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Liu Y.,Shanghai Fuhua Plastic and Aesthetic Hospital | Lei M.,Shenzhen Second Peoples Hospital | Wang Y.,Shanghai Ninth Peoples Hospital | Mu X.,Fudan University
Aesthetic Plastic Surgery | Year: 2012

Background: Ethnic characteristics of the Asian upper eyelid include the lack of a superior palpebral fold, excessive fat, laxity of pretarsal skin, and a medial epi-canthal fold. We present the lazy S-curve epicanthoplasty for correction of the medial epicanthal fold. Methods: The lazy S-curve incision was made as an entrance step. Then the connective and orbicularis oculi muscle dense fibers underlying the epicanthal folds were released and shifted. To reduce the tension of the new medial canthus, we anchored the canthus by suture fixation of both the subdermal and medial orbital periosteum. Rotation of the S-curve flap was settled as the last step. Results: From December 2005 to December 2009, the authors corrected the epicanthal folds on the eyelids of 156 Asian patients using the lazy S-curve epicanthoplasty. Results were satisfactory in most of the follow-up cases. Conclusion: Lazy S-curve epicanthoplasty is a reliable and effective method to eliminate not only the epicanthal fold but also the undesirable orbicularis oculi muscle. © Springer Science+Business Media, LLC and International Society of Aesthetic Plastic Surgery 2011.

Chen H.,East China Normal University | Huang J.,East China Normal University | Huang J.,Wuhan University of Technology | Yu J.,East China Normal University | And 2 more authors.
International Journal of Biological Macromolecules | Year: 2011

This research is aimed to develop cationic nanofibrous mats with improved cellular adhesion profiles and stability of three-dimensional fibrous structure as potential scaffolds for skin tissue engineering. Firstly, amino-remained chitosan- graft-poly (e{open}-caprolactone) (CS- g-PCL) was synthesized with a facile one-step manner by grafting e{open}-caprolactone oligomers onto the hydroxyl groups of CS via ring-opening polymerization by using methanesulfonic acid as solvent and catalyst. And then, CS- g-PCL/PCL nanofibrous mats were obtained by electrospinning of CS- g-PCL/PCL mixed solution. Scanning electron microscopy (SEM) images showed that the morphologies and diameters of the nanofibers were mainly affected by the weight ratio of CS- g-PCL to PCL. The enrichment of amino groups on the nanofiber surface was confirmed by X-ray photoelectron spectroscopy (XPS). With the increase of CS- g-PCL in CS- g-PCL/PCL nanofiber, the content of amino groups on the nanofiber surface increased, which resulted in the increase of zeta-potential of nanofibers. Studies on cell-scaffold interaction were carried out by culturing mouse fibroblast cells (L929) on CS- g-PCL/PCL nanofibrous mats with various contents of CS-g-PCL by assessing the growth, proliferation and morphologies of cells. The results of MTS assay and SEM observation showed that CS- g-PCL/PCL (2/8) mats with a moderate surface zeta-potential (ζ= 3 mV) were the best in promoting the cell attachment and proliferation. Toluidine blue staining further confirmed that L929 cells grew well and exhibited a normal morphology on the CS- g-PCL/PCL (2/8) mats. These results suggested the potential utilization of CS- g-PCL/PCL (2/8) nanofibrous mats for skin tissue engineering. © 2010 Elsevier B.V.

Wang W.,Harvard University | Wang W.,Xian Jiaotong University | Tsai T.-Y.,Harvard University | Yue B.,Shanghai Ninth Peoples Hospital | And 2 more authors.
Knee | Year: 2014

Background: The effect of posterior condylar offset (PCO) on maximal flexion of the knee after TKA is controversial. Another parameter, the posterior condylar offset ratio (PCOR), has been recently introduced to describe the posterior condylar geometry. This study measured the posterior femoral condyle geometry of a Chinese population and compared with those of a Western population published in the literature. Methods: We measured the PCO and PCOR of 100 Chinese knees (50 males, 50 females). The distances from the anterior and posterior femoral shaft cortex line to the most posterior femoral condyle tangent line were defined as the anterior-posterior dimension (ACP) and posterior condylar offset (PCO). The PCOR was calculated as PCO/ACP. The measured PCO and PCOR were compared to those of a Western population reported in the literature. Results: The PCOs were 25.80. ±. 2.71 and 27.32. ±. 2.34. mm for the Chinese females and males, respectively, where the PCO of the females was significantly smaller than that of the males (p. <. 0.05). The PCORs were 0.47. ±. 0.04 and 0.46. ±. 0.03 for the Chinese females and males, respectively, where the PCORs were similar among the Chinese males and females (p. >. 0.05). Conclusions: While the PCO of the Chinese females was smaller than that of the males, their PCORs were similar. Compared to the data of a Western population reported in literature, the PCO of the Chinese population is significantly smaller, but the PCOR is significantly larger. © 2013 Elsevier B.V.

Wang H.,Shanghai JiaoTong University | Zhou M.,Shanghai JiaoTong University | Shi B.,Shanghai JiaoTong University | Zhang Q.,University of South China | And 9 more authors.
Neoplasia | Year: 2011

Several types of epidermal growth factor receptor (EGFR) gene alternations have been observed in human tumors. Here we present a novel EGFR variant with aberrant splicing of exon 4 (named as de4 EGFR). Variant-specific polymerase chain reaction showed that de4 EGFR was expressed in some glioma (4/40), prostate cancer (3/11), and ovarian cancer (3/9) tissues but not in tissues adjacent to tumors or normal tissues. de4 EGFR displayed an enhanced transformation and a higher metastasis-promoting capacity in comparison to wild-type EGFR. With minimal EGFbinding activity, de4 EGFR underwent ligand-independent autophosphorylation and self-dimerization. Moreover, in serum-starved condition, de4 EGFR expression in U87 MG cells significantly upregulated the extracellular signal-regulated kinase and AKT phosphorylation and expression of JUN and Src. Importantly, E-cadherin expression was barely detectable in the U87 MG cells expressing de4 EGFR and restored expression of E-cadherin in these cells inhibited their metastatic behaviors. Taken together, we identified a novel EGFR variant with increased metastasispromoting activity that may become a promising new target for cancer therapy. © 2011 Neoplasia Press, Inc. All rights reserved.

Zhang S.-Z.,Shandong University | Zhang Z.-Y.,Shanghai Ninth Peoples Hospital | Zhang C.-P.,Shanghai Ninth Peoples Hospital | Kirwan J.,Florida College | Mendenhall W.M.,Florida College
Laryngoscope | Year: 2012

Objectives/Hypothesis: Is the severity of acute oral mucositis in patients who receive postoperative intensity-modulated radiotherapy (PO-IMRT) for oral tongue squamous cell carcinoma (SCC) reduced by sparing the oral mucosa outside of the planning target volume (PTV)? Study Design: Prospective, randomized trial. Methods: Forty-eight patients with oral tongue SCC who received PO-IMRT at our institution were randomized to two groups: the oral-sparing (OR-SP) group and oral-unsparing (OR-USP) group. For the OR-SP group (n = 24), the oral mucosa outside of the PTV was spared. Furthermore, the mucosa including the bilateral cheeks, upper lip, and lower lip was defined as the united site and given <32 Gy. For the OR-USP group (n = 24), none of the oral mucosa was protected. The severity of clinical acute mucositis in each patient was assessed weekly during PO-IMRT until completely healed. Oral mucositis was graded according to the National Cancer Institute Common Terminology Criteria for Adverse Events version 3.0. Dosimetry and therapeutic measures related to acute mucositis between the two groups were compared. Results: During PO-IMRT, no patient experienced grade 4+ acute mucositis in any oral site. Compared to the OR-USP group, there was less grade 2 and 3 mucositis in the united site of the OR-SP group (0% and 25% vs. 45.8% and 54.2%, respectively; P =.000). Also, the mean dose to the united site was significantly lower with OR-SP compared to OR-USP (41.8 ± 7.4 Gy vs. 58.8 ± 2.2 Gy; P =.000). The OR-SP group was associated with significant reductions in the use of analgesics (P =.043) and intravenous antibiotics (P =.039). No recurrences were detected in the vicinity of the spared oral mucosa (the united site) during a median follow-up time of 30 months. Conclusions: OR-SP PO-IMRT for patients with oral tongue SCC resulted in a significant decrease in the severity of acute mucositis and improved quality of life. The sparing of the oral mucosa outside of the PTV is safe and does not compromise oncologic outcomes. © 2011 The American Laryngological.

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