Baoshan District, China
Baoshan District, China

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Shen X.,Shanghai Parling PharmaTech Co. | Yang J.,Shanghai Parling PharmaTech Co. | Zhan H.,Shanghai Parling PharmaTech Co. | Wang H.,Shanghai Parling PharmaTech Co. | And 2 more authors.
Chinese Journal of Chemistry | Year: 2013

An efficient semi-synthetic method was developed to construct docetaxel 1 by using N,N-di-Boc protected linear isoserine derivative 5 as the side chain source, in which, bulky protecting group on the nitrogen atom blocked C-2′ position and prohibited unavoidable racemization in previous studies. An efficient semi-synthetic method was developed to construct docetaxel 1 by using N,N-di-Boc protected linear isoserine derivative 5 as the side chain source. Copyright © 2013 SIOC, CAS, Shanghai & WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.


Patent
SHANGHAI PARLING PHARMAtECH CO. and ARCH PHARMALABS Ltd | Date: 2010-11-18

Disclosed herein is a process for preparation of imatinib free base which comprises condensing 4-Methyl-N-(4-pyridin-3-yl-pyrimidin-2-yl)-benzene-1,3-diamine with 4-(4-Methyl-piperazin-1-ylmethyl)-benzoic acid ester in the presence of base including organic bases and inorganic bases in an organic solvent to form imatinib.

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