coexisting constituents present in saliva could be obtained within 14 min in a 10 mmol/L His-90 mmol/L HAc buffer (pH 3.70) at the separation voltage of -18 kV. The limits of detection and limits of quantification of the three analytes were within the range of 3.1-4.9 ng/mL (S/N = 3) and 10-16 ng/mL (S/N = 10), respectively. The average recovery data were in the range of 81-108% at three different concentrations. This method provides a simple, rapid and direct approach for metabolite analyses of nitric oxide and cyanide based on noninvasive saliva sample, which presents a potential fast screening tool for clinical test. © 2016 Elsevier B.V. Source


Shi J.,University of Science and Technology Beijing | Shi J.,Harvard University | Hang J.-Q.,Shanghai Putuo District Peoples Hospital | Mehta A.J.,Harvard University | And 7 more authors.
American Journal of Respiratory and Critical Care Medicine | Year: 2010

Rationale: The degree to which chronic respiratory health effects caused by exposures to cotton dust and endotoxin is reversible after cessation of textile work is unknown. Objectives: To investigate changes in lung function and respiratory symptoms after cessation of textile work and to determine whether past exposure to cotton dust and endotoxin or smoking history modify the associations. Methods: We performed a prospective cohort study consisting of 447 cotton textile workers exposed to cotton dust and 472 unexposed silk textile workers, with a 25-year follow-up. Spirometry testing and respiratory questionnaires were conducted at 5-year intervals. Generalized estimated equations were used to model the average 5-year change in FEV1 and odds ratios of respiratory symptom prevalence. Measurements and Main Results: Years since cessation of textile work was positively associated with 11.3 ml/yr and 5.6 ml/yr gains in 5-year FEV1 change for cotton and silk workers, respectively. Among male cotton workers, smokers gained more FEV 1 per year after cessation of exposure than did nonsmokers, and the risk of symptoms of chronic bronchitis and byssinosis was larger for smoking than for nonsmoking male cotton workers. Conclusions: Cessation of textile work was significantly associated with improvement in lung function and respiratory symptoms. The positive effect of work cessation was greater for cotton workers than for silk workers. For cotton workers, the improvement in lung function loss after cessation of textile work was greater among smokers, but no differences were observed for silk workers. Source


Gaffney A.W.,Massachusetts General Hospital | Hang J.-Q.,Shanghai Putuo District Peoples Hospital | Lee M.-S.,Harvard University | Su L.,Harvard University | And 3 more authors.
BMC Public Health | Year: 2016

Background: An inverse association between socioeconomic status and pulmonary function has emerged in many studies. However, the mediating factors in this relationship are poorly understood, and might be expected to differ between countries. We sought to investigate the relationship between socioeconomic status and lung function in China, a rapidly industrializing nation with unique environmental challenges, and to identify potentially-modifiable environmental mediators. Methods: We used data from the Shanghai Putuo Study, a cross-sectional study performed in Shanghai, China. Participants completed a questionnaire and spirometry. The primary exposure was socioeconomic status, determined by education level. The primary outcomes were FEV1 and FVC percent predicted. Multiple linear regressions were used to test this association, and the percent explained by behavioral, environmental, occupational, and dietary variables was determined by adding these variables to a base model. Results: The study population consisted of a total of 22,878 study subjects that were 53.3 % female and had a mean age of 48. In the final multivariate analysis, the effect estimates for FEV1 and FVC percent predicted for low socioeconomic status (compared to high) were statistically significant at a p-value of <0.01. Smoking, biomass exposure, mode of transportation to work, a diet low in fruits or vegetables, and occupational category partially attenuated the relationship between SES and lung function. In a fully-adjusted age-stratified analysis, the socioeconomic disparity in lung function widened with increasing age. Conclusions: We found cross-sectional evidence of socioeconomic disparities in pulmonary function in Shanghai. These differences increased with age and were partially explained by potentially modifiable exposures. © 2016 Gaffney et al. Source


Gaffney A.W.,Massachusetts General Hospital | Hang J.-Q.,Shanghai Putuo District Peoples Hospital | Lee M.-S.,Harvard University | Su L.,Harvard University | And 3 more authors.
European Respiratory Journal | Year: 2016

Exposure to air pollution can be particularly high during commuting and may depend on the mode of transportation. We investigated the impact of commuting mode on pulmonary function in Shanghai, China. The Shanghai Putuo Study is a cross-sectional, population-based study. Our primary outcomes were forced expiratory volume in 1 s (FEV1) and forced vital capacity (FVC) % predicted, and the secondary outcome was spirometric airflow obstruction. We tested the association between mode of transportation and these outcomes after adjusting for confounders. The study population consisted of 20102 subjects. After adjusting for confounders, the change (95% CI) in FEV1 was-2.15% pred (-2.88-1.42% pred) among pedestrians,-1.32% pred (-2.05-0.59% pred) among those taking buses without air conditioning,-1.33% pred (-2.05-0.61% pred) among those taking buses with air conditioning and-2.83% pred (-5.56-0.10% pred) among those using underground railways, as compared to cyclists (the reference group). The effects of mode on FVC % predicted were in the same direction. Private car use had a significant protective effect on FVC % predicted and the risk of airflow obstruction (defined by Global Initiative for Chronic Obstructive Lung Disease but not by lower limit of normal criteria). Mode of transportation is associated with differences in lung function, which may reflect pollution levels in different transportation microenvironments. © ERS 2016. Source

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