Shanghai Key laboratory of Functional Materials Chemistry

laboratory of, China

Shanghai Key laboratory of Functional Materials Chemistry

laboratory of, China
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Yang J.,Shanghai Key Laboratory of Functional Materials Chemistry | Li M.,North China Electrical Power University | Kang L.,Key Laboratory for Green Processing of Chemical Engineering of Xinjiang Bingtuan | Zhu W.,Shanghai Key Laboratory of Functional Materials Chemistry
Science China Chemistry | Year: 2017

A novel versatile dicyanomethylene-4H-pyran (DCM) based derivative bearing ferrocenyl group (DCM-N-Fc) is designed as modulator to construct “off-on” logic operation. The optical properties of DCM-N-Fc are characterized by absorption and steady-state fluorescence technique, showing that the fluorescence from DCM chromophore via intramolecular charge transfer (ICT) is strongly quenched by photoinduced electron transfer (PET) process from ferrocene moiety. In contrast with the references (DCM-N and DCM-Fc), the fluorescence of DCM-N-Fc can be triggered by oxidizing ferrocenyl unit either chemically or electrochemically, exhibiting a characteristic emission modulation at around 610 nm with an electrofluorochromic behavior. Furthermore, the free energy and the fluorescence lifetime in the PET path verify the thermodynamic feasibility. Cyclic voltammetry, absorption spectroscopy, time-resolved fluorescence as well as DFT calculation have been used to elaborate the manipulation via both PET and ICT processes. © 2017 Science China Press and Springer-Verlag Berlin Heidelberg


Jiao C.-P.,Shanghai Key Laboratory of Functional Materials Chemistry | Ye Y.-J.,Shanghai Key Laboratory of New Drug Design | Ye Y.-J.,East China University of Science and Technology | Zhang Y.,Shanghai First Peoples Hospital | And 3 more authors.
Chinese Journal of Pharmacology and Toxicology | Year: 2013

OBJECTIVE: To elucidate silica nanoparticle-induced cytotoxicity and its mechanism by investigating the effect of silica nanoparticles on cells. METHODS: Cell viability was examined by MTT assay after A549 cells were exposed to 20- and 50 nm silica nanoparticles for 24 h. Radical anion (O2 -·), hydroxyl radical (·OH), hydrogen peroxide (H 2O2), nitric oxide (NO·), reactive oxygen species (ROS), malondialdehyde (MDA) contents and ATPase activity were determined after cells were treated with SiO2 nanoparticles 25, 50 and 100 mg·L-1 for 24 h. Cell apoptosis and necrosis were assessed under silica nanoparticle-exposed conditions. RESULTS: After exposure to silica nanoparticles for 24 h, the median lethal dose (LD50) was 30 ± 4 and (120 ± 14) mg·L-1 for 20- and 50 nm silica, respectively. Compared with normal control group, the content of intracellular O2 -·, ·OH, H2O2, NO·, ROS and MDA significantly increased (P < 0.05), while ATPase activity significantly decreased (P < 0.05). There was a significant reverse-correlation between cell viability and ROS or MDA content (R2 = 0.954 and R2 = 0.937). Hoechst33342/PI nucleus staining also displayed that silica nanoparticles could induce cell apoptosis and necrosis. CONCLUSION: SiO2 nanoparticles can cause cytotoxicity in A549 cells. The mechanism is possibly the overproduction of free radicals and an elevated level of oxidative stress, resulting in lipid peroxidation, cellular membrane damage, cell function disorder, cell apoptosis and necrosis.


Li J.,Shanghai Key Laboratory of Functional Materials Chemistry | Li J.,State Environmental Protection Key Laboratory of Environmental Risk Assessment and Control on Chemical Process | Lin K.,Shanghai Key Laboratory of Functional Materials Chemistry | Lin K.,State Environmental Protection Key Laboratory of Environmental Risk Assessment and Control on Chemical Process | And 9 more authors.
Huanjing Kexue Xuebao/Acta Scientiae Circumstantiae | Year: 2012

The leaching characteristics of PBDEs from the particles of crushed printed circuit boards collected from an E-waste dismantling area in Taizhou, Zhejiang were investigated in various solvents including toluene, ethanol, trichloroethylene solution and actual landfill leachate. Eight PBDEs congeners were identified and determined by GC-NCI-MS. The results showed that after reaching the equilibrium (toluene: 48 h, ethanol: 96 h, TCE: 240 h), the concentrations of the ∑ 8PBDEs leached from particles of crushed printed circuit boards (diameter ranging from 180 μm to 380 μm) were 2320.06 mg·kg -1, 1946.17 mg·kg -1 and 79.38 mg·kg -1 in toluene, ethanol and trichloroethylene solution, respectively. With the equilibrium reached after 30 days, the concentrations of the ∑ 8PBDEs were 1042.12 μg·kg -1 and 23.63 μg·kg -1 in untreated and treated actual landfill leachate, respectively, with the predominated congeners by BDE99 and BDE47. The particle size had significant effect on PBDEs leaching. The smaller the particle diameter was, the easier for the PBDEs to be leached out.


Ye Y.-J.,East China University of Science and Technology | Wang Y.,East China University of Science and Technology | Lou K.-Y.,East China University of Science and Technology | Chen Y.-Z.,East China University of Science and Technology | And 3 more authors.
International Journal of Nanomedicine | Year: 2015

A novel biocompatible and biodegradable drug-delivery nanoparticle (NP) has been developed to minimize the severe side effects of the poorly water-soluble anticancer drug paclitaxel (PTX) for clinical use. PTX was loaded into the hydrophobic cavity of a hydrophilic cyclodextrin derivative, heptakis (2,6-di-O-methyl)-β-cyclodextrin (DM-β-CD), using an aqueous solution-stirring method followed by lyophilization. The resulting PTX/DM-β-CD inclusion complex dramatically enhanced the solubility of PTX in water and was directly incorporated into chitosan (CS) to form NPs (with a size of 323.9–407.8 nm in diameter) using an ionic gelation method. The formed NPs had a zeta potential of +15.9–23.3 mV and showed high colloidal stability. With the same weight ratio of PTX to CS of 0.7, the loading efficiency of the PTX/DM-β-CD inclusion complex-loaded CS NPs was 30.3-fold higher than that of the PTX-loaded CS NPs. Moreover, it is notable that PTX was released from the DM-β-CD/CS NPs in a sustained-release manner. The pharmacokinetic studies revealed that, compared with reference formulation (Taxol®), the PTX/DM-β-CD inclusion complex-loaded CS NPs exhibited a significant increase in AUC0→24h (the area under the plasma drug concentration–time curve over the period of 24 hours) and mean residence time by 2.7-fold and 1.4-fold, respectively. Therefore, the novel drug/DM-β-CD inclusion complex-loaded CS NPs have promising applications for the significantly improved delivery and controlled release of the poorly water-soluble drug PTX or its derivatives, thus possibly leading to enhanced therapeutic efficacy and less severe side effects. © 2015 Ye et al.

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