Shanghai Meishan Hospital
Shanghai Meishan Hospital
Gao Y.,Nanjing University |
Gui Q.,Shanghai Meishan Hospital |
Jin L.,Nanjing University |
Yu P.,Nanjing University |
And 4 more authors.
Neuroscience Letters | Year: 2017
Background Hydrogen-rich saline can selectively scavenge reactive oxygen species (ROS) and protect brain against ischemia reperfusion (I/R) injury. Endoplasmic reticulum stress (ERS) has been implicated in the pathological process of cerebral ischemia. However, very little is known about the role of hydrogen-rich saline in mediating pathophysiological reactions to ERS after I/R injury caused by cardiac arrest. Methods The rats were randomly divided into three groups, sham group (n = 30), ischemia/reperfusion group (n = 40) and hydrogen-rich saline group (n = 40). The rats in experimental groups were subjected to 4 min of cardiac arrest and followed by resuscitation. Then they were randomized to receive 5 ml/kg of either hydrogen-rich saline or normal saline. Results Hydrogen-rich saline significantly improves survival rate and neurological function. The beneficial effects of hydrogen-rich saline were associated with decreased levels of oxidative products, as well as the increased levels of antioxidant enzymes. Furthermore, the protective effects of hydrogen-rich saline were accompanied by the increased activity of glucose-regulated protein 78 (GRP78), the decreased activity of cysteinyl aspartate specific proteinase-12 (caspase-12) and C/EBP homologous protein (CHOP). Conclusions Hydrogen-rich saline attenuates brain I/R injury may through inhibiting hippocampus ERS after cardiac arrest in rats. © 2017 Elsevier B.V.
Chan S.-M.,Shanghai Meishan Hospital |
Ou X.-L.,Nanjing Southeast University |
Sun W.-H.,Nanjing Medical University |
Zhu X.-B.,Shanghai Meishan Hospital
World Chinese Journal of Digestology | Year: 2016
AIM: To investigate the prevalence of and risk factors for fatty liver (FL) in Meishan community, Nanjing and its relationship with other components of the metabolic syndrome.METHODS: A retrospective study was performed to analyze the prevalence of and risk factors for FL in 25897 residents in Meishan community, Nanjing who participated in health examination at the Shanghai Meishan Hospital. Variables for the analysis included gender, age, body mass index (BMI), laboratory tests and abdominal ultrasound examination. FL status and its relationship with other components of the metabolic syndrome were analyzed.RESULTS: The total prevalence rate of fatty liver was 29.81%, and the prevalence between age groups was statistically significant (P < 0.05). The prevalence of fatty liver was significantly associated with age in the female group (P <0.05), but not in the male group (P > 0.05). The prevalence of fatty liver in the 41-50 age groupwas significantly higher in males than in females (P < 0.05). Logistic multivariate regression analysis indicated that the prevalence of FL was correlated to BMI, systolic blood pressure, red blood cell count, platelet, blood glucose, ALT, triglyceride, and cholesterol.CONCLUSION: The prevalence of FL in Meishan community, Nanjing is higher and related to multiple metabolic factors. Bad living habits need to be improved in patients with fatty liver and positive interventions should be taken to prevent and treat fatty liver. © 2016 Baishideng Publishing Group Inc. All rights reserved.
Chan S.,Shanghai Meishan Hospital |
Sun W.,Nanjing Medical University |
Zhu X.,Shanghai Meishan Hospital |
Ou X.,Nanjing Southeast University
Chinese Journal of Gastroenterology | Year: 2016
Background: Recent studies have showed that high homocysteine (Hcy) level can increase the risk of gastric cancer, but no related studies have been reported on role of Hcy in gastric precancerous diseases. Aims: To investigate the role of serum Hcy, folic acid and vitamin B12 in patients with gastric cancer and precancerous diseases. Methods: Eighty-six normal controls, 46 atrophic gastritis, 46 gastric ulcer, 31 gastric polyp, 52 gastric cancer patients diagnosed by gastroscopy and pathology were enrolled. Serum levels of Hcy, folic acid and vitamin B12 were determined, and their correlations with clinicopathological features in gastric cancer were analyzed. Results: Compared with normal controls, serum Hcy level in patients with atrophic gastritis and gastric cancer was significantly increased (P<0.05); serum folic acid and vitamin B12 levels in patients with gastric ulcer, gastric polyp and gastric cancer were significantly decreased (P<0.05). Serum Hcy level in patients with gastric cancer was positively correlated with depth of tumor infiltration, TNM staging and lymph node metastasis (P<0.05), however, serum folic acid and vitamin B12 levels had no correlation with clinicopathological features. Conclusions: Hcy level is increased in chronic atrophic gastritis, gastric cancer; levels of folic acid and vitamin B12 are decreased in gastric ulcer, gastric polyp and gastric cancer. High level of Hcy is involved in infiltration and metastasis of gastric cancer. Intervention in patients with high level of Hcy, low levels of folic acid and vitamin B12 might be an effective strategy for the prevention and treatment of gastric cancer and precancerous diseases. COPYRIGHT © 2016 by the Editorial Office of Chinese Journal of Gastroenterology.
PubMed | Nanjing University and Shanghai Meishan Hospital
Type: | Journal: Neuroscience letters | Year: 2017
Hydrogen-rich saline can selectively scavenge reactive oxygen species (ROS) and protect brain against ischemia reperfusion (I/R) injury. Endoplasmic reticulum stress (ERS) has been implicated in the pathological process of cerebral ischemia. However, very little is known about the role of hydrogen-rich saline in mediating pathophysiological reactions to ERS after I/R injury caused by cardiac arrest.The rats were randomly divided into three groups, sham group (n=30), ischemia/reperfusion group (n=40) and hydrogen-rich saline group (n=40). The rats in experimental groups were subjected to 4minutes of cardiac arrest and followed by resuscitation. Then they were randomized to receive 5ml/kg of either hydrogen-rich saline or normal saline.Hydrogen-rich saline significantly improves survival rate and neurological function. The beneficial effects of hydrogen-rich saline were associated with decreased levels of oxidative products, as well as the increased levels of antioxidant enzymes. Furthermore, the protective effects of hydrogen-rich saline were accompanied by the increased activity of glucose-regulated protein 78 (GRP78), the decreased activity of cysteinyl aspartate specific proteinase-12 (caspase-12) and C/EBP homologous protein (CHOP).Hydrogen-rich saline attenuates brain I/R injury may through inhibiting hippocampus ERS after cardiac arrest in rats.
Zhu A.,Nanjing Medical University |
Ge D.,Shanghai Meishan Hospital |
Zhang J.,Nanjing Medical University |
Teng Y.,Nanjing Medical University |
And 5 more authors.
European Journal of Medical Research | Year: 2014
Background: Airway inflammation, especially neutrophilic airway inflammation, is a cardinal pathophysiologic feature in chronic obstructive pulmonary disease (COPD) patients. The ideal biomarkers characterizing the inflammation might have important potential clinical applications in disease assessment and therapeutic intervention. Sputum myeloperoxidase (MPO) is recognized as a marker of neutrophil activity. The purpose of this meta-analysis is to determine whether sputum MPO levels could reflect disease status or be regulated by regular medications for COPD. Methods. Studies were identified by searching PubMed, Embase, the Cochrane Database, CINAHL and for relevant reports published before September 2012. Observational studies comparing sputum MPO in COPD patients and healthy subjects or asthmatics, or within the COPD group, and studies comparing sputum MPO before and after treatment were all included. Data were independently extracted by two investigators and analyzed using STATA 10.0 software. Results: A total of 24 studies were included in the meta-analysis. Sputum MPO levels were increased in stable COPD patients when compared with normal controls, and this increase was especially pronounced during exacerbations as compared with MPO levels during the stable state. Theophylline treatment was able to reduce MPO levels in COPD patients, while glucocorticoid treatment failed to achieve the same result. Conclusion: Sputum MPO might be a promising biomarker for guiding COPD management; however, further investigations are needed to confirm this. © 2014 Zhu et al.; licensee BioMed Central Ltd.
Yuhua L.,Shanghai Meishan Hospital
Chinese Journal of Infection and Chemotherapy | Year: 2011
Objective This survey was undertaken to characterize the nosocomial infections in oncology patients and analyze the relevant risk factors so that specific effective measures can be put in place to prevent such infections. Methods The survey was conducted both prospectively and retrospectively. Of the 2 239 oncology patients treated in our hospital during a 4-year period, a total of 152 episodes of hospital infections were documented in 142 patients. The clinical data of these patients were reviewed and analyzed. Results The proportion of patients with hospital infection was 6.3%. The prevalence of nosocomial infection was 6.8%. Lower respiratory tract was the most common site of infection. The most common underlying disease was lung cancer (34%, 52/152). Old age (60 years or older), long hospital stay (10 days or more), and underlying lung cancer were the predisposing factors of these nosocomial infections. The pathogens were mainly E. coli, Klebsiella spp, and Candida albicans. Conclusions The patients with malignant disease are a population at high risk of nosocomial infection. Preventive interventions should be put in place actively in order to improve the quality of life in patients with a malignant tumor.
An H.-L.,Shanghai Meishan Hospital |
Cheng M.,Shanghai Meishan Hospital |
Ma Z.-Q.,Shanghai Meishan Hospital |
Shi Y.-Z.,Shanghai Meishan Hospital
Chinese Journal of New Drugs | Year: 2013
Canagliflozin is an inhibitor of sodium-glucose co-transporter-2. Canagliflozin lowers renal threshold for glucose reabsorption and increases urinary glucose excretion, resulting in decreased plasma glucose in patients with hyperglycaemia. Also, it has effects of mild osmotic diuresis and net caloric loss (by loss of glucose), promoting weight loss. Canagliflozin is a new antidiabetic drug for symptomatic treatment of type 2 diabetes mellitus in adult patients with a novel mechanism of action. In patients receiving insulin and oral antihyperglycaemic therapy, canagliflozin is well tolerated without evidence for glucose malabsorption, and its pharmacokinetic characteristics are consistent with once-daily dosing. Adverse effects of canagliflozin reported in clinical trials include urinary tract and genital infections, occurring in about 10% of patients. The mechanism, pharmacodynamics, pharmacokinetics, drug interaction, clinical evaluation, and safety of canagliflozin were reviewed.
Xu C.-z.,Shanghai Meishan Hospital |
Yang W.-g.,Shanghai Meishan Hospital |
He X.-f.,Shanghai Meishan Hospital |
Zhou L.-t.,Shanghai Meishan Hospital |
And 2 more authors.
Journal of Clinical Rehabilitative Tissue Engineering Research | Year: 2011
BACKGROUND: Previous studies have confirmed that nano-hydroxyapatite/collagen (nHAC) and mesenchymal stem cells for repair of bone defect have the ability of bone formation in vivo. OBJECTIVE: To observe the effects of vascular endothelial growth factor (VEGF) and bone marrow mesenchymal stem cells (BMSCs), nHAC composite in the repair of femoral defect in rats. METHODS: Sprague-Dawley rat models of middle part of the femur defect were established and randomly assigned to two groups. Control group was implanted with BMSCs/nHAC composite. Experimental group was implanted with VEGF/BMSCs/nHAC composite. At 2, 4 and 8 weeks postoperation, imaging and histology observation of femoral samples were performed. At 8 weeks postoperation, scanning electron microscopy was performed in new bony callus environment. RESULTS AND CONCLUSION: nHAC composite implantation in the rats did not show rejection or inflammatory reaction. Moreover, bone formed rapidly using VEGF and BMSCs, nHAC composite, which exhibited better bone regeneration capacity compared with BMSCs/nHAC composite. The way of ossification mainly was endochondral ossification. It is presumed that VEGF promoted the formation of local microvessels, differentiation and proliferation of osteoblasts, speeded up the speed of endochondral ossification, shortened bone repair time, and elevated the quality and velocity of osteanagenesis.