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Zheng H.,Fudan University | Zhu Z.-H.,Shanghai Minhang District Center Hospital | Zhang N.,Fudan University
Journal of Practical Oncology | Year: 2014

Objective: To evaluate the efficacy and safety of modified docetaxel, cisplatin and 5-fluorouracil (mDCF) regimen for patients with advanced gastric and esophago-gastric junction cancer.Methods: The clinical data of 80 patients with advanced gastric and esophago-gastric junction cancer undergoing two-week mDCF as first-line chemotherapy were retrospectively analyzed. A total dose of 37.5 mg/m2 docetaxel was given i. v. at d1 and d8, 20 mg/m2 cisplatin i. v. at d1-2 and d8-9, 1 000 mg/m2 5-fluorouracil (5-FU) was continuously infused for 48 h with 21 d as a cycle. All patients were treated more than two cycles. Clinical efficacy and safety were evaluated.Results: Seventy-eight patients were evaluable for efficacy and toxicity. Objective response rate(ORR)was 35.9% (28/78), disease control rate(DCR)was 78.2% (61/78), median time to progression (TTP) was 5.0 months (95%CI: 4.3~5.7 months), median overall survival time (OS) was 8.9 months (95%CI: 6.8-11.0 months) and 1-year survival rate was 33.3% (26/78). There was no chemotherapy-related fatality.Conclusion: For patients with advanced gastric and esophago-gastric junction cancer, mDCF regimen demonstrates certain efficacy with minimal toxicity, suggesting that the modified regimen can be used as first-line chemotherapy for patients who may not tolerate to standard DCF regimen. Source


Xu J.,Shanghai Minhang District Center Hospital | Lin X.,Shanghai Minhang District Center Hospital | Zhu H.,Shanghai Minhang District Center Hospital | Zhang Z.,Shanghai Minhang District Center Hospital | Yang B.,Shanghai Minhang District Center Hospital
Molecular Biology Reports | Year: 2013

Excessive estrogenic influence is known to be associated with initiation/promotion of endometrial cancer (EC). Common variants among genes coding for enzymes in sex steroid biosynthetic pathways may influence the risk of EC. Cytochrome P450c17α (CYP17), a gene that codes for a key enzyme (cytochrome P450c17α) in a rate-limiting step of estrogen biosynthesis has attracted considerable attention as a candidate gene for EC. The relationship between CYP17 and EC has been reported in various ethnic groups; however, these studies have yielded contradictory results. To investigate this inconsistency, we performed a meta-analysis of 13 studies involving a total of 3,258 cases and 4,614 controls for -34T>C (rs743572) polymorphism of the CYP17 gene to evaluate the effect of CYP17 on genetic susceptibility for EC. An overall random effects odds ratio of 0.71 (95 % confidence interval 0.58-0.88, P = 0.001) was found under recessive genetic model. Stratified analysis based on ethnicity, sample size and Hardy-Weinberg equilibrium status was conducted to explore potential heterogeneity. This meta-analysis demonstrated that the C allele of -34T>C in CYP17 is a protective factor associated with decreased EC susceptibility, but these associations vary in different ethnic populations. © 2013 Springer Science+Business Media Dordrecht. Source

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