Shanghai JiaoTongUniversity

Shanghai, China

Shanghai JiaoTongUniversity

Shanghai, China
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Chang C.,Shanghai JiaoTong University | Ye B.,Shanghai JiaoTongUniversity | Xie W.,Shanghai JiaoTong University | Zhang D.,Shanghai JiaoTong University | And 2 more authors.
Hellenic Journal of Nuclear Medicine | Year: 2016

Silent myocardial ischemia is typically defined as objective evidence of myocardial ischemia in patients without subjective ischemia symptoms. Currently, coronary artery angiography is the gold standard for diagnosis of asymptomatic coronary artery disease (CAD). Computed tomography coronary angiography (CTCA) can visually demonstrate the morphology, trend and extent of coronary stenosis and is commonly used in clinical screening of CAD. Myocardial perfusion imaging can be used not only to identify whether anatomical stenosis causes myocardial dysfunction, but to also assess the risk stratication and prognosis of myocardial disease (MD). Myocardial perfusion imaging using morphing combined with CTCA can simultaneously show the relationship between CAD and myocardial ischemia from an anatomical and functional aspect. This allows earlier diagnosis of asymptomatic CAD myocardial ischemia, accurate identification of the culprit vessels, and could prevent unnecessary interventional therapy. The 1-day dobutamine stress/resting met-hod is also one of the methods used. The combination of CTCA and the morphing technique can provide anatomical and functional information on coronary arteries at the same time, signicantly improving the diagnostic sensitivity, specificity, and accuracy of MD.


Wang L.,Beihang University | Xu L.D.,Shanghai JiaoTongUniversity | Xu L.D.,Old Dominion University | Bi Z.,Indiana University - Purdue University Fort Wayne | Xu Y.,China National Institute of Standardization
IEEE Transactions on Industrial Informatics | Year: 2014

Today's manufacturing environments are very dynamic and turbulent. Traditional enterprise information systems (EISs) have mostly been implemented upon hierarchical architectures, which are inflexible to adapt changes and uncertainties promptly. Next-generation EISs must be agile and adaptable to accommodate changes without significant time delays. It is essential for an EIS to obtain real-time data from the distributed and dynamic manufacturing environment for decision making. Wireless sensor networks (WSNs) and radio-frequency identification (RFID) systems provide an excellent infrastructure for data acquisition, distribution, and processing. In this paper, some key challenges related to the integration of WSN and RFID technologies are discussed. A five-layer system architecture has been proposed to achieve synergistic performance. For the integration of WSN and RFID, one of the critical issues is the low efficiency of communication due to redundant data as redundant data increases energy consumption and causes time delay. To address it, an improved data cleaning algorithm has been proposed; its feasibility and effectiveness have been verified via simulation and a comparison with a published algorithm. To illustrate the capacity of the developed architecture and new data cleaning algorithm, their application in relief supplies storage management has been discussed. © 2005-2012 IEEE.


Liu R.,Fudan University | Li N.,Shanghai JiaoTongUniversity | Lin Y.,Shanghai JiaoTongUniversity | Wang M.,Shanghai JiaoTongUniversity | And 4 more authors.
PLoS ONE | Year: 2016

Glucagon-like peptide-1 (GLP-1) plays a role in the regulation of adipogenesis; however, the precise underlying molecular mechanism has not been fully defined. Wnt was recently identified as an important regulator of adipogenesis. This study aimed to investigate the involvement of the Wnt signaling pathway in the effects of GLP-1 on adipocyte differentiation. 3T3-L1 cells were induced to differentiate. The changes in the expression levels of adipogenic transcription factors and Wnts and the phosphorylation level and subcellular localization of β-catenin were quantified after GLP-1 treatment. GLP-1 stimulated adipocyte differentiation and lipid accumulation, which were accompanied by the expression of adipocyte marker genes. The expression of Wnt4 was upregulated in the process of adipocyte differentiation, which was further enhanced by treatment with GLP-1. β-catenin, an important mediator of the Wnt pathway, was immediately dephosphorylated and translocated from cytoplasm to nucleus when differentiation was induced. In the presence of GLP-1, however, β-catenin was redirected to the cell plasma membrane leading to its decreased accumulation in the nucleus. Knockdown of Wnt4 blocked the effect of GLP-1 on the cellular localization of β-catenin and expression level of adipogenic transcription factors. Our findings showed that GLP-1 promoted adipogenesis through the modulation of the Wnt4/βcatenin signaling pathway, suggesting that the GLP-1-Wntβ-catenin system might be a new target for the treatment of metabolic disease. © 2016 Liu et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


PubMed | Fudan University, University of Toronto and Shanghai JiaoTongUniversity
Type: Journal Article | Journal: PloS one | Year: 2016

Glucagon-like peptide-1 (GLP-1) plays a role in the regulation of adipogenesis; however, the precise underlying molecular mechanism has not been fully defined. Wnt was recently identified as an important regulator of adipogenesis. This study aimed to investigate the involvement of the Wnt signaling pathway in the effects of GLP-1 on adipocyte differentiation. 3T3-L1 cells were induced to differentiate. The changes in the expression levels of adipogenic transcription factors and Wnts and the phosphorylation level and subcellular localization of -catenin were quantified after GLP-1 treatment. GLP-1 stimulated adipocyte differentiation and lipid accumulation, which were accompanied by the expression of adipocyte marker genes. The expression of Wnt4 was upregulated in the process of adipocyte differentiation, which was further enhanced by treatment with GLP-1. -catenin, an important mediator of the Wnt pathway, was immediately dephosphorylated and translocated from cytoplasm to nucleus when differentiation was induced. In the presence of GLP-1, however, -catenin was redirected to the cell plasma membrane leading to its decreased accumulation in the nucleus. Knockdown of Wnt4 blocked the effect of GLP-1 on the cellular localization of -catenin and expression level of adipogenic transcription factors. Our findings showed that GLP-1 promoted adipogenesis through the modulation of the Wnt4/-catenin signaling pathway, suggesting that the GLP-1-Wnt-catenin system might be a new target for the treatment of metabolic disease.


Mai H.,Foshan Power Supply Bureau | Chen X.X.,Shanghai JiaoTongUniversity | Li Y.R.,Shanghai JiaoTongUniversity | Wei C.,Shanghai JiaoTongUniversity | Zhang Y.M.,Shanghai JiaoTongUniversity
Advanced Materials Research | Year: 2014

To suppress the stochastic pulse interference in XLPE Cables, this paper uses equivalent time-frequency method to extract pulse feature values, adaptive fuzzy clustering to classify pulses, phase concentration as an index to distinguish PD and stochastic pulses. Analysis results of on-site data show that this method can effectively suppress stochastic pulse interference in the PD signal, providing a useful theoretical and practical basis to assess the state of XLPE cable insulation. © (2014) Trans Tech Publications, Switzerland.


Wang Q.,Shanghai JiaoTongUniversity | Lu Z.,Shanghai JiaoTongUniversity | Zheng H.,Shanghai JiaoTongUniversity
European Physical Journal B | Year: 2016

The coupling effects on the optical absorption spectrum of semiconductor quantum dots arestudied by using the standard model with valence and conduction band levels coupled todispersive quantum phonons of infinite modes. By deducing the analytical expression of theoptical absorption coefficient, the relationship between the measurable quantities and theintrinsic properties of the semiconductor quantum dot is established. By this expression,the peak position, the line shape, the linewidth, and the energy shift of the absorptionspectrum of semiconductor quantum dot can be calculated precisely for a wide range ofparameters. The role of coupling strength as a mechanism of absorption line asymmetry isinvestigated, and the calculation results clearly show the coupling-induced asymmetry inthe absorption line. This analytical approach is applied to GaAs quantum dot, and theresults are consistent with those of experiment observations. © 2016, EDP Sciences, SIF, Springer-Verlag Berlin Heidelberg.


Ying G.,Shanghai JiaotongUniversity | Meng G.,Shanghai JiaotongUniversity | Long X.,Shanghai JiaotongUniversity | Jing J.,Shanghai JiaotongUniversity
Jixie Qiangdu/Journal of Mechanical Strength | Year: 2010

The whole engine system was divided into main body subsystem and manifold-turbocharger subsystem. The dynamics models of these two subsystems were established separately, and were synthesized by free interface modal synthesis method. The vibration modes and vibration responses were obtained from the synthesized system equations. The calculated results agreed well with the experiment results. Through this study, the response of turbocharger bearing block, which is regard as the foundation excitation for turbocharger rotor dynamics, can be determined by the proposal method.

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