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Xu Y.,Shanghai Changning District Central Hospital | Shentu Y.,Shanghai Lung Tumor Clinical Medical Center | Zheng M.,Shanghai Changning District Central Hospital | Guo M.,Shanghai Changning District Central Hospital
Chinese Journal of Lung Cancer | Year: 2010

Background and objective: The aim of this study is the clinical value of preoperative routine surgical staging to mediastinal lymph nodes on lung cancer. Methods: Seventy-six cases underwent lymph nodes biopsy with mediastinoscopy. The diagnostic efficacy of thoracic CT scan and mediastinoscopy on mediastinal lymph nodes metastasis were compared. Results: The sensitivity, specificity, accuracy, positive predictive value and negative predictive value of thoracic CT scan and mediastinoscopy on diagnosing mediastinal lymph nodes metastasis were 68.5%, 66.7%, 68.4%, 84.6%, 16.7% and 87.5%, 100%, 84.2%, 100%, 60%, respectively. Conclusion: Routine preoperative mediastinoscopy had obvious advantage compared with thoracic CT scan on mediastinal lymph nodes staging. !e routine preoperative surgical staging of mediastinal lymph nodes on lung cancer had high clinical value. Source


He Y.,Fudan UniversityShanghai China | Chen Z.,Shanghai Lung Tumor Clinical Medical Center | Jie Z.,Fudan UniversityShanghai China
Clinical Respiratory Journal | Year: 2015

Background and Aims: Genetic predisposition and environmental factors impact the development of lung cancer. The aim of this study was to investigate the association of single nucleotide polymorphisms (SNPs) of the IL-17A and IL-17F genes with lung cancer risk in Chinese Han population. Methods: A total of 678 subjects were enrolled, including 320 lung cancer patients and 358 healthy controls. Six SNPs of IL-17A (rs2275913, rs3748067 and rs3819025) and IL-17F (rs763780, rs1266828 and rs12203582) were genotyped using the polymerase chain reaction (PCR) and ligase detection reaction (LDR). Results: The distribution of IL-17A alleles and A and AA genotype for rs2275913 had a significant association with lung cancer risk (OR: 1.26, 95% confidence interval=1.01-1.56 and OR: 2.08, 95% confidence interval=1.311-3.31, respectively). In the subgroup analysis, people carrying homozygous variants of rs2275913 and rs12203582 were more likely to develop lung cancer both in adenocarcinoma (OR: 2.33, 95% confidence interval=1.34-4.05; OR: 1.84, 95% confidence interval=1.04-3.25) and advanced (OR: 2.35, 95% confidence interval=1.46-3.80; OR: 1.74, 95% confidence interval=1.06-2.87) groups. Although no interaction was found between variants of rs2275913 and rs12203582 and tobacco smoking (P>0.05), smokers carrying homozygous variants of rs2275913 and rs12203582 are at high risk of lung cancer, while no relationship were found among non-smokers. No significant associations between rs3748067, rs3819025, rs763780 and rs1266828 polymorphisms and lung cancer risk were observed. Conclusions: Polymorphisms of both IL-17A and IL-17F may increase lung cancer risk in Chinese population, and are associated differently with subtypes of clinical-pathologic features and tobacco smoking history of lung cancer patients. SNPs of IL-17A and IL-17F predict lung cancer risk. © 2015 John Wiley & Sons Ltd. Source


Wang W.L.,Tongji University | Mao F.,Shanghai Lung Tumor Clinical Medical Center | Shen-Tu Y.,Shanghai Lung Tumor Clinical Medical Center | Mei Y.Q.,Tongji University
Chinese Journal of Lung Cancer | Year: 2013

Background and objective Lymphatic metastasis is the most important way for the spread of lung cancer and is one of the important factors affecting the prognosis. Existing studies showed that compared to middle or lower lobe NSCLC, upper lobe non-small cell lung cancer (NSCLC) has a higher probability of occurring regional mediastinal lymph node metastasis. The purpose of this study is to research the prognostic factors and lymphadenectomy of stage Ib upper lobe NSCLC. Methods A retrospective study of 147 consecutive subjects (76 and 71 for right and left upper lobe NSCLC respectively) who had undergone curative resection for stage Ib upper lobe NSCLC was performed. A total of 925 lymph nodes were removed during the surgery in all enrolled patients and a total of 491 mediastinal lymph nodes (266 and 225 for superior and inferior mediastinal lymph nodes respectively) were removed. Kaplan-Meier product method and Log-rank test were used for univariate survival analysis and Cox regression model was used for multivariate survival analysis. Results {circled digit one}Both univariate and multivariate analysis showed that age, tumor size and number of removed superior mediastinal lymph node stations were the important prognostic factors of stage Ib upper lobe NSCLC; {circled digit two}For stage Ib right upper lobe NSCLC, station 4 lymph node was of statistical significance to the prognosis (P=0.021); while for stage Ib left upper lobe NSCLC, station 5 lymph node was of statistical significance to the prognosis (P=0.024). Conclusion In surgically treated stage Ib upper lobe NSCLC patients, age, tumor size and number of removed superior mediastinal lymph node stations are the important prognostic factors. And in this kind of patients, lobe-specific systematic lymph node dissection may be a more efficient procedure during the surgery. Source


Wang W.,Shanghai Lung Tumor Clinical Medical Center | Shentu Y.,Shanghai Lung Tumor Clinical Medical Center
Chinese Journal of Lung Cancer | Year: 2010

Lymphatic metastasis is the main metastatic route for lung cancer, and is also one of the most important prognostic factors. Therefore, lymph node dissection has been an important procedure in standard lung cancer surgery. But so far, the mode and the extent of lymph node dissection during surgery are controversial for lung cancer in different pathological types, stages, or in different lobes. In this review, we summarize advances on the clinical significance, modes and extents of lymph node dissection during lung cancer surgery. Source


Goldstraw P.,Imperial College London | Chansky K.,Cancer Research and Biostatistics | Crowley J.,Cancer Research and Biostatistics | Rami-Porta R.,University of Barcelona | And 130 more authors.
Journal of Thoracic Oncology | Year: 2016

The IASLC Staging and Prognostic Factors Committee has collected a new database of 94,708 cases donated from 35 sources in 16 countries around the globe. This has now been analysed by our statistical partners at Cancer Research And Biostatistics and, in close collaboration with the members of the committee proposals have been developed for the T, N, and M categories of the 8th edition of the TNM Classification for lung cancer due to be published late 2016. In this publication we describe the methods used to evaluate the resultant Stage groupings and the proposals put forward for the 8th edition. © 2015 International Association for the Study of Lung Cancer. Published by Elsevier Inc. All rights reserved. Source

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