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Zhou Q.,Fudan University | Zhou Q.,The Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases | Zhang W.,Capital Medical University | Xu H.,Fudan University | And 7 more authors.
International Journal of Gynecology and Obstetrics | Year: 2014

Objective: To investigate the prevalence of preterm premature rupture of membranes (PPROM) in urban areas in China and examine the associated risk factors. Methods: A population-based, prospective study was undertaken in 14 cities in China between January 1, 2011, and January 31, 2012. Women were recruited at their first prenatal-care visit, when maternal characteristics were recorded. Risk factors were analyzed by one-way analysis of variance. Results: Of 112 439 women included in analyses, 3077 (2.7%) had PPROM. Univariate analysis showed an increased risk of PPROM before 28 weeks of pregnancy in migrant women (odds ratio [OR] 2.25; 95% confidence interval [CI] 1.53-3.30; P < 0.001), in those with a history of recurrent induced abortions (OR 2.75; 95% CI 1.66-4.56; P < 0.001), and in those with a history of preterm birth (OR 3.90; 95% CI 0.77-19.61; P < 0.001). The associations were maintained in multivariate analysis (P < 0.001). Conclusion: Migration as a result of urbanization, high rates of induced abortion, and preterm birth are potential risk factors for PPROM in Chinese women. © 2014.

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