Hu C.,Shanghai Pundong New Area Gongli Hospital |
Jiang N.,Shanghai Pundong New Area Gongli Hospital |
Wang G.,Shanghai Pundong New Area Gongli Hospital |
Zheng J.,Shanghai Pundong New Area Gongli Hospital |
And 2 more authors.
Journal of B.U.ON. | Year: 2014
Purpose: Hepatocyte growth factor activator inhibitor type-1 (HAI-1) is an integral-membrane proteinase inhibitor. Some studies have shown that HAI-1 as a matriptase inhibitor that plays a significant role in regulating cancer progression and metastasis. In this study, we attempted to clarify whether the levels of HAI-1 could be a useful marker in patients with prostate cancer (Pca). Methods: HAI-1 protein was evaluated by immunohisto-chemistry (IHC) and HAI-1 mRNA was evaluated by reverse transcription-polymerase chain reaction (RT-PCR) in 48 patients with Pca and 20 patients with benign prostate hyperplasia (BPH). The association between HAI-1 and olinicopathological features and survival were analyzed. Results: A high level of HAI-1 protein and mRNA expres- sion was detected in BPH compared to Pea specimens. The HAI-1 expression inversely correlated with Gleason score and pathological stage (p<0.05). It was significantly stronger in N0M0 tumors than in N+ or M+ tumors (p<0.05). Furthermore, low HAI-1 expression was a significant predictor for poor prognosis when compared with high HAI-1 expression (disease-free survival/DFS rate, p=0.0487; overall survival/OS rate; p=0.0492). Conclusion: The results of the present study identified HAI-1 as a favorable prognostic marker for Pca and may indicate that HAI-1 could be a therapeutic target for the treatment of this malignancy.