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Ye Y.-J.,East China University of Science and Technology | Wang Y.,East China University of Science and Technology | Lou K.-Y.,East China University of Science and Technology | Chen Y.-Z.,East China University of Science and Technology | And 3 more authors.
International Journal of Nanomedicine | Year: 2015

A novel biocompatible and biodegradable drug-delivery nanoparticle (NP) has been developed to minimize the severe side effects of the poorly water-soluble anticancer drug paclitaxel (PTX) for clinical use. PTX was loaded into the hydrophobic cavity of a hydrophilic cyclodextrin derivative, heptakis (2,6-di-O-methyl)-β-cyclodextrin (DM-β-CD), using an aqueous solution-stirring method followed by lyophilization. The resulting PTX/DM-β-CD inclusion complex dramatically enhanced the solubility of PTX in water and was directly incorporated into chitosan (CS) to form NPs (with a size of 323.9–407.8 nm in diameter) using an ionic gelation method. The formed NPs had a zeta potential of +15.9–23.3 mV and showed high colloidal stability. With the same weight ratio of PTX to CS of 0.7, the loading efficiency of the PTX/DM-β-CD inclusion complex-loaded CS NPs was 30.3-fold higher than that of the PTX-loaded CS NPs. Moreover, it is notable that PTX was released from the DM-β-CD/CS NPs in a sustained-release manner. The pharmacokinetic studies revealed that, compared with reference formulation (Taxol®), the PTX/DM-β-CD inclusion complex-loaded CS NPs exhibited a significant increase in AUC0→24h (the area under the plasma drug concentration–time curve over the period of 24 hours) and mean residence time by 2.7-fold and 1.4-fold, respectively. Therefore, the novel drug/DM-β-CD inclusion complex-loaded CS NPs have promising applications for the significantly improved delivery and controlled release of the poorly water-soluble drug PTX or its derivatives, thus possibly leading to enhanced therapeutic efficacy and less severe side effects. © 2015 Ye et al. Source


Li J.,Shanghai Key laboratory of Functional Materials Chemistry | Li J.,State Environmental Protection Key Laboratory of Environmental Risk Assessment and Control on Chemical Process | Lin K.,Shanghai Key laboratory of Functional Materials Chemistry | Lin K.,State Environmental Protection Key Laboratory of Environmental Risk Assessment and Control on Chemical Process | And 9 more authors.
Huanjing Kexue Xuebao/Acta Scientiae Circumstantiae | Year: 2012

The leaching characteristics of PBDEs from the particles of crushed printed circuit boards collected from an E-waste dismantling area in Taizhou, Zhejiang were investigated in various solvents including toluene, ethanol, trichloroethylene solution and actual landfill leachate. Eight PBDEs congeners were identified and determined by GC-NCI-MS. The results showed that after reaching the equilibrium (toluene: 48 h, ethanol: 96 h, TCE: 240 h), the concentrations of the ∑ 8PBDEs leached from particles of crushed printed circuit boards (diameter ranging from 180 μm to 380 μm) were 2320.06 mg·kg -1, 1946.17 mg·kg -1 and 79.38 mg·kg -1 in toluene, ethanol and trichloroethylene solution, respectively. With the equilibrium reached after 30 days, the concentrations of the ∑ 8PBDEs were 1042.12 μg·kg -1 and 23.63 μg·kg -1 in untreated and treated actual landfill leachate, respectively, with the predominated congeners by BDE99 and BDE47. The particle size had significant effect on PBDEs leaching. The smaller the particle diameter was, the easier for the PBDEs to be leached out. Source

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