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Goldstraw P.,Imperial College London | Chansky K.,Cancer Research and Biostatistics | Crowley J.,Cancer Research and Biostatistics | Rami-Porta R.,University of Barcelona | And 131 more authors.
Journal of Thoracic Oncology | Year: 2016

The IASLC Staging and Prognostic Factors Committee has collected a new database of 94,708 cases donated from 35 sources in 16 countries around the globe. This has now been analysed by our statistical partners at Cancer Research And Biostatistics and, in close collaboration with the members of the committee proposals have been developed for the T, N, and M categories of the 8th edition of the TNM Classification for lung cancer due to be published late 2016. In this publication we describe the methods used to evaluate the resultant Stage groupings and the proposals put forward for the 8th edition. © 2015 International Association for the Study of Lung Cancer. Published by Elsevier Inc. All rights reserved.

He Y.,Fudan UniversityShanghai China | Chen Z.,Shanghai Lung Tumor Clinical Medical Center | Jie Z.,Fudan UniversityShanghai China
Clinical Respiratory Journal | Year: 2015

Background and Aims: Genetic predisposition and environmental factors impact the development of lung cancer. The aim of this study was to investigate the association of single nucleotide polymorphisms (SNPs) of the IL-17A and IL-17F genes with lung cancer risk in Chinese Han population. Methods: A total of 678 subjects were enrolled, including 320 lung cancer patients and 358 healthy controls. Six SNPs of IL-17A (rs2275913, rs3748067 and rs3819025) and IL-17F (rs763780, rs1266828 and rs12203582) were genotyped using the polymerase chain reaction (PCR) and ligase detection reaction (LDR). Results: The distribution of IL-17A alleles and A and AA genotype for rs2275913 had a significant association with lung cancer risk (OR: 1.26, 95% confidence interval=1.01-1.56 and OR: 2.08, 95% confidence interval=1.311-3.31, respectively). In the subgroup analysis, people carrying homozygous variants of rs2275913 and rs12203582 were more likely to develop lung cancer both in adenocarcinoma (OR: 2.33, 95% confidence interval=1.34-4.05; OR: 1.84, 95% confidence interval=1.04-3.25) and advanced (OR: 2.35, 95% confidence interval=1.46-3.80; OR: 1.74, 95% confidence interval=1.06-2.87) groups. Although no interaction was found between variants of rs2275913 and rs12203582 and tobacco smoking (P>0.05), smokers carrying homozygous variants of rs2275913 and rs12203582 are at high risk of lung cancer, while no relationship were found among non-smokers. No significant associations between rs3748067, rs3819025, rs763780 and rs1266828 polymorphisms and lung cancer risk were observed. Conclusions: Polymorphisms of both IL-17A and IL-17F may increase lung cancer risk in Chinese population, and are associated differently with subtypes of clinical-pathologic features and tobacco smoking history of lung cancer patients. SNPs of IL-17A and IL-17F predict lung cancer risk. © 2015 John Wiley & Sons Ltd.

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