Shanghai JiaoTong University
Shanghai, China

Shanghai Jiao Tong University , also referred to as SJTU, Shanghai Jiaotong University or simply Jiaotong University, is a public research university located in Shanghai, China. Established in 1896 by an imperial edict issued by the Guangxu Emperor, the university is renowned as one of the oldest and most prestigious and selective universities in China. SJTU is a member of China's C9 League and Yangtze Delta Universities Alliance.The university also annually produces the Academic Ranking of World Universities. Wikipedia.

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Shanghai JiaoTong University | Date: 2017-04-12

The present invention relates to the preparation methods and applications of biodegradable zinc-copper alloys, which can be applied to medical implant materials. The alloy of present invention is mainly composed of copper (1-10 wt. %), the balance of zinc and trace impurity elements. As-cast alloy ingot is homogenized and then hot processed to refine microstructure. The mechanical properties of the alloys are improved due to the refined microstructure. The alloys are capable of being further fabricated into micro-tubes, wires and plates. There are many advantages of these Zn alloys such as excellent mechanical properties, easy to process, appropriate corrosion resistance, good biocompatibility and so on, which correspondingly can be applied to many kinds of biodegradable medical implant devices. With excellent mechanical properties, good biocompatibility and degrading completely in 6-18 months, the Zn alloys meet the requirements of implant materials for mechanical properties and biosafety.

A photosensitive resin composition, comprising a binder polymer, a photopolymerizable compound, and a photopolymerization initiator, wherein the photopolymerization initiator contains a compound represented by the following general formula (1): [In the formula (1), R^(1), R^(2), R^(3 )and R^(4 )each independently represent an alkyl group, an aryl group, an aralkyl group, OR^(5), COOR^(6 )or OCOR^(7); and R^(5), R^(6 )and R^(7 )each independently represent an alkyl group, an aryl group or an aralkyl group.]

Provided are uses of Bacteroides in preparation of a medicament. The medicament is for use in treatment or prevention of obesity and obesity-related diseases. Also provided are a pharmaceutical composition, a medicament, a food product, and an animal feed that comprise Bacteroides, uses thereof in treatment or prevention of obesity and obesity-related diseases, and a method for treatment or prevention of obesity and obesity-related diseases.

The invention provides novel amphiphilic drug-drug conjugates useful as cancer therapeutics, and compositions and methods thereof.

Shanghai JiaoTong University | Date: 2014-10-31

A cooling device with small structured rib-dimple hybrid structures, comprising a substrate, a cooling channel, a plurality of small structured ribs and a plurality of dimples. The cooling channel, the plurality of small structured ribs and the plurality of dimples are all disposed on the wall surface of the substrate; the plurality of dimples are in a staggered arrangement or in a longitudinal arrangement, forming a dimple array; an upstream wall surface of each dimple or a plurality of dimples is provided with the small structured ribs, thus forming an small structured rib-dimple hybrid structure.

BOE Technology Group and Shanghai JiaoTong University | Date: 2015-11-05

This invention provides a thin film transistor and a manufacturing method thereof, an array substrate, and a display apparatus. This thin film transistor comprises an organic semiconductor layer and a source drain electrode layer, and further comprises a metal oxide insulating layer, wherein the metal oxide insulating layer is provided between the organic semiconductor layer and the source drain electrode layer and has a work function higher than that of the source drain electrode layer. In the thin film transistor provided by this invention, the metal oxide insulating layer having a higher work function can generate an interface dipole barrier so as to reduce the difficulty for the carriers in the source drain electrode to enter the organic semiconductor layer and thereby it is possible to decrease the contact resistance between the source drain electrode layer and the semiconductor layer and improve electrical properties of the thin film transistor.

The Regents Of The University Of California and Shanghai JiaoTong University | Date: 2017-09-13

The present invention is directed to methods of treating tuberculosis by providing a pharmaceutically effective amount of a combination of drug compounds.

Ma J.,Shanghai JiaoTong University
Nature Genetics | Year: 2017

Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disease with a strong genetic component characterized by autoantibody production and a type I interferon signature. Here we report a missense variant (g.74779296G>A; p.Arg90His) in NCF1, encoding the p47phox subunit of the phagocyte NADPH oxidase (NOX2), as the putative underlying causal variant that drives a strong SLE-associated signal detected by the Immunochip in the GTF2IRD1–GTF2I region at 7q11.23 with a complex genomic structure. We show that the p.Arg90His substitution, which is reported to cause reduced reactive oxygen species (ROS) production, predisposes to SLE (odds ratio (OR) = 3.47 in Asians (Pmeta = 3.1 × 10-104), OR = 2.61 in European Americans, OR = 2.02 in African Americans) and other autoimmune diseases, including primary Sjögren's syndrome (OR = 2.45 in Chinese, OR = 2.35 in European Americans) and rheumatoid arthritis (OR = 1.65 in Koreans). Additionally, decreased and increased copy numbers of NCF1 predispose to and protect against SLE, respectively. Our data highlight the pathogenic role of reduced NOX2-derived ROS levels in autoimmune diseases. © 2017 Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved.

Zhao L.,Shanghai JiaoTong University
Nature Reviews Microbiology | Year: 2013

The gut microbiota has been linked with chronic diseases such as obesity in humans. However, the demonstration of causality between constituents of the microbiota and specific diseases remains an important challenge in the field. In this Opinion article, using Koch's postulates as a conceptual framework, I explore the chain of causation from alterations in the gut microbiota, particularly of the endotoxin-producing members, to the development of obesity in both rodents and humans. I then propose a strategy for identifying the causative agents of obesity in the human microbiota through a combination of microbiome-wide association studies, mechanistic analysis of host responses and the reproduction of diseases in gnotobiotic animals. © 2013 Macmillan Publishers Limited. All rights reserved.

Wang Y.Z.,Shanghai JiaoTong University
Molecular neurobiology | Year: 2011

Acidosis is a common feature of many neuronal diseases and often accompanied with adverse consequences such as pain and neuronal injury. Before the discovery of acid-sensing ion channels (ASICs), protons were usually considered as a modulator of other ion channels, such as voltage-gated calcium channels, N-methyl-D-aspartate, and γ-amino butyric acid(A) receptor channels. Accordingly, the functional effects of acidosis were considered as consequences of modulations of these channels. Since the first cloning of ASICs in 1997, the conventional view on acidosis-mediated pain and cell injury has been dramatically changed. To date, ASICs, which are directly activated by extracellular protons, are shown to mediate most of the acidosis-associated physiological and pathological functions. For example, ASIC1a channels are reported to mediate acidosis-induced ischemic neuronal death. In this article, we will review the possible mechanisms that underlie ASIC1a channel-mediated neuronal death and discuss ASIC1a channel modulators involved in this process.

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