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Zhou B.,CAS Shanghai Institute of Materia Medica | Li X.,CAS Shanghai Institute of Materia Medica | Li X.,Shanghai Pharmaceutical Group Co. | Feng H.,CAS Shanghai Institute of Materia Medica | Li Y.,CAS Shanghai Institute of Materia Medica
Tetrahedron | Year: 2010

An efficient synthesis of triptophenolide methyl ether 4 from the readily available abietic acid 3 in nine steps is described and successfully applied to the synthesis of (-)-triptolide 1.The route is of characteristic of low cost, high yield and easy operation.In addition, every reaction in this route has been successfully scaled-up to a 100 g substrate level without loss of yield. © 2010 Elsevier Ltd.All rights reserved. Source


Sph

Trademark
Shanghai Pharmaceutical Group Co. | Date: 2005-04-06

pharmaceuticals, medicines for human use for the treatment of cardiovascular diseases; digestive system diseases; cancers; anti- infection agents; hormones; thyroid hormones; adrenocorticosteroids; raw materials for use in the manufacture of the aforesaid medicines; prepared Chinese medicines for the treatment of cardiovascular diseases; digestive system diseases; cancers; Dietetic foods adapted for medical use; depuratives for body; medicines for veterinary purposes, namely pain medications, anti- infection agents, hormones; preparations for destroying noxious animals; namely biocides; first-aid kits; filling for teeth.


Chen Q.,CAS Shanghai Institute of Materia Medica | Li B.,Shanghai Pharmaceutical Group Co. | Xia G.,Shanghai Pharmaceutical Group Co.
Acta Crystallographica Section E: Structure Reports Online | Year: 2010

In the title compound, C11H21NO5, the H atoms of the hydroxy groups are disordered over two positions, each in a 1:1 ratio. In the crystal, inter-molecular O-H⋯O hydrogen bonds link pairs of molecules into centrosymmetric dimers. Weak inter-molecular O-H⋯O inter-actions further link these dimers into chains extended in the [100] direction. Source


Wang H.,CAS Shanghai Institute of Materia Medica | Xia G.,Shanghai Pharmaceutical Group Co. | Liu X.,Shanghai Pharmaceutical Group Co. | Shen J.,CAS Shanghai Institute of Materia Medica
Acta Crystallographica Section E: Structure Reports Online | Year: 2011

The title compound, C24H30N2O4, was obtained by the reaction of (2R,6S)-4-(tert-but-oxy-carbon-yl)-6-methyl- morpho-line-2-carb-oxy-lic acid with diphenyl-methanamine in dimethyl-formamide solution. The morpholine ring is in a chair conformation. In the crystal, weak inter-molecular C - H⋯O hydrogen bonds link mol-ecules into chains along the b axis. Source


Liu L.,CAS Shanghai Institute of Materia Medica | Xia G.,Shanghai Pharmaceutical Group Co. | Liu X.,Shanghai Pharmaceutical Group Co. | Xie J.,Shanghai Pharmaceutical Group Co. | Shen J.,CAS Shanghai Institute of Materia Medica
Acta Crystallographica Section E: Structure Reports Online | Year: 2010

The title compound, C18H23N3O3, crystallized with two independent molecules (A and B) in the asymmetric unit. The phenyl ring and the 1,2,4-oxadiazole ring are inclined to one another by 19.9 (3)° in molecule A and 7.3 (3)° in molecule B. The absolute structure of the title compound was referred to the transfered chiral center (S) of one of the starting reacta-nts. In the crystal, A molecules are linked by C-H⋯N inter-actions involving the two oxadiazole N atoms. Source

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