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Shanghai, China

Shanghai Jiao Tong University , also referred to as SJTU, Shanghai Jiaotong University or simply Jiaotong University, is a public research university located in Shanghai, China. Established in 1896 by an imperial edict issued by the Guangxu Emperor, the university is renowned as one of the oldest and most prestigious and selective universities in China. SJTU is a member of China's C9 League and Yangtze Delta Universities Alliance.The university also annually produces the Academic Ranking of World Universities. Wikipedia.

Shen Q.,Shanghai JiaoTong University
International journal of nanomedicine | Year: 2011

The effect of eugenol on colchicine transport across an isolated rat intestinal membrane was studied using an in vitro diffusion chamber system. We found that eugenol increased the absorptive transport of the drug efficiently. The effect of eugenol on intestinal absorption of colchicine in an oral administrative nanoemulsion formulation was also demonstrated in vivo. The colchicine nanoemulsion was prepared with isopropyl myristate, eugenol, Tween80, ethanol and water, and eugenol was used as an oil phase in the formulation; an average particle size of this nanoemulsion was 41.2 ± 7.2 nm. The permeation of colchicine in the nanoemulsion across the intestinal membrane was significantly different from that of the control group (0.2 mM colchicine). Finally, co-administration of eugenol in colchicine nanoemulsion to enhance the colchicine bioavailability was investigated by an oral administration method. After oral administration of colchicine (8 mg/kg) in the form of either the nanoemulsion or in free colchicine solution, the relative bioavailability of nanoemulsion and eugenol-nanoemulsion were enhanced by about 1.6- and 2.1-fold, respectively, compared with free colchicine solution. The procedure indicated that the intestinal absorption of colchicine was enhanced significantly by eugenol in the tested nanoemulsion. All the results suggested that eugenol is an efficient component in an oral administrative formulation for improving the intestinal absorption of colchicine.

Yu R.,Renmin University of China | Yu R.,Shanghai JiaoTong University | Si Q.,Rice University
Physical Review Letters | Year: 2015

Motivated by the properties of the iron chalcogenides, we study the phase diagram of a generalized Heisenberg model with frustrated bilinear-biquadratic interactions on a square lattice. We identify zero-temperature phases with antiferroquadrupolar and Ising-nematic orders. The effects of quantum fluctuations and interlayer couplings are analyzed. We propose the Ising-nematic order as underlying the structural phase transition observed in the normal state of FeSe, and discuss the role of the Goldstone modes of the antiferroquadrupolar order for the dipolar magnetic fluctuations in this system. Our results provide a considerably broadened perspective on the overall magnetic phase diagram of the iron chalcogenides and pnictides, and are amenable to tests by new experiments. © 2015 American Physical Society.

The therapeutic strategies for malignant melanoma are still cancer chemotherapy, radiotherapy, and tumor resection. However, these therapeutic strategies often lead to a reduced neutrophilic granulocyte count or loss of more blood after surgical tumor resection. In this study, we developed a formulation of hemostatic gauze impregnated with sustained-release granulocyte colony-stimulating factor (G-CSF) with increasing of the neutrophilic granulocyte count in the blood following chemotherapy and decreasing blood loss after surgical tumor resection. We designed a formulation with both hemostatic properties and increased neutrophil content to be used in cancer chemotherapy, radiotherapy, and tumor resection, comprising a hemostatic gauze as a scaffold and (G-CSF)-loaded dextran nanoparticles coated with polylactic-co- glycolic acid (PLGA) solution fabricated by direct spray-painting onto the scaffold and then vacuum-dried at room temperature. The performance of this system was evaluated in vitro and in vivo. Nearly zero-order release of G-CSF was recorded for 12-14 days, and the cumulative release of G-CSF retained over 90% of its bioactivity in a NFS-60 cell line proliferation assay when the scaffold was incubated in phosphate-buffered saline (pH 7.4) at 37°C. The in vivo hemostatic efficacy of this formulation was greater than that of native G-CSF, the scaffold directly spray-painted with G-CSF solution or PLGA organic solution as a coating, or when a blank scaffold was covered with the coating. Our results suggest that this formulation has both hemostatic properties and increased neutrophil activity.

Yu G.-F.,Shanghai JiaoTong University
Journal of the Physical Society of Japan | Year: 2014

A multi-component derivative coupled integrable dispersionless equations is presented. The multisoliton solution to the system is expressed by the pfaffians. © 2014 The Physical Society of Japan The author is indebted to the referees for their careful reading and valuable suggestions. The author would also express his thanks to Professor Mikhail Tyaglov for his helpful discussion and language promotion. The work is supported by National Natural Science Foundation of China (Grant No. 11371251).

Dong L.Y.,Shanghai JiaoTong University
European review for medical and pharmacological sciences | Year: 2013

Ischemic preconditioning (IP) has been used to reduce ischemia-reperfusion injury in several models. It remains unknown whether IP is sufficient to prevent deep hypothermic circulatory arrest (DHCA) cardiopulmonary bypass (CPB) induced lung injury. Twenty-four piglets were randomly divided into four groups: routine CPB (CPB), CPB + DHCA (DHCA), CPB + IP + DHCA (IP-1) and CPB + hypoxia-ischemia preconditioning + DHCA (IP-2). Lung static compliance (Cstat) and pulmonary vascular resistance (PVR) were measured as indicators of lung function at three points during CPB. TNF-α, IL-8 and IL-10 expressions were detected by radioimmunoassay. CD18 expression was determined by flow cytometer. Some lung tissues were excised to measure the wet/dry weight ratio (W/D) and some were fixed to observe pathological changes. Cstat significantly decreased whereas PVR increased in DHCA group. IP prevented DHCA-induced lung functional impairment, especially IP-2 treatment. More cytokines were produced after CPB in all groups, but with varying level. Left atrium/pulmonary artery ratio of CD18 expression on monocytes decreased only in DHCA group, whereas which on polymorphonuclear neutrophils decreased in DHCA group, IP-1 group at 1h post-CPB and IP-2 group. Although lung W/D was increased in IP-2 group compared with pre-CPB, but significantly lower than that in DHCA group. Histological findings showed less lung injuries in IP groups than DHCA group. DHCA aggravates lung inflammatory injury and IP may reverse this injury. Maintaining ventilation with pulmonary artery perfusion in the lung IP process during CPB seems to be more superior to single pulmonary artery perfusion.

Deng Y.,Southwest University | Deng Y.,Shanghai JiaoTong University | Chan F.T.S.,Hong Kong Polytechnic University
Expert Systems with Applications | Year: 2011

Supplier selection is a multi-criterion decision making problem under uncertain environments. Hence, it is reasonable to hand the problem in fuzzy sets theory (FST) and Dempster Shafer theory of evidence (DST). In this paper, a new MCDM methodology, using FST and DST, based on the main idea of the technique for order preference by similarity to an ideal solution (TOPSIS), is developed to deal with supplier selection problem. The basic probability assignments (BPA) can be determined by the distance to the ideal solution and the distance to the negative ideal solution. Dempster combination rule is used to combine all the criterion data to get the final scores of the alternatives in the systems. The final decision results can be drawn through the pignistic probability transformation. In traditional fuzzy TOPSIS method, the quantitative performance of criterion, such as crisp numbers, should be transformed into fuzzy numbers. The proposed method is more flexible due to the reason that the BPA can be determined without the transformation step in traditional fuzzy TOPSIS method. The performance of criterion can be represented as crisp number or fuzzy number according to the real situation in our proposed method. The numerical example about supplier selection is used to illustrate the efficiency of the proposed method. © 2011 Published by Elsevier Ltd.

Xu N.,Shanghai JiaoTong University
International journal of nanomedicine | Year: 2011

Amphotericin B deoxycholate (AmB), a classic antifungal drug, remains the initial treatment of choice for deep fungal infections, but it is not appropriate for treatment of cryptococcal meningitis due to its inability to pass through the blood-brain barrier (BBB). We examined the efficacy of amphotericin B-polybutylcyanoacrylate nanoparticles (AmB-PBCA-NPs) modified with polysorbate 80 that had a mean particle diameter less than 100 nanometers (69.0 ± 28.6 nm). AmB-PBCA-NPs were detected in the brain 30 minutes after systemic administration into BALB/c mice and had a higher concentration than systemically administered AmB liposome (AmB-L, P < 0.05); AmB was not detected in the brain. Following infection for 24 hours and then 7 days of treatment, the survival rate of mice in the AmB-PBCA-NP group (80%) was significantly higher than that of the AmB (0%) or AmB-L (60%) treatment groups. Fungal load was also lower when assessed by colony-forming unit counts obtained after plating infected brain tissue (P < 0.05). Our study indicates that AmB-PBCA-NPs with polysorbate 80 coating have the capacity to transport AmB across the BBB and is an efficient treatment against cryptococcal meningitis in a mouse model.

Shen H.-S.,Shanghai JiaoTong University
Mechanics Research Communications | Year: 2013

Buckling and postbuckling analysis is presented for microtubules subjected to torsion in thermal environments. The microtubule is modeled as a nonlocal shear deformable cylindrical shell which contains small scale effects. The governing equations are based on a higher order shear deformation theory. The thermal effects are included and the material properties are assumed to be temperature-dependent. The small scale parameter e0a is estimated by matching the buckling twist angle of microtubules obtained from the nonlocal shear deformable shell model with the existing result. The results show that the small scale effect plays an important role in the postbuckling of microtubules. © 2013 Elsevier Ltd. All rights reserved.

Xiao G.,Shanghai JiaoTong University
International Journal of Antennas and Propagation | Year: 2014

This paper discusses the application of loop-flower basis functions for solving surface integral equations involved in electromagnetic scattering problems on perfectly electrically conducting surfaces. Flower-shaped basis functions are proposed to replace the conventional star basis functions. The flower basis functions are defined based on mesh nodes instead of surface triangles. It is shown that the loop-flower basis functions not only can be used to handle the electromagnetic scattering problems at very low frequencies, but also can be directly used to implement Calderon preconditioners for EFIEs. © 2014 Gaobiao Xiao.

Shen H.-S.,Shanghai JiaoTong University | Xiang Y.,University of Western Sydney
Engineering Structures | Year: 2014

Nonlinear bending analysis is presented for nanocomposite cylindrical panels subjected to a transverse uniform or sinusoidal load resting on elastic foundations in thermal environments. Carbon nanotubes are used to reinforce the cylindrical panels in two distinguished patterns, namely, uniformly distributed (UD) and functionally graded (FG) reinforcements. The material properties of CNTRCs are assumed to be temperature-dependent and are estimated by a micromechanical model. The governing equations of the panel are derived based on a higher-order shear deformation theory with a von Kármán-type of kinematic nonlinearity and are solved by a two-step perturbation technique. The nonlinear bending behaviors of the CNTRC panels with different CNT volume fraction distributions, foundation stiffnesses, temperature rise, and the character of in-plane boundary conditions are studied in details. © 2014 Elsevier Ltd.

Wang L.,Shanghai JiaoTong University | Jia H.,Northeast Forestry University
Asian Journal of Control | Year: 2014

This paper deals with the trajectory tracking problem of a six-degree of freedom (6-DOF) quadrotor unmanned aerial vehicle (UAV). The problem of simplified kinematics based on Euler angles is analyzed and the modified Rodrigues parameters (MRPs) technique is introduced to model the rotational dynamics of the rigid body. A nonlinear system error model is established based on the trajectory tracking problem, and, due to the coupling property between the translational and rotational dynamics, we divide the complete closed-loop system into two reduced-order subsystems and a coupling term. The Rodrigues theorem is applied to analyze the internal connections between the coupling term and MRPs. Therefore, the global stability conclusions, by which the trajectory tracking controller of the quadrotor UAV could be designed based on the subsystem directly in future works, are proved based on several assumptions of the subsystems. Thereafter, the controllers, using the backstepping approach and nonlinear disturbance observer/sliding mode control approach, which stabilize the quadrotor UAV globally & #55349;& #56486; -exponentially and globally uniformly bounded, are proposed based on the stability theorem proofs mentioned above. Numerical simulations are provided to show that the theoretical conclusions and the controller proposed are effective. © 2013 Chinese Automatic Control Society and Wiley Publishing Asia Pty Ltd.

We investigated a novel application of phrenic nerve stimulation (PNS) in diaphragm dysfunction induced by mechanical ventilation (MV). Twenty-one Sprague-Dawley rats were assigned randomly to 3 groups: spontaneous breathing, 18-h controlled MV, and 18-h controlled MV with PNS. Upon completion of the experimental protocol, diaphragm contractility, gene expression of insulin-like growth factor-1 (IGF-1) and ubiquitin ligases, and serum IGF-1 levels were analyzed. Compared with the spontaneously breathing rats, impaired diaphragm contractile function, including force-related properties and force-frequency responses, were pronounced with MV. Furthermore, MV suppressed IGF-1 and induced muscle ring finger 1 mRNA expression in the diaphragm. In contrast, PNS counteracted MV-induced gene expression changes in the diaphragm and restored diaphragm function. PNS exerted a protective effect against MV-induced diaphragm dysfunction by counteracting altered expression of IGF-1 and ubiquitin ligase in the diaphragm. Copyright © 2013 Wiley Periodicals, Inc.

Wang X.-Z.,Shanghai JiaoTong University
Journal of Physics A: Mathematical and Theoretical | Year: 2010

The reversible Carnot cycle in reversible thermodynamics is composed of two reversible heat exchange processes and two reversible adiabatic processes. We construct an irreversible cycle in linear irreversible thermodynamics by analogy with the reversible Carnot cycle. The irreversible cycle is composed of two linear irreversible heat exchange processes and two linear irreversible adiabatic processes. It is found that the Curzon-Alhborn efficiency can be attained if the power for each of the four linear irreversible processes reaches its maximum. The maximum efficiency is the Carnot efficiency. The strong coupling condition is prerequisite for the respective attainment of the Curzon-Alhborn efficiency and the Carnot efficiency. © 2010 IOP Publishing Ltd.

Yao Y.,Shanghai JiaoTong University
Renewable and Sustainable Energy Reviews | Year: 2016

Applications of ultrasonic energy to enhance a wide variety of processes or to improve system efficiency have been explored since about 1960s. This work makes an overview of recent studies about the applications of ultrasound in the field of Heating, Ventilation and Air-Conditioning (HVAC), including air humidification/dehumidification, desiccant regeneration, air cleaning, heat enhancement and fouling reduction of heat exchanger, defrosting or frost suppression for evaporator of air-conditioner. The mechanisms for these ultrasonic applications can be illustrated by a series of ultrasonically induced effects such as acoustic cavitation, streaming and vibration. The literature reviews manifest that the parametric studies on the ultrasound-assisted enhancement are the main interest of people to help in the design, optimization, and scale-up of the ultrasound-assisted process. As a new technology applied to the HVAC, the possible major challenges are the design and development of efficient power ultrasonic systems capable of large scale successful operation specifically adapted to each individual process. © 2015 Elsevier Ltd. All rights reserved.

Gu P.-H.,Shanghai JiaoTong University
Journal of Cosmology and Astroparticle Physics | Year: 2014

We propose an SO(10)×SO(10)′ model to simultaneously realize a seesaw for Dirac neutrino masses and a leptogenesis for ordinary and dark matter-antimatter asymmetries. A (16 × 16′)H scalar crossing the SO(10) and SO(10)′ sectors plays an essential role in this seesaw-leptogenesis scenario. As a result of lepton number conservation, the lightest dark nucleon as the dark matter particle should have a determined mass around 15GeV to explain the comparable fractions of ordinary and dark matter in the present universe. The (16×16′)H scalar also mediates a U(1)em × U(1)′em kinetic mixing after the ordinary and dark left-right symmetry breaking so that we can expect a dark nucleon scattering in direct detection experiments and/or a dark nucleon decay in indirect detection experiments. Furthermore, we can impose a softly broken mirror symmetry to simplify the parameter choice.

Wang L.,Shanghai JiaoTong University
Zhonghua zheng xing wai ke za zhi = Zhonghua zhengxing waike zazhi = Chinese journal of plastic surgery | Year: 2012

To evaluate the clinical effect of cell-assisted lipotransfer (CAL) for breast augmentation. 18 patients accepted breast augmentation using CAL. 10 patients completed 6-month follow-up and were involved in the study. The adipose tissue was harvested from patients' thighs, flanks and lower abdomen with Lipokit. After standing, 250 ml fatty portion and 500 ml fluid portion of suction aspirates were processed according to the procedures reported in reference. Flow-cytometry was used to detect the percentage of adipose-derived stem cells(ADSCs) in distilled stromal vascular fraction (SVF). The differentiation function of cultured cells also was assessed. The breast volume and images were evaluated by using MRI before operation, 3 and 6 months after operation. The breast volume was marked as V0, V3 and V6 respectively. The resorption rate of transplanted adipose tissue for each breast was calculated and marked as R3 and R6. Averagely, the percentage of ADSCs in freshly distilled SVF was 41.67%. The in-vitro cultured cell grew well and could differentiate into fat, bone and cartilage. Statistics showed that V0, V3 and V6 was (416.19 +/- 40.43) ml, (551.72 +/- 59.86) ml and (538.81 +/- 68.35) ml respectively. R3 and R6 was (51.20 +/- 11.96)% and (54.22 +/- 12.73)%. There was significant difference between V3 and V0 (P < 0.05), V6 and V0. However, no significant difference was showed between V3 and V6 or R3 and R6. In addition, no cyst or calcification was seen in all MRI images. In process of breast augmentation using CAL, the distilled SVF contains 41.67% ADSCs which have adipogenic, osteogenic and chondrogenic function. Within 3-month post-operation, the breast volume decreases obviously but the volume sustains after that. Compared with the preoperative volume, the 6-month postoperative volume is significantly increased and the breasts' contour is improved greatly. This study indicates that CAL is a safe and effective way for breast augmentation.

Fei S.-W.,Shanghai JiaoTong University
Expert Systems with Applications | Year: 2010

Diagnosis of arrhythmia cordis is very significant to ensure human health and save human lives. Support vector machine (SVM) is a new machine learning method based on statistical learning theory, which can solve the classification problem with small sampling, non-linear and high dimension. However, the practicability of SVM is affected due to the difficulty of selecting appropriate SVM parameters. Particle swarm optimization (PSO) is a new optimization method, which is motivated by social behavior of bird flocking or fish schooling. The optimization method not only has strong global search capability, but also is very easy to implement. Thus, in the study, the proposed PSO-SVM model is applied to diagnosis of arrhythmia cordis, in which PSO is used to determine free parameters of support vector machine. The experimental data from MIT-BIH ECG database are used to illustrate the performance of proposed PSO-SVM model. The experimental results indicate that the PSO-SVM method can achieve higher diagnostic accuracy than artificial neural network in diagnosis of arrhythmia cordis. © 2010 Published by Elsevier Ltd.

Liang L.,Shanghai JiaoTong University
Respirology (Carlton, Vic.) | Year: 2013

Ozone exposure worsens the development of allergen-induced asthma. The p38 mitogen-activated protein kinase (MAPK) pathway plays an important role in the development of the inflammatory response, airway hyperresponsiveness (AHR) and airway remodelling. In this study, the role of the p38 MAPK pathway on the effects of chronic ozone exposure in ovalbumin (OVA)-sensitized and -challenged mice was investigated. Mice were sensitized and challenged with OVA followed by ozone exposure. Dexamethasone (Dex) and SB239063, a p38 MAPK inhibitor, were used as preventive treatment. Compared with OVA-challenged mice, ozone exposure of OVA-challenged mice led to enhanced recruitment of inflammatory cells in bronchoalveolar lavage fluid, increases in inflammation scores, collagen accumulation, bronchial wall thickness and messenger RNA levels of inflammatory cytokines, along with activation of p38 MAPK/HSP27 and downregulation of MAPK phosphatase-1 (MKP-1) in the lung tissue. Dex treatment partially attenuated lung inflammation, while the cotreatment of Dex and SB239063 effectively reduced lung inflammation, inhibited airway remodelling, inactivated p38 MAPK/HSP27 and upregulated MKP-1 in the lung tissue. Ozone exposure aggravated airway inflammation, airway remodelling, activation of p38 MAPK and downregulation of MKP-1 in OVA-sensitized and -challenged mice, which was ineffectively controlled by corticosteroids. p38 MAPK activation is a likely pathway involved in corticosteroid insensitivity. © 2013 The Authors. Respirology © 2013 Asian Pacific Society of Respirology.

Zhang Z.,Shanghai JiaoTong University
International Journal of Solids and Structures | Year: 2013

The virtual internal bond (VIB) is a micro-macro constitutive model. Although this model is based on a postulated discrete microstructure, it ultimately returns to a continuum constitutive relation through a homogenization process. The homogenization process can reduce the internal degrees of freedom, but it omits the effect of the individual micro bond that may play an important role in the fracture process. The present research develops a discrete system to represent the nonlinear elasticity by discretizing the continuous VIB. This discrete system is composed of unit cells, which can adopt any geometry with any number of bonds. The system is characterized by the force-displacement, not the stress-strain constitutive relationship. The nonlinear properties of this discrete system are governed by the micro-bond potential. The micro bond properties are related to Young's modulus of the material, the volume and the bond number of the unit cell. For a given material, the unit cell has a certain topological structure and configuration. A discussion of two specific cases (the 2D triangular and 3D tetrahedral unit cells) suggests that the discrete system converges with decreasing unit cell size. In the unstructured unit cell scheme, the discrete system can almost precisely represent the initial Young's modulus and the Poisson ratio of a nonlinear continuum. A mixed fracture example demonstrates that the present method can efficiently simulate the fracture propagation. The present paper provides a theory for developing a lattice-type mechanical model for nonlinear elasticity and provides new method for the fracture simulation of a nonlinear elastic material. © 2013 Elsevier Ltd. All rights reserved.

Wang J.,Chinese University of Hong Kong | Wang J.,Shanghai JiaoTong University
IEEE Transactions on Neural Networks | Year: 2010

This paper presents a k-winners-take-all (kWTA) neural network with a single state variable and a hard-limiting activation function. First, following several kWTA problem formulations, related existing kWTA networks are reviewed. Then, the kWTA model model with a single state variable and a Heaviside step activation function is described and its global stability and finite-time convergence are proven with derived upper and lower bounds. In addition, the initial state estimation and a discrete-time version of the kWTA model are discussed. Furthermore, two selected applications to parallel sorting and rank-order filtering based on the kWTA model are discussed. Finally, simulation results show the effectiveness and performance of the kWTA model. © 2006 IEEE.

Zhao C.Y.,Shanghai JiaoTong University
International Journal of Heat and Mass Transfer | Year: 2012

Thermal transport in metal foams has received growing attention in both academic research and industrial applications. In this paper the recent research progress of thermal transport in metal foams has been reviewed. This paper aims to provide the comprehensive state-of-the-art knowledge and research results of thermal transport in open celled cellular metal foams, which covers the effective thermal conductivity, forced convection, natural convection, thermal radiation, pool boiling and flow boiling heat transfer, solid/liquid phase change heat transfer and catalytic reactor. The forced convection and thermal conductivity have been extensively investigated, while less research were performed on two-phase (boiling and solid/liquid phase change heat transfer) and thermal radiation in metal foams. Also most research still treats the metal foam as one type of effective continuous porous media, very few researchers investigated the detailed thermal behaviours at the pore level either by numerical or experimental approaches. © 2012 Elsevier Ltd. All rights reserved.

Sukmak P.,Suranaree University of Technology | Horpibulsuk S.,Suranaree University of Technology | Shen S.-L.,Shanghai JiaoTong University
Construction and Building Materials | Year: 2013

This paper presents the role of influential factors on the strength development in a clay-fly ash geopolymer that a silty clay is used as fine aggregates and fly ash, FA is used as a pozzolanic material. A liquid alkaline activator, L is a mixture of sodium silicate solution (Na2SiO 3) and sodium hydroxide solution (NaOH). The studied influential factors are Na2SiO3/NaOH ratio, L/FA ratio and heat conditions. The optimum ingredient for the clay-FA geopolymer is the Na 2SiO3/NaOH ratio of 0.7 and the L/FA ratio of 0.6. The Na2SiO3/NaOH ratio required for the clay-FA geopolymer is less than that of the FA geopolymer because the clay has high cation absorption ability and then absorbs some of the input NaOH. For a given Na 2SiO3/NaOH content, the strength increases with increasing the liquid alkaline activator. The excess input alkaline activator causes the precipitation at very early stage before the condensation process in geopolymerization and results in the cracks on the FA particles. The overheating (very high temperature) and excess heat duration cause the micro-cracks on the specimens. The relationship between the strength and heat energy is proposed to integrate the role of heat temperature and duration on the geopolymerization. The compressive strength increases with increasing heat energy up to a certain level. Beyond this level, the specimens shrink and crack due to the reduction in pore fluid, which results in the strength reduction. The relationship between strength and heat energy can be used as fundamental for further study on the strength development and the mix design method for the clay-FA geopolymer with different specimen dimensions, clay minerals, liquid alkaline activators, pozzolanic materials and clay:FA ratios. © 2012 Elsevier Ltd. All rights reserved.

PURPOSE:: To investigate the choroidal thickness in unilateral idiopathic macular hole (IMH) eyes and compare them with normal control eyes using enhanced depth imaging optical coherence tomography (EDI-OCT). METHODS:: In this cross-sectional study, the subfoveal choroidal thickness (SFCT) and choroidal thickness at 1 mm and 3 mm nasal, temporal, superior, and inferior to the fovea of IMH eyes and normal control eyes were measured using EDI-OCT. Univariate and multivariate linear regression analyses were performed to evaluate the correlation between choroidal thickness at various locations and clinical factors. A meta-analysis was conducted using the Stata software package to calculate the summary of weighted mean differences (WMDs). RESULTS:: Thirty-two unilateral IMH patients and 32 controls were enrolled in this study. The IMH eyes had a thinner choroid than the control eyes at all macular locations (all P < 0.001). Multivariate linear regression analysis further showed that the choroidal thickness at any of the nine points was significantly thinner in association with the IMH diagnosis, as well as being somewhat thinner in association with age and axial length. The result of our cross-sectional study was consistent with the meta-analysis with a pooled WMD of −56.99 (95% confidence interval [CI]: −68.58 to −45.41) for subfoveal choroidal thickness. CONCLUSION:: The study of Chinese unilateral IMH patients, along with the comprehensive meta-analysis, suggested that the choroidal thickness at all macular locations in unilateral IMH eyes significantly decreased relative to the control group. © 2016 by Ophthalmic Communications Society, Inc.

Thermal post-buckling and nonlinear vibration behaviors of FGM beams are analyzed by using concept of physical neutral surface, von Kármán strain-displacement relationships and high order shear deformation theory. Material properties are assumed to be temperature dependent and vary along the thickness. The prominent character of physical neutral surface higher-order shear deformation beam theory is that stretching-bending couplings are eliminated in constitutive equations, and governing equations have the similar forms as homogeneous isotropic beams. Approximate solutions are given out by Ritz method, and influences played by different supported boundaries, thermal environmental conditions and volume fraction index are discussed in detail. © 2013 Springer Science+Business Media Dordrecht.

Fei P.,Shanghai JiaoTong University
Retina | Year: 2016

PURPOSE:: To report the management of complicated advanced familial exudative vitreoretinopathy in a predominantly young population. METHODS:: This retrospective study was performed on 34 eyes of 25 patients with severe complications of advanced familial exudative vitreoretinopathy, including retinal detachment, corneal opacity, shallow or flat anterior chamber, cataract, posterior pupillary adhesion, secondary glaucoma, vitreous hemorrhage, and preretinal hemorrhage. Preoperative and postoperative clinical information was reviewed. RESULTS:: The average age of the patients was 3.52 ± 5.94 years. Of the 34 eyes, 22 underwent lensectomy, 9 underwent lensectomy combined with vitrectomy, 2 underwent staged lensectomy and vitrectomy, and 1 underwent lens-sparing vitrectomy. After surgery, the shallow or flat anterior chamber became normal in 26/28 eyes; corneal opacity disappeared or improved in 10/22 eyes; and secondary glaucoma was controlled in 22/24 eyes. Among the 12 eyes operated by vitrectomy, the retina was attached in 5 eyes and partly attached in 7. Final visual acuity ranged from no light perception to 30/200 (n = 17). All 5 eyes with preoperative and postoperative visual acuity records showed improvement. CONCLUSION:: Surgical intervention is recommended to resolve complications of advanced familial exudative vitreoretinopathy and to preserve visual function. Staged lensectomy and vitrectomy is an alternative for advanced familial exudative vitreoretinopathy with corneal complications and/or vascularly active fibrovascular proliferation. © 2016 by Ophthalmic Communications Society, Inc.

In this paper, model of the FGM plates resting on two-parameter elastic foundations is put forward by using on physical neutral surface and high-order shear deformation theory. Material properties are assumed to be temperature dependent and vary along the thickness, while Poisson's ratio depends weakly on temperature change and position and is assumed to be a constant. It is worth noting that physical neutral surface will be changed with temperature. The character of physical neutral surface higher-order shear deformation plate theory is that the displacements have special forms, stretching-bending couplings are eliminated in constitutive equations, and governing equations have the simple and similar forms as homogeneous isotropic plates. The validity of physical neutral surface higher-order shear deformation plate theory can be confirmed by comparing with related researchers' results. Nonlinear bending approximate solutions of FGM rectangular plates with six cases of boundary conditions are given out using Ritz method, and influences played by different supported boundaries, foundation stiffnesses, thermal environmental conditions, and volume fraction index are discussed in detail. © 2013 Springer-Verlag Berlin Heidelberg.

Zhang D.-G.,Shanghai JiaoTong University
Composite Structures | Year: 2013

Model of the FGM beams is first put forward by using on physical neutral surface and high-order shear deformation theory. Nonlinear von Kármán strain-displacement relationships are adopted, and material properties are assumed to be temperature dependent and vary along the thickness. It is worth noting that physical neutral surface will be changed with temperature. Therefore, the displacements have special forms, there are no stretching-bending couplings in constitutive equations, and governing equations have the simple forms, so the solution procedure is similar as homogeneous isotropic beams. The validity of physical neutral surface higher-order shear deformation beam theory can be confirmed by comparison with related researchers' results. Nonlinear bending approximate solutions are given out using Ritz method. Physical neutral surface theory has many merits in the engineering application due to its easiness and simplicity. © 2013 Elsevier Ltd.

Lu R.Q.,Shanghai JiaoTong University
Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery | Year: 2012

To sort CD133(+) subset cells in human gastric cancer (GC) and to identify their tumor initiating cell-like properties. The tissues of GC and normal tissues adjacent to GC were obtained from 50 patients. Samples were stained for CD133 by immunohistochemistry. Likewise, assessments of CD133 were undertaken by Western blot. Flow cytometry was used to determine the proportion of CD133(+) cells in four GC cell lines therein the KATO-III was sorted by magnetic activated cell sorting (MACS) method. The growing characteristics and the tumorigenic ability of CD133(+) cells were evaluated in vitro and in vivo. Meanwhile, the growth of single cells in suspension culture was observed and expression of stem cell-specific marker were determined using reverse transcription-polymerase chain reaction (RT-PCR). The expression of CD133 was demonstrated on the cell membranes in the mucosa and submucosa of primary GC, which were higher than those in the normal gastric tissues adjacent to cancer (P<0.05). Four GC cell lines including KATO-III, SGC-7901, AGS and MKN-45 were found to contain (28 ± 2)%, (17 ± 2)%, (6 ± 2)%, and (4 ± 2)% of CD133(+) cells respectively. In addition, the purity of CD133(+) cells isolated from KATO-III by MACS was (91 ± 3)% and up to(95 ± 2)% after 1-week culture. CCK-8 detection showed that population doubling time of the CD133(+) cells was (21 ± 3)h, significantly shorter than that of the CD133(-) cells[(40 ± 8)h, P<0.05]. Notably, there was a remarkable difference of tumor formation rate between CD133(+) cells (100%), non-sorted cells (80%), and CD133(-) cells(0). The average mass and volume of tumor in group of CD133(+) cells was larger and heavier than those in non-sorted cells (P<0.05, P<0.05). Furthermore, the single cell proliferated well, formed the big sphere and semi-quantitative RT-PCR showed expression of stem cell markers such as Oct-4, Nanog, Sox-2, Musashi-1 and EGFR. CD133 protein expression in primary lesions is higher than those in the normal gastric tissues. CD133(+) subset cells can be isolated, purified, and amplified in human GC, and possess some properties including the ability of self-renewal, proliferation, and higher tumorigenic ability in vivo and can express some stem cell markers.

Iwabuchi S.J.,University of Nottingham | Krishnadas R.,University of Glasgow | Li C.,Shanghai JiaoTong University | Auer D.P.,University of Nottingham | And 2 more authors.
Neuroscience and Biobehavioral Reviews | Year: 2015

Resting-state fMRI studies investigating the pathophysiology of depression have identified prominent abnormalities in large-scale brain networks. However, it is unclear if localized dysfunction of specialized brain regions contribute to network-level abnormalities. We employed a meta-analytical procedure and reviewed studies conducted in China investigating changes in regional homogeneity (ReHo), a measure of localized intraregional connectivity, from resting-state fMRI in depression. Exploiting the statistical power gained from pooled analysis, we also investigated the effects of age, gender, illness duration and treatment on ReHo. The medial prefrontal cortex (MPFC) showed the most robust and reliable increase in ReHo in depression, with greater abnormality in medication-free patients with multiple episodes. Brain networks that relate to this region have been identified previously to show aberrant connectivity in depression, and we propose that the localized neuronal inefficiency of MPFC exists alongside wider network level disruptions involving this region. © 2015 Elsevier Ltd.All rights reserved.

Liu M.,Shanghai JiaoTong University
Pattern Recognition | Year: 2010

Fingerprint classification is an important indexing scheme to narrow down the search of fingerprint database for efficient large-scale identification. It is still a challenging problem due to the intrinsic class ambiguity and the difficulty for poor quality fingerprints. In this paper, we presents a fingerprint classification algorithm that uses Adaboost learning method to model multiple types of singularity features. Firstly, complex filters are used to detect the singularities. For powerful representation, we compute the complex filter responses of the detected singularities at multiple scales and a feature vector is constructed for each scale that consists of the relative position and direction and the certainties of the singularities. Adaboost learning method is then applied on decision trees to design a classifier for fingerprint classification. Finally, fingerprint class is determined by the ensemble of the classification results at multiple scales. The experimental results and comparisons on NIST-4 database have shown the effectiveness and superiority of the fingerprint classification algorithm. © 2009 Elsevier Ltd. All rights reserved.

Sheng G.G.,Changsha University of Science and Technology | Wang X.,Shanghai JiaoTong University
Composites Part B: Engineering | Year: 2013

An analytical method and a new simplifying model of smart FG (functionally graded) laminated cylindrical shells with thin piezoelectric layers are presented based on Hamilton's principle, Von Kármán nonlinear theory and constant-gain negative velocity feedback approach. The thin piezoelectric layers embedded on inner and outer surfaces of the smart FG laminated cylindrical shell are acted as distributed sensor and actuator, which is used to control nonlinear vibration of the smart FG laminated cylindrical shell. The coupled nonlinear partial differential equations are discretized based on a series expansion of linear modes and a multiterm Galerkin's method. The coupled nonlinear equations of motion are then solved by Runge-Kutta numerical method. © 2013 Elsevier Ltd.

Li Y.,Beijing University of Technology | Chen B.,Shanghai JiaoTong University
Construction and Building Materials | Year: 2013

Magnesium phosphate cement (MPC) was prepared with dead burned magnesia oxide (MgO), potassium di-hydrogen phosphate (KH2PO4) and some retarders in a given proportion used in the same manner as Portland cement. Factors such as the w/c ratio, casting temperature and fly ash contents that affect the properties of MPC were studied in this paper. The experimental results demonstrate that the setting time was significantly affected by the w/c ratio and casting temperature. Adding fly ash can increase the setting time and flowability of fresh MPC paste. The compressive strengths of MPC paste prepared using various w/c ratios were measured at ages of 3 h, 1 d, 7 d and 28 d. The 3-, 7- and 28-day compressive strengths of MPC mortar prepared using various fly ash contents were also measured. The compressive strength of MPC paste decreased with an increasing w/c ratio, and the aged compressive strengths of MPC mortar increased with increasing fly ash content. The results also indicate that adding fly ash can improve the water resistance and dry shrinkage of MPC mortar. Finally, the hydrate products were analyzed using XRD and SEM. © 2013 Elsevier B.V. All rights reserved.

Guan N.,National University of Defense Technology | Tao D.,Intelligent Systems Technology, Inc. | Luo Z.,National University of Defense Technology | Yuan B.,Shanghai JiaoTong University
IEEE Transactions on Signal Processing | Year: 2012

Nonnegative matrix factorization (NMF) is a powerful matrix decomposition technique that approximates a nonnegative matrix by the product of two low-rank nonnegative matrix factors. It has been widely applied to signal processing, computer vision, and data mining. Traditional NMF solvers include the multiplicative update rule (MUR), the projected gradient method (PG), the projected nonnegative least squares (PNLS), and the active set method (AS). However, they suffer from one or some of the following three problems: slow convergence rate, numerical instability and nonconvergence. In this paper, we present a new efficient NeNMF solver to simultaneously overcome the aforementioned problems. It applies Nesterov's optimal gradient method to alternatively optimize one factor with another fixed. In particular, at each iteration round, the matrix factor is updated by using the PG method performed on a smartly chosen search point, where the step size is determined by the Lipschitz constant. Since NeNMF does not use the time consuming line search and converges optimally at rate O(1/k2) in optimizing each matrix factor, it is superior to MUR and PG in terms of efficiency as well as approximation accuracy. Compared to PNLS and AS that suffer from numerical instability problem in the worst case, NeNMF overcomes this deficiency. In addition, NeNMF can be used to solve L 1-norm, L 2-norm and manifold regularized NMF with the optimal convergence rate. Numerical experiments on both synthetic and real-world datasets show the efficiency of NeNMF for NMF and its variants comparing to representative NMF solvers. Extensive experiments on document clustering suggest the effectiveness of NeNMF. © 2012 IEEE.

Zhang D.-G.,Shanghai JiaoTong University
International Journal of Mechanical Sciences | Year: 2013

In this paper, model of the FGM plate is successfully constructed by physical neutral surface and high-order shear deformation theory. Material properties are assumed to be temperature-dependent, while Poisson's ratio depends weakly on temperature change and position and is assumed to be a constant. It is worth noting that physical neutral surface will be changed with temperature. Therefore, the displacements have special forms, there are no stretching-bending couplings in constitutive equations, and governing equations have the simple forms, so the solution procedure is similar as homogeneous isotropic plate. The validity of physical neutral surface higher-order shear deformation plate theory can be confirmed by comparison with related researchers' results. Using this new model, post-buckling, nonlinear bending and vibration approximate solutions are given out using Ritz method, and influences played by different supported boundaries, thermal environmental conditions and volume fraction index are discussed in detail. Physical neutral surface theory has many merits in the engineering application due to its easiness and simplicity. © 2013 Elsevier Ltd.

Sheng G.G.,Changsha University of Science and Technology | Wang X.,Shanghai JiaoTong University
Composite Structures | Year: 2013

An analytical method and a new simplifying model of FG (functionally graded) cylindrical shells are presented based on Hamilton's principle, Von Kármán non-linear theory and the first-order shear deformation theory, and subjected to thermal and axial loads. The coupled non-linear partial differential vibration equations are discretized based on a series expansion of linear modes and a multiterm Galerkin's method. Neglecting the membrane inertias and rotary inertias, the equation of motion is transformed into a reduced equation in the generalised transverse displacement. Adopting multiple scales method, the amplitude frequency dependence and the non-linear forced frequency response are obtained in the case of a single mode assumption. The good agreement found was very satisfactory, in comparison with previous theoretical approaches. The purpose of this approach was to provide engineers and designers with an easy method for determining the non-linear vibration behaviour of FG cylindrical shells. © 2012 Elsevier Ltd.

Luo X.-G.,Shenyang University | Chen S.-D.,Shanghai JiaoTong University
Translational Neurodegeneration | Year: 2012

It has been nearly a century since the early description of microglia by Rio-Hortega; since then many more biological and pathological features of microglia have been recognized. Today, microglia are generally considered to be beneficial to homeostasis at the resting state through their abilities to survey the environment and phagocytose debris. However, when activated microglia assume diverse phenotypes ranging from fully inflamed, which involves the release of many pro-inflammatory cytokines, to alternatively activated, releasing anti-inflammatory cytokines or neurotrophins, the consequences to neurons can range from detrimental to supportive. Due to the different experimental sets and conditions, contradictory results have been obtained regarding the controversial question of whether microglia are " good" or " bad." While it is well understood that the dual roles of activated microglia depend on specific situations, the underlying mechanisms have remained largely unclear, and the interpretation of certain findings related to diverse microglial phenotypes continues to be problematic. In this review we discuss the functions of microglia in neuronal survival and neurogenesis, the crosstalk between microglia and surrounding cells, and the potential factors that could influence the eventual manifestation of microglia. © 2012 Luo and Chen; licensee BioMed Central Ltd.

Shull P.B.,Shanghai JiaoTong University | Damian D.D.,Harvard University
Journal of NeuroEngineering and Rehabilitation | Year: 2015

Sensory impairments decrease quality of life and can slow or hinder rehabilitation. Small, computationally powerful electronics have enabled the recent development of wearable systems aimed to improve function for individuals with sensory impairments. The purpose of this review is to synthesize current haptic wearable research for clinical applications involving sensory impairments. We define haptic wearables as untethered, ungrounded body worn devices that interact with skin directly or through clothing and can be used in natural environments outside a laboratory. Results of this review are categorized by degree of sensory impairment. Total impairment, such as in an amputee, blind, or deaf individual, involves haptics acting as sensory replacement; partial impairment, as is common in rehabilitation, involves haptics as sensory augmentation; and no impairment involves haptics as trainer. This review found that wearable haptic devices improved function for a variety of clinical applications including: rehabilitation, prosthetics, vestibular loss, osteoarthritis, vision loss and hearing loss. Future haptic wearables development should focus on clinical needs, intuitive and multimodal haptic displays, low energy demands, and biomechanical compliance for long-term usage. © 2015 Shull and Damian.

Shen H.-S.,Shanghai JiaoTong University
International Journal of Structural Stability and Dynamics | Year: 2011

Postbuckling, nonlinear bending, and nonlinear vibration analyses are presented for a simply supported EulerBernoulli beam resting on a two-parameter elastic foundation. The nonlinear model is introduced by using the exact expression of the curvature. Two kinds of end conditions, namely movable and immovable, are considered. The nonlinear equation of motion, including beamfoundation interaction, is derived separately for these two kinds of end conditions. The analysis uses a two-step perturbation technique to determine the postbuckling equilibrium paths of an axially loaded beam, the static large deflections of a bending beam subjected to a uniform transverse pressure, and the nonlinear frequencies of a beam with or without initial stresses. The numerical results confirm that the foundation stiffness has a significant effect on the nonlinear behavior of EulerBernoulli beams. The results also reveal that the end condition has a great effect on the nonlinear bending and nonlinear vibration behaviors of EulerBernoulli beams with or without elastic foundations. © 2011 World Scientific Publishing Company.

Xu K.,Shanghai JiaoTong University | Simaan N.,Columbia University
IEEE Transactions on Robotics | Year: 2010

This paper presents the intrinsic capability of full-wrench estimation of multisegment continuum robots with multiple flexible backbones. Intrinsic-full-wrench estimation refers to the ability of continuum robots to also serve as force and moment sensors by using measurements of axial loads on their backbones. This end-effector-as-sensor approach fulfills the rapidly increasing needs for miniature-robotic-surgical tools with haptic sensing ability subject to various limitations, such as size, magnetic resonance imaging (MRI) compatibility, sterilizability, etc. A performance index for the intrinsic wrench-sensing capability is introduced and evaluated to show how this index can serve as a design guide for continuum robots that provide force sensing. © 2010 IEEE.

He J.-H.,National institute for astrophysics | Wang B.,Shanghai JiaoTong University
Physical Review D - Particles, Fields, Gravitation and Cosmology | Year: 2013

We reconstruct an f(R) gravity model that gives rise to the particular ΛCDM background evolution of the Universe. We find well-defined, real-valued analytical forms for the f(R) model to describe the Universe both in the early epoch from the radiation to matter dominated eras and the late time acceleration period. We further examine the viability of the derived f(R) model and find that it is viable to describe the evolution of the Universe in the past and the future singularity does not exist in the Lagrangian. © 2013 American Physical Society.

Leung J.Y.-T.,New Jersey Institute of Technology | Pinedo M.,New York University | Wan G.,Shanghai JiaoTong University
Operations Research | Year: 2010

We consider a scheduling environment with m (m≥ 1) identical machines in parallel and two agents. Agent A is responsible for n1 jobs and has a given objective function with regard to these jobs; agent B is responsible for n 2 jobs and has an objective function that may be either the same or different from the one of agent A. The problem is to find a schedule for the n1 + n2 jobs that minimizes the objective of agent A (with regard to his n 1 jobs) while keeping the objective of agent B (with regard to his n2 jobs) below or at a fixed level Q. The special case with a single machine has recently been considered in the literature, and a variety of results have been obtained for two-agent models with objectives such as f max, ∑wjCj , and ∑Uj . In this paper, we generalize these results and solve one of the problems that had remained open. Furthermore, we enlarge the framework for the two-agent scheduling problem by including the total tardiness objective, allowing for preemptions, and considering jobs with different release dates; we consider also identical machines in parallel. We furthermore establish the relationships between two-agent scheduling problems and other areas within the scheduling field, namely rescheduling and scheduling subject to availability constraints. ©2010 INFORMS.

Zhang L.,University of Arizona | Chen J.-J.,Shanghai JiaoTong University
Canadian Geotechnical Journal | Year: 2012

In this paper, the effect of spatial correlation of standard penetration test (SPT) data on the bearing capacity of driven piles in sand is analyzed. First, the direct approach for using SPT data to determine the bearing capacity of piles in sand is used to derive the expressions for probabilistic prediction of pile bearing capacity by considering the spatial correlation of the SPT data. To analyze the relationship between the probability of failure and the factor of safety, a procedure based on the advanced first-order, second-moment (FOSM) method is used. Then parametric studies are conducted on the spatial correlation between the spatial average of SPT numbers over the pile length, NLV, and the spatial average of SPT numbers over an interval near the pile base, NbV, and its effect on the bearing capacity of piles. The results indicate that it is important to consider the spatial correlation between NLV and NbV in the probabilistic prediction of pile bearing capacity. Ignoring this spatial correlation will underestimate the probability of failure and lead to unsafe design. Finally, three tested piles are analyzed to demonstrate the probabilistic analysis of piles by considering the spatial correlation of SPT data and the procedure for probabilistic analysis of pile bearing capacity is summarized.

Wu F.,Shanghai JiaoTong University | Vaidya N.,University of Illinois at Urbana - Champaign
IEEE Transactions on Mobile Computing | Year: 2013

With the growing deployment of wireless communication technologies, radio spectrum is becoming a scarce resource. Thus, mechanisms to efficiently allocate the available spectrum are of interest. In this paper, we model the radio spectrum allocation problem as a sealed-bid reserve auction, and propose SMALL, which is a Strategy-proof Mechanism for radio spectrum ALLocation. Furthermore, we extend SMALL to adapt to multiradio spectrum buyers, which can bid for more than one radio. We evaluate SMALL with simulations. Simulation results show that SMALL has good performance in median to large scale spectrum auctions. © 2002-2012 IEEE.

Yin Z.W.,Shanghai JiaoTong University
CAD Computer Aided Design | Year: 2011

An extended STL file format is presented in this paper. Differing with existing solutions, it proposes a new format to produce and store triangles. The format uses a cluster unit composed of several triangles. The main advantages of the format are that it contains both geometry and topological information and has improved storage capability. Direct generation of the extended STL from the scanned data has a great advantage in that it can reduce the time and error in modeling process. In order to obtain the format from unorganized point cloud, a new triangulation algorithm was introduced. The algorithm is based on reconstructing the relative Delaunay triangulation of the sample points on the surface. Other advantages of the extended STL format were also presented in this paper. © 2011 Elsevier Ltd. All rights reserved.

Peng C.,Shanghai JiaoTong University
Biophysical journal | Year: 2010

We present a novel sampling approach to explore large protein conformational transitions by determining unique substates from instantaneous normal modes calculated from an elastic network model, and applied to a progression of atomistic molecular dynamics snapshots. This unbiased sampling scheme allows us to direct the path sampling between the conformational end states over simulation timescales that are greatly reduced relative to the known experimental timescales. We use adenylate kinase as a test system to show that instantaneous normal modes can be used to identify substates that drive the structural fluctuations of adenylate kinase from its closed to open conformations, in which we observe 16 complete transitions in 4 mus of simulation time, reducing the timescale over conventional simulation timescales by two orders of magnitude. Analysis shows that the unbiased determination of substates is consistent with known pathways determined experimentally. Copyright 2010 Biophysical Society. Published by Elsevier Inc. All rights reserved.

Kong L.T.,Shanghai JiaoTong University
Computer Physics Communications | Year: 2011

A method to measure the phonon dispersion of a crystal based on molecular dynamics simulation is proposed and implemented as an extension to an open source classical molecular dynamics simulation code LAMMPS. In the proposed method, the dynamical matrix is constructed by observing the displacements of atoms during molecular dynamics simulation, making use of the fluctuation-dissipation theory. The dynamical matrix can then be employed to compute the phonon spectra by evaluating its eigenvalues. It is found that the proposed method is capable of yielding the phonon dispersion accurately, while taking into account the anharmonic effect on phonons simultaneously. The implementation is done in the style of fix of LAMMPS, which is designed to run in parallel and to exploit the functions provided by LAMMPS; the measured dynamical matrices could be passed to an auxiliary postprocessing code to evaluate the phonons. Program summary: Program title: FixPhonon, version 1.0 Catalogue identifier: AEJB-v1-0 Program summary URL: http://cpc.cs.qub.ac.uk/ summaries/AEJB-v1-0.html Program obtainable from: CPC Program Library, Queens University, Belfast, N. Ireland Licensing provisions: GNU General Public license No. of lines in distributed program, including test data, etc.: 105 393 No. of bytes in distributed program, including test data, etc.: 3 231 800 Distribution format: tar.gz Programming language: C++ Computer: All Operating system: Linux Has the code been vectorized or parallelized?: Yes. 1 to N processors may be used RAM: Depends on problem, ≈1 kB to several MB Classification: 7.8 External routines: MPI, FFT, LAMMPS version 15, January 2010 (http://lammps.sandia.gov/) Nature of problem: Atoms in solids make ceaseless vibrations about their equilibrium positions, and a collective vibration forms a wave of allowed wavelength and amplitude. The quantum of such lattice vibration is called the phonon, and the so-called "lattice dynamics" is the field of study to find the normal modes of these vibrations. In other words, lattice dynamics examines the relationship between the frequencies of phonons and the wave vectors, i.e., the phonon dispersion. The evaluation of the phonon dispersion requires the construction of the dynamical matrix. In atomic scale modeling, the dynamical matrices are usually constructed by deriving the derivatives of the force field employed, which cannot account for the effect of temperature on phonons, with an exception of the tedious "quasi- harmonic" procedure. Solution method: We propose here a method to construct the dynamical matrix directly from molecular dynamics simulations, simply by observing the displacements of atoms in the system thus making the constructing of the dynamical matrix a straightforward task. Moreover, the anharmonic effect was taken into account in molecular dynamics simulations naturally, the resultant phonons therefore reflect the finite temperature effect simultaneously. Restrictions: A well defined lattice is necessary to employ the proposed method as well as the implemented code to evaluate the phonon dispersion. In other words, the system under study should be in solid state where atoms vibrate about their equilibrium positions. Besides, no drifting of the lattice is expected. The method is best suited for periodic systems, although non-periodic system with a supercell approach is also possible, it will however become inefficient when the unit cell contains too many atoms. Additional comments: The readers are encouraged to visit http://code.google.com/ p/fix-phonon for subsequent update of the code as well as the associated postprocessing code, so as to keep up with the latest version of LAMMPS. Running time: Running time depends on the system size, the numbers of processors used, and the complexity of the force field, like a typical molecular dynamics simulation. For the third example shown in this paper, it took about 2.5 hours on an Intel Xeon X3220 architecture (2.4G, quadcore). References: C. Campañá, M.H. Müser, Phys. Rev. B 74 (2006) 075420.L.T. Kong, G. Bartels, C. Campañá, C. Denniston, M.H. Müser, Comp. Phys. Commun. 180 (6) (2009) 1004-1010. © 2011 Elsevier B.V. All rights reserved.

Liu L.,Shanghai JiaoTong University
Qualitative health research | Year: 2012

In this study we explored the perceptions of Chinese patients with schizophrenia about their treatment, mental state, social relationships, and daily life throughout the psychotic episodes. A purposive sample of 16 schizophrenia patients with heterogeneous demographic backgrounds was recruited. We collected data through face-to-face semistructured interviews. We conducted a qualitative data analysis and identified three central themes inductively: (a) negative experiences, (b) sense of powerlessness, and (c) ambivalent therapeutic relationship. Several subthemes were derived under each central theme. The participants' narratives revealed a complex picture of disadvantage and difficulties throughout their psychotic episodes and rehabilitation processes. The themes identified are explored in detail, and their links with existing research and potential clinical implications are considered.

Wang L.,Case Western Reserve University | McCleese C.,Case Western Reserve University | Kovalsky A.,Case Western Reserve University | Zhao Y.,Shanghai JiaoTong University | Burda C.,Case Western Reserve University
Journal of the American Chemical Society | Year: 2014

CH3NH3PbI3 perovskite layered films deposited on substrates with and without a titania support structure have been prepared and studied using time-resolved femtosecond transient absorption (fs-TA) spectroscopy in the visible light range (450-800 nm). The electron injection dynamics from the photoexcited perovskite layers to the neighboring film structures could be directly monitored via the transient bleaching dynamics of the perovskite at ∼750 nm and thus systematically studied as a function of the layer-by-layer architecture. In addition, for the first time we could spectrally distinguish transient bleaching at ∼750 nm from laser-induced fluorescence that occurs red-shifted at ∼780 nm. We show that an additional bleach feature at ∼510 nm appears when PbI2 is present in the perovskite film. The amplitudes of the PbI2 and perovskite TA peaks were compared to estimate relative amounts of PbI2 in the samples. Kinetic analysis reveals that perovskite films with less PbI2 show faster relaxation rates than those containing more PbI2. These fast dynamics are attributed to charge carrier trapping at perovskite grain boundaries, and the slower dynamics in samples containing PbI2 are due to a passivation effect, in line with other recently reported work. © 2014 American Chemical Society.

Zhao Y.,Shanghai JiaoTong University | Zhu K.,National Renewable Energy Laboratory
Journal of the American Chemical Society | Year: 2014

Hybrid organometallic halide perovskite CH3NH 3PbI2Br (or MAPbI2Br) nanosheets with a 1.8 eV band gap were prepared via a thermal decomposition process from a precursor containing PbI2, MABr, and MACl. The planar solar cell based on the compact layer of MAPbI2Br nanosheets exhibited 10% efficiency and a single-wavelength conversion efficiency of up to 86%. The crystal phase, optical absorption, film morphology, and thermogravimetric analysis studies indicate that the thermal decomposition process strongly depends on the composition of precursors. We find that MACl functions as a glue or soft template to control the initial formation of a solid solution with the main MAPbI2Br precursor components (i.e., PbI2 and MABr). The subsequent thermal decomposition process controls the morphology/surface coverage of perovskite films on the planar substrate and strongly affects the device characteristics. © 2014 American Chemical Society.

Yang X.,Japan National Institute of Materials Science | Yanagida M.,Japan National Institute of Materials Science | Han L.,Japan National Institute of Materials Science | Han L.,Shanghai JiaoTong University
Energy and Environmental Science | Year: 2013

Dye-sensitized solar cells (DSCs) have attracted great interest as potential candidates of "low cost solar cells" in the solution of global energy demand. To accelerate the progress of DSCs, it is important to evaluate device performance with reliable measurements that will enable more effective comparison and application of new findings in materials and technologies by different research groups. In this perspective, we review existing measurement methods and summarize the appropriate techniques for the evaluation of DSCs based mainly on our experience, which helped us to obtain reliable results close to those certified by public test centres. The key factors in the measurements that correlate to device performance are discussed, including the calibration of the solar simulator using reference cells, the measurement time of the current-voltage characteristics and the incident photon-to-current conversion efficiency, and the area for determination with a proper shading mask. We demonstrate the causes and solutions of measurement errors in the results of device performance, such as short circuit photocurrent density, open circuit voltage, fill factor, and energy conversion efficiency. Finally, a list of appropriate measurements for a more reliable evaluation of DSCs is proposed. © The Royal Society of Chemistry 2013.

Cao L.,Shanghai JiaoTong University
Movement disorders : official journal of the Movement Disorder Society | Year: 2010

Mutation detection in the guanosine triphosphate cyclohydrolase I gene (GCH1) was performed from 4 female patients with dopa-responsive dystonia (DRD). DNA sequencing revealed the presence of four novel mutations including c.2T>C(M1T), c.239G>A(S80N), c.245T>C(L82P), and IVS5+3 del AAGT. These four mutations were not found in 100 genetically unrelated healthy controls with the same ethnic background band. In all 3 childhood-onset patients, DRD started in the legs, and missense mutations were located in the coding region of GCH1. Deletion mutation in the fifth exon-intron boundary of GCH1 was detected in the adult-onset patient. Although the data presented here do not provide sufficient evidence to establish a genotype-phenotype correlation of DRD, it is important to know the clinic features and genetic defects of DRD patients, which will help prenatal diagnosis, early diagnosis, evaluate the prognosis, and facilitate causal therapy with levodopa. 2010 Movement Disorder Society

Nakata T.,Chiba University | Liu H.,Chiba University | Liu H.,Shanghai JiaoTong University
Proceedings of the Royal Society B: Biological Sciences | Year: 2012

Insect wings are deformable structures that change shape passively and dynamically owing to inertial and aerodynamic forces during flight. It is still unclear how the three-dimensional and passive change of wing kinematics owing to inherent wing flexibility contributes to unsteady aerodynamics and energetics in insect flapping flight. Here, we perform a systematic fluid-structure interaction based analysis on the aerodynamic performance of a hovering hawkmoth, Manduca, with an integrated computational model of a hovering insect with rigid and flexible wings. Aerodynamic performance of flapping wings with passive deformation or prescribed deformation is evaluated in terms of aerodynamic force, power and efficiency. Our results reveal that wing flexibility can increase downwash in wake and hence aerodynamic force: first, a dynamic wing bending is observed, which delays the breakdown of leading edge vortex near the wing tip, responsible for augmenting the aerodynamic force-production; second, a combination of the dynamic change of wing bending and twist favourably modifies the wing kinematics in the distal area, which leads to the aerodynamic force enhancement immediately before stroke reversal. Moreover, an increase in hovering efficiency of the flexible wing is achieved as a result of the wing twist. An extensive study of wing stiffness effect on aerodynamic performance is further conducted through a tuning of Young's modulus and thickness, indicating that insect wing structures may be optimized not only in terms of aerodynamic performance but also dependent on many factors, such as the wing strength, the circulation capability of wing veins and the control of wing movements. © 2011 The Royal Society.

Shao X.-F.,Shanghai JiaoTong University
International Journal of Production Economics | Year: 2012

This research examines demand-side reactive strategies for supply disruption in a multiple assemble-to-order system. We consider an assemble-to-order system with two substitute products where the demand is price-sensitive and disruption-sensitive. Two different supply disruption situations are examined: disruption of the low-value component and disruption of the high-value component. We propose and compare the performance of four reactive strategies for managing supply disruptions, namely, the backordering strategy, the upgrading/downgrading strategy, the compensation strategy, and the mixed strategy. We find that the compensation strategy and the mixed strategy can keep more customers than the backordering strategy and the upgrading strategy during the supply disruption of the low-value product. For the disruption of the high-value product, the total number of customers keeps constant. But it does lead to the reallocation of customers among the products. We find that the mixed strategy is the best reactive strategy and the backordering strategy is the worst one among the four reactive strategies. © 2011 Elsevier B.V.

Liu Y.,Shanghai JiaoTong University
Lixue Xuebao/Chinese Journal of Theoretical and Applied Mechanics | Year: 2012

The lateral vibration of an axially moving beam is a dynamics problem with practical engineering background. In this paper the Cosserat's model of elastic rod was applied to discuss the dynamics modeling and stability of an axially moving beam with circular cross section. The arc-coordinate along the center line of the beam was used instead of the fixed coordinate. The deformation process of the beam was expressed by the attitude motion of the cross section with the variation of the arc-coordinate and time. Considering the inertial effect and shear strain of the cross section, the dynamics equations of the beam with large deformation were established from the view point of the concept of velocity field of Euler. The three-dimensional motion of an axially moving Timoshenko's beam can be regarded as a special case of small deformation. The stability problem of quasi-stationary state of the axially moving beam was discussed in the static and dynamic states, and the critical axial velocity before buckling was derived. It was proved that the Euler's stability conditions of the moving beam in the space domain are the necessary conditions of Lyapunov's stability in the time domain.

Fang L.Q.,Shanghai University | Ge X.-H.,Shanghai University | Kuang X.-M.,Shanghai JiaoTong University
Nuclear Physics B | Year: 2013

We explore the properties of the holographic fermions in extremal R-charged black hole background with a running chemical potential, as well as the dipole coupling between fermions and the gauge field in the bulk. We find that although the running chemical potential effect the location of the Fermi surface, it does not change the type of fermions. We also study the onset of the Fermi gap and the gap effected by running chemical potential and the dipole coupling. The spectral function in the limit ω. →. 0 and the existence of the Fermi liquid are also investigated. The running chemical potential and the dipole coupling altogether can make a non-Fermi liquid become the Landau-Fermi type. © 2013 Elsevier B.V.

Zhang Y.,Shanghai JiaoTong University
European journal of histochemistry : EJH | Year: 2013

Nucleoside triphosphate pyrophosphohydrolase (NTP-PPase) functions as one of the mechanisms to guarantee the fidelity of DNA replication through the cleavage of non-canonical nucleotides into di- or monophosphates. Human NTP-PPase is poorly understood and investigated. In the present study, by using tissue microassays with the paired cancer and adjacent regions, we found that with the prevalent expression of dCTP pyrophosphohydrase (DCTPP1) in the cytosol and nucleus in tumors investigated, DCTPP1 was inclined to accumulate in the nucleus of cancer cells compared to the paired adjacent tissue cells in multiple carcinoma including lung, breast, liver, cervical, gastric and esophagus cancer. More significantly, the higher DCTPP1 expression in the nucleus of lung, gastric and esophagus cancer cells was associated with histological subtypes. The nucleic accumulation of DCTPP1 was apparently observed as well when cancer cell line MCF-7 was treated with H2O2 in vitro. Considering the roles of DCTPP1 on restricting the concentration of non-canonical nucleotides in the nucleotide pool, accumulation of DCTPP1 in the nucleus of cancer cells might suffice for maintaining the proper DNA replication in order to fulfill the requirement for the survival and proliferation of tumor cells.

Han Z.-G.,Shanghai JiaoTong University | Han Z.-G.,Chinese National Human Genome Center at Shanghai
Annual Review of Genomics and Human Genetics | Year: 2012

Liver cancer is the sixth-most-common cancer overall but the third-most-frequent cause of cancer death. Among primary liver cancers, hepatocellular carcinoma (HCC), the major histological subtype, is associated with multiple risk factors, including hepatitis B and C virus infection, alcohol consumption, obesity, and diet contamination. Although previous studies have revealed that certain genetic and epigenetic changes, such as TP53 and β-catenin mutations, occur in HCC cells, the pathogenesis of this cancer remains obscure. Functional genomic approaches-including genome-wide association studies, whole-genome and whole-exome sequencing, array-based comparative genomic hybridization, global DNA methylome mapping, and gene or noncoding RNA expression profiling-have recently been applied to HCC patients with different clinical features to uncover the genetic risk factors and underlying molecular mechanisms involved in this cancer's initiation and progression. The genome-wide analysis of germline and somatic genetic and epigenetic events facilitates understanding of the pathogenesis and molecular classification of liver cancer as well as the identification of novel diagnostic biomarkers and therapeutic targets for cancer. © 2012 by Annual Reviews. All rights reserved.

Cooley C.G.,Shanghai JiaoTong University | Parker R.G.,Virginia Polytechnic Institute and State University
Applied Mechanics Reviews | Year: 2014

This article summarizes published journal articles on planetary and epicyclic gear dynamics and vibration. Research in this field has increased dramatically over the past two decades. The wide range of research topics demonstrates the technical challenges of understanding and predicting planetary gear dynamics and vibration. The research in this review includes mathematical models, vibration mode properties, dynamic response predictions including nonlinearities and time-varying mesh stiffness fluctuations, the effects of elastic compliance, and gyroscopic effects, among other topics. Practical aspects are also included, for example, planet load sharing, planet phasing, tooth surface modifications, and characteristics of measured vibration response. © 2014 by ASME.

Gu Y.X.,Shanghai JiaoTong University
Journal of biomedical materials research. Part B, Applied biomaterials | Year: 2012

The modification on the titanium (Ti) implant surface is an effective method to improve the bioactivity of Ti. In this study, a hydroxyapatite (HA)-deposited nanotubular Ti surface was prepared by anodization coupled with an alternative immersion method (AIM). Surface physicochemical characteristics including morphology, microstructure, composition, roughness were evaluated by field-emission scanning electron microscopy (FE-SEM), X-ray diffraction (XRD), Fourier-transformed infrared spectroscopy (FTIR), X-ray photoelectron spectroscopy (XPS) and atomic force microscopy (AFM). Preosteoblast cell (MC3T3-E1) behavior on the HA-deposited nanotube surface, including cell morphology, proliferation, alkaline phosphatase (ALP) activity, osteocalcin secretion, and mineralization, were also investigated. The untreated nanotube surface and bare Ti were used as controls. The results showed that synthetic HA crystals could be efficiently grown on/inside the nanotubes after AIM treatment in saturated Ca(OH)(2) and 0.02M (NH(4))(2) HPO(4). The amount of synthetic HA on nanotube layer was dependent on the number of dipping cycles. Significant increases in ALP activity and osteocalcin production on day 7 and 14 and calcium deposition on day 21 (P < 0.05) were observed for HA-deposited nanotubular Ti surface when compared with untreated nanotube layer and bare Ti. However, the cell proliferation rate on HA-deposited nanotube surfaces was slowed down significantly (P < 0.05). All these results indicated that this HA-deposited nanotube surface might have the potential benefit to enhance implant osseointegration. The synthetic HA TiO(2) nanotube loading might be a highly promising path to improve the bioactivity of Ti-based implants. Copyright © 2012 Wiley Periodicals, Inc.

Zheng Y.X.,Shanghai JiaoTong University
World journal of gastroenterology : WJG | Year: 2012

To investigate the relationship and molecular features of CD74/macrophage migration inhibitory factor (MIF)/Toll-like receptor 4 (TLR4) in gastric cancer. CD74, MIF and TLR4 expression in the paraffin-embedded sections of gastric cancer from 120 patients were detected by immunohistochemical staining. Knock down of CD74 expression in gastric cancer cell line MKN-45 was performed by lentivirus transduction and detected by Western blotting. MKN-45 cell proliferation assay under the stimulants was measured by the cell counting kit 8 (CCK8) assay and MIF concentration in the culture medium was detected by enzyme-linked immunosorbent assay. Surface staining of CD74 in the MKN-45 cell line under the stimulation of lipopolysaccharide (LPS) was measured by flow cytometry. MIF, CD74 and TLR4 co-localization in the MKN-45 cell line was performed by the immunoprecipitation. CD74, MIF and TLR4 were found to be expressed in gastric cancer and increased significantly in the advanced stage, and were also associated with lymph node metastasis. Correlation analysis revealed that CD74 was positively correlated with MIF (r = 0.2367, P < 0.01) and both proteins were also associated with TLR4 (r = 0.4414, r = 0.5001, respectively, P < 0.01). LPS can significantly promote MKN-45 cell proliferation (3.027 ± 0.388 vs 4.201 ± 0.092, P < 0.05), induce MIF production (54.333 ± 2.906 pg/mL vs 29.667 ± 3.180 pg/mL, P < 0.01) and cell surface expression of CD74 (75.6% ± 4.046% vs 9.4% ± 0.964%, P < 0.01) at LPS concentration of 1 μg/mL compared to medium control. Knockdown of CD74 or using anti-CD74 and MIF antagonist ISO-1 significantly reduced LPS-induced MKN-45 cell proliferation (4.201 ± 0.092 vs 3.337 ± 0.087, 4.534 ± 0.222 vs 3.368 ± 0.290, 4.058 ± 0.292 vs 2.934 ± 0.197, respectively, P < 0.01). MIF, CD74 and TLR4 could co-localize in the MKN-45 cell line. Upregulation of MIF, CD74 and TLR4 are associated with increasing clinical stage and provide an opportunity as novel gastric cancer chemoprevention and/or treatment strategy.

Huo F.,National University of Singapore | Xi X.-C.,Shanghai JiaoTong University | Poo A.-N.,National University of Singapore
International Journal of Machine Tools and Manufacture | Year: 2012

The model-based Taylor series expansion error compensation (TSEEC) method has been shown to be capable of eliminating contour errors in biaxial CNC machines. However, it has been developed for only linear and circular contours. In this paper, an extension of TSEEC, a generalized TSEEC or GTSEEC, is proposed which is capable of compensating for the contour errors of arbitrary two-dimensional contours. A new real-time algorithm is used to estimate the contour error so that GTSEEC can be applied even in cases where the function of the contour is unknown. Simulation results using linear, circular and parabolic contours are presented which show that, with perfect knowledge of the axial dynamics, GTSEEC can perfectly eliminate the contour errors for any contour, even when there is significant mismatch in the axes dynamics. Experiments on a small two-axis computer-controlled machine indicate the effectiveness and better performance of GTSEEC in reducing contour errors for free-form contour following tasks when compared with two other leading approaches, the zero phase error tracking control (ZPETC) and cross-coupled control (CCC). © 2011 Elsevier Ltd All rights reserved.

Song J.,Nanyang Technological University | Guo F.,Shanghai JiaoTong University
Thin-Walled Structures | Year: 2013

The collapse of thin-walled tubes under axial and oblique loading is frequently encountered in real crash events. The windowing and multi-cell methods are effective in improving tubes' energy absorbing performance. In this paper, a comparative study on the performance of windowed and multi-cell square tubes of the same weight under axial and oblique loading is conducted numerically. The results show that the multi-cell tube can achieve higher mean crushing force than the windowed tube but the windowed tube has lower initial peak force. The effectiveness of both methods reduces as the load angle increases. Moreover, the multi-cell and windowed tubes may have worse performance than the conventional tube if the former two collapse in global bending and the later in axial mode. © 2013 Elsevier Ltd.

Wang X.,Shanghai JiaoTong University | Su H.,Huazhong University of Science and Technology
Annual Reviews in Control | Year: 2014

In practice, directly control every node in a dynamical networked system with a huge number of nodes might be impossible or unnecessary; therefore, pinning control is a desirable approach. This paper surveys advances in pinning control approaches to making a dynamical networked system have a desired behavior. For a network with fixed topology, we review the feasibility, stability and effectiveness of pinning control. We then focus on pinning-based consensus and flocking control of mobile multi-agent networked systems. One of the main challenges with consensus and flocking control is that the topology of the corresponding dynamical network is time-varying, which depends on the states of all the agents in the network. Looking forward to the next decade, we expect to have a much deeper understanding of the relationship between the effectiveness of pinning control and the structural properties of a complex network, which may result in better control of large scale networked systems. © 2014 Elsevier Ltd. All rights reserved.

Lou Y.,Nanjing Southeast University | Zhao Y.,Shanghai JiaoTong University | Chen J.,Nanjing Southeast University | Zhu J.-J.,Nanjing University
Journal of Materials Chemistry C | Year: 2014

Colloidal semiconductor nanocrystals or quantum dots (QDs) have been facilitating the development of sensitive fluorescence sensors over the past decade, due to their unique photophysical properties, versatile surface chemistry and ligand binding ability, and the possibility of the encapsulation in different materials or attachment to different functional materials, while retaining their native luminescence property. The optical metal ion chemosensors with high sensitivity and selectivity have been developed due to the importance of the metal ions' fundamental roles, possessed in a wide range of biological processes and the aquatic environment. This review addresses the different sensing strategies with chemically modified QD hybrid structures for the sensing of metal ions in aqueous solution or an in vivo environment, and discusses the photophysical mechanisms in the different sensor systems while comparing their detecting/sensing selectivity. The perspectives for the future potential developments in QD based optical sensing for metal ions are discussed. © 2013 The Royal Society of Chemistry.

Fu Q.,Shanghai JiaoTong University | Cao Y.-L.,Shanghai Tissue Engineering Research and Development Center
Urology | Year: 2012

Objective: To review the advances in the basic research and clinical application of tissue engineering and stem cell technology in urethral reconstruction. Urethral defects resulting from congenital malformations, trauma, inflammation, or cancer are a common urologic issue. Traditional urethral reconstruction is associated with various complications. Tissue engineering and stem cell technology hold novel therapeutic promise for urethral reconstruction. Methods: One of us searched the PubMed database (January 1999 to January 2011) using the English search terms "tissue engineering," "stem cells," "urethral reconstruction," and "urethra." A total of 86 reports were retrieved. After the repetitive and irrelevant reports were excluded, 40 were included in the final analysis. The review outlined and evaluated the advances in basic research and clinical application and the current status and prospects of tissue engineering and stem cell technology in urinary reconstruction. Results: Two therapeutic strategies are available for urethral reconstruction using tissue engineering: the acellular matrix bioscaffold model and the cell-seeded bioscaffold model. The acellular matrix bioscaffold model has been successfully used in the clinic and the cell-seeded bioscaffold model is making its transition from bench to bedside. Conclusion: Stem cells can provide the seed cells for urologic tissue engineering, but much basic research is still needed before their clinical use is possible. © 2012 Elsevier Inc. All Rights Reserved.

Fang L.Q.,Shanghai University | Ge X.-H.,Shanghai University | Kuang X.-M.,Shanghai JiaoTong University
Physical Review D - Particles, Fields, Gravitation and Cosmology | Year: 2012

We investigate the properties of holographic fermions in charged Lifshitz black holes at finite temperature through the AdS/CFT correspondence. In the charged Lifshitz background with the dynamical exponent z=2, we find that the dispersion relation is linear. The scaling behavior of the imaginal part of the Green function relative to k=k-k F is also discussed. We find, although the system has a linear dispersion relation and quadratic quasiparticle width, it does not satisfy Luttinger's theorem. We also find that the variation of the scaling parameters α and β is small as the charge q varies. Furthermore, we also discuss the effect of the dynamical exponent z by considering the cases z=4 and z=6 and show that ImG ii become smooth when the dynamical exponent z increases. © 2012 American Physical Society.

Liao S.,Shanghai JiaoTong University
Science China: Physics, Mechanics and Astronomy | Year: 2012

It is well-known that the celebrated Camassa-Holm equation has the peaked solitary waves, which have been not reported for other mainstream models of shallow water waves. In this letter, the closed-form solutions of peaked solitary waves of the KdV equation, the BBM equation and the Boussinesq equation are given for the first time. All of them have either a peakon or an anti-peakon. Each of them exactly satisfies the corresponding Rankine-Hogoniot jump condition and could be understood as weak solution. Therefore, the peaked solitary waves might be common for most of shallow water wave models, no matter whether or not they are integrable and/or admit breaking-wave solutions. © 2012 Science China Press and Springer-Verlag Berlin Heidelberg.

Su J.,Shanghai JiaoTong University | Xie W.,China Aerospace Science and Technology Corporation
IEEE Transactions on Systems, Man, and Cybernetics, Part B: Cybernetics | Year: 2011

This paper proposes a general motion planning and coordination strategy for robot systems. The representation space (RS) of a robot system is constructed to describe the distributions of system attributes. The reachable area in the RS, denoting the attribute set that the system can be of, indicates the system's ability to accomplish tasks. Moreover, it also describes the influences of the internal and external constraints on the system's capability. Task realization is transformed to finding a trajectory in the RS for the system attributes to transit along under constraints. Meanwhile, the realizable conditions of a prescribed task by the robot system of specific configurations are discussed. If the task is realizable, the optimal strategy for task execution could further be figured out. Otherwise, it could be transformed to be realizable via task reassignment or system reconfigurations so that a connected path could be found for the transition of the system attributes from the starting point to the goal in the RS. The proposed scheme contributes to designing, planning, and coordination of the robotic tasks. Experiments on path planning of a robot manipulator and formation movement of a multirobot system, as well as coordination of a mobile manipulator system, are conducted to show the validity and generalization of the proposed method. © 2010 IEEE.

Chen G.,Shanghai JiaoTong University
Archivum Immunologiae et Therapiae Experimentalis | Year: 2010

Rheumatoid arthritis is a chronic disorder for which there is no known cure. Concentrating on specific elements of the abnormal immune response that characterizes the disease, scientists are reaching into biotechnology's bag of tricks to develop immunotherapeutic techniques. This paper will present some advances in the immunotherapy of rheumatoid arthritis targeting inflammatory cytokines and autoreactive T cells. © 2009 L. Hirszfeld Institute of Immunology and Experimental Therapy, Wroclaw, Poland.

Xu W.,Pacific Northwest National Laboratory | Wang J.,Pacific Northwest National Laboratory | Wang J.,Shanghai JiaoTong University | Ding F.,Tianjin Institute of Power Sources | And 5 more authors.
Energy and Environmental Science | Year: 2014

Lithium (Li) metal is an ideal anode material for rechargeable batteries due to its extremely high theoretical specific capacity (3860 mA h g -1), low density (0.59 g cm-3) and the lowest negative electrochemical potential (-3.040 V vs. the standard hydrogen electrode). Unfortunately, uncontrollable dendritic Li growth and limited Coulombic efficiency during Li deposition/stripping inherent in these batteries have prevented their practical applications over the past 40 years. With the emergence of post-Li-ion batteries, safe and efficient operation of Li metal anodes has become an enabling technology which may determine the fate of several promising candidates for the next generation energy storage systems, including rechargeable Li-air batteries, Li-S batteries, and Li metal batteries which utilize intercalation compounds as cathodes. In this paper, various factors that affect the morphology and Coulombic efficiency of Li metal anodes have been analyzed. Technologies utilized to characterize the morphology of Li deposition and the results obtained by modelling of Li dendrite growth have also been reviewed. Finally, recent development and urgent need in this field are discussed. © The Royal Society of Chemistry.

Li Z.,Shanghai JiaoTong University | Li Z.,South China University of Technology | Yang C.,University of Plymouth
IEEE Transactions on Control Systems Technology | Year: 2012

The wheeled inverted pendulum (WIP) models have been widely applied in the transportation vehicles formed by a mobile wheeled inverted pendulum system with an operator (demonstrated in Fig.1 ). In this paper, we focus on the study of nonlinear control design for the WIP model-based vehicles, for which accurate dynamics could not be obtained beforehand due to the presence of uncertainties caused by the human operator as well as the vehicle. We develop an output feedback adaptive neural network (NN) control incorporating a linear dynamic compensator to achieve stable dynamic balance and tracking of the desired given trajectories. Comparison simulation studies demonstrate guaranteed tracking performance and stable dynamics balance in the presence of uncertainties and thus verify the efficiency of the developed nonlinear controller. © 2012 IEEE.

Shao X.-F.,Shanghai JiaoTong University
IEEE Transactions on Engineering Management | Year: 2013

This paper explores the effectiveness of mass customization strategies in a manufacturing firm. The manufacturing firm produces standard products in a flexible factory where mass customization is technologically feasible. We integrate product strategy and channel design to explore whether the firm should adopt mass customization and how the distribution channel should be configured for custom products. We find that the mixed mass customization strategy dominates the pure standard product strategy in the centralized system. For the decentralized system, we identify the parameters that would impact superiority of each product strategy. We further discuss two channel structures for mass customization: single-channel strategy and dual-channel strategy, and find that the dual-channel strategy is always superior to the single-channel strategy when mixed mass customization is adopted. © 1988-2012 IEEE.

Background: Glutamine (Gln) is the most abundant amino acid in blood and tissue fluids and is considered to be essential in certain catabolic conditions. A series of studies has shown that glutamine can attenuate cytokine release, reduce organ damage and improve survival in a rat model of endotoxaemia. The hypothesis for this rat model study is that pre-treatment with Gln reduces the expression of ICAM-1 and attenuates lung injury induced by intestinal ischaemia-reperfusion (I/R). Methods: Sprague-Dawley rats were randomised into five groups, namely sham group (sham surgery), Gln groups (three different doses) and control group. Lung injury caused by intestinal I/R was evaluated using Evans blue dye concentration and histopathologic examination. The level of myeloperoxidase (MPO) was measured using biochemistry method. The expression of heat shock protein 70 (HSP 70) and ICAM-1 were detected using Western blot and real-time polymerase chain reaction (PCR) methods, respectively. Results: Compared with the control group, rats pre-treated with Gln before intestinal I/R demonstrated decreased Evans Blue content and MPO activities in lung tissue, reduced the expression of ICAM-1, attenuated lung injury evidenced by pathological change compared with lactated Ringer pre-treated rats. Gln administration increased HSP 70 mRNA and protein expression in lung tissue compared with control group. Conclusion: Ischaemia-reperfusion injury increases the expression of ICAM-1 in the lung. This may contribute to the migration, accumulation and activation of neutrophils. Pre-treatment with Gln attenuates rat lung injury and reduces ICAM-1 expression. © 2009 Elsevier Ltd.

Jannati M.,Amirkabir University of Technology | Hosseinian S.H.,Amirkabir University of Technology | Vahidi B.,Amirkabir University of Technology | Li G.-J.,Shanghai JiaoTong University
Renewable and Sustainable Energy Reviews | Year: 2014

As the wind power capacity increases, the effect of wind power fluctuations on the system stability becomes more significant. Despite its high costs, utilizing energy storage resources such as batteries is inevitable in the smoothing process of wind power fluctuations. In a wind power plant, the place where batteries are located has considerable direct effect on their required capacity and thus on the initial investment cost. Therefore, in this paper a suitable configuration which significantly reduces the batteries investment cost is proposed and then the wind power fluctuation of a large wind power plant connected to a smart distribution grid is smoothed. Additionally, existing configurations for installing batteries in large wind power plants are investigated. The proposed configuration utilizes smart parks as aggregated storage resources in load side and an aggregated battery energy storage system with limited capacity in plant side as well. Therefore, in addition to accurate smoothing of wind power fluctuations, the energy storage investment cost is reduced significantly utilizing the proposed configuration. Simulation studies in MATLAB software package are carried out to verify the performance of the proposed approach. © 2013 Published by Elsevier Ltd.

Zhao Y.,Shanghai JiaoTong University | Zhu K.,National Renewable Energy Laboratory
Journal of Physical Chemistry Letters | Year: 2014

Organic and inorganic hybrid perovskites (e.g., CH3NH3PbI3) have emerged as a revolutionary class of light-absorbing semiconductors that has demonstrated a rapid increase in efficiency within a few years of active research. Controlling perovskite morphology and composition has been found critical to developing high-performance perovskite solar cells. The recent development of solution chemistry engineering has led to fabrication of greater than 15-17%-efficiency solar cells by multiple groups, with the highest certified 17.9% efficiency that has significantly surpassed the best-reported perovskite solar cell by vapor-phase growth. In this Perspective, we review recent progress on solution chemistry engineering processes and various control parameters that are critical to the success of solution growth of high-quality perovskite films. We discuss the importance of understanding the impact of solution-processing parameters and perovskite film architectures on the fundamental charge carrier dynamics in perovskite solar cells. The cost and stability issues of perovskite solar cells will also be discussed. © 2014 American Chemical Society.

Qi Z.,Shanghai JiaoTong University
Renewable and Sustainable Energy Reviews | Year: 2014

There is a rising interest in electric vehicle's climate control system including cooling and heating. Electric vehicles (EVs, including hybrid electric vehicles and full electric vehicles) have inadequate waste heat to warm up the cabin and the climate control system has a very significant effect on the energy consumption efficiency and operating mileage. Heat pump (HP) is one approach for energy consumption efficiency improvement in EVs which can supply cooling and heating capacity. A literature review was performed on the vapor compression HP cycle design, performance characteristics, and challenges for variable working fluids for electric vehicles. The non-vapor compressor HP systems were also analyzed including the applications of magnetocaloric effect and thermoelectric effect. It seems heat pump system is a reasonable and feasible option in EV's climate control system if some essential issues could be solved. The mobile climate control systems based on magnetocaloric effect and thermoelectric effect could be the supplementary methods in future applications. © 2014 Elsevier Ltd.

Bao H.,Shanghai JiaoTong University
Wuli Xuebao/Acta Physica Sinica | Year: 2013

Anharmonic lattice dynamics method is employed to investigate the phonon frequency and relaxation time without any fitting parameters. The phonon relaxation time is used in Boltzmann transport equation to predict the lattice thermal conductivity of solid argon between 10 K and 80 K, and the results agree very well with experimental data. The effects of calculation parameters on the prediction accuracy are also analyzed, including mesh size of the reciprocal lattice points, and the broadening factor of delta function. The contribution of each individual phonon mode to the thermal conductivity is investigated. It is found that higher frequency phonons contribute more to the thermal conductivity at higher temperature, which is consistent with previous theoretical results. © 2013 Chinese Physical Society.

Bahk C.-J.,Ohio State University | Parker R.G.,Shanghai JiaoTong University
Journal of Computational and Nonlinear Dynamics | Year: 2011

Planetary gears are parametrically excited by the time-varying mesh stiffness that fluctuates as the number of gear tooth pairs in contact changes during gear rotation. At resonance, the resulting vibration causes tooth separation leading to nonlinear effects such as jump phenomena and subharmonic resonance. This work examines the nonlinear dynamics of planetary gears by numerical and analytical methods over the meaningful mesh frequency ranges. Concise, closed-form approximations for the dynamic response are obtained by perturbation analysis. The analytical solutions give insight into the nonlinear dynamics and the impact of system parameters on dynamic response. Correlation between the amplitude of response and external torque demonstrates that tooth separation occurs even under large torque. The harmonic balance method with arclength continuation confirms the perturbation solutions. The accuracy of the analytical and harmonic balance solutions is evaluated by parallel finite element and numerical integration simulations. © 2011 American Society of Mechanical Engineers.

Optimization of extraction of Tremella fuciformis polysaccharides was investigated using response surface methodology in this paper. T. fuciformis polysaccharides were extracted using boiling water at different extraction temperatures (80-100 °C), times (3.5-4.5 h) and ratios of solvent to raw material (4-6). The effect of extraction conditions on the yield of T. fuciformis polysaccharides were studied using a three-level three-factor Box-Behnken design. The results showed that the highest yield (3.08%) of T. fuciformis polysaccharides was reached at extraction temperature 100 °C, extraction time 4.5 h and ratio of solvent to raw material 5 (v/v). In addition, T. fuciformis polysaccharides could scavenge superoxide anion and hydroxyl radicals. At last, it could still be found that antitumour activities of T. fuciformis polysaccharides increased from 73.4% to 92.1% with increasing concentration of polysaccharides. Pharmacology experiment indicated that T. fuciformis polysaccharides was useful to the therapy of free radical injury and cancer diseases. © 2010.

Chen J.,Shanghai JiaoTong University | Rentzepis P.M.,University of California at Irvine
Journal of Physical Chemistry Letters | Year: 2014

This Perspective article considers an experimental system that consists of ultrafast optical, electron, and X-ray time-resolved components. These techniques are used simultaneously on the same sample to study, in real time, the events that occur immediately upon disturbance with an ultrafast optical pulse. Excited states and metastable species are generated on the surface, and the electrical and mechanical waves propagating through the sample are recorded with subpicosecond and sub-Angstrom resolution. The characteristic of each technique is briefly described as a means of introducing the experimental system that intergrates these techniques. The processes evolved after femtosecond excitation of a Au single crystal have been monitored by these techniques. The data presented show changes with a resolution of 0.3 ± 0.1 ps in optical thermoreflectance, 1.0 ± 0.2 ps in electron Bragg diffraction, and 0.6 ± 0.1 ps in X-ray diffraction intensity accompanying shift and broadening. © 2013 American Chemical Society.

Shen H.-S.,Shanghai JiaoTong University
Journal of Engineering Mechanics | Year: 2013

This paper presents a study on the thermal postbuckling response of a shear deformable functionally graded cylindrical shell of finite length embedded in a large outer elastic medium. The surrounding elastic medium is modeled as a Pasternak foundation. Two kinds of micromechanics models, namely the Voigt model and Mori-Tanaka model, are considered. The governing equations are based on a higher-order shear deformation shell theory that includes shell-foundation interaction. The thermal effects are also included and the material properties of functionally graded materials (FGMs) are assumed to be temperature dependent. The governing equations are solved by a singular perturbation technique. The numerical results show that in some cases the FGM cylindrical shell with intermediate volume fraction index does not have intermediate buckling temperature and thermal postbuckling strength. The results reveal that Voigt model and Mori-Tanaka model have the same accuracy for predicting the thermal buckling and postbuckling behavior of FGM shells. The results confirm that for the case of heat conduction, the postbuckling equilibrium path for geometrically perfect FGM cylindrical shells with simply supported boundary conditions is no longer of the bifurcation type. © 2013 American Society of Civil Engineers.

Duan H.,Shanghai JiaoTong University | Hueste M.B.D.,Texas A&M University
Engineering Structures | Year: 2012

This paper investigates the seismic performance of a multi-story reinforced concrete frame building designed according to the provisions of the current Chinese seismic code (GB50011-2010). A typical five-story reinforced concrete frame building is designed. Seven natural earthquake acceleration records, selected and adjusted for compatibility with the adopted design spectrum, are used. The frame structure is evaluated using both a nonlinear static (push-over) analysis and nonlinear dynamic time-history analysis. The assessment of seismic performance is based on both global and member level criteria. According to the numerical results, the building frame designed by GB50011-2010 provides the inelastic behavior and response intended by the code and satisfies the interstory drift and maximum plastic rotation limits suggested by ASCE/SEI 41-06. However, the push-over analysis indicated the potential for a soft first story mechanism under significant lateral demands. Design recommendations are provided to help ensure the preferred strong-column, weak-beam damage mechanism. © 2012 Elsevier Ltd.

Du S.,Shanghai JiaoTong University | Lv J.,East China Normal University
International Journal of Production Economics | Year: 2013

Though traditional control charts have been widely used as effective tools in statistical process control (SPC), they are not applicable in many industrial applications where the process variables are highly auto-correlated. In this study, one new minimal Euclidean distance (MED) based monitoring approach is proposed for enhancing the monitoring mean shifts of auto-correlated processes. Support vector regression (SVR) is used to predict the values of a variable in time series. Through calculating minimal Euclidean distance (MED) values over time series, a novel MED chart is developed for monitoring mean shifts, and it can provide a comprehensive and quantitative assessment for the current process state. The performance of the proposed MED control chart is evaluated based on average run length (ARL). Simulation experiments are conducted and one industrial case is illustrated to validate the effectiveness of the developed MED control chart. The analysis results indicate that the developed MED control chart is more effective than other control charts for small process mean shifts in auto-correlated processes, and it can be used as a promising tool for SPC. © 2012 Elsevier B.V. All rights reserved.

Fang Y.,Fudan University | Xue J.-L.,Fudan University | Shen Q.,Fudan University | Chen J.,Fudan University | And 2 more authors.
Hepatology | Year: 2012

MicroRNAs (miRNAs) are known to be involved in carcinogenesis and tumor progression in hepatocellular carcinoma (HCC). Recently, microRNA-7 (miR-7) has been proven to play a substantial role in glioblastoma and breast cancer, but its functions in the context of HCC remain unknown. Here, we demonstrate that miR-7 inhibits HCC cell growth and metastasis invitro and in vivo. We first screened and identified a novel miR-7 target, phosphoinositide 3-kinase catalytic subunit delta (PIK3CD). Overexpression of miR-7 would specifically and markedly down-regulate its expression. miR-7-overexpressing subclones showed significant cell growth inhibition by G 0/G 1-phase cell-cycle arrest and significant impairment of cell migration in vitro. To identify the mechanisms, we investigated the phosphoinositide 3-kinase (PI3K)/Akt pathway and found that Akt, mammalian target of rapamycin (mTOR), and p70S6K were down-regulated, whereas 4EBP1 was up-regulated in miR-7-overexpressing subclones. We also identified two novel, putative miR-7 target genes, mTOR and p70S6K, which further suggests that miR-7 may be a key regulator of the PI3K/Akt pathway. In xenograft animal experiments, we found that overexpressed miR-7 effectively repressed tumor growth (3.5-fold decrease in mean tumor volume; n = 5) and abolished extrahepatic migration from liver to lung in a nude mouse model of metastasis (n = 5). The number of visible nodules on the lung surface was reduced by 32-fold. A correlation between miR-7 and PIK3CD expression was also confirmed in clinical samples of HCC. Conclusion: These findings indicate that miR-7 functions as a tumor suppressor and plays a substantial role in inhibiting the tumorigenesis and reversing the metastasis of HCC through the PI3K/Akt/mTOR-signaling pathway in vitro and in vivo. By targeting PIK3CD, mTOR, and p70S6K, miR-7 efficiently regulates the PI3K/Akt pathway. Given these results, miR-7 may be a potential therapeutic or diagnostic/prognostic target for treating HCC. © 2012 American Association for the Study of Liver Diseases.

Zhang D.-G.,Shanghai JiaoTong University
International Journal of Non-Linear Mechanics | Year: 2013

In this paper, non-linear bending analysis is first presented for super elliptical thin plates with simply supported edge and clamped edge based on classical plate theory. Approximate solutions of super elliptical thin plates are obtained by Ritz method, convergence studies are discussed, and the validity can be confirmed by comparison with related researchers' results. It can be observed that the characteristics of non-linear bending are significantly influenced by different boundary conditions, ratio of major to minor axis, as well as the power of the super ellipse. © 2013 Elsevier Ltd.

Wu Q.W.,Shanghai JiaoTong University
American Journal of Translational Research | Year: 2016

Early stages of melanoma can be treated by surgical resection of tumor, but there is still no effective treatment once it is progressed to metastatic phases. Although growing family of both metastasis promoting and metastasis suppressor genes have been reported, the molecular mechanisms governing melanoma metastatic cascade are still not completely understood. Therefore, defining the molecules that govern melanoma metastasis may aid the development of more effective therapeutic strategies for combating cancer. In the present study, we found that Serpin Peptidase Inhibitor 2, Serpine2 was involved in the metastasis of melanoma cells. The requirement of Serpine2 in the migration of melanoma cells was confirmed by gene silencing and over-expression in vitro. Moreover, down-regulation of Serpine2 expression strikingly inhibited melanoma cellular metastasis in vivo. Finally, we found that Serpine2 promotes melanoma metastasis through the glycogen synthesis kinase 3β, GSK-3β signaling pathway. To conclude, our findings suggested a novel mechanism underlying the metastasis of melanoma cells which might serve as a new intervention target for the treatment of melanoma. © 2016, E-Century Publishing Corporation. All rights reserved.

Min Z.,Shanghai JiaoTong University
The American journal of drug and alcohol abuse | Year: 2011

To conduct a pilot assessment of relapse prevention (RP) group therapy for heroin-dependent patients in a drug rehabilitation center in China. A randomized case-control study was conducted to assess the efficacy of RP delivered over a 2-month period to male heroin addicts (n = 50, RP group) in the Shanghai Labor Drug Rehabilitation Center (LDRC) compared with an equal number of participants (n = 50, labor rehabilitation (LR) group) in the LDRC program receiving standard-of-care treatment. Outcomes were assessed by the Beck Depression Inventory (BDI), the Self-Rating Anxiety Scale (SAS), the Self-Efficacy Scale (SE), and the Self-Esteem Scale (SES) after completion of RP, and by the Addiction Severity Index (ASI) and abstinence rates of heroin use at 3-month follow-up post release from the LDRC for both groups. Significant improvements in scores on SAS, SE, and SES were found in the RP group after completion of the 2-month RP group therapy compared with the LR group (SAS 7.85 ± 6.20 vs 1.07 ± 5.42, SE 3.88 ± 3.60 vs .08 ± 2.89, and SES 3.83 ± 3.31 vs .78 ± 2.55). At 3-month follow-up, the RP group participants had more improvements on ASI scores in most domains and had higher abstinence rates than that in the LR group (37.2% vs 16.7%). An RP component can be effective in increasing abstinence rates among post-program heroin-dependent individuals and may help reduce anxiety and improve self-esteem and self-efficacy during and following treatment. SCIENTIFIC SIGNIFICANCE: This study suggests RP as a potentially effective component of treatment for heroin addicts.

Gu J.-Y.,Fudan University | Li L.-W.,Shanghai JiaoTong University
Archives of Medical Research | Year: 2014

Background and Aims: Emerging evidences have shown that the Glu504Lys variant in ALDH2 gene may greatly reduce the ability of ALDH2 to metabolize acetaldehyde, which could increase the risk of coronary artery disease (CAD) and myocardial infarction (MI). However, the reported results are still conflicting. To investigate the association between ALDH2 Glu504Lys polymorphism and the risk of CAD and MI in Asians, we analyzed all available studies in a meta-analysis. Methods: A literature search of PubMed, Embase, Web of Science and Chinese BioMedical (CBM) databases was conducted for articles published before March 1, 2013. The principal outcome measure was the crude odds ratios (ORs) with their corresponding confidence intervals (95% CIs) for evaluating the strength of the association. Results: Meta-analysis showed that carriers of ALDH2*504lys allele were associated with increased risks of both CAD and MI (CAD: OR= 1.28, 95% CI: 1.10-1.48, p= 0.001; MI: OR= 1.58, 95% CI: 1.15-2.19, p= 0.005). Subgroup analysis by country showed significant correlations between mutant genotypes (Glu/Lys+ Lys/Lys) and increased risk to MI among Chinese and Korean populations (Chinese: OR= 1.89, 95% CI: 1.16-3.09, p= 0.011; Korean: OR= 1.69, 95%CI: 1.12-2.55, p= 0.013), whereas similar associations were not observed among Japanese populations. Conclusions: The current meta-analysis provides strong evidence that ALDH2 Glu504Lys polymorphism may be associated with increased risk of CAD and MI in East Asians, especially among Chinese and Korean populations. However, more detailed and well-designed studies are still warranted to confirm these findings. © 2014 IMSS.

Zhu K.,Shanghai JiaoTong University
Cancer Research and Clinic | Year: 2015

Long non-coding RNA (IncRNA) is a group of length more than 200 nucleotides without coding protein RNA. It plays an important role in cell proliferation, differentiation, senescence, death, tumor occurrence and development. This article reviews the main characteristics of IncRNA and its role in tumor drug resistance.

Jin Z.,Shanghai University | Jin Z.,Shanghai JiaoTong University
Annals of the rheumatic diseases | Year: 2014

OBJECTIVE: To summarise the evidence regarding the dose-response association between alcohol consumption and risk of rheumatoid arthritis (RA).METHOD: Studies were identified from search of MEDLINE, Embase and Web of Science databases between 1 January 1946 and 10 April 2013, and from review of the conference abstracts and the reference lists of retrieved articles. Prospective studies that reported relative risks (RRs) with 95% CIs for the association between alcohol consumption and the risk of RA were included. Results from individual studies were pooled using a dose-response meta-analysis.RESULTS: Up to 10 April 2013, 8 prospective studies contained 195 029 participants and 1878 RA cases were included. The results indicated that low to moderate alcohol consumption yielded a preventive effect on RA development (RR: 0.86; 95% CI 0.78 to 0.94), and provided some evidence of a non-linear relationship between alcohol consumption and risk of RA. Dose-response meta-analysis of the study data revealed that compared with that for no alcohol consumption, the adjusted RR was 0.93 (95% CI 0.88 to 0.98) for 3 g/day of alcohol consumption, 0.86 (95% CI 0.76 to 0.97) for 9 g/day, 0.88 (95% CI 0.78 to 0.99) for 12 g/day, 0.91 (95% CI 0.81 to 1.03) for 15 g/day, and 1.28 (95% CI 0.94 to 1.73) for 30 g/day. Subgroup analysis indicated that women who had low to moderate alcohol consumption had a 19% reduction in RA risk. Regardless of sex, a consistent low to moderate alcohol consumption for a period of at least 10 years was found to have a 17% reduction in RA risk.CONCLUSIONS: Low to moderate alcohol consumption inversely associated with the development of RA in a manner that appears to be dose-dependent, time-dependent and sex-dependent. Large prospective studies that investigate gene-environment interactions are required to further clarify the aetiology of RA. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

Yuan X.-Z.,Shanghai JiaoTong University
Physical Review A - Atomic, Molecular, and Optical Physics | Year: 2013

The stationary continuous-variable entanglement between an optical cavity and a nanomechanical resonator beam is generated by their common interaction with a quantum dot. To deal with the quantum dot which is modeled as a two-level system, we do not use the low excitation limit approximation to bosonize the spin operators, but we keep them in the quantum Langevin equations. We linearize the quantum Langevin equations reasonably and investigate the stationary continuous-variable entanglement in detail, and finally we show that a high degree of entanglement can be achieved for experimentally feasible parameters. © 2013 American Physical Society.

Mi J.,Shanghai JiaoTong University
Frontiers of Medicine in China | Year: 2011

Acute promyelocytic leukemia (APL) is a unique subtype of acute myeloid leukemia (AML). The prognosis of APL has changed from the worst among the AMLs to currently the best. The application of all-trans retinoic acid (ATRA) in the induction therapy of APL decreases the high mortality of newly diagnosed patients, thereby significantly improving the response rate. ATRA combined with anthracycline-based chemotherapy is the current standard treatment, and for high-risk patients, high doses cytarabine have a beneficial effect on relapse prevention. In recent years, the indications of arsenic trioxide (ATO) therapy for APL have been extended from the salvage therapy for relapse patients to the first-line treatment of de novo APL. The introduction of both ATRA and ATO represents great achievements in translational medicine. In this review article, we discuss the therapeutic strategies for this disease, including the initial approaches to newly diagnosed patients, prevention, and treatment of side effects and relapse to ensure the best and timely treatment for each newly diagnosed APL patient. © 2011 Higher Education Press and Springer-Verlag Berlin Heidelberg.

Shi C.,Shanghai JiaoTong University | Parker R.G.,Virginia Polytechnic Institute and State University
Journal of Sound and Vibration | Year: 2013

This work studies the symmetry breaking effects on the vibration mode structure of centrifugal pendulum vibration absorber (CPVA) systems when multiple groups of absorbers are used. An absorber group is a set of equally spaced, identical absorbers. Absorbers within a group are cyclically symmetric while the entire system is asymmetric because the groups have no pre-defined relative angular spacing. One rotational and two translational degrees of freedom for the rotor and a single arclength degree of freedom for each absorber are considered in the planar model. The well-defined structure of the vibration modes is obtained by analytical and numerical investigations of the associated eigenvalue problem. This vibration mode structure is similar to that for CPVA systems with equally spaced, identical absorbers. Thus, the disrupted symmetry from multiple absorber groups does not destroy the vibration mode structure resulting from the cyclic symmetry within each group. The critical speeds and flutter instability of the system are investigated. © 2013 Elsevier B.V. All rights reserved.

Shao J.,Zhejiang GongShang University | Cao Z.,Shanghai JiaoTong University
Information Sciences | Year: 2012

At ACNS 2007, Ateniese and Green proposed the concept of ID-based proxy re-encryption (IBPRE), where a semi-trusted proxy with some information (a.k.a. re-encryption key), can transform a ciphertext under an identity to another ciphertext under another identity with the same plaintext. However, the proxy cannot obtain the plaintext. Recently, Wang et al. revisited this primitive by allowing the chosen ciphertext attack when the ciphertext could be transformed several times. They also proposed a concrete multi-use unidirectional ID-based proxy re-encryption (MUIBPRE) scheme, which is proven secure in the random oracle. Nonetheless, they left the problem of constructing a multi-use unidirectional IBPRE scheme in the standard model. What is worse, their scheme cannot resist the collusion attack, which is an important security requirement for unidirectional proxy re-encryption. To solve this problem, in this paper we present a conversion from non-anonymous hierarchical identity-based encryption (NaHIBE) with strongly CPA security to CCA-secure and collusion-resistant MUIBPRE. Furthermore, based on the NaHIBE scheme proposed by Waters at Crypto'09, we give the first CCA-secure and collusion-resistant MUIBPRE scheme in the standard model. © 2012 Elsevier Inc. All rights reserved.

Lu M.,Shanghai JiaoTong University
Nature Reviews Molecular Cell Biology | Year: 2016

Many proteins originally identified as cytoplasmic — including many associated with the cytoskeleton or cell junctions — are increasingly being found in the nucleus, where they have specific functions. Here, we focus on proteins that translocate from the cytoplasm to the nucleus in response to external signals and regulate transcription without binding to DNA directly (for example, through interaction with transcription factors). We propose that proteins with such characteristics are classified as a distinct group of extracellular signalling effectors, and we suggest the term STRaND (shuttling transcriptional regulators and non-DNA binding) to refer to this group. Crucial roles of STRaNDs include linking cell morphology and adhesion with changes in transcriptional programmes in response to signals such as mechanical stresses. © 2016 Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved.

Azuma T.,Setsunan University | Morita T.,University of Kentucky | Takeuchi S.,Shanghai JiaoTong University
Physical Review Letters | Year: 2014

It is expected that the Gregory-Laflamme (GL) instability in the black string in gravity is related to the Rayleigh-Plateau instability in fluid mechanics. Especially, the orders of the phase transitions associated with these instabilities depend on the number of the transverse space dimensions, and they are of first and second order below and above the critical dimension. Through the gauge-gravity correspondence, the GL instability is conjectured to be thermodynamically related to the Hagedorn instability in large-N gauge theories, and it leads to a prediction that the order of the confinement-deconfinement transition associated with the Hagedorn instability may depend on the transverse dimension. We test this conjecture in the D-dimensional bosonic D0-brane model using numerical simulation and the 1/D expansion, and confirm the expected D dependence. © 2014 American Physical Society.

Zhang T.,Shanghai JiaoTong University
International journal of psychiatry in medicine | Year: 2012

In order to explore age-related differences in personality pathology between psychotic disorder (PSD) and mood and/or anxiety disorder (MAD) among psychiatric outpatients, 2,354 subjects were sampled randomly from outpatients in Shanghai and divided into two groups: PSD (N = 951) and MAD (N = 1403). Dimensional scores for personality disorder (PD) traits were assessed by using a self-reported personality diagnostic questionnaire (PDQ4+). Significant age differences were observed in most of the PD traits in MAD patients. Cluster B and C PD traits displayed an apparent decrease with age in MAD group, but such decline trend was not evident in PSD group. In both groups, the decline of self-reported Cluster A PD traits were less visible than the other clusters. Age-related mellowing of some PD traits such as "dramatic, erratic, anxious" occurred primarily in MAD patients; however the same traits in PSD patients appear to be less resistant to aging. Besides, "old eccentric" PD traits in both MAD and PSD patients seem to be maintained and less modified by aging.

Lei X.L.,Shanghai JiaoTong University
Materials Science and Engineering R: Reports | Year: 2010

This article gives a brief introduction to the magnetoresistance oscillations in high-mobility two-dimensional semiconductors at low temperatures, which are induced by a microwave radiation, a dc current, a branch of acoustic phonons, or a combination of them, and a comprehensive review of a balance-equation model for nonlinear magnetotransport in systems with short thermalization time, which enables a unified description for all these magnetoresistance oscillations. The appearance of these magnetoresistance oscillations is referred to an additional average energy Δε obtained (or released) by an electron during its transition between different states due to impurity and phonon-assisted scatterings. This energy provided by a microwave photon of frequency ω (Δε=ω), by a dc current of density J=Nsev (Δε≈ωj=2kFv with v the drift velocity, kF the Fermi wavevector and Ns the sheet density of 2D electrons), by an acoustic phonon of wavevector 2kF having velocity vs (Δε≈ωs=2kFvs), or by a combination of them, results in a frequency shift ω, ωj, ωs, or, e.g., ω+ωj-ωs, in the periodic electron-density- correlation function Π2(q,Ω) of the 2D system in a magnetic field. When the frequency shift varies by an amount of cyclotron frequency ωc the magnetoresistivity and other transport quantities experience a change of one oscillation period, suggesting parameter ω≡ωωc, j≡ωjωc, s≡ωsωc, or ω+j-s, to control the corresponding oscillation. Thus achieves a unified picture of microwave-, dc current-, acoustic phonon-, and their combination-induced magnetoresistance oscillations. The balance-equation model not only reproduces the main features of all these magnetoresistance oscillations, but also explains many other prominent experimental observations. © 2010 Elsevier B.V. All rights reserved.

Wu B.,Shanghai JiaoTong University
PloS one | Year: 2012

The aim of this research was to evaluate the economic outcomes of radiotherapy (RT), temozolomide (TMZ) and nitrosourea (NT) strategies for glioblastoma patients with different prognostic factors. A Markov model was developed to track monthly patient transitions. Transition probabilities and utilities were derived primarily from published reports. Costs were estimated from the perspective of the Chinese healthcare system. The survival data with different prognostic factors were simulated using Weibull survival models. Costs over a 5-year period and quality-adjusted life years (QALYs) were estimated. Probabilistic sensitivity and one-way analyses were performed. The baseline analysis in the overall cohort showed that the TMZ strategy increased the cost and QALY relative to the RT strategy by $25,328.4 and 0.29, respectively; and the TMZ strategy increased the cost and QALY relative to the NT strategy by $23,906.5 and 0.25, respectively. Therefore, the incremental cost effectiveness ratio (ICER) per additional QALY of the TMZ strategy, relative to the RT strategy and the NT strategy, amounts to $87,940.6 and $94,968.3, respectively. Subgroups with more favorable prognostic factors achieved more health benefits with improved ICERs. Probabilistic sensitivity analyses confirmed that the TMZ strategy was not cost-effective. In general, the results were most sensitive to the cost of TMZ, which indicates that better outcomes could be achieved by decreasing the cost of TMZ. In health resource-limited settings, TMZ is not a cost-effective option for glioblastoma patients. Selecting patients with more favorable prognostic factors increases the likelihood of cost-effectiveness.

Zhang G.H.,University of Warwick | Bon S.A.F.,University of Warwick | Zhao C.Y.,Shanghai JiaoTong University
Solar Energy | Year: 2012

In this paper, nanocapsules containing n-octadecane with an average 50. nm thick shell of poly(ethyl methacrylate) (PEMA) and poly(methyl methacrylate) (PMMA), and a core/shell weight ratio of 80/20 were synthesized by the direct miniemulsion method, respectively. The average size of the capsules is 140. nm and 119. nm, respectively. The chemical structure of the sample was analyzed using Fourier Transformed Infrared Spectroscopy (FTIR). Crystallography of nanocapsules was investigated by X-ray diffractometer. The surface morphology was studied by Scanning Electron Microscopy (SEM) and Transmission Electron Microscopy (TEM). The thermal properties and thermal stability of the sample were obtained from Differential Scanning Calorimeter (DSC) and Thermal Gravimetric Analysis (TGA). The temperatures and latent heats of melting and crystallizing of PEMA nanocapsule were determined as 32.7 and 29.8 °C, 198.5 and -197.1. kJ/kg, respectively. TGA analysis indicated that PEMA/octadecane nanocapsule had good thermal stability. The nanocapsules prepared in this work had a much higher encapsulation ratio (89.5%) and encapsulation efficiency (89.5%). Therefore, the findings of the work lead to the conclusion that the present work provides a novel method for fabricating nanoencapsulated phase change material, and it has a better potential for thermal energy storage. © 2012 Elsevier Ltd.

Yang G.,Shanghai JiaoTong University
The Tohoku journal of experimental medicine | Year: 2011

Impaired wound healing in surgical patients with diabetes increases the incidence of infection, prolongs hospitalization, and even increases the rate of mortality. Low-energy extracorporeal shock wave treatment (ESWT) was reported to accelerate chronic wound healing by promoting revascularization and tissue regeneration; however, it is not known if ESWT could also improve healing of acute surgical incisional wounds in diabetes. In this study, using a rat model of diabetes, we investigated the effect of low-energy ESWT on collagen content in wound tissues and its efficacy in incisional wound healing. A single dorsal incisional wound was inflicted in streptozotocin-induced diabetic rats, and they received ESWT at different time post-wounding. Rats were sacrificed on days 7 and 14 post-wounding. Wound breaking strength, hydroxyproline content, histological characteristics and the expression of transforming growth factor beta 1 (TGF-β1) were analyzed. As a result, the wound breaking strength was significantly enhanced and the hydroxyproline content in wound tissues was increased at each time point examined. The number of fibroblasts was signicantly increased, and the new collagen fibers were more abundant at the wound site after ESWT. Furthermore, the expression of TGF-β1 was up-regulated after ESWT on day 7 post-wounding. These results suggest that low-energy ESWT can increase collagen content, enhance wound breaking strength and improve the healing of incisional wound in diabetic rats. The increased collagen content may be attributed, at least in part, to the up-regulation of TGF-β1 expression in wound tissues.

Zhang X.B.,Shanghai JiaoTong University
The Journal of international medical research | Year: 2012

This study investigated bilateral uterine artery chemoembolization (BUACE) combined with dilation and curettage (D&C) in caesarean scar pregnancy (CSP). Nineteen women with CSP were referred for interventional radiology. In 13 patients, BUACE was performed before D&C, following a diagnosis of CSP. A further six patients received BUACE for massive vaginal bleeding after D&C for inevitable miscarriage; the diagnosis of CSP was subsequently confirmed ultrasonographically. BUACE of the uterine arteries was performed using gelfoam particles following intra-arterial infusion of 100 mg/m(2) methotrexate. BUACE was technically successful and immediate haemostasis was achieved in all patients. Blood loss was significantly greater during D&C undertaken before BUACE compared with D&C after BUACE, but this bleeding was controlled by BUACE. No patient required further surgical intervention and there were no severe complications. The gestational sac and placenta could no longer be detected ultrasonographically and the menstrual cycle returned to normal 2-3 months after treatment in all patients. BUACE followed by D&C seems to be a safe and effective treatment for CSP and should be considered as a treatment of choice.

Wu D.,Hubei University for Nationalities | Long M.,Shanghai JiaoTong University
ACS Applied Materials and Interfaces | Year: 2011

The visible-light-induced self-cleaning property of cotton has been realized by coating N-TiO 2 film and loading AgI particles simultaneously. The physical properties were characterized by means of XRD, SEM, TEM, XPS, and DRS techniques. The visible light photocatalytic activities of the materials were evaluated using the degradation of methyl orange. In comparison with TiO 2-cotton, the dramatic enhancement in the visible light photocatalytic performance of the AgI-N-TiO 2-cotton could be attributed to the synergistic effect of AgI and N-TiO 2, including generation of visible light photocatalytic activity and the effective electron-hole separations at the interfaces of the two semiconductors. The photocatalytic activity of the AgI-N-TiO 2-cotton was fully maintained upon several numbers of photodegradation cycles. In addition, according to the XRD patterns of the AgI-N-TiO 2-cotton before and after reaction, AgI was stable in the composites under visible light irradiation. Moreover, a possible mechanism for the excellent and stable photocatalytic activity of AgI-N-TiO 2-cotton under visible light irradiation was also proposed. © 2011 American Chemical Society.

Li L.,Shanghai JiaoTong University | Scott K.,Northumbria University | Yu E.H.,Northumbria University
Journal of Power Sources | Year: 2013

Gold nanoparticles supported on MnO 2-carbon nanocomposite (Au/MnO 2-C) are synthesised as the catalyst for the anodic oxidation of glucose for use in a direct glucose alkaline fuel cell (DGAFC). Characterisation of the catalyst is carried out using physical and electrochemical methods. It is observed that gold nanoparticles are uniformly dispersed onto the MnO 2-carbon nanocomposite support. Cyclic voltammetry shows that the prepared Au/MnO 2-carbon catalysts exhibit higher electro-catalytic activity for glucose oxidation than that of commercial Pt/C and Au/C catalysts. A maximum power density, at 30 °C, of 1.1 mW cm -2 is obtained using an Au/MnO 2-C anode catalyst in DGAFC, which is higher than that of the commercial Au/C catalyst. The enhanced activity is attributed to a catalytic effect of MnO 2 towards glucose oxidation. MnO 2-C nanocomposite is a promising approach for reducing noble metal catalyst loading in addition to improving the catalytic activity of gold catalyst for glucose oxidation. © 2012 Elsevier B.V. All rights reserved.

Ge X.,Shanghai JiaoTong University
Cochrane database of systematic reviews (Online) | Year: 2012

Central venous access (CVA) is widely used. However, its thrombotic, stenotic and infectious complications can be life-threatening and involve high-cost therapy. Research revealed that the risk of catheter-related complications varied according to the site of CVA. It would be helpful to find the preferred site of insertion to minimize the risk of catheter-related complications. This review was originally published in 2007 and was updated in 2011. 1. Our primary objective was to establish whether the jugular, subclavian or femoral CVA routes resulted in a lower incidence of venous thrombosis, venous stenosis or infections related to CVA devices in adult patients.2. Our secondary objective was to assess whether the jugular, subclavian or femoral CVA routes influenced the incidence of catheter-related mechanical complications in adult patients; and the reasons why patients left the studies early. We searched CENTRAL (The Cochrane Library 2011, Issue 9), MEDLINE, CINAHL, EMBASE (from inception to September 2011), four Chinese databases (CBM, WANFANG DATA, CAJD, VIP Database) (from inception to November 2011), Google Scholar and bibliographies of published reviews. The original search was performed in December 2006. We also contacted researchers in the field. There were no language restrictions. We included randomized controlled trials comparing central venous catheter insertion routes. Three authors assessed potentially relevant studies independently. We resolved disagreements by discussion. Dichotomous data on catheter-related complications were analysed. We calculated relative risks (RR) and their 95% confidence intervals (CI) based on a random-effects model. We identified 5854 citations from the initial search strategy; 28 references were then identified as potentially relevant. Of these, we Included four studies with data from 1513 participants. We undertook a priori subgroup analysis according to the duration of catheterization, short-term (< one month) and long-term (> one month) defined according to the Food and Drug Administration (FDA).No randomized controlled trial (RCT) was found comparing all three CVA routes and reporting the complications of venous stenosis.Regarding internal jugular versus subclavian CVA routes, the evidence was moderate and applicable for long-term catheterization in cancer patients. Subclavian and internal jugular CVA routes had similar risks for catheter-related complications. Regarding femoral versus subclavian CVA routes, the evidence was high and applicable for short-term catheterization in critically ill patients. Subclavian CVA routes were preferable to femoral CVA routes in short-term catheterization because femoral CVA routes were associated with higher risks of catheter colonization (14.18% or 19/134 versus 2.21% or 3/136) (n = 270, one RCT, RR 6.43, 95% CI 1.95 to 21.21) and thrombotic complications (21.55% or 25/116 versus 1.87% or 2/107) (n = 223, one RCT, RR 11.53, 95% CI 2.80 to 47.52) than with subclavian CVA routes. Regarding femoral versus internal jugular routes, the evidence was moderate and applicable for short-term haemodialysis catheterization in critically ill patients. No significant differences were found between femoral and internal jugular CVA routes in catheter colonization, catheter-related bloodstream infection (CRBSI) and thrombotic complications, but fewer mechanical complications occurred in femoral CVA routes (4.86% or 18/370 versus 9.56% or 35/366) (n = 736, one RCT, RR 0.51, 95% CI 0.29 to 0.88). Subclavian and internal jugular CVA routes have similar risks for catheter-related complications in long-term catheterization in cancer patients. Subclavian CVA is preferable to femoral CVA in short-term catheterization because of lower risks of catheter colonization and thrombotic complications. In short-term haemodialysis catheterization, femoral and internal jugular CVA routes have similar risks for catheter-related complications except internal jugular CVA routes are associated with higher risks of mechanical complications.

Chronic pain is the most prominent and disabling symptom of osteoarthritis (OA). Clinical data suggest that subchondral bone lesions contribute to the occurrence of joint pain. The present study investigated the effect of the inhibition of subchondral bone lesions on joint pain. Osteoarthritic pain was induced by an injection of monosodium iodoacetate (MIA) into the rat knee joint. Zoledronic acid (ZOL), a third generation of bisphosphonate, was used to inhibit subchondral bone lesions. Joint histomorphology was evaluated using X-ray micro computed tomography scanning and hematoxylin-eosin staining. The activity of osteoclast in subchondral bone was evaluated using tartrate-resistant acid phosphatase staining. Joint pain was evaluated using weight-bearing asymmetry, the expression of calcitonin gene-related peptide (CGRP) in the dorsal root ganglion (DRG), and spinal glial activation status using glial fibrillary acidic protein (GFAP) and ionized calcium binding adaptor molecule-1 (Iba-1) immunofluorescence. Afferent neurons in the DRGs that innervated the joints were identified using retrograde fluorogold labeling. MIA injections induced significant histomorphological alterations and joint pain. The inhibition of subchondral bone lesions by ZOL significantly reduced the MIA-induced weight-bearing deficit and overexpression of CGRP in DRG neurons, GFAP and Iba-1 in the spinal dorsal horn at 3 and 6 weeks after MIA injection; however, joint swelling and synovial reaction were unaffected. The inhibition of subchondral bone lesions alleviated joint pain. Subchondral bone lesions should be a key target in the management of osteoarthritic joint pain.

Paralleling the rapid growth in computers and internet connections, adolescent internet addiction (AIA) is becoming an increasingly serious problem, especially in developing countries. This study aims to explore the prevalence of AIA and associated symptoms in a large population-based sample in Shanghai and identify potential predictors related to personal characteristics. In 2007, 5,122 adolescents were randomly chosen from 16 high schools of different school types (junior, senior key, senior ordinary and senior vocational) in Shanghai with stratified-random sampling. Each student completed a self-administered and anonymous questionnaire that included DRM 52 Scale of Internet-use. The DRM 52 Scale was adapted for use in Shanghai from Young's Internet Addiction Scale and contained 7 subscales related to psychological symptoms of AIA. Multiple linear regression and logistic regression were both used to analyze the data. Of the 5,122 students, 449 (8.8%) were identified as internet addicts. Although adolescents who had bad (vs. good) academic achievement had lower levels of internet-use (p < 0.0001), they were more likely to develop AIA (odds ratio 4.79, 95% CI: 2.51-9.73, p < 0.0001) and have psychological symptoms in 6 of the 7 subscales (not in Time-consuming subscale). The likelihood of AIA was higher among those adolescents who were male, senior high school students, or had monthly spending >100 RMB (all p-values <0.05). Adolescents tended to develop AIA and show symptoms in all subscales when they spent more hours online weekly (however, more internet addicts overused internet on weekends than on weekdays, p < 0.0001) or when they used the internet mainly for playing games or real-time chatting. This study provides evidence that adolescent personal factors play key roles in inducing AIA. Adolescents having aforementioned personal characteristics and online behaviors are at high-risk of developing AIA that may compound different psychological symptoms associated with AIA. Spending excessive time online is not in itself a defining symptom of AIA. More attention is needed on adolescent excessive weekend internet-use in prevention of potential internet addicts.

The observed continuum spectra in the low-luminosity active galactic nuclei, M81, can be reproduced by the advection-dominated accretion flow (ADAF)+thin disk/corona accretion flow model. We find that the best fit to the spectral energy distribution of M81 requires accretion rate for Rtr = 60 RS. The observed H-like and He-like iron lines may probably be emitted from the transition layer between the vertically connected hot corona and cold thin disk. We model a power-law function of height z for the electron temperature in the transition layer, and calculate the thermal H-like and He-like iron line emission from M81. Combining the observations with our results, we find that the thickness of the transition layer is ∼14%-23% of the thickness of the corona at the same radius. We discuss that the observed stronger H-like line emission than He-like line emission cannot be explained with the pure ADAF model. Our results provide useful constraints on the theoretical model for disk-corona connection. © 2013. The American Astronomical Society. All rights reserved.

Zhou D.,University of Warwick | Zhao C.Y.,University of Warwick | Zhao C.Y.,Shanghai JiaoTong University
Applied Thermal Engineering | Year: 2011

This paper presents an experimental study on heat transfer characteristics of PCMs embedded in open-cell metal foams and expanded graphite, respectively. In this study the paraffin wax RT 27 and calcium chloride hexahydrate are employed as the heat storage media and the transient heat transfer behavior is measured. The results indicate that the addition of porous materials, either open-cell metal foams or expanded graphite, can enhance the heat transfer rate of PCMs. Especially for metal foams, the results show that they can double the overall heat transfer rate during the melting processes. The effect of mass ratio of expanded graphite on heat transfer is examined. © 2010 Elsevier Ltd. All rights reserved.

Su H.,Shanghai JiaoTong University
Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention | Year: 2012

The restoration of microscopy images makes the segmentation and detection of cells easier and more reliable, which facilitates automated cell tracking and cell behavior analysis. In this paper, the authors analyze the image formation process of phase contrast images and propose an image restoration method based on the dictionary representation of diffraction patterns. By formulating and solving a min-l1 optimization problem, each pixel is restored into a feature vector corresponding to the dictionary representation. Cells in the images are then segmented by the feature vector clustering. In addition to segmentation, since the feature vectors capture the information on the phase retardation caused by cells, they can be used for cell stage classification between intermitotic and mitotic/apoptotic stages. Experiments on three image sequences demonstrate that the dictionary-based restoration method can restore phase contrast images containing cells with different optical natures and provide promising results on cell stage classification.

Chemoresistance is a major cause of treatment failure in patients with lung cancer. Although the extensive efforts have been made in overcoming chemoresistance, the underlying mechanisms are still elusive. Cancer cells reprogram cellular metabolism to satisfy the demands of malignant phenotype. To reveal roles of cancer metabolism in regulating chemoresistance, we profiled the metabolic characteristics in paclitaxel-resistant lung cancer cells by flux assay. Glucose and oleate metabolism were significantly different between resistant and non-resistant cells. In addition, targeting metabolism as a strategy to overcome drug resistance was investigated using specific metabolic inhibitors. Inhibition of glycolysis and oxidative phosphorylation by 2-deoxyglucose and malonate, respectively, potentiated the effects of paclitaxel on nonresistant lung adenocarcinoma cells but not paclitaxel-resistant cells. By contrast, inhibition of lipolysis by mercaptoacetate or etomoxir synergistically inhibited drug-resistant lung adenocarcinoma cell proliferation. We conclude that lipolysis inhibition potentially be a therapeutic strategy to overcome drug resistance in lung cancer.

We investigated the antitumor effect and mechanism of hematoporphyrin monomethyl ether-mediated photodynamic therapy (HMME-PDT) in sarcomas. Intracellular uptake of HMME by osteosarcoma cells (LM8 and K7) was time- and dose-dependent, while this was not observed for myoblast cells (C2C12) and fibroblast cells (NIH/3T3). HMME-PDT markedly inhibited the proliferation of sarcoma cell lines (LM8, MG63, Saos-2, SW1353, TC71, and RD) (P<0.05), and the killing effect was improved with increased HMME concentration and energy intensity. Flow cytometry analysis revealed that LM8, MG63, and Saos-2 cells underwent apoptosis after treatment with HMME-PDT. Additionally, apoptosis was induced after HMME-PDT in a three-dimensional culture of osteosarcoma cells. Hoechst 33342 staining confirmed apoptosis. Cell death caused by PDT was rescued by an irreversible inhibitor (Z-VAD-FMK) of caspase. However, cell viability was not markedly decreased compared with the HMME-PDT group. Expression levels of caspase-1, caspase-3, caspase-6, caspase-9, and poly (ADP-ribose) polymerase (PARP) proteins were markedly up-regulated in the treatment groups and increased with HMME concentration as determined by western blot analysis. In vivo, tumor volume markedly decreased at 7-16 days post-PDT. Hematoxylin and eosin staining revealed widespread necrotic and infiltrative inflammatory cells in the HMME-PDT group. Immunohistochemistry analysis also showed that caspase-1, caspase-3, caspase-6, caspase-9, and PARP proteins were significantly increased in the HMME-PDT group. These results indicate that HMME-PDT has a potent killing effect on osteosarcoma cells in vitro and significantly inhibits tumor growth in vivo, which is associated with the caspase-dependent pathway.

Sirt6 is a histone deacetylase with NAD+-dependent activity. Sirt6 has been shown as a tumor suppressor partially via inhibiting the expression of c-Myc target genes and ribosome biogenesis. However, how to regulate Sirt6 activity is largely unknown. In this study, we identify that Sirt6 can be modified by small ubiquitin-like modifier. Sirt6 SUMOylation deficiency specifically decreases its deacetylation of H3K56 but not H3K9 in vivo. Mechanistically, we find that SUMOylation deficiency decreases Sirt6 binding with c-Myc, decreasing Sirt6 occupancy on the locus of c-Myc target genes. Therefore, Sirt6 SUMOylation deficiency reduces its deacetylation of H3k56 and its repression of c-Myc target genes. Moreover, Sirt6 SUMOylation deficiency reduces its suppression of cell proliferation and tumorigenesis. Thus, these results reveal that SUMOylation has an important role in regulation of Sirt6 deacetylation on H3K56, as well as its tumor suppressive activity.Oncogene advance online publication, 22 February 2016; doi:10.1038/onc.2016.24. © 2016 Macmillan Publishers Limited

Liu Z.,Shanghai JiaoTong University | Zhu Q.,Shanghai University of Electric Power
Energy Conversion and Management | Year: 2011

An experimental study was carried out to investigate the effects of aqueous CuO nanofluids on thermal performance of a horizontal mesh heat pipe working at steady sub-atmospheric pressures. The nanofluid was composed of deionized water and CuO nanoparticles with an average diameter of 50 nm. The experimental results show that adding CuO nanoparticles into deionized water can significantly enhance heat transfer coefficients of both evaporator and condenser, and the maximum heat flux of the heat pipe. There is an optimal mass concentration of nanoparticles corresponding to the maximum heat transfer enhancement. The operating pressure has an apparent impact on both the evaporating and condensing heat transfer enhancements. The heat transfer enhancement effects increase distinctly with the decrease of the pressure. The present investigation discovers that the thermal performance of a mesh heat pipe can be evidently strengthened by substituting CuO nanofluids for deionized water under sub-atmospheric pressures. © 2010 Elsevier Ltd. All rights reserved.

Yu Z.,East China University of Science and Technology | Li S.,Shanghai JiaoTong University | Du H.,East China University of Science and Technology
International Journal of Robust and Nonlinear Control | Year: 2013

This paper addresses the problem of adaptive neural control for a class of uncertain stochastic pure-feedback nonlinear systems with time-varying delays. Major technical difficulties for this class of systems lie in: (1) the unknown control direction embedded in the unknown control gain function; and (2) the unknown system functions with unknown time-varying delays. Based on a novel combination of the Razumikhin-Nussbaum lemma, the backstepping technique and the NN parameterization, an adaptive neural control scheme, which contains only one adaptive parameter is presented for this class of systems. All closed-loop signals are shown to be 4-Moment semi-globally uniformly ultimately bounded in a compact set, and the tracking error converges to a small neighborhood of the origin. Finally, two simulation examples are given to demonstrate the effectiveness of the proposed control schemes. Copyright © 2012 John Wiley & Sons, Ltd. Copyright © 2012 John Wiley & Sons, Ltd.

Liao S.-I.,Shanghai JiaoTong University
Journal of Hydrodynamics | Year: 2010

We give a short review on the current development of homotopy analysis method (HAM), an analytic technique for strongly nonlinear problems, and its applications in fluid mechanics. © 2010 Publishing House for Journal of Hydrodynamics.

Wu X.,McMaster University | Zhai G.,Shanghai JiaoTong University
IEEE Signal Processing Magazine | Year: 2013

A new paradigm of information display, called temporal psychoviusal modulation (TPVM), which is conceived as an ingenious interplay of signal processing, optoelectronics, and psychophysics, is proposed. In TPVM, a high-speed display sequentially emits a set of atom frames. Unlike in time multiplexing, these atom frames are not completely formed images but rather constituent parts of images; these atom frames are amplitude modulated by display-synchronized shutter devices. TPVM can be implemented by a combination of a high-speed display and display synchronized active liquid crystal (LC) glasses. The signal processing operations performed optoelectronically via the display-glasses coupling and the resulting psychovisual effects of TPVM can be mathematically modeled. A defining and unique characteristic of the new TPVM display system is that the optoelectronic modulator is coupled with a biological demodulator.

Wu Y.,Shanghai JiaoTong University | Wu Y.,Baylor College of Medicine | Le W.,Baylor College of Medicine | Jankovic J.,Baylor College of Medicine
Archives of Neurology | Year: 2011

The search for markers of preclinical Parkinson disease (PD) is becoming increasingly important because pathogenesis-targeted neuroprotective strategies are being developed for future use in at-risk populations, even before clinical onset of disease. Advances in clinical recognition of early symptoms and signs, development of new neuroimaging probes and technologies, identification of new neuropathological markers of PD, and breakthroughs in genetics and basic neuroscience are gradually translating into better understanding of predisposing and preclinical factors that lead to progressive neurodegeneration. Coupled with system biology tools, progress is being made in the identification of new genomic, transcriptomic, proteomic, lipidomic, and metabolomic molecules and new signaling pathways that are relevant to the pathogenesis of neurodegeneration in PD. These new tools will be critical not only in the discovery of sensitive, specific, and reliable biomarkers of preclinical PD but also in the development of tests that will aid in the early detection and differential diagnosis of parkinsonian disorders and in monitoring disease progression. ©2011 American Medical Association. All rights reserved.

Wu Z.-S.,Max Planck Institute for Polymer Research | Winter A.,Bielefeld University | Chen L.,Max Planck Institute for Polymer Research | Sun Y.,Max Planck Institute for Polymer Research | And 4 more authors.
Advanced Materials | Year: 2012

A simplified prototype device of high-performance all-solid-state supercapacitors (ASSSs) based on 3D nitrogen and boron co-doped monolithic graphene aerogels (BN-GAs) is demonstrated for the first time. The resulting ASSSs show high specific capacitance, good rate capability, and enhanced energy density or power density. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Ma W.-X.,University of South Florida | Zhu Z.-N.,Shanghai JiaoTong University
Computers and Mathematics with Applications | Year: 2010

Beginning with Lax pairs from special non-semisimple matrix Lie algebras, we establish a scheme for constructing nonlinear discrete integrable couplings. Discrete variational identities over the associated loop algebras are used to build Hamiltonian structures for the resulting integrable couplings. We illustrate the application of the scheme by means of an enlarged Volterra spectral problem and present an example of nonlinear discrete integrable Hamiltonian couplings for the Volterra lattice equations. © 2010 Elsevier Ltd. All rights reserved.

To assess the effect of cardioselective β-blockers on pulmonary function in patients with chronic obstructive pulmonary disease (COPD). The Embase and MEDLINE™ databases and the Cochrane Controlled Trials Register were searched comprehensively to identify all relevant clinical trials in humans published between January 1966 and May 2011. Randomized, blinded, placebo-controlled trials that studied the effects of cardioselective β-blockers on the forced expiratory volume in 1 s (FEV(1)) and the responsiveness of the FEV(1) to β-agonist administration in patients with COPD were included in the analysis. Five studies were identified: four of these assessed both cardioselective and nonselective β-blockers; one assessed only cardioselective β-blockers. The FEV(1) was shown to decrease by 0.14 l with nonselective β-blockers and by 0.03 l with cardioselective β-blockers. The responsiveness of the FEV(1) to β-agonist administration decreased significantly by 13.42% after nonselective β-blockers, but did not change significantly after cardioselective β-blocker administration. This metaanalysis suggests that the use of β-blockers, especially cardioselective β-blockers, should not be contraindicated in patients with COPD.

Chen C.,Shanghai JiaoTong University
Acta biochimica et biophysica Sinica | Year: 2013

Community-acquired pneumonia (CAP) is a major concern in hospitals and the bacterial community of which has not been systemically discussed yet. Sputum from patients in the acute stages is a kind of accessible sample reflecting its features. In our study, we analyzed 45 sputum samples from 45 patients with CAP. Eighteen sputum samples from healthy people were chosen as the controls. Pyrosequencing of the 16s rDNA V3 hypervariable regions of all the bacteria contained in the sputum was used as a culture-independent method to disclose the community constitution. Also, our published data for hospital-acquired pneumonia (HAP) in sputum was used for comparison. By pyrosequencing, >90,000 DNA reads were detected. After being analyzed by tools in the Ribosomal Database Project, the reads were classified into five main phyla and >100 genera. At the phyla level, the reads' distribution of CAP is similar to that of healthy people and at genera level, the occurrence of each genus possesses their feature in three categories. Genera such as Streptococcus and Neisseria showed stability in their percentages, indicating that such genera are rarely affected by exogenous bacteria or antibiotics. The role of other genera such as Moraxella and Rothia in CAP should be emphasized. According to our analysis, the bacterial communities of CAP are with slight change when compared with those of healthy people, but have a large gap between HAP. Meanwhile, Rothia might be an important endogenous pneumonia-causing factor.

Lyon T.P.,Institute of Commerce and Business | Yin H.,Shanghai JiaoTong University
Energy Journal | Year: 2010

Renewable portfolio standards (RPSs) for electricity generation are politically popular in many U.S. states although economic analysis suggests they are not first-best policies. We present an empirical analysis of the political and economic factors that drive state governments to adopt an RPS, and the factors that lead to the inclusion of in-state requirements given the adoption of an RPS. Although advocates claim an RPS will stimulate job growth, we find that states with high unemployment rates are slower to adopt an RPS. Local environmental conditions and preferences have no significant effect on the timing of adoption. Overall, RPS adoption seems to be driven more by political ideology and private interests than by local environmental and employment benefits, raising questions as to when environmental federalism serves the public interest. Copyright © 2010 by the IAEE. All rights reserved.

Sheng L.,Shanghai JiaoTong University
The Tohoku journal of experimental medicine | Year: 2011

The delivery of bone marrow-derived mononulear cells (BM-MNCs) has been proved to be effective at promoting neovascularization of ischemic skin flaps. However, the limited source of BM-MNCs restricts their clinical application. Stromal vascular fraction (SVF) contains a group of heterogeneous cells in the adipose tissue, including adipose tissue-derived stem cells, and it has abundant reserve in human body. In this study, we evaluated the therapeutic potential of SVF to promote neovascularization of random skin flaps. Female Wistar rats were randomly devided into three groups with 8 in each group and received allogeneic SVF, BM-MNCs and phosphate-buffered saline (PBS), respectively, before surgery. Two days after cell administration, a 10 × 3 cm random skin flap was elevated. Flap survival, blood flow perfusion and capillary density were examined 7 days after surgery, and the relevant mechanism was also explored. Results showed that SVF group and BM-MNCs group had higher survival percentage (72.2 ± 2.0% and 76.4 ± 3.1%, respectively) as compared with the control group (56.8 ± 4.6%, P < 0.05). Blood flow perfusion and capillary density of flap tissues in SVF and BM-MNCs groups were both improved. The expression levels of vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) were increased in flap tissues of SVF and BM-MNCs groups detected by ELISA. These results indicate that SVF could promote vascularization and increase flap survival probably by secreting VEGF and bFGF. The effect of transplantation of SVF on therapeutic angiogenesis of skin flaps is equivalent to that of BM-MNCs.

Hong-Qi Y.,Zhengzhou University | Zhi-Kun S.,Zhengzhou University | Sheng-Di C.,Shanghai JiaoTong University
Translational Neurodegeneration | Year: 2012

Alzheimer's disease (AD) is a neurodegenerative disorder that impairs mainly the memory and cognitive function in elderly. Extracellular beta amyloid deposition and intracellular tau hyperphosphorylation are the two pathological events that are thought to cause neuronal dysfunction in AD. Since the detailed mechanisms that underlie the pathogenesis of AD are still not clear, the current treatments are those drugs that can alleviate the symptoms of AD patients. Recent studies have indicated that these symptom-reliving drugs also have the ability of regulating amyloid precursor protein processing and tau phosphorylation. Thus the pharmacological mechanism of these drugs may be too simply-evaluated. This review summarizes the current status of AD therapy and some potential preclinical considerations that target beta amyloid and tau protein are also discussed. © 2012 Hong-Qi et al.; licensee BioMed Central Ltd.

Gankyrin is a regulatory subunit of the 26kD proteasome complex. As a novel oncoprotein, gankyrin is expressed aberrantly in cancers from several different sites and has been shown to contribute to oncogenesis in endometrial and cervical carcinomas. Neither gankyrin’s contribution to the development of epithelial ovarian cancer nor its interaction with follicle-stimulating hormone (FSH)-driven proliferation in ovarian cancer has been studied. Here we have found that gankyrin is overexpressed in ovarian cancers compared with benign ovarian cystadenomas and that gankyrin regulates FSH upregulation of cyclin D1. Importantly, gankyrin regulates PI3K/AKT signaling by downregulating PTEN. Prolonged AKT activation by FSH stimulation of the FSH receptor (FSHR) promotes gankyrin expression, which, in turn, enhances AKT activation by inhibiting PTEN. Overexpression of gankyrin decreases hypoxia inducible factor-1α (HIF-1α) protein levels, but has little effect on HIF-1α mRNA levels, which could be attributed to gankyrin mediating HIF-1α protein stability via the ubiquitin–proteasome pathway. Reduction in HIF-1α protein stability led to attenuation of the binding with cyclin D1 promoter, resulted in abolishment of the negative regulation of cyclin D1 by HIF-1α, which promotes proliferation of ovarian cancer cells. Our results document that gankyrin regulates HIF-1α protein stability and cyclin D1 expression, ultimately mediating FSH-driven ovarian cancer cell proliferation.Oncogene advance online publication, 14 September 2015; doi:10.1038/onc.2015.316. © 2015 Macmillan Publishers Limited

Wu H.,Shanghai JiaoTong University
Arteriosclerosis, Thrombosis, and Vascular Biology | Year: 2016

OBJECTIVE—: Cathepsin S (CatS) participates in atherogenesis through several putative mechanisms. The ability of cathepsins to modify histone tail is likely to contribute to stem cell development. Histone deacetylase 6 (HDAC6) is required in modulating the proliferation and migration of various types of cancer cells. Here, we investigated the cross talk between CatS and HADC6 in injury-related vascular repair in mice. APPROACH AND RESULTS—: Ligation injury to the carotid artery in mice increased the CatS expression, and CatS-deficient mice showed reduced neointimal formation in injured arteries. CatS deficiency decreased the phosphorylation levels of p38 mitogen-activated protein kinase, Akt, and HDAC6 and toll-like receptor 2 expression in ligated arteries. The genetic or pharmacological inhibition of CatS also alleviated the increased phosphorylation of p38 mitogen-activated protein kinase, Akt, and HDAC6 induced by platelet-derived growth factor BB in cultured vascular smooth muscle cells (VSMCs), and p38 mitogen-activated protein kinase inhibition and Akt inhibition decreased the phospho-HDAC6 levels. Moreover, CatS inhibition caused decrease in the levels of the HDAC6 activity in VSMCs in response to platelet-derived growth factor BB. The HDAC6 inhibitor tubastatin A downregulated platelet-derived growth factor–induced VSMC proliferation and migration, whereas HDAC6 overexpression exerted the opposite effect. Tubastatin A also decreased the intimal VSMC proliferation and neointimal hyperplasia in response to injury. Toll-like receptor 2 silencing decreased the phosphorylation levels of p38 mitogen-activated protein kinase, Akt, and HDAC6 and VSMC migration and proliferation. CONCLUSIONS—: This is the first report detailing cross-interaction between toll-like receptor 2–mediated CatS and HDAC6 during injury-related vascular repair. These data suggest that CatS/HDAC6 could be a potential therapeutic target for the control of vascular diseases that are involved in neointimal lesion formation.Arteriosclerosis, Thrombosis, and Vascular Biology is published on behalf of the American Heart Association, Inc., by Wolters Kluwer. This is an open access article under the terms of the Creative Commons Attribution Non-Commercial-NoDervis License, which permits use, distribution, and reproduction in any medium, provided that the original work is properly cited, the use is noncommercial, and no modifications or adaptations are made. © 2016 American Heart Association, Inc.

Epithelial-to-mesenchymal transition (EMT), marked by the dissolution of cell–cell junctions, loss of cell polarity and increased cell motility, is one of the essential steps for prostate cancer metastasis. However, the underlying mechanism has not been fully explored. We report in this study that Shp2 is upregulated in prostate cancers and is associated with a poor disease outcome, namely tumor metastasis and shortened patient survival. Overexpression of wild-type Shp2 or an oncogenic Shp2 mutant leads to increased prostate cancer cell proliferation, colony and sphere formation, and in vivo tumor formation. Opposite effects are seen in Shp2-knockdown cells. Moreover, Shp2 promotes in vitro migration and in vivo metastasis of prostatic tumor cells. Mechanistically, Shp2 interacts with PAR3 (partitioning-defective 3) via its Src homology-2 domain. Ectopic expression of Shp2 attenuates the phosphorylation of PAR3 and the formation of the PAR3/PAR6/atypical protein kinase C polarity protein complex, resulting in disrupted cell polarity, dysregulated cell–cell junctions and increased EMT. These findings provide a novel mechanism by which oncogenic signal-transduction molecules regulate cell polarity and induction of EMT.Oncogene advance online publication, 8 June 2015; doi:10.1038/onc.2015.184. © 2015 Macmillan Publishers Limited

Xu Y.-D.,Shanghai JiaoTong University
Astrophysical Journal | Year: 2011

We explore thermal X-ray iron line emission from the galactic X-ray binary GX 339?4 in the off state, using the models of the advection-dominated accretion flow (ADAF) without or with outflows. The equivalent widths of hydrogen-like and helium-like thermal iron lines are calculated with different model parameters including viscosity parameter α, mass accretion rate at the outer radius of the ADAF ṁout, and outflow strength parameter p. Our calculations show that the equivalent widths of thermal iron lines emitted from the pure ADAF, i.e., the ADAF without outflows, should be very small, assuming a solar metallicity for the accreting gas in the accretion flow. Strong thermal iron lines are expected to be emitted from the ADAF with relatively strong outflows. For a reasonable choice of parameters, the total equivalent width of the He-like and H-like thermal iron lines reaches to ≳500 eV for accreting gas with solar metallicity. The observation of strong thermal X-ray lines from GX 339?4 at the off state may give a clue to the accretion mode of the source and provide evidence for the presence of outflows/winds in the accretion flow around the black hole in GX 339?4. It is found that the values of ṁout and p are degenerate, i.e., the observed X-ray continuum spectrum can be fairly well reproduced with different sets of the parameters ṁoutand p. Such degeneracy can be broken when the thermal X-ray line emission data are available. We also compare our results with those in a previous similar work. © 2011. The American Astronomical Society. All rights reserved.

Zhang Z.,Shanghai JiaoTong University
Machine Learning | Year: 2014

We are concerned with an approximation problem for a symmetric positive semidefinite matrix due to motivation from a class of nonlinear machine learning methods. We discuss an approximation approach that we call matrix ridge approximation. In particular, we define the matrix ridge approximation as an incomplete matrix factorization plus a ridge term. Moreover, we present probabilistic interpretations using a normal latent variable model and a Wishart model for this approximation approach. The idea behind the latent variable model in turn leads us to an efficient EM iterative method for handling the matrix ridge approximation problem. Finally, we illustrate the applications of the approximation approach in multivariate data analysis. Empirical studies in spectral clustering and Gaussian process regression show that the matrix ridge approximation with the EM iteration is potentially useful. © 2014, The Author(s).

Sanetuntikul J.,Daegu Gyeongbuk Institute of Science and Technology | Hang T.,Shanghai JiaoTong University | Shanmugam S.,Daegu Gyeongbuk Institute of Science and Technology
Chemical Communications | Year: 2014

Hollow nitrogen-doped carbon spheres (HNCSs) were prepared by a facile method as non-precious catalysts for the oxygen reduction reaction (ORR). The HNCS catalysts exhibited ORR activity comparable with a commercial Pt/C catalyst and superior stability in alkaline electrolyte medium. This journal is © the Partner Organisations 2014.

Su H.,Huazhong University of Science and Technology | Chen M.Z.Q.,University of Hong Kong | Wang X.,Shanghai JiaoTong University | Lam J.,University of Hong Kong
IEEE Transactions on Industrial Electronics | Year: 2014

This paper studies the observer-based leader-following consensus of a linear multiagent system on switching networks, in which the input of each agent is subject to saturation. Based on a low-gain output feedback method, distributed consensus protocols are developed. Under the assumptions that the networks are connected or jointly connected and that each agent is asymptotically null controllable with bounded controls and detectable, semiglobal observer-based leader-following consensus of the multiagent system can be reached on switching networks. A numerical example is presented to illustrate the theoretical results. © 1982-2012 IEEE.

Gliomas are highly malignant brain tumors that are highly invasive and resistant to conventional therapy. Receptor tyrosine kinases (RTKs) such as PDGFRα (platelet-derived growth factor receptor-α), which show frequent aberrant activation in gliomas, are associated with a process of epithelial–mesenchymal transition (EMT), a cellular alteration that confers a more invasive and drug-resistant phenotype. Although this phenomenon is well documented in human cancers, the processes by which RTKs including PDGFRα mediate EMT are largely unknown. Here, we report that SHP-2 (encoded by PTPN11) upregulates an EMT inducer, ZEB1, to mediate PDGFRα-driven glioma EMT, invasion and growth in glioma cell lines and patient-derived glioma stem cells (GSCs) using cell culture and orthotopic xenograft models. ZEB1 and activated PDGFRα were coexpressed in invasive regions of mouse glioma xenografts and clinical glioma specimens. Glioma patients with high levels of both phospho-PDGFRα (p-PDGFRα) and ZEB1 had significantly shorter overall survival compared with those with low expression of p-PDGFRα and ZEB1. Knockdown of ZEB1 inhibited PDGFA/PDGFRα-stimulated glioma EMT, tumor growth and invasion in glioma cell lines and patient-derived GSCs. PDGFRα mutant deficient of SHP2 binding (PDGFRα-F720) or phosphoinositide 3-kinase (PI3K) binding (PDGFRα-F731/42), knockdown of SHP2 or treatments of pharmacological inhibitor for PDGFRα-signaling effectors attenuated PDGFA/PDGFRα-stimulated ZEB1 expression, cell migration and GSC proliferation. Importantly, SHP-2 acts together with PI3K/AKT to regulate a ZEB1-miR-200 feedback loop in PDGFRα-driven gliomas. Taken together, our findings uncover a new pathway in which ZEB1 functions as a key regulator for PDGFRα-driven glioma EMT, invasiveness and growth, suggesting that ZEB1 is a promising therapeutic target for treating gliomas with high PDGFRα activation.Oncogene advance online publication, 4 April 2016; doi:10.1038/onc.2016.100. © 2016 Macmillan Publishers Limited

Wang J.,Beijing Institute of Biotechnology | Yang X.,Beijing Institute of Biotechnology | Yang X.,Shanghai JiaoTong University
Cellular and Molecular Life Sciences | Year: 2012

Cardiac hypertrophy is an adaptive enlargement of the myocardium in response to altered stress or injury. The cellular responses of cardiomyocytes and noncardiomyocytes to various signaling pathways should be tightly and delicately regulated to maintain cardiac homeostasis and prevent pathological cardiac hypertrophy. MicroRNAs (miRNAs) are endogenous, single-stranded, short non-coding RNAs that act as regulators of gene expression by promoting the degradation or inhibiting the translation of target mRNAs. Recent studies have revealed expression signatures of miRNAs associated with pathological cardiac hypertrophy and heart failure in humans and mouse models of heart diseases. Increasing evidence indicates that dysregulation of specific miRNAs could alter the cellular responses of cardiomyocytes and non-cardiomyocytes to specific signaling upon the pathological hemodynamic overload, leading to cardiac hypertrophy and heart failure. This review summarizes the cell-autonomous functions of cardiomyocyte miRNAs regulated by different pathways and the roles of non-cardiomyocyte miRNAs in cardiac hypertrophy. The therapeutic effects of a number of miRNAs in heart diseases are also discussed. © 2012 The Author(s).

Guan N.,National University of Defense Technology | Tao D.,University of Technology, Sydney | Luo Z.,National University of Defense Technology | Yuan B.,Shanghai JiaoTong University
IEEE Transactions on Neural Networks | Year: 2011

In this paper, we present a non-negative patch alignment framework (NPAF) to unify popular non-negative matrix factorization (NMF) related dimension reduction algorithms. It offers a new viewpoint to better understand the common property of different NMF algorithms. Although multiplicative update rule (MUR) can solve NPAF and is easy to implement, it converges slowly. Thus, we propose a fast gradient descent (FGD) to overcome the aforementioned problem. FGD uses the Newton method to search the optimal step size, and thus converges faster than MUR. Experiments on synthetic and real-world datasets confirm the efficiency of FGD compared with MUR for optimizing NPAF. Based on NPAF, we develop non-negative discriminative locality alignment (NDLA). Experiments on face image and handwritten datasets suggest the effectiveness of NDLA in classification tasks and its robustness to image occlusions, compared with representative NMF-related dimension reduction algorithms. © 2011 IEEE.

Liu Y.,Shanghai JiaoTong University
The Tohoku journal of experimental medicine | Year: 2011

Lymphotoxin-alpha (LTA), a pro-inflammatory cytokine, has been implicated in the pathogenesis of coronary atherosclerosis. Meanwhile, association of some single nucleotide polymorphisms (SNPs) of LTA gene with coronary artery disease (CAD) has been evaluated; however, the results are irreproducible. We therefore investigated the relationship between four SNPs of LTA gene and CAD in Han Chinese: G+10A (rs1800683, 5'-untranslated region), A+80C (rs2239704, 5'-untranslated region), T+496C (Cys13Arg, rs2229094, exon 2), and C+804A (Thr26Asn, rs1041981, exon 3). Genotyping was performed in 438 CAD patients and 330 healthy controls. Single-locus analysis showed that the genotype and allele frequencies of G+10A polymorphism exhibited marginal differences between CAD patients and controls, although no statistical significance was observed after the Bonferroni correction. Logistic regression analysis revealed that GG genotype of G+10A polymorphism was significantly associated with the risk of CAD under the dominant mode, whereas no significant association was detected between A+80C polymorphism and CAD. In contrast, individuals carrying TT or TC genotype of T+496C polymorphism showed a decreased CAD risk relative to those with CC genotype under the recessive mode. Likewise, CC genotype of C+804A polymorphism was associated with a protective effect on CAD under the dominant mode. Further, in haplotype analysis, the haplotype G-C-T-C (in order of rs1800683, rs2239704, rs2229094 and rs1041981) was significantly associated with a decreased risk of CAD after assigning the most common haplotype A-C-T-A as a reference. In conclusion, we show a protective effect of the haplotype G-C-T-C on the occurrence of CAD, suggesting the involvement of LTA in CAD pathogenesis.

Background: The HIV prevalence and incidence among men who have sex with men (MSM) are high. Unprotected anal intercourse (UAI) with male regular partners (RP) is an important but under-emphasized risk behavior. The current study aimed to describe the prevalence of UAI with regular partner and the associated multi-dimensional factors with UAI among MSM in Hong Kong, China.Methods: Respondent Driven Sampling method was used to recruit participants. A total of 285 participants were recruited, of whom 211 (75.1%) had had anal sex with RP in the last six months and their data were analyzed in this report. Weighed data were presented and logistic regression methods were fit.Results: Participants' high risk behaviors in the last six months included high prevalence of having had UAI with RP (45.8%), having had non-regular male sex partners (NRP: 27.3%) and UAI with such partners (18.9%). Adjusted for socio-demographic variables, factors associated with UAI with RP included: 1) substances use prior to having anal sex (65.7% versus 43.8%; AOR =2.36; 95% CI =1.07-5.18), 2) worry that condom use symbolizes mistrust (67.9% versus 44.3%; AOR = 2.91; 95% CI =1.19-7.10), 3) a lower perceived degree of the RP's acceptance of condom use (91.7% versus 38.3%; AOR = 22.70; 95% CI =6.20-83.10), and 4) a higher level of impulsivity (61.1% versus 35.0%; AOR =4.02; 95% CI = 1.62-9.97). Two of these four variables, substances use (ORm = 2.28, 95% CI = 1.01-5.16) and perceived lower level of RP's acceptance of condom use (ORm = 17.22; 95% CI = 5.06-58.62) were selected by the forward stepwise logistic regression model.Conclusions: MSM with RP in Hong Kong is subjected to high risk of HIV transmission. Risk factors of UAI are multi-dimensional and interventions need to take into account factors of structural, interpersonal and individual levels. © 2014 Cai and Lau; licensee BioMed Central Ltd.

Fan J.-G.,Shanghai JiaoTong University
Journal of Gastroenterology and Hepatology (Australia) | Year: 2013

The prevalence of patients presenting with fatty liver disease (FLD) in China has approximately doubled over the past two decades. At present, FLD, which is typically diagnosed by imaging, is highly prevalent (~27% urban population) in China and is mainly related to obesity and metabolic syndrome (MetS). However, the percentage of alcoholic liver disease (ALD) among patients with chronic liver diseases in clinic is increasing as well, and a synergetic effect exists between heavy alcohol drinking and obesity in ALD. Prevalence figures reveal regional variations, with a median prevalence of ALD and nonalcoholic FLD (NAFLD) of 4.5% and 15.0%, respectively. The prevalence of NAFLD in children is 2.1%, although the prevalence increases to 68.2% among obese children. With the increasing pandemic of obesity and MetS in the general population, China is likely to harbor an increasing reservoir of patients with FLD. The risk factors for FLD resemble to those of Caucasian counterparts, but the ethnic-specific definitions of obesity and MetS are more useful in assessment of Chinese people. Therefore, FLD/NAFLD has become a most common chronic liver disease in China. Public health interventions are needed to halt the worldwide trend of obesity and alcohol abuse to ameliorate liver injury and to improve metabolic health. © 2013 Journal of Gastroenterology and Hepatology Foundation and Wiley Publishing Asia Pty Ltd.

Sun Q.J.,Shanghai JiaoTong University
World journal of gastroenterology : WJG | Year: 2010

To investigate the resistance of Helicobacter pylori (H. pylori) to 6 commonly used antibiotics from 2000 to 2009 in Shanghai. A total of 293 H. pylori strains were collected from 2000 to 2009 in Shanghai and tested for their susceptibility to metronidazole, clarithromycin, amoxicillin, furazolidone, levofloxacin and tetracycline using agar dilution. The resistant rates of H. pylori to clarithromycin (8.6%, 9.0% and 20.7%) and levofloxacin (10.3%, 24.0% and 32.5%) increased from 2000 to 2009 in Shanghai. The resistant rate of H. pylori to metronidazole remained stable (40%-50%). Only one strain of H. pylori isolated in 2005 was resistant to tetracycline. All strains were sensitive to amoxicillin and furazolidone. The resistant rate of H. pylori to antibiotics was not related with the sex, age and clinical outcome of patients. Resistance of H. pylori to antibiotics plays an important role in making treatment strategies against H. pylori-associated diseases.

Wang Y.,Shanghai JiaoTong University
International Journal of Fatigue | Year: 2010

The fatigue life of a ship structural detail is calculated by using a spectral approach. The wave-induced vertical and horizontal bending moments, two base vessel loading conditions and the non-operating time have all been taken into account in the spectral fatigue damage calculation. The predicted fatigue life value by using the spectral approach is compared with the one calculated by using the IACS R 56, and various factors inducing uncertainties in the spectral method are further identified and investigated. Finally, recommendations on how to choose the specific parameters and how to model the random wave environment in the spectral approach are outlined. © 2009 Elsevier Ltd. All rights reserved.

Shen H.-S.,Shanghai JiaoTong University
Mechanics of Advanced Materials and Structures | Year: 2010

Compressive postbuckling under thermal environments and thermal postbuckling due to uniform temperature field are presented for an anisotropic laminated cylindrical thin shell with piezoelectric fiber reinforced composite (PFRC) actuators. The governing equations are based on the classical shell theory with a von Kármán-Donnell-type of kinematic nonlinearity and including the extension-twist, extension-flexural and flexural-twist couplings. The thermo-piezoelectric effects are also included and the material properties are assumed to be temperature-dependent and the electric field considered only has non-zero-valued component EZ. The nonlinear prebuckling deformations and initial geometric imperfections of the shell are both taken into account. A singular perturbation technique is employed to determine buckling loads (temperature) and postbuckling equilibrium paths. The numerical illustrations concern the compressive and thermal postbuckling behavior of perfect and imperfect, anisotropic laminated cylindrical shells with fully covered or embedded PFRC actuators under different sets of thermal and electric loading conditions, from which results for monolithic piezoelectric actuators are obtained as comparators. The results reveal that, in the compressive buckling case, the control voltage only has a small effect on the postbuckling load-deflection curves of the shell with PFRC actuators, whereas in the thermal buckling case, the effect of control voltage is more pronounced for the shell with PFRC actuators, compared to the results of the same shell with monolithic piezoelectric actuators. Copyright © Taylor & Francis Group, LLC.

Wang W.,Shanghai JiaoTong University | Wang W.,University of Bonn
International Journal of Modern Physics A | Year: 2014

In Standard Model, CP violation arises from an irreducible complex phase in the quark mixing matrix, now under the name Cabibbo-Kobayashi-Maskawa matrix. This description has shown remarkable overall agreement with various experimental measurements. In this review, we discuss recent experimental data and theoretical developments on three quantities of CKM matrix that are most uncertain: the Vub, including its magnitude and the phase γ in standard parametrization, and the Bs-B̄s mixing phase βs. © 2014 World Scientific Publishing Company.

Li W.,Shanghai JiaoTong University | Chen X.,U.S. National Institutes of Health
Nanomedicine | Year: 2015

Photoacoustic (PA) imaging is a biomedical imaging modality that provides functional information regarding the cellular and molecular signatures of tissue by using endogenous and exogenous contrast agents. There has been tremendous effort devoted to the development of PA imaging agents, and gold nanoparticles as exogenous contrast agents have great potential for PA imaging due to their inherent and geometrically induced optical properties. The gold-based nanoparticles that are most commonly employed for PA imaging include spheres, rods, shells, prisms, cages, stars and vesicles. This article provides an overview of the current state of research in utilizing these gold nanomaterials for PA imaging of cancer, atherosclerotic plaques, brain function and image-guided therapy. © 2015 Future Medicine Ltd.

Yang X.,Shanghai JiaoTong University
Journal of Statistical Physics | Year: 2011

We study the half space boundary layer problem for Boltzmann equation with cut-off potentials in all the cases -3 < γ ≤ 1, while the boundary condition is imposed on the incoming particles of Dirichlet type, and the solution is assumed to approach to a global Maxwellian at the far field. The same as for cut-off hard sphere model, there is an implicit solvability condition on the boundary data which gives the co-dimensions of the boundary data in terms of positive characteristic speeds. © 2011 Springer Science+Business Media, LLC.

Kuang Z.-B.,Shanghai JiaoTong University
Acta Mechanica | Year: 2013

Two fundamental theories are discussed in this paper. In the nonlinear electro-magneto-elastic analysis, different authors give different formulas. It means that the fundamental theory should still be studied. In this paper, we give a review of different theories and extend the physical variational principle to the material with electromagnetic body couple. For the temperature wave, we compare the inertial entropy theory and the Cattaneo-Vernotte's theory in detail and show that the former is more appropriate. These theories may be interesting and need further research. © 2013 Springer-Verlag Wien.

Wang C.,Shanghai JiaoTong University
BMC systems biology | Year: 2012

The C4 photosynthetic cycle supercharges photosynthesis by concentrating CO2 around ribulose-1,5-bisphosphate carboxylase and significantly reduces the oxygenation reaction. Therefore engineering C4 feature into C3 plants has been suggested as a feasible way to increase photosynthesis and yield of C3 plants, such as rice, wheat, and potato. To identify the possible transition from C3 to C4 plants, the systematic comparison of C3 and C4 metabolism is necessary. We compared C3 and C4 metabolic networks using the improved constraint-based models for Arabidopsis and maize. By graph theory, we found the C3 network exhibit more dense topology structure than C4. The simulation of enzyme knockouts demonstrated that both C3 and C4 networks are very robust, especially when optimizing CO2 fixation. Moreover, C4 plant has better robustness no matter the objective function is biomass synthesis or CO2 fixation. In addition, all the essential reactions in C3 network are also essential for C4, while there are some other reactions specifically essential for C4, which validated that the basic metabolism of C4 plant is similar to C3, but C4 is more complex. We also identified more correlated reaction sets in C4, and demonstrated C4 plants have better modularity with complex mechanism coordinates the reactions and pathways than that of C3 plants. We also found the increase of both biomass production and CO2 fixation with light intensity and CO2 concentration in C4 is faster than that in C3, which reflected more efficient use of light and CO2 in C4 plant. Finally, we explored the contribution of different C4 subtypes to biomass production by setting specific constraints. All results are consistent with the actual situation, which indicate that Flux Balance Analysis is a powerful method to study plant metabolism at systems level. We demonstrated that in contrast to C3, C4 plants have less dense topology, higher robustness, better modularity, and higher CO2 and radiation use efficiency. In addition, preliminary analysis indicated that the rate of CO2 fixation and biomass production in PCK subtype are superior to NADP-ME and NAD-ME subtypes under enough supply of water and nitrogen.

Proteins that interact in vivo tend to reside within the same or "adjacent" subcellular compartments. This observation provides opportunities to reveal protein subcellular localization in the context of the protein-protein interaction (PPI) network. However, so far, only a few efforts based on heuristic rules have been made in this regard. We systematically and quantitatively validate the hypothesis that proteins physically interacting with each other probably share at least one common subcellular localization. With the result, for the first time, four graph-based semi-supervised learning algorithms, Majority, χ2-score, GenMultiCut and FunFlow originally proposed for protein function prediction, are introduced to assign "multiplex localization" to proteins. We analyze these approaches by performing a large-scale cross validation on a Saccharomyces cerevisiae proteome compiled from BioGRID and comparing their predictions for 22 protein subcellular localizations. Furthermore, we build an ensemble classifier to associate 529 unlabeled and 137 ambiguously-annotated proteins with subcellular localizations, most of which have been verified in the previous experimental studies. Physical interaction of proteins has actually provided an essential clue for their co-localization. Compared to the local approaches, the global algorithms consistently achieve a superior performance.

Dai D.-C.,Shanghai JiaoTong University
Monthly Notices of the Royal Astronomical Society | Year: 2015

We study the orientation and density profiles of the cosmological voids with Sloan Digital Sky Survey (SDSS; Ahn et al.) 10 data. Using voids to test Alcock-Paczynski effect has been proposed and tested in both simulations and actual SDSS data. Previous observations imply that there exist an empirical stretching factor which plays an important role in the voids' orientation. Simulations indicate that this empirical stretching factor is caused by the void galaxies' peculiar velocities. Recently Hamaus et al. found that voids' density profiles are universal and their average velocities satisfy linear theory very well. In this paper, we first confirm that the stretching effect exists using independent analysis.We then apply the universal density profile to measure the cosmological parameters. We find that the void density profile can be a tool to measure the cosmological parameters. © 2015 The Authors. Published by Oxford University Press on behalf of the Royal Astronomical Society.

Chen D.,Shanghai JiaoTong University | Gyllensten U.,Uppsala University
Carcinogenesis | Year: 2014

The major histocompatibility complex class I polypeptide-related sequence A gene (MICA) encodes a membrane-bound protein acting as a ligand to stimulate an activating receptor, NKG2D, expressed on the surface of essentially all human natural killer (NK), γδ T and CD8(+) αβ T cells. MICA protein is absent from most cells but can be induced by infections and oncogenic transformation and is frequently expressed in epithelial tumors. Upon binding to MICA, NKG2D activates cytolytic responses of NK and γδ T cells against infected and tumor cells expressing MICA. Therefore, membrane-bound MICA acts as a signal during the early immune response against infection or spontaneously arising tumors. On the other hand, human tumor cells spontaneously release a soluble form of MICA, causing the downregulation of NKG2D and in turn severe impairment of the antitumor immune response of NK and CD8(+) T cells. This is considered to promote tumor immune evasion and also to compromise host resistance to infections. MICA is the most polymorphic non-classical class I gene. A possible association of MICA polymorphism with genetic predisposition to different cancer types has been investigated in candidate gene-based studies. Two genome-wide association studies have identified loci in MICA that influence susceptibility to cervical neoplasia and hepatitis C virus-induced hepatocellular carcinoma, respectively. Given the current level of interest in the field of MICA gene, we discuss the genetics and biology of the MICA gene and the role of its polymorphism in cancer. Gaps in our understanding and future research needs are also discussed. © The Author 2014. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

Ruan J.,Shanghai JiaoTong University
International journal of nanomedicine | Year: 2011

Efficient preparation and labeling of human induced pluripotent stem (iPS) cells is a great challenge in stem cell research and development. With the aim of investigating the feasibility of using nanotechnology to enhance the preparation efficiency of iPS cells and to label iPS cells for long-term tracing and imaging, in this paper, four transcription factor genes, ie, Oct4, Sox2, LIN28, and Nanog, and packaging plasmids such as PSPAX2 and PMD2.G were cotransfected into 293T cells using Generation 5.0 polyamidoamine dendrimer-modified magnetic nanoparticles (dMNPs) as a delivery system. The resultant supernatant liquids were incubated with human fibroblast cells at 37°C for 21 days, then the embryonic stem (ES) cell-like clones were screened, cultured, and identified. Finally, the prepared iPS cells were labeled with fluorescent magnetic nanoparticles (FMNPs). The results showed that dMNPs can efficiently deliver all vectors into 293T cells. The resultant lentiviruses' titers were 10-fold more than those based on Lipofectamine™ 2000. Reverse transcription polymerase chain reaction analysis showed that four genes (Oct4, Sox2, LIN28, and Nanog) exhibited different expressions in iPS cells. Immunostaining analysis showed that specific surface markers of ES cells such as SSEA-3, SSEA-4, Tra-1-60, and Tra-1-81 were positive in iPS cells, and the terotomas were formed in NOD-SCID mice that were implanted with iPS cells. Red fluorescent signals could be observed in iPS cells labeled with FMNPs by fluorescent microscopy, and the magnetic signals were detected in labeled iPS cells by magnetic resonance imaging. In conclusion, human iPS cells can be efficiently generated using polyamidoamine dMNPs and lentivirus and labeled with FMNPs for long-term observation and tracking, which has great potential application in the research and development of stem cells in the near future.

Mao Y.,Comprehensive Breast Health Center | Keller E.T.,University of Michigan | Garfield D.H.,Comprehensive Breast Health Center | Garfield D.H.,Aurora University | And 2 more authors.
Cancer and Metastasis Reviews | Year: 2013

Cancer is a systemic disease encompassing multiple components of both tumor cells themselves and host stromal cells. It is now clear that stromal cells in the tumor microenvironment play an important role in cancer development. Molecular events through which reactive stromal cells affect cancer cells can be defined so that biomarkers and therapeutic targets can be identified. Cancer-associated fibroblasts (CAFs) make up the bulk of cancer stroma and affect the tumor microenvironment such that they promote cancer initiation, angiogenesis, invasion, and metastasis. In breast cancer, CAFs not only promote tumor progression but also induce therapeutic resistance. Accordingly, targeting CAFs provides a novel way to control tumors with therapeutic resistance. This review summarizes the current understandings of tumor stroma in breast cancer with a particular emphasis on the role of CAFs and the therapeutic implications of CAFs. In addition, the effects of other stromal components such as endothelial cells, macrophages, and adipocytes in breast cancer are also discussed. Finally, we describe the biologic markers to categorize patients into a specific and confirmed subtype for personalized treatment. © 2012 Springer Science+Business Media New York.

Kuang Z.-B.,Shanghai JiaoTong University
Acta Mechanica | Year: 2014

The physical variational principle (PVP) in a static magneto-elastic field without source current is discussed first, and then, the PVP in a general electromagnetic field is derived. It is especially useful in the plate vibration problem. Using the PVP and the pseudo total stress principle, the electro-magneto-elastic thin plate bending theory in first order and a Mindlin-type plate bending theory for a moderate thickness plate are easily obtained. This method significantly simplifies the derivation of the governing equations of the thin and moderate plates with nonlinear electromagnetic behavior. The Maxwell stress is naturally included in the governing equation. Using the governing equation of a thin plate, the analyses of the stability and vibration of a plate in an external homogeneous magnetic field are discussed. © 2014 Springer-Verlag Wien.

Li Y.,China Jiliang University | Ding H.,Shanghai JiaoTong University
Tribology International | Year: 2012

This paper describes a simplified performance calculation method of aerostatic thrust bearing with multiple pocketed orifice-type restrictors. It also explains theoretically the influence of film thickness, orifice diameter, gas property, supply pressure, and structural parameters on the bearing's performance. Compared to finite element method (FEM) and computational fluid dynamics (CFD), this method is much easier. Furthermore, it simplifies the performance prediction and parameters optimization, and facilitates the application of this kind of bearing. © 2012 Elsevier Ltd. All rights reserved.

Rong Y.,Shanghai JiaoTong University
Jinshu Xuebao/Acta Metallurgica Sinica | Year: 2011

The quenching-partitioning-tempering (Q-P-T) process was developed from quenching & partitioning (Q&P) process and their difference are first described in this paper. The development of Q-P-T steels from ultrahigh strength to high strength-ductility is summarized. Novel Q-P-T process and conventional quenching-tempering (Q-T) process and their different effects on mechanical properties are compared. The micro-mechanism of the ductility enhancement from retained austenite in unltrahigh strength steels during deformation is emphasized in discussion, which provides guidance for microstructural design and control on the further development of advanced high strength steels. © Right.

Li M.,Shanghai JiaoTong University
Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery | Year: 2011

Platelet-rich plasma (PRP) can enhance the chondrocyte proliferation and repair of cartilage defects. To explore the safety and efficacy of intra-knee-articular injection of PRP to treat knee articular cartilage degeneration by comparing with injecting sodium hyaluronate (SH). Thirty consecutive patients (30 knees) with knee articular cartilage degeneration were selected between January 2010 and June 2010. According to different injections, 30 patients were randomly divided into PRP group (test group, n = 15) and SH group (control group, n = 15). There was no significant difference in gender, age, body mass index, and Kellgren-Lawrence grade between 2 groups (P > 0.05). Test group received 3.5 mL of PRP intra-knee-articular injections while control group received 2 mL of SH during the same time period. Both treatments were administered in series of 3 intra-knee-articular injections at 3-week intervals. Then, adverse reactions were recorded. International Knee Documentation Committee (IKDC) score, Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) score, and Lequesne index were used for evaluation of treatment results. The patients of 2 groups were followed up 6 months. There were significant differences in IKDC score, WOMAC score, and Lequesne index between pre- and post-injection in 2 groups (P < 0.05); no significant difference was found between different time points (3, 4, and 6 months) in test group (P > 0.05), while significant differences were found between the postoperative 6th month and the postoperative 3rd and 4th months in control group (P < 0.05). There was no significant difference in IKDC score, WOMAC score, and Lequesne index between 2 groups within 4 months (P > 0.05), but the effectiveness of test group was significantly better than that of control group at 6 months after injection (P < 0.05). Adverse reactions occurred in 12 patients (31 injections) of test group and in 12 patients (30 injections) of control group. No significant difference in onset time, termination time, and duration of adverse reactions were found between 2 groups (P > 0.05). Intra-knee-articular injection of PRP to treat knee articular cartilage degeneration is safe, which can alleviate symptoms of pain and swelling and improve the quality of life of patients; however, further data of large samples and long-term follow-up are needed to confirm the safety and effectiveness.

Liang H.-W.,Max Planck Institute for Polymer Research | Wei W.,Max Planck Institute for Polymer Research | Wu Z.-S.,Max Planck Institute for Polymer Research | Feng X.,Max Planck Institute for Polymer Research | And 2 more authors.
Journal of the American Chemical Society | Year: 2013

A family of mesoporous nonprecious metal (NPM) catalysts for oxygen reduction reaction (ORR) in acidic media, including cobalt-nitrogen-doped carbon (C-N-Co) and iron-nitrogen-doped carbon (C-N-Fe), was prepared from vitamin B12 (VB12) and the polyaniline-Fe (PANI-Fe) complex, respectively. Silica nanoparticles, ordered mesoporous silica SBA-15, and montmorillonite were used as templates for achieving mesoporous structures. The most active mesoporous catalyst was fabricated from VB12 and silica nanoparticles and exhibited a remarkable ORR activity in acidic medium (half-wave potential of 0.79 V, only ∼58 mV deviation from Pt/C), high selectivity (electron-transfer number >3.95), and excellent electrochemical stability (only 9 mV negative shift of half-wave potential after 10 000 potential cycles). The unprecedented performance of these NPM catalysts in ORR was attributed to their well-defined porous structures with a narrow mesopore size distribution, high Brunauer-Emmett-Teller surface area (up to 572 m2/g), and homogeneous distribution of abundant metal-Nx active sites. © 2013 American Chemical Society.

Li H.-P.,Shanghai JiaoTong University | Chen X.,Soochow University of China | Li M.-Q.,Fudan University
International Journal of Clinical and Experimental Pathology | Year: 2013

Metabolic impairments in maternal obesity and gestational diabetes mellitus (GDM) induce an abnormal environment in peripheral blood and cause vascular structure alterations which affect the placental development and function. A GDM model was developed using C57BL/6J female mice fed with high fat food (HF) (40% energy from fat) and a control group with control food (CF) (14% energy from fat) for 14 weeks before mating and throughout the gestation period. A subset of dams was sacrificed at gestational day (GD) 18.5 to evaluate the fetal and placental development. HF-fed dams exhibited significant increase in the maternal weight gain and homeostasis model assessment for insulin resistance index (HOMA-IR), impaired insulin secretion of glucose stimulus and glucose clearance of insulin stimulus before pregnancy; in addition, they also had the increase in the fetal and placental weight. HF-fed dams at GD 18.5 showed the high level of circulating maternal inflammation factors and were associated with increased oxidative stress and hypoxia in the labyrinth, abnormal vascular development with a high level of hypoxia inducible factor-1a (HIF-1a) and VEGF-A expression, but without a parallel increase in CD31 level; were induced an exaggerated inflammatory response in placental vascular endothelial cell. Our findings show that GDM induces more maternal weight gain and fetus weight, with abnormal maternal circulating metabolic and inflammation factors, and forms a placental hypoxia environment and impacts the placental vascular development. Our findings indicate that gestational diabetes induce excessive chronic hypoxia stress and inflammatory response in placentas which may contribute mechanisms to the high risks of perinatal complications of obesity and GDM mothers.

Meng Z.,Shanghai JiaoTong University | Lin Z.,University of Virginia | Ren W.,University of California at Riverside
Systems and Control Letters | Year: 2012

In this paper, swarm tracking problems with group dispersion and cohesion behaviors are discussed for a group of Lagrange systems. The agent group is separated into two subgroups. One is called the leader group, whose members are encapsulated with the desired generalized coordinates and generalized coordinate derivatives. The other one, referred to as the follower group, is guided by the leader group. The objective is to guarantee distributed tracking of generalized coordinate derivatives for the followers and to drive the generalized coordinates of the followers close to the convex hull formed by those of the leaders. Both the case of constant leaders' generalized coordinate derivatives and the case of time-varying leaders' generalized coordinate derivatives are considered. The proposed control algorithms are shown to achieve velocity matching, connectivity maintenance and collision avoidance. In addition, the sum of the steady-state distances between the followers and the convex hull formed by the leaders is shown to be bounded and the bound is explicitly given. Simulation results are presented to validate the effectiveness of theoretical conclusions. © 2011 Elsevier B.V. All rights reserved.

Han D.,Shanghai JiaoTong University | Li J.,China Medical University at Heping
Cell and Tissue Research | Year: 2013

A large hurdle in orthopedics today is the difficulty of dealing with the non-union of fractured bones. We therefore evaluated the effects of runt-related transcription factor II (Runx II), a factor used to create gene-modified tissue-engineered bone, combined with vascular bundle implantation for repairing segmental bone defects. Adenovirus Runx II gene (Ad-Runx II)-modified rabbit adipose-derived stem cells (ADSCs) were seeded onto polylactic acid/polycaprolacton (PLA/PCL) scaffolds to construct gene-modified tissue-engineered bone. The following four methods were used for repair in rabbit radial-defect (1.5 cm long) models: gene-modified tissue-engineered bone with vascular bundle (Group A), gene-modified tissue-engineered bone (Group B), non-gene-modified tissue-engineered bone with vascular bundle (Group C), and PLA/PCL scaffolds only (Group D). X-ray, histological examination, biomechanics analysis, and micro-angiography were conducted 4, 8, and 12 weeks later to determine angiogenesis and osteogenesis. The volume and speed of production of newly formed bones in Group A were significantly superior to those in other groups, and de-novo vascular network circulation from the vessel bundle through newly formed bone tissue was observed, with the defect being completely repaired. Group B showed a slightly better effect in terms of speed and quality of bone formation than Group C, whereas the bone defect in Group D was replaced by fibrous tissue. The maximal anti-bending strength in Group A was significantly higher than that in the other groups. Runx II gene therapy combined with vascular bundle implantation thus displays excellent abilities for osteoinduction and vascularization and is a promising method for the treatment of bone non-union and defect. © 2013 Springer-Verlag Berlin Heidelberg.

Ye Q.,Shanghai JiaoTong University | Ye Q.,CAS Shanghai Institutes for Biological Sciences | Miao Q.-L.,CAS Shanghai Institutes for Biological Sciences
Matrix Biology | Year: 2013

Perineuronal nets (PNNs) are extracellular matrix structures consisting of chondroitin sulfate proteoglycans (CSPGs), hyaluronan, link proteins and tenascin-R (Tn-R). They enwrap a subset of GABAergic inhibitory interneurons in the cerebral cortex and restrict experience-dependent cortical plasticity. While the expression profile of PNN components has been widely studied in many areas of the central nervous system of various animal species, it remains unclear how these components are expressed during the postnatal development of mouse primary visual cortex (V1). In the present study, we characterized the developmental time course of the formation of PNNs in the mouse primary visual cortex, using the specific antibodies against the two PNN component proteins aggrecan and tenascin-R, or the lectin Wisteria floribunda agglutinin (WFA) that directly binds to glycosaminoglycan chains of chondroitin sulfate proteoglycans (CSPGs). We found that the fluorescence staining signals of both the WFA staining and the antibody against aggrecan rapidly increased in cortical neurons across layers 2-6 during postnatal days (PD) 10-28 and reached a plateau around PD42, suggesting a full construction of PNNs by the end of the critical period. Co-staining with antibodies to Ca2+ binding protein parvalbumin (PV) demonstrated that the majority of PNN-surrounding cortical neurons are immunoreactive to PV. Similar expression profile of another PNN component tenascin-R was observed in the development of V1. Dark rearing of mice from birth significantly reduced the density of PNN-surrounding neurons. In addition, the expression of two recently identified CSPG receptors - Nogo receptor (NgR) and leukocyte common antigen-related phosphatase (LAR), showed significant increases from PD14 to PD70 in layer 2-6 of cortical PV-positive interneurons in normal reared mice, but decreased significantly in dark-reared ones. Taken together, these results suggest that PNNs form preferentially in cortical PV-positive interneurons in an experience-dependent manner, and reach full maturation around the end of the critical period of V1 development. © 2013 International Society of Matrix Biology.

Guan N.,National University of Defense Technology | Tao D.,Intelligent Systems Technology, Inc. | Luo Z.,National University of Defense Technology | Yuan B.,Shanghai JiaoTong University
IEEE Transactions on Image Processing | Year: 2011

Nonnegative matrix factorization (NMF) has become a popular data-representation method and has been widely used in image processing and pattern-recognition problems. This is because the learned bases can be interpreted as a natural parts-based representation of data and this interpretation is consistent with the psychological intuition of combining parts to form a whole. For practical classification tasks, however, NMF ignores both the local geometry of data and the discriminative information of different classes. In addition, existing research results show that the learned basis is unnecessarily parts-based because there is neither explicit nor implicit constraint to ensure the representation parts-based. In this paper, we introduce the manifold regularization and the margin maximization to NMF and obtain the manifold regularized discriminative NMF (MD-NMF) to overcome the aforementioned problems. The multiplicative update rule (MUR) can be applied to optimizing MD-NMF, but it converges slowly. In this paper, we propose a fast gradient descent (FGD) to optimize MD-NMF. FGD contains a Newton method that searches the optimal step length, and thus, FGD converges much faster than MUR. In addition, FGD includes MUR as a special case and can be applied to optimizing NMF and its variants. For a problem with 165 samples in R1600 , FGD converges in 28 s, while MUR requires 282 s. We also apply FGD in a variant of MD-NMF and experimental results confirm its efficiency. Experimental results on several face image datasets suggest the effectiveness of MD-NMF. © 2011 IEEE.

Ma R.C.W.,Hong Kong Institute of Diabetes and Obesity | Ma R.C.W.,Chinese University of Hong Kong | Lin X.,CAS Shanghai Institutes for Biological Sciences | Jia W.,Shanghai JiaoTong University
The Lancet Global Health | Year: 2014

The prevalence of diabetes in China has increased substantially over recent decades, with more than 100 million people estimated to be affected by the disease presently. During this period there has been an increase in the rates of obesity and a reduction in physical activity. Many of the changes in lifestyle and diet are a result of increased economic development and urbanisation. In addition to an increasingly westernised diet, the traditional Chinese diet also plays a part, with the quantity and quality of rice intake linked to the risk of type 2 diabetes. Familial factors including inherited genetic variants are important, although differences in the genetic architecture suggest a different combination of genetic variants could be most relevant in Chinese when compared with Europeans. Recent advances have also emphasised the role of early life factors in the epidemic of diabetes and non-communicable diseases: maternal undernutrition, maternal obesity, and gestational diabetes are all linked to increased risk of diabetes in offspring. A mismatch between developmentally programmed biology and the modern environment is relevant for countries like China where there has been rapid economic transformation. Multisectoral efforts to address the risks will be needed at different stages throughout the lifecourse to reduce the burden of diabetes. © 2014 Elsevier Ltd.

Thiopeptide antibiotics are an important class of natural products resulting from posttranslational modifications of ribosomally synthesized peptides. Cyclothiazomycin is a typical thiopeptide antibiotic that has a unique bridged macrocyclic structure derived from an 18-amino-acid structural peptide. Here we reported cloning, sequencing, and heterologous expression of the cyclothiazomycin biosynthetic gene cluster from Streptomyces hygroscopicus 10-22. Remarkably, successful heterologous expression of a 22.7-kb gene cluster in Streptomyces lividans 1326 suggested that there is a minimum set of 15 open reading frames that includes all of the functional genes required for cyclothiazomycin production. Six genes of these genes, cltBCDEFG flanking the structural gene cltA, were predicted to encode the enzymes required for the main framework of cyclothiazomycin, and two enzymes encoded by a putative operon, cltMN, were hypothesized to participate in the tailoring step to generate the tertiary thioether, leading to the final cyclization of the bridged macrocyclic structure. This rigorous bioinformatics analysis based on heterologous expression of cyclothiazomycin resulted in an ideal biosynthetic model for us to understand the biosynthesis of thiopeptides.

Niu W.,Shanghai JiaoTong University | Qi Y.,Capital Medical University
Circulation: Cardiovascular Genetics | Year: 2015

Background - The cholesteryl ester transfer protein (CETP) plays a central role in reverse cholesterol transport. Currently, it remains unresolved whether circulating CETP is causally associated with coronary heart disease (CHD). We aimed to investigate this causal association using CETP gene rs708272 polymorphism as an instrument in a Mendelian randomization meta-analysis. Methods and Results - We searched PubMed and EMBASE before May 2014. Data and study quality were assessed in duplicate. Thirty-four articles (17 813 CHD patients and 22 203 controls) were qualified. Overall analyses revealed a significant association of rs708272-B1 allele with a reduced CHD risk compared with B2 allele under allelic (odds ratio and 95% confidence interval: 0.87 and 0.82-0.92; P<0.001), homozygous genotypic (0.74 and 0.66-0.83; P<0.001), and dominant (0.87 and 0.80-0.94; P<0.001) models. Carriers of rs708272-B1B1 genotype (weighted mean difference and 95% confidence interval: -0.21 and -0.41 to 0.00 μg/dL; P=0.052) or B1 allele (-0.15 and -0.30 to 0.00 μg/dL; P=0.056) had a marginally lower circulating CETP level compared with B2B2 genotype carriers. In Mendelian randomization analysis, there was a 25% (odds ratio and 95% confidence interval: 0.75 and 0.19-0.91) and a 17% (0.83 and 0.41-0.96) significantly reduced risk of CHD by a reduction of 0.2 μg/mL in circulating CETP for the comparison of B1B1 genotype and B1 allele with B2B2 genotype, respectively. There were low probabilities of publication bias. Conclusions - Our findings demonstrate that the long-term genetically reduced circulating CETP might be causally associated with the low risk of CHD. © 2015 American Heart Association, Inc.

Zhang X.,Shanghai JiaoTong University
Communications in Mathematical Physics | Year: 2011

In this paper we mainly study the global structure of the quaternion Bernoulli equations q = aq + bqn for q ∈ H, the quaternion field and also some other form of cubic quaternion differential equations. By using the Liouvillian theorem of integrability and the topological characterization of 2-dimensional torus: orientable compact connected surface of genus one, we prove that the quaternion Bernoulli equations may have invariant tori, which possesses a full Lebesgue measure subset of H. Moreover, if n = 2 all the invariant tori are full of periodic orbits; if n = 3 there are infinitely many invariant tori fulfilling periodic orbits and also infinitely many invariant ones fulfilling dense orbits. © 2011 Springer-Verlag.

Shen H.-S.,Shanghai JiaoTong University
Journal of Theoretical Biology | Year: 2010

This paper presents an investigation on the buckling and postbuckling of microtubules (MTs) subjected to a uniform external radial pressure in thermal environments. The microtubule is modeled as a nonlocal shear deformable cylindrical shell which contains small scale effects. The governing equations are based on higher order shear deformation shell theory with a von Kármán-Donnell-type of kinematic nonlinearity and include the extension-twist and flexural-twist couplings. The thermal effects are also included and the material properties are assumed to be temperature-dependent. A singular perturbation technique is employed to determine the buckling pressure and postbuckling equilibrium paths. The small scale parameter e0a is estimated by matching the buckling pressure of MTs measured from the experiments with the numerical results obtained from the nonlocal shear deformable shell model. The numerical results show that buckling pressure and postbuckling behavior of MTs are very sensitive to the small scale parameter e0a. The results reveal that the 13_3 microtubule has a stable postbuckling path, whereas the 13_2 microtubule has an unstable postbuckling behavior due to the presence of skew angles. © 2010 Elsevier Ltd.

Wang X.-Z.,Shanghai JiaoTong University
Physica A: Statistical Mechanics and its Applications | Year: 2011

In 1975, Curzon and Ahlborn [2] showed that the efficiency of the finite-time Carnot cycle at maximum power is universal. This raises the issue of universality of the efficiency at maximum power. In 2005, Van den Broeck [3] demonstrated that in the linear regime, the efficiency of a steady-state heat engine at maximum power is universal. Further studies indicated that the values of the linear and quadratic coefficients of the efficiency at maximum power are universal for several strong coupling steady-state models and for an overdamped Brownian particle in a time-dependent harmonic potential [M. Esposito, K. Lindenberg, C. Van den Broeck, Phys. Rev. Lett. 102 (2009) 130602]. In this paper, we demonstrate that in the linear regime, the efficiency of an unsteady-state heat engine at maximum instantaneous power is universal. © 2011 Elsevier B.V. All rights reserved.

Liu X.,Duke University | He Y.,Chongqing Medical University | Li F.,Duke University | Huang Q.,Shanghai JiaoTong University | And 3 more authors.
Molecular Cell | Year: 2015

Apoptosis is typically considered an anti-oncogenic process since caspase activation can promote the elimination of genetically unstable or damaged cells. We report that a central effector of apoptosis, caspase-3, facilitates rather than suppresses chemical- and radiation-induced genetic instability and carcinogenesis. We found that a significant fraction of mammalian cells treated with ionizing radiation can survive despite caspase-3 activation. Moreover, this sublethal activation of caspase-3 promoted persistent DNA damage and oncogenic transformation. In addition, chemically induced skin carcinogenesis was significantly reduced in mice genetically deficient in caspase-3. Furthermore, attenuation ofEndoG activity significantly reduced radiation-induced DNA damage and oncogenic transformation, identifying EndoG as a downstream effector of caspase-3 in this pathway. Our findings suggest that rather than acting as a broad inhibitor of carcinogenesis, caspase-3 activation may contribute to genome instability and play a pivotal role in tumor formation following damage. © 2015 Elsevier Inc.

Zhu Z.,Shanghai JiaoTong University
Oncogene | Year: 2015

Dysregulation of lipid metabolism is common in breast cancer. However, the underlying mechanisms remain elusive and the contribution of aberrant lipid metabolism to the malignant phenotypes of breast cancer is poorly understood. Here, we show that the nuclear protein p54nrb/Nono is highly expressed in breast cancer tissues as compared with the adjacent normal tissues in human patients. To determine the functions of p54nrb in breast cancer, we performed a biochemical screen and identified SREBP-1a, a master activator for genes involved in lipid biosynthesis, as a novel interacting protein of p54nrb. In human breast cancer tissues, the levels of p54nrb and SREBP-1a proteins were positively correlated with each other. Our biochemical analyses showed that the conserved Y267 residue of p54nrb was required for its binding to the nuclear form of SREBP-1a. Interestingly, p54nrb binding to nuclear SREBP-1a caused an increase of nuclear SREBP-1a protein stability. As a result, p54nrb stimulates SREBP-1-meidated transcription of lipogenic genes and lipid production in breast cancer cells. Moreover, both p54nrb and SREBP-1a were required for breast cancer cell growth in vitro, and p54nrb binding to nuclear SREBP-1a was also critical for breast tumor development in vivo. Together, we conclude that p54nrb is a novel regulator of SREBP-1a in the nucleus, and our data suggest that p54nrb regulation of SREBP-1a supports the increased cellular demand of lipids for breast cancer growth. Thus, the SREBP pathway may represent a novel target for treating breast cancer.Oncogene advance online publication, 6 July 2015; doi:10.1038/onc.2015.197. © 2015 Macmillan Publishers Limited

Digital speckle pattern interferometry (DSPI) fringes contain low spatial information degraded with speckle noise and background intensity. The denoising technique proposed recently based on bi-dimensional empirical mode decomposition (BEMD) could implement noise reduction adaptively. However, the major drawback of BEMD, called mode mixing, has affected its practical application. With noise-assisted data analysis (NADA) method, bi-dimensional ensemble empirical mode decomposition (BEEMD) was proposed, which has solved the problem of mode mixing. The denoising approach based on BEEMD will be presented, compared with other classic denoising methods and evaluated both qualitatively and quantitatively using computer-simulated and experimental DSPI fringes. © 2011 Optical Society of America.

He X.-G.,Shanghai JiaoTong University | He X.-G.,National Taiwan University | Tandean J.,National Central University
Physical Review D - Particles, Fields, Gravitation and Cosmology | Year: 2011

Recent LHC searches have not found a clear signal of the Higgs boson h of the standard model (SM) with three or four families in the mass range m h=120-600GeV. If the Higgs had an unexpectedly large invisible branching ratio, the excluded mh regions would shrink. This can be realized in the simplest weakly interacting massive particle dark matter (DM) model, which is the SM plus a real gauge-singlet scalar field D as the DM, via the invisible mode h→DD. Current data allow this decay to occur for D-mass values near, but below, mh/2 and those compatible with the light DM hypothesis. For such D masses, h→DD can dominate the Higgs width depending on mh, and thus sizable portions of the mh exclusion zones in the SM with three or four families may be recovered. Increased luminosity at the LHC may even reveal a Higgs having SM-like visible decays still hiding in the presently disallowed regions. The model also accommodates well the new possible DM hints from CRESST-II and will be further tested by improved data from future DM direct searches. © 2011 American Physical Society.

Wang Z.-P.,University of Hong Kong | Wang Z.-P.,Shanghai JiaoTong University | Zhang T.,University of Hong Kong
Water Research | Year: 2010

Soluble microbial products (SMP) in the wastewater treatment process not only cause fouling to the membrane, but also generate disinfection by-products (DBP) in the effluent, thus get increasing attention. In this study, SMP produced by activated sludge and isolates under different stressful conditions, i.e. starvation, salinity, heavy metals, low pH and high temperature, were characterized to investigate the effects of these conditions on the amount of SMP and their compositions. The analysis results using size exclusion chromatography (SEC), high pressure liquid chromatography (HPLC) and fluorescence excitation emission matrix (FEEM) showed that activated sludge and isolates suffered with the same stressful condition contained almost the same concentration and composition of SMP, indicating that the stressful condition instead of the microbial species played the crucial role in the production of SMP. Among of stressful conditions tested, high temperature had stimulated the production of polysaccharides and polycarboxylate-type humic acid with high hydrophilicity, which is in positive proportion to the foulants formation potential, thus should be avoided in membrane bioreactors. Low pH had promoted the generation of hydrophobic humic acid-like or protein-like organics, which had been proved as the main disinfection byproduct (DBP) precursor, thus should be avoided in the biological treatment. Starvation had less effect on SMP production as the seeding microbes had no substrates. © 2010 Elsevier Ltd.

He X.-G.,Shanghai JiaoTong University | He X.-G.,National Taiwan University | Zee A.,University of California at Santa Barbara
Physical Review D - Particles, Fields, Gravitation and Cosmology | Year: 2011

We explore some ways of minimally modifying the neutrino mixing matrix from tribimaximal, characterized by introducing at most one mixing angle and a CP violating phase thus extending our earlier work. One minimal modification, motivated to some extent by group theoretic considerations, is a simple case with the elements Vα2 of the second column in the mixing matrix equal to 1/√3. Modifications by keeping one of the columns or one of the rows unchanged from tribimaximal mixing all belong to the class of minimal modification. Some of the cases have interesting experimentally testable consequences. In particular, the T2K and MINOS collaborations have recently reported indications of a nonzero θ13. For the cases we consider, the new data sharply constrain the CP violating phase angle δ, with δ close to 0 (in some cases) and π disfavored. © 2011 American Physical Society.

Zhong N.,Shanghai JiaoTong University
PloS one | Year: 2013

Cognitive impairment in patients with schizophrenia is a core symptom of this disease. The computerized CogState Battery (CSB) has been used to detect seven of the most common cognitive domains in schizophrenia. The aim of this study was to examine the reliability and validity of the Chinese version of the CSB (CSB-C), in Chinese patients with schizophrenia. Sixty Chinese patients with schizophrenia and 58 age, sex, and education matched healthy controls were enrolled. All subjects completed the CSB-C and the Repeated Battery for the Assessment of Neuropsychological Status (RBANS). To examine the test-retest reliability of CSB-C, we tested 33 healthy controls twice, at a one month interval. The Cronbach α value of CSB-C in patients was 0.81. The test-retest correlation coefficients of the Two Back Task, Gronton Maze Learning Task, Social Emotional Cognition Task, and Continuous Paired Association Learning Task were between 0.39 and 0.62 (p<0.01) in healthy controls. The composite scores and all subscores for the CSB-C in patients were significantly (p<0.01) lower than those of healthy controls. Furthermore, composite scores for patients on the RBANS were also significantly lower than those of healthy controls. Interestingly, there was a positive correlation (r = 0.544, p<0.001) between the composite scores on CSB-C and RBANS for patients. Additionally, in the attention and memory cognitive domains, corresponding subsets from the two batteries correlated significantly (p<0.05). Moreover, factor analysis showed a two-factor model, consisting of speed, memory and reasoning. The CSB-C shows good reliability and validity in measuring the broad cognitive domains of schizophrenia in affected Chinese patients. Therefore, the CSB-C can be used as a cognitive battery, to assess the therapeutic effects of potential cognitive-enhancing agents in this cohort.

Qi Z.,Shanghai JiaoTong University
Renewable and Sustainable Energy Reviews | Year: 2013

This paper presents the recent advances in water retention and drainage performance on air side of heat exchangers under wet and dehumidifying conditions. The experimental and numerical research results are addressed. The water retention and drainage characteristics of the widely-used heat exchangers (fin-and-tube type and flat-tube type), the effects of heat exchanger surface materials, long term dry/wet cycles and liquid droplet shape on performance are highlighted. The current research results on modeling of water retention and drainage on heat exchangers are summarized. © 2013 Elsevier Ltd.

Shao X.-F.,Shanghai JiaoTong University
International Journal of Logistics Research and Applications | Year: 2013

This research investigates the impact of supply chain characteristic factors on disruption mitigation capabilities. We intend to derive specific supply chain factors that either contribute to or conversely impact a firm's supply chain disruption mitigation capabilities. We find that supply chain geographic dispersion has a negative impact on a firm's disruption mitigation capabilities. Supply chain agility has a positive impact on a firm's disruption recovery capability. Supply chain integration has direct positive impacts on a company's disruption warning capability and recovery capability. And supply chain visibility enhances a company's disruption warning capability. In addition, high level of disruption warning capability enhances a company's disruption recovery capability. The results offer guidelines for supply chain managers to enhance disruption mitigation capabilities through understanding the role of supply chain characteristic factors. © 2013 Copyright Taylor and Francis Group, LLC.

Qi Z.,Shanghai JiaoTong University
Applied Thermal Engineering | Year: 2013

The widely used evaporators with two different type were experimentally studied in psychrometric calorimeter room using HFO-1234yf as working fluids. The evaporators types are laminated plate and microchannel parallel flow (PF) type. The experimental results compared with R134a system show that cooling capacity has different features in laminated plate evaporator and microchannel PF evaporator under different refrigerant pressure at expansion valve inlet. In general, cooling capacity of laminated plate evaporator of HFO-1234yf is reduced up to 8.0%. But in microchannel PF evaporator, cooling capacity is comparable and/or larger than that of R134a up to 6.5%. The HFO-1234yf evaporator air off temperature deviation is larger than that of R134a evaporator. The air side pressure drop is very close for both evaporators and refrigerants. HFO-1234yf refrigerant side pressure drop is larger than that of R134a for both evaporators. © © 2013 Elsevier Ltd. All rights reserved.

He J.,Shanghai JiaoTong University
Journal of Structural Engineering (United States) | Year: 2012

A numerical method for estimating the useful spectral characteristics of responses of classically damped linear elastic structures to the Yeh-Wen model of fully nonstationary random earthquake loads is developed. The derivation of the method is carried out in three steps. First, the stationary Gaussian white noise process in the space of a frequency modulation function is transformed to the uniformly modulated Gaussian white noise process in the time space. Second, the numerical computation procedure for the unit impulse response functions in the time domain of the Clough-Penzien filters modified in the space of a frequency modulation function is proposed. Finally, the numerical solutions for the useful spectral characteristics of responses of linear structures to the Yeh-Wen model are given, from which the first-passage reliability problem can be solved by using Vanmarcke's approximation. Numerical investigation of a simple oscillator shows the effect of the frequency modulation functions on the numerical results and computational efficiency of the developed method. The numerical analysis of the spectral characteristics and first-passage probabilities of a response of a supertall television tower demonstrates how to implement the numerical method in practical applications. © 2012 American Society of Civil Engineers.

Xia M.,Tsinghua University | Xu Z.,PLA University of Science and Technology | Liao H.,Shanghai JiaoTong University
IEEE Transactions on Fuzzy Systems | Year: 2013

Preference relations are powerful techniques to express the preferences over alternatives (or criteria) and mainly fall into two categories: fuzzy preference relations (also called reciprocal preference relations) and multiplicative preference relations. For a pair of alternatives, a fuzzy preference relation only gives the degree that an alternative is prior to another; thus, the intuitionistic fuzzy preference relation is introduced by adding the degree that an alternative is not prior to another, which can describe the preferences over two alternatives more comprehensively. However, the intuitionistic fuzzy preference uses the symmetrical scale to express the decision makers' preference relations, which are inconsistent with our intuition in some situations. If we use the unsymmetrical scale to express the preferences about two alternatives instead of the symmetrical scale in intuitionistic fuzzy preference relation, then a new concept is introduced, which we call the intuitionistic multiplicative preference relation reflecting our intuition more objectively. In this paper, we study the aggregation of intuitionistic multiplicative preference information, propose some aggregation techniques, investigate their properties, and apply them to decision making based on intuitionistic multiplicative preference relations. © 2012 IEEE.

Tian Y.,University of Warwick | Zhao C.Y.,Shanghai JiaoTong University
Applied Energy | Year: 2013

Thermal applications are drawing increasing attention in the solar energy research field, due to their high performance in energy storage density and energy conversion efficiency. In these applications, solar collectors and thermal energy storage systems are the two core components. This paper focuses on the latest developments and advances in solar thermal applications, providing a review of solar collectors and thermal energy storage systems. Various types of solar collectors are reviewed and discussed, including both non-concentrating collectors (low temperature applications) and concentrating collectors (high temperature applications). These are studied in terms of optical optimisation, heat loss reduction, heat recuperation enhancement and different sun-tracking mechanisms. Various types of thermal energy storage systems are also reviewed and discussed, including sensible heat storage, latent heat storage, chemical storage and cascaded storage. They are studied in terms of design criteria, material selection and different heat transfer enhancement technologies. Last but not least, existing and future solar power stations are overviewed. © 2012 Elsevier Ltd.

BACKGROUND:: Activin receptor-like kinase 4 (ALK4), a downstream receptor of transforming growth factor-β superfamily, is highly expressed in the mammal heart. Upregulated ALK4 expression and activated ALK4–small mother against decapentaplegic (Smad)2/3 signaling have been reported to play a pivotal role in tumorigenesis and in the development of systemic sclerosis. However, the role of ALK4–Smad2/3 pathway in the pathogenesis of cardiac hypertrophy and cardiac fibrosis remains unknown. METHODS AND RESULTS:: In this study, the mice with heterozygous knocking out of ALK4 gene (ALK4) were generated and subjected to aortic banding for 4 weeks. We found that ALK4 expression was upregulated in aortic banding-induced model of cardiac hypertrophy and cardiac fibrosis in wild-type mice. Compared with the wild-type mice, ALK4mice demonstrated a similar extent of aortic banding-induced cardiac hypertrophy, but a significant suppression of cardiac fibrosis to 64.8% of the basal level, and a subsequent amelioration in the cardiac dysfunction (left ventricle ejection fraction: 59.0?±?6.4 in wild-type mice vs. 75.6?±?3.9% in ALK4 mice; left ventricle end-diastolic pressure: 16.6?±?4.7?mmHg in wild-type mice vs. 6.6?±?2.8?mmHg in ALK4 mice) associated with inhibition of cardiac fibroblast activation and cardiomyocyte apoptosis. In vitro, ALK4 haploinsufficiency blocked the cellular proliferation/differentiation and collagen production in cultured cardiac fibroblasts after angiotensin-II stimulation. Mechanistically, ALK4 haploinsufficiency resulted in the suppression of Smad2/3 activity. CONCLUSION:: Our results demonstrate that ALK4 haploinsufficiency ameliorates cardiac fibrosis and dysfunction in a mouse pressure-overload model associated with inhibition of cardiac fibroblast activation and cardiomyocyte apoptosis through the suppression of Smad2/3 activity, and suggest that ALK4 is a novel therapeutic target in treating pressure overload-induced cardiac remodeling and heart failure. Copyright © 2016 Wolters Kluwer Health, Inc. All rights reserved.

Wang M.M.,Shanghai JiaoTong University
Digestive diseases and sciences | Year: 2014

The interaction between hepatitis B virus (HBV) infection and hepatic steatosis remains unclear. We aimed to explore the trend of prevalence of hepatic steatosis and its relationship with virological factors in HBV infected patients. Consecutive untreated patients with chronic HBV infection at Shunde Hospital between 2002 and 2011 were included. Quantification of HBV replication markers was performed by enzyme immunoassay, real-time polymerase chain reaction assay and immunohistochemical staining. Hepatic steatosis was defined as at least 5% hepatocytes affected. A total of 3,212 patients (2,574 men) with a mean age of 32 ± 9.3 years were analyzed. Serological testing showed detectable HBsAg in all, HBeAg in 63.8% and HBV DNA in 78.4% of patients. Liver biopsies demonstrated HBsAg- and HBcAg-positive immunostaining in 96.6 and 71% patients, respectively. Hepatic steatosis was present in 554 (17.3%) patients, with annual prevalence increased over time from 8.2 to 31.8% (trend analysis, x (2) = 51.657, P < 0.001). Compared to patients without steatosis, the percentages of serum HBeAg-positive and detectable HBV DNA, and intrahepatic HBsAg- and HBcAg-positive staining were decreased in steatosis patients (all P < 0.001). Adjusted for age and gender, intrahepatic HBsAg-positive staining remained as an independent factor associated with lower risk of steatosis (adjusted odds ratio 0.90, 95% confidence interval 0.835, 0.971) in multivariate analysis. Hepatic steatosis in HBV infected patients has been raging over the past decade, and it is negatively associated with intrahepatic expression of HBsAg. Lifestyle intervention may be needed to halt the onset of steatosis in chronic HBV infection.

Wu Z.-S.,Max Planck Institute for Polymer Research | Sun Y.,Max Planck Institute for Polymer Research | Tan Y.-Z.,Max Planck Institute for Polymer Research | Yang S.,Max Planck Institute for Polymer Research | And 3 more authors.
Journal of the American Chemical Society | Year: 2012

Three-dimensional graphene-based frameworks (3D-GFs) with hierarchical macro- and meso-porous structures are presented. The interconnected macropores are derived from hydrothermally assembled 3D graphene aerogels (GAs), while the mesopores are generated by the silica networks uniformly grown on the surface of graphene. The resulting 3D-GFs exhibit narrow mesopore size distribution (2-3.5 nm), high surface area, and low mass density. These intriguing features render 3D-GFs a promising template for creating various 3D porous materials. Specifically, 3D GA-based mesoporous carbons (GA-MC) and metal oxide hybrids (GA-Co3O4, GA-RuO2) can be successfully constructed via a nanocasting technology. Benefiting from the integration of meso- and macroporous structures, 3D GA-MC manifests outstanding specific capacitance (226 F g-1), high rate capability, and excellent cycling stability (no capacitance loss after 5000 cycles) when it is applied in electrochemical capacitors. © 2012 American Chemical Society.

Shi G.,Shanghai JiaoTong University
Analog Integrated Circuits and Signal Processing | Year: 2013

Applying symbolic techniques for analog circuit analysis is a traditional research subject, which has lasted for over half a century. The past decade has witnessed a significant advancement of the symbolic techniques developed specifically for large analog integrated circuits. The key methodology introduced is a data structure called binary decision diagram (BDD) which was established originally for logic design and verification. The application of the BDD technique for analog circuit analysis has the following features: (1) It is a compact data structure so that data redundancy in symbolic analysis can be eliminated. (2) It provides a mechanism for implicit enumeration method so that exhaustive enumeration commonly performed in symbolic analysis can be avoided. (3) Numerical evaluation on a BDD can be made extremely efficient, making it an excellent means for repetitive analysis. More advanced features are yet to be explored. This survey brings together the significant research results published in the past decade and provides a tutorial overview on the basic principles of applying BDD to analog circuit analysis. Some new directions that are potentially valuable for developing future analog design automation tools are discussed and a design example is given to illustrate the application of symbolic techniques. © Springer Science+Business Media, LLC 2012.

Paired box gene 4 (PAX4) is a transcriptional modulator located on chromosome 7q32, and its expression is dysregulated in a variety of human cancers, suggesting that PAX4 may be important in multiple tumors as a driver gene. Here, we show that PAX4 promoted migration and invasion in human epithelial cancers by decreasing miR-144 and miR-451 (miR-144/451) expression levels. Accordingly, miR-144/451 suppressed the migratory and invasive phenotypes, even in PAX4-expressing cells. Mechanistically, miR-144/451 inhibits cancer metastasis by targeting the A disintegrin and metalloproteinase (ADAM) protein family members ADAMTS5 and ADAM10. Their dysregulation is associated with increased tumor invasiveness and metastasis, then reduced patient prognosis in certain epithelial cancers. This discovery suggests that a PAX4-miR-144/451-ADAMs axis regulates human epithelial cancer metastasis, thus opening up therapeutic possibilities and predicting prognosis for those cancer types.Oncogene advance online publication, 25 August 2014; doi:10.1038/onc.2014.259.

Wu Z.-S.,Max Planck Institute for Polymer Research | Yang S.,Max Planck Institute for Polymer Research | Sun Y.,Max Planck Institute for Polymer Research | Parvez K.,Max Planck Institute for Polymer Research | And 3 more authors.
Journal of the American Chemical Society | Year: 2012

Three-dimensional (3D) N-doped graphene aerogel (N-GA)-supported Fe 3O 4 nanoparticles (Fe 3O 4/N-GAs) as efficient cathode catalysts for the oxygen reduction reaction (ORR) are reported. The graphene hybrids exhibit an interconnected macroporous framework of graphene sheets with uniform dispersion of Fe 3O 4 nanoparticles (NPs). In studying the effects of the carbon support on the Fe 3O 4 NPs for the ORR, we found that Fe 3O 4/N-GAs show a more positive onset potential, higher cathodic density, lower H 2O 2 yield, and higher electron transfer number for the ORR in alkaline media than Fe 3O 4 NPs supported on N-doped carbon black or N-doped graphene sheets, highlighting the importance of the 3D macropores and high specific surface area of the GA support for improving the ORR performance. Furthermore, Fe 3O 4/N-GAs show better durability than the commercial Pt/C catalyst. © 2012 American Chemical Society.

Yang Q.,Shanghai JiaoTong University
Cell Death and Differentiation | Year: 2016

Multiple sclerosis (MS) is a chronic and debilitating autoimmune disease, characterized by chronic inflammatory demyelination in the nervous tissue and subsequent neurological dysfunction. Spermidine, a natural polyamine, has been shown to affect inflammation in some experimental models. We show here that spermidine could alleviate experimental autoimmune encephalomyelitis (EAE), a model for MS, through regulating the infiltration of CD4+ T cells and macrophages in central nervous system. Unexpectedly, we found that spermidine treatment of MOG-specific T cells did not affect their pathogenic potency upon adaptive transfer; however, spermidine diminished the ability of macrophages in activating MOG-specific T cells ex vivo. Depletion of macrophages in diseased mice completely abolished the therapeutic effect of spermidine, indicating a critical role of spermidine-activated macrophages. Mechanistically, spermidine was found to specifically suppress the expression of interleukin-1beta (IL-1β), IL-12 and CD80 while enhance the expression of arginase 1 in macrophages. Interestingly, macrophages from spermidine-treated mice could also reverse EAE progression, while pretreatment of those macrophages with the arginase 1 inhibitor abrogated the therapeutic effect. Therefore, our studies revealed a critical role of macrophages in spermidine-mediated treatment on EAE and provided novel information for better management of MS.Cell Death and Differentiation advance online publication, 22 July 2016; doi:10.1038/cdd.2016.71. © 2016 The Author(s)

Pan Q.,Hunan Normal University | Jing J.,Hunan Normal University | Wang B.,Shanghai JiaoTong University
Physical Review D - Particles, Fields, Gravitation and Cosmology | Year: 2011

We study the effect of the quadratic field strength correction to the usual Maxwell field on the holographic dual models in the backgrounds of AdS black hole and AdS soliton. We find that in the black hole background, the higher correction to the Maxwell field makes the condensation harder to form and changes the expected relation in the gap frequency. This effect is similar to that caused by the curvature correction. However, in the soliton background we find that, unlike the curvature effect correction, the correction to the Maxwell field does not influence the holographic superconductor and insulator phase transition. © 2011 American Physical Society.

Cai C.,Shanghai JiaoTong University
Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery | Year: 2013

To examine the association between CD133 expression and invasion of gastric cancer, and to elucidate whether CD133 can promote the invasion and metastasis of gastric cancer via epithelial-mesenchymal transition (EMT). The CD133(+) and CD133(-) KATO-III( cells were sorted by magnetic activated cell sorting (MACS). The invasion ability was detected by Transwell method. RT-PCR and Western blot were used to detect the expression of EMT-related factors in KATO-III( cells before and after CD133 was knocked out by siRNA method. The expressions of CD133 and EMT-related proteins of cancer and adjacent normal tissues in 50 patients with gastric cancer were detected by Western blot, and correlations among protein expressions were also analyzed. As compared to CD133(-) cells, the number of broken-membrane cells was significantly higher (67.7±10.5 vs. 13.3±6.8, P=0.001) and the invasion ability was stronger (P<0.05) in CD133(+) cells, while the mRNA expression levels of Snail and N-cadherin were significantly higher in CD133(+) cells (0.311±0.015 vs. 0.223±0.016, P=0.040; 0.581±0.020 vs. 0.270±0.018,P=0.004), and the protein expression levels of Snail and N-cadherin were significantly higher in CD133(+) cells as well (0.513±0.015 vs. 0.179±0.023, P=0.030; 0.538±0.028 vs. 0.202±0.032, P=0.020), but E-cadherin mRNA and protein levels were significantly lower in CD133(+) cells (0.231±0.009 vs. 0.460±0.015, P=0.040; 0.426±0.030 vs. 0.748±0.027, P=0.040). After CD133 knock-out, the expressions of Snail and N-cadherin were down-regulated (P<0.05) and the expression of E-cadherin was up-regulated (P<0.05). As compared to normal mucosal tissues, the protein expression levels of Snail, N-cadherin and CD133 in gastric cancer tissues were significantly higher(0.635±0.119 vs. 0.485±0.116, P=0.029; 0.599±0.114 vs. 0.259±0.108, P=0.020; 0.754±0.154 vs. 0.329±0.134, P=0.001), while the protein expression of E-cadherin in gastric cancer tissues was lower (0.378±0.123 vs. 0.752±0.156, P=0.003). The protein expressions of Snail and N-cadherin were positively correlated with CD133 expression (r=0.278, P=0.048; r=0.406, P=0.003) and the protein expression of E-cadherin was negatively correlated with CD133 expression (r=-0.504, P=0.000). CD133(+) cells in primary lesion of gastric cancer have relatively higher invasion ability, which may promote the metastasis of gastric cancer via up-regulation of EMT-related factors.

Wang K.,Shanghai JiaoTong University | Crow M.L.,Missouri University of Science and Technology
IEEE Transactions on Power Systems | Year: 2013

This paper presents an analysis of the evolution of the probability density function of the dynamic trajectories of a single machine infinite bus power system. The probability density function can be used to determine the impact of random (stochastic) load perturbations on system stability. The evolution of the state probability density function over time leads to several interesting observations regarding stability regions as a function of damping parameter. The Fokker-Planck equation (FPE) is used to describe the evolution of the probability density of the states. The FPE is solved numerically using PDE solvers (such as finite difference method). Based on the results, the qualitative changes of the stationary density produce peak-like, ridge-like and other complicated shapes. Lastly, the numerical FPE solution combined with SMIB equivalent techniques lay the framework extended to the multimachine system. © 1969-2012 IEEE.

Yu Y.X.,Shanghai JiaoTong University
Zhongguo gu shang = China journal of orthopaedics and traumatology | Year: 2012

To investigate the failure of internal fixation on displaced femoral neck fractures in adults under fifty-five years old retrospectively inorder to pay more attention to the treatment of these fractures. From Junary 2007 to June 2010,18 failed cases of internal fixation on displaced femoral neck fractures in adults under fifty-five years old were treated,there were 13 males and 5 females with an average age of (48.0 +/- 6.0) years old ranging from 27 to 55. Among them, 17 patients were treated with cannulated screws and 1 patient was treated with intramedullary nail; 16 patients were diagnosed as osteonecrosis and 2 patients as osteonecrosis associated with nonunion. The average time from internal fixation to failure was 23 months (ranged, 8 to 32 months). The quality of fracture reduction in Garden index was poor. The Harris Hip Score was (56.0 +/- 12.5) (ranged,33 to 80). Eight cases of osteonecrosis and 2 cases of nonunion combinated osteonecrosis were received total hip arthroplasty. Hip resurfacing arthroplasty were performed for other 5 osteonecrosis. Because of no evident clinical symptoms,the other 3 cases received conservative treatment. The patients with total hip arthroplasty and hip resurfacing arthroplasty were followed-up for 34 months ranging from 12 to 53 months. After operation,the Harris score was (94.0 +/- 3.0) ranged 89 to 96. Osteonecrosis is a common complication after internal fixation on displaced femoral neck fracture in adults under fifty-five years old. More attention should be paid to the treatment of displaced femoral neck fracture in those patients.

Cheng J.,Shanghai JiaoTong University
The Tohoku journal of experimental medicine | Year: 2010

Mid-gestational mammalian skin has unique capacity to heal without scar. Fetal skin undergoes phenotypic transition from scarless healing to scar repairing during embryonic development. However, the molecular mechanisms underlying the scarless phenotype and phenotypic transition remain largely unknown. MicroRNAs (miRNAs) are a novel class of small regulatory RNAs emerged as post-transcriptional gene repressors and play essential roles in diverse pathophysiological processes including skin morphogenesis and pathogenesis. Here, we performed a genome-wide miRNA profiling to identify the differentially expressed miRNAs between mid-gestational (E16 day) and late-gestational (E19 day) mouse skin, corresponding to scarless and scarring phenotype, respectively. Two miRNAs (miR-29b and miR-29c) with highest fold changes were further validated independently by real-time RT-PCR. Functional annotations of putative targets of differentially expressed miRNAs via bioinformatics approaches revealed that these predicted targets, including Smads, beta-catenin and Ras, were significantly enriched and involved in several signaling pathways important for scarless wound healing. In addition, Dicer, one of the key RNase III responsible for miRNA biogenesis and functions, was found to be up-regulated in the E19 fetal skin as compared with the E16 counterpart. Taken together, our results identified differentially expressed miRNAs between mid-and late-gestational fetal skin that correlated with phenotypic transition from scarless to scarring repair during skin development. Our bioinformatics' analysis suggests that miRNAs might contribute to this phenotypic transition probably by affecting multiple target genes and signaling pathways.

A comprehensive evaluation of the benefits of mineralocorticoid receptor antagonists on cardiac remodeling is lacking. We aimed to evaluate the impact of mineralocorticoid receptor antagonists on changes in cardiac structure and function of left ventricular dysfunction. Articles were identified by online searches in PubMed, EMBASE, Cochrane, and ClinicalTrials.gov databases before June 2012, by hand searches of reviews and relevant journals, and by contact with the authors. Qualified articles were restricted to randomized controlled trials. There were, respectively, 12, 4, and 3 qualified trials that randomized 572, 647, and 407 patients to spironolactone, canrenoate, and eplerenone, and 531, 655, and 395 patients to placebo or active treatment, respectively. Overall, under mineralocorticoid receptor antagonist treatment there was improvement in left ventricular ejection fraction (weighted mean difference, 2.97; 95% confidence interval [95% CI], 2.26-3.67; P<0.0005), left ventricular end-systolic and end-diastolic volume index (weighted mean difference, -5.64; 95% CI, -7.94 to -3.34; P<0.0005 and weighted mean difference, -7.46; 95% CI, -11.63 to -3.3; P<0.0005), serum amino-terminal peptide of procollagen type-III (weighted mean difference, -1.12; 95% CI, -1.49 to -0.74; P<0.0005), B-type natriuretic peptide (weighted mean difference, -67.06; 95% CI, -91.24 to -42.88; P<0.0005), peak velocities of early mitral inflow (E; weighted mean difference, -9.57; 95% CI, -12.98 to -6.17; P<0.0005), and E wave deceleration time (weighted mean difference, 7.08; 95% CI, 4.07-10.09; P<0.0005). There was low probability of heterogeneity and publication bias. Our findings demonstrate that mineralocorticoid receptor antagonist treatment may exert beneficial effects on the reversal of cardiac remodeling and improvement of left ventricular function.

Wang R.,Shanghai JiaoTong University
Nan fang yi ke da xue xue bao = Journal of Southern Medical University | Year: 2013

To investigate the association of the expressions of angiopoietin-2 (Ang-2), vascular endothelial growth factor (VEGF) in colorectal cancer tissues with Dukes' clinicopathological features. Ang-2 and Tie-2 mRNA expressions were detected in colorectal cancer tissues, adjacent tissues, and normal tissues by real time-PCR. Quantikine immunoassays were used to measure the protein expressions of Ang-2 and VEGF in the tissues and serum samples. Ang-2 and Tie-2 levels were significantly higher in the serum of the patients than in the normal tissues (P<0.05), and their expressions were strongly correlated (r=0.879, P=0.000). Tumor tissue Ang-2 and VEGF levels were significantly higher than their levels in the adjacent and normal tissues (P<0.05). In colorectal cancer patients, the peripheral blood level of Ang-2 was significantly higher than that in healthy control subjects, and comparable with that in mesenteric blood (P>0.05). In Dukes' stage C and D patients, serum Ang-2 and VEGF levels were significantly higher than those in patients in Dukes' stage A and B (P<0.05). Ang-2 and VEGF over expressions may play an important role in the occurrence and progression of colorectal cancer.

Gao J.,Boston University | Gao J.,Shanghai JiaoTong University | Buldyrev S.V.,Yeshiva University | Havlin S.,Bar - Ilan University | Stanley H.E.,Boston University
Physical Review Letters | Year: 2011

Network research has been focused on studying the properties of a single isolated network, which rarely exists. We develop a general analytical framework for studying percolation of n interdependent networks. We illustrate our analytical solutions for three examples: (i) For any tree of n fully dependent Erdos-Rényi (ER) networks, each of average degree k̄, we find that the giant component is P=p[1-exp(-k̄P)]n where 1-p is the initial fraction of removed nodes. This general result coincides for n=1 with the known second-order phase transition for a single network. For any n>1 cascading failures occur and the percolation becomes an abrupt first-order transition. (ii) For a starlike network of n partially interdependent ER networks, P depends also on the topology-in contrast to case (i). (iii) For a looplike network formed by n partially dependent ER networks, P is independent of n. © 2011 American Physical Society.

Chen L.-W.,Shanghai JiaoTong University | Chen L.-W.,Accelerator Centre
Physical Review C - Nuclear Physics | Year: 2011

Within the Skyrme-Hartree-Fock (SHF) approach, we show that for a fixed mass number A, both the symmetry energy coefficient asym(A) in the semiempirical mass formula and the nuclear matter symmetry energy E sym(ρA) at a subsaturation reference density ρA can be determined essentially by the symmetry energy E sym(ρ0) and its density slope L at saturation density ρ0. Meanwhile, we find the dependence of asym(A) on Esym(ρ0) or L is approximately linear and very similar to the corresponding linear dependence displayed by Esym(ρ A), providing an explanation for the relation Esym(ρ A)ρasym(A). Our results indicate that a value of Esym(ρA) leads to a linear correlation between E sym(ρ0) and L and thus can put important constraints on Esym(ρ0) and L. Particularly, the values of E sym(ρ0)=30.5±3 MeV and L= 52.5±20 MeV are simultaneously obtained by combining the constraints from recently extracted Esym(ρA=0.1 fm-3) with those from recent analyses of neutron skin thickness of Sn isotopes in the same SHF approach. © 2011 American Physical Society.

Wu J.C.,Shanghai JiaoTong University
Journal of endocrinological investigation | Year: 2011

Glyoxalase I (GLO1), which is the major enzyme that catalyzes the metabolism of methylglyoxal (MG), may play an important role in the pathogenesis of diabetic microvascular complications. To investigate whether the C-7T and A419C polymorphisms of the GLO1 gene are associated with nephropathy and retinopathy in Chinese Type 2 diabetic patients. A total of 364 Type 2 diabetic patients and 301 healthy controls were enroled in the study. Diabetic microvascular complications were determined by urinary albumin excretion measurements and ophthalmological examinations. Genetic analyses were performed using either Taqman PCR or direct sequencing. The effect of C-7T polymorphism on promoter activity was measured by reporter gene assays. The albumin/ creatinine ratio (ACR) and prevalence of nephropathy and retinopathy were significantly higher in diabetic patients with GLO1 -7CC genotype than in patients with -7CT and -7TT genotypes (p=0.02, p=0.02, and p=0.04, respectively). The - 7CC genotype is independently associated with ACR (β=0.13, p=0.01) and the risk for retinopathy [odds ratio (OR): 2.30, 95% confidence interval (CI): 1.25-4.24, p<0.01]. The luciferase activity of the -7T promoter was higher than that of the -7C promoter (13.2±0.2 vs 11.7±0.8, p=0.04). No differences were found between ACR and the prevalence of nephropathy and retinopathy for A419C polymorphism in Type 2 diabetic patients. GLO1 C-7T polymorphism alters promoter activity and confers susceptibility to nephropathy and retinopathy to Type 2 diabetic patients.

Background: Decreased tryptophan (TRP) and increased kynurenine (KYN) and kynurenic acid (KYNA) in blood have been reported in patients and experimental animals with renal diseases. We investigated if these compounds could be used as new biomarkers for the assessment of renal function. Methods: Eighty hospitalized hypertensive patients (20 with chronic kidney disease (CKD), and other 60 were considered as control) were enrolled for the investigation. Plasma TRP, KYN, and KYNA were determined by high-performance liquid chromatography. Change rate (CR) was employed to evaluate the sensitivity of the parameters of renal function. Results: CR of plasma KYNA/TRP ratio (+103%) was much higher than the CRs of blood urea nitrogen (+44%), serum creatinine (+56%) and estimated glomerular filtration rate (-35%). Plasma KYNA/TRP ratio was in close relationship with blood urea nitrogen (r = 0.622), serum creatinine (r = 0.797), urine micro-albumin/24-h (r = 0.518) and estimated glomerular filtration rate (r = -0.662), respectively, with all p-values <0.001. Conclusions: Plasma KYNA/TRP ratio was sensitive and reliable to indicate renal function and could be used as a new biomarker to assess the risk or presence of kidney disease. Copyright © 2013 Informa Healthcare USA, Inc.

Jiang C.,Shanghai JiaoTong University
Applied Physics B: Lasers and Optics | Year: 2011

An uniform silicon waveguide is proposed featuring ultralow-dispersion slow light. The core of the waveguide consists of one silicon trip and two pairs of air/silicon strip and the cladding is composed of several alternative silicon and air strips, which form a transverse band gap to confine propagating light in the core. The waveguide has several nearly linear photonic bands in a large frequency range, which can support broadband slow modes with a group velocity of 0.03-0.08c and tolerable group velocity dispersion. © 2010 Springer-Verlag.

He D.,Shanghai JiaoTong University
IEEE Transactions on Vehicular Technology | Year: 2013

A cooperative spectrum-sensing technique in cognitive radio (CR) networks based on the data fusion of various chaotic stochastic resonance (CSR) energy detectors is proposed in this paper. Due to noisy uncertainty in unpredictable wireless communication environments, detection performance of conventional energy detection cannot be guaranteed. By introducing the CSR system with various CSR noise types, and with the data fusion on these CSR-based energy detectors, the detection probability can be improved under the same constant false-alarm rate (CFAR), particularly under low signal-to-noise ratio (SNR) circumstances. Theoretical analyses and computer simulation results verify the effectiveness of the proposed novel cooperative spectrum-sensing approach under serious wireless conditions. © 1967-2012 IEEE.

Le W.,Dalian Medical University | Le W.,Shanghai JiaoTong University
Parkinsonism and Related Disorders | Year: 2014

Iron homeostasis requires the regulation of iron influx, iron efflux and iron storage, which are all essential to the execution of the multiple functions of the central nervous system. Abnormal accumulation of iron in the brain has been implicated in several neurodegenerative diseases, including Parkinson's disease (PD) and neurodegeneration with brain iron accumulation (NBIA). Although the cause of the neurodegenerative process in PD remains unclear, recent evidence suggests that failure of the ubiquitin-proteasome system (UPS) may play an important role in the pathogenesis of this disease. Our studies have shown that injection of the proteasome inhibitor lactacystin in the substantia nigra (SN) of rodents causes significant loss of dopamine (DA) neurons and induces intracellular inclusion body formation, which is accompanied by excessive iron accumulation in the midbrain. In the in vitro model, lactacystin causes a marked increase in labile iron, reactive oxygen species, alteration of iron regulatory protein (IRP)/iron response element expression levels, and an increase in the aggregation of ubiquitin-conjugated proteins prior to cell injury and death. Furthermore, we have demonstrated that synthetic iron chelators and a genetic iron chelator are neuroprotective against proteasome inhibitor-induced DA neuron degeneration, suggesting that iron chelation might be a promising therapeutic target for PD. © 2013 Elsevier Ltd.

Huang Z.,Shanghai JiaoTong University
Zhonghua er ke za zhi. Chinese journal of pediatrics | Year: 2013

Combined methylmalonic acidemia with homocystinuria is a common form of methylmalonic acidemia in China. Patients with this disease can progress to death without timely and effective treatment. This study aimed to analyze the treatment outcomes of patients with combined methylmalonic acidemia and homocystinuria. From September 2004 to April 2012, 58 patients with combined methylmalonic acidemia and homocystinuria (34 males and 24 females) were diagnosed and treated in our hospital. Fifty cases were from clinical patients including 42 early-onset cases and 8 late-onset cases. Their age when they were diagnosed ranged from 18 days to 30.8 years. The other 8 cases were from newborn screening. All the patients were treated with vitamin B12, betaine, folic acid, vitamin B6, and L-carnitine. The physical and neuropsychological development, general laboratory tests, the levels of amino acids, acylcarnitines, and homocysteine in blood, and organic acids in urine were followed up. The follow-up period ranged from 1 month to 7.1 years. Three cases died (all were early-onset cases). In the other patients after treatment, the symptoms such as recurrent vomiting, seizures, lethargy, and poor feeding disappeared, muscle strength and muscle tension were improved, and general biochemical abnormalities such as anemia and metabolic acidosis were corrected. Among the surviving 55 cases, 49 had neurological impairments such as developmental delay and mental retardation. The median levels of blood propionylcarnitine and its ratio with acetylcarnitine, serum homocysteine, and urine methylmalonic acid were significantly decreased (P < 0.01), from 7.73 μmol/L (ranged from 1.5 to 18.61 μmol/L), 0.74 (ranged from 0.29 to 2.06), 97.3 μmol/L (ranged from 25.1 to 250 μmol/L) and 168.55 (ranged from 3.66 to 1032.82) before treatment to 2.74 μmol/L (ranged from 0.47 to 12.09 μmol/L), 0.16 (ranged from 0.03 to 0.62), 43.8 μmol/L (ranged from 17 to 97.8 μmol/L) and 6.81 (ranged from 0 to 95.43) after treatment, respectively. Patients with combined methylmalonic acidemia and homocystinuria respond to a combined treatment consisting of supplementation of hydroxycobalamin, betaine, folic acid, vitamin B6 and L-carnitine with clinical and biochemical improvement. But the long-term outcomes are unsatisfactory, with neurological sequelae in most patients.

Are there differences in the morphology, spectrum and biochemical phenotype between Sertoli cells from non-obstructive azoospermia (NOA) patients and those from obstructive azoospermia (OA) patients with normal spermatogenesis? Sertoli cells from NOA patients are distinct from those from OA patients in terms of morphological features, Raman spectrum and phenotype including the expression of genes and proteins (e.g. SCF, BMP4 and GDNF). NOA affects 10% of infertile men and has been diagnosed in 60% of azoospermic men. In contrast with OA patients who have normal spermatogenesis, NOA patients have an impaired spermatogenesis. This case-control study included 100 NOA patients (as cases) and 100 OA patients with normal spermatogenesis (as controls). The study was performed between January 2012 and January 2013. Karyotype analysis was performed to check the chromosome content and multiplex PCR was carried out to determine the expression of numerous Y chromosome genes in NOA patients. Human Sertoli cells were then isolated from the testes of NOA and OA patients by two-step enzymatic digestion and differential plating. Transmission electron microscopy was used to determine the ultrastructure of the Sertoli cells and real-time Raman microspectroscopy was used to assess their spectrum. We further compared the two groups of patients for expression of SCF, GDNF and BMP4 in Sertoli cells, using RT-PCR, microarray analysis, immunofluorescence, immunohistochemistry and Western blots. NOA patients had normal chromosome karyotypes and Y chromosome microdeletions were excluded. In morphology, Sertoli cells isolated from NOA patients had a series of abnormal ultrastructural features compared with the control Sertoli cells: (i) existence of small and spindle-shaped nuclei, (ii) smaller diameter, (iii) deficient nucleolus or endoplasmic reticulum and (iv) more vacuoles. Spectral intensities in Sertoli cells of NOA patients were distinct at four typical Raman peaks compared with the control Sertoli cells. In phenotype, SCF, BMP4 and GDNF transcripts and proteins were significantly lower in Sertoli cells of NOA patients than in the control Sertoli cells. The Sertoli cells of NOA patients were not compared with Sertoli cells of normal fertile men due to the fact that it is hard to obtain adult testes from normal donors. This study provides novel insights into understanding the underlying causes for NOA and might offer a basis for developing new therapeutic strategies for patients with NOA.

Basan syndrome is a rare autosomal dominant genodermatosis, characterized by rapidly healing congenital acral bullae, congenital milia and lack of fingerprints. A mutation in the SMARCAD1 gene was recently reported to cause Basan syndrome in one family. Here, we present a large Chinese family with Basan syndrome; some patients presented with hyperpigmentation and knuckle pads in addition to previously reported clinical manifestations. We used genome-wide linkage analysis and whole-genome sequencing (WGS) to identify the pathogenic gene in this unique pedigree. Genome-wide linkage analysis successfully mapped the candidate gene to 4p15.31-4p14 and 4q13.2-4q23. The maximal LOD score was 3.01. WGS in one patient identified a splice variant (c.378+1G>T) in the SMARCAD1 gene (NG_031945.1) that was confirmed by Sanger sequencing. Co-segregation of the variant was confirmed in this pedigree. The same variant was recently found to be associated with isolated adermatoglyphia (ADG) in another family, suggesting that this variant is causative for both Basan syndrome and autosomal dominant ADG (OMIM 136 000). This indicates that ADG and Basan syndrome may be the phenotypic variants of the same disease. Further studies should be performed to elucidate the pathogenic mechanisms induced by this variant. This report increases the phenotypic spectrum of Basan syndrome and furthers our understanding of the genetic basis of this disease. Our results also highlight the power of combining WGS and genome-wide linkage analysis in identifying causative genes in pedigrees with a genetic disorder.European Journal of Human Genetics advance online publication, 2 March 2016; doi:10.1038/ejhg.2016.15. © 2016 Macmillan Publishers Limited

Shang Y.L.,Shanghai JiaoTong University
Science China Information Sciences | Year: 2011

2-connectivity is the basic graph theoretical metric for fault tolerance to node failures, and it is an extremely desirable property in network design. For a one-dimensional finite ad hoc network formed by n nodes uniformly and independently distributed in a closed interval [0, z] (z ∈ ℝ+), we give a closed form expression for the probability that a connected one-dimensional finite ad hoc network becomes disconnected after removing a node. We also sketch a procedure of finding the exact formula for 2-connectivity in a one-dimensional ad hoc network. © 2010 Science China Press and Springer-Verlag Berlin Heidelberg.

Gao J.,Shanghai JiaoTong University | Li D.,Chinese University of Hong Kong
Operations Research | Year: 2013

One long-standing challenge in both the optimization and investment communities is to devise an efficient algorithm to select a small number of assets from an asset pool such that a portfolio objective is optimized. This cardinality constrained investment situation naturally arises due to the presence of various forms of market friction, such as transaction costs and management fees, or even due to the consideration of mental cost. Unfortunately, the combinatorial nature of such a portfolio selection problem formulation makes the exact solution process NP-hard in general. We focus in this paper on the cardinality constrained mean-variance portfolio selection problem. Instead of tailoring such a difficult problem into the general solution framework of mixed-integer programming formulation, we explore the special structures and rich geometric properties behind the mathematical formulation. Applying the Lagrangian relaxation to the primal problem results in a pure cardinality constrained portfolio selection problem, which possesses a symmetric property, and to which geometric approaches can be developed. Different from the existing literature that has primarily focused on some direct relaxations of the cardinality constraint, we consider modifying the objective function to some separable relaxations, which are immune to the hard cardinality constraint. More specifically, we develop efficient lower bounding schemes by using the circumscribed box, the circumscribed ball, and the circumscribed axis-aligned ellipsoid to approximate the objective contour of the problem. In particular, all these cardinality constrained relaxation problems can be solved analytically. Furthermore, we derive efficient polynomial-time algorithms for the corresponding dual search problems. Most promisingly, the lower bounding scheme using the circumscribed axis-aligned ellipsoid leads to a semidefinite programming (SDP) formulation and offers a sharp bound and high-quality feasible solution. By integrating these lower bounding schemes into a branch-and-bound algorithm (BnB), our solution scheme outperforms CPLEX significantly in identifying the exact optimal portfolio. ©2013 INFORMS.

Liu M.,Shanghai JiaoTong University | Yap P.-T.,University of North Carolina at Chapel Hill
Pattern Recognition | Year: 2012

Orientation fields can be used to describe interleaved ridge and valley patterns of fingerprint image, providing features useful for fingerprint recognition. However, for tasks such as fingerprint indexing, additional image alignment is often required to avoid confounding effects caused by pose differences. In this paper, we propose to employ a set of polar complex moments (PCMs) for extraction of rotation invariant fingerprint representation. PCMs are capable of describing fingerprint ridge flow structures, including singular regions, and are tolerant to spurious orientations in noisy fingerprints. From the orientation fields, a set of rotation moment invariants are derived to form a feature vector for comprehensive fingerprint structural description. This feature vector gives a compact and rotation invariant representation that is important for pose-robust fingerprint indexing. A clustering-based fingerprint indexing scheme is employed to facilitate efficient and effective retrieval of the most likely candidates from a fingerprint database. Our experimental results on NIST and FVC fingerprint databases indicate that the proposed invariant representation improves the performance of fingerprint indexing as compared to state-of-the-art methods. © 2012 Elsevier Ltd. All rights reserved.

Dan Y.,Shanghai JiaoTong University
Applied Physics Letters | Year: 2015

Surface trap states play a dominant role in the optoelectronic properties of nanoscale devices. Understanding the surface trap states allows us to properly engineer the device surfaces for better performance. But characterization of surface trap states at nanoscale has been a formidable challenge using the traditional capacitive techniques. Here, we demonstrate a simple but powerful optoelectronic method to probe the density of nanowire surface trap states to the single state limit. In this method, we choose to tune the quasi-Fermi level across the bandgap of a silicon nanowire photoconductor, allowing for capture and emission of photogenerated charge carriers by surface trap states. The experimental data show that the energy density of nanowire surface trap states is in a range from 109cm-2/eV at deep levels to 1012cm-2/eV near the conduction band edge. This optoelectronic method allows us to conveniently probe trap states of ultra-scaled nano/quantum devices at extremely high precision. © 2015 AIP Publishing LLC.

Xu L.,Shanghai JiaoTong University
Frontiers in Bioscience | Year: 2013

Pancreatic cancer (PC) is an aggressive malignancy with a high incidence of distant metastasis and mortality. Emerging evidence has demonstrated that pancreatic cancer stem cells (CSCs), which have the potential to self-renew and are pluripotent, are crucially important in the progression and therapy of PC. The origin of pancreatic CSCs was suggested to be pancreatic acinar cells, centroacinar cells, or acinar-ductal metaplasia. And several CSC-specific markers for pancreatic cancer have been reported, including CD133, CD24, CD44 and CXCR4. Several studies reported the molecular mechanisms regulating human pancreatic CSCs characteristics. In the progression of PC, CSCs are linked with the aggressiveness of PC with association of epithelial to mesenchymal transition (EMT). In the therapy of PC, especially chemotherapy, CSCs offer new insight into PC therapy, especially the mechanism of drug resistance. Therefore, strategies for modulating and treating CSCs can lead to novel targeted therapies for pancreatic cancer.

Du J.,Shanghai JiaoTong University | Shu C.,Chinese University of Hong Kong
Journal of Lightwave Technology | Year: 2013

With cascaded and multisection Sagnac interferometers, all-optical fast Fourier transform (FFT) has been demonstrated for optical demultiplexing (DEMUX) of orthogonal frequency division multiplexing (OFDM) signals. The transmission characteristics of the interferometers have been investigated theoretically and experimentally. The scalability and tunability of the all-optical OFDM DEMUX are analyzed and demonstrated for 5-channel OFDM signals. © 1983-2012 IEEE.

The Conte-Peng's equations for a fully nonstationary model of an earthquake are reformulated as modulated filtered white-noise processes so that the reliabilities of a linear structure under the fully nonstationary earthquake model can be estimated through calculating the first passage time probabilities of several time-varying linear systems subjected to independent white-noise processes. Each time-varying linear system consists of a second-order single-degree-of-freedom (SDOF) linear oscillator, a deterministic time-modulating function applied at the stationary oscillator's responses and the linear structure considered. The unit impulse response functions of these time-varying linear systems are derived, from which the useful spectral characteristics of system responses in estimating the crossing rates and limiting decay rates can be numerically calculated. To save computation time, efficient matrix procedures in the time domain are proposed. The reliability analysis of a moment-resisting steel frame subjected to El-Centro-like earthquake demonstrates the effectiveness, accuracy and application of the numerical method. © 2010 Elsevier Ltd.

Kuang Z.-B.,Shanghai JiaoTong University
Acta Mechanica | Year: 2010

The universal thermodynamic variational principle proposed in the previous papers for nonlinear dielectrics and thermopiezoelectricity is extended to the thermodiffusion theory in pyroelectricity, and it is used as a fundamental physical principle to derive the simple complete governing equations of the generalized thermo-electro-diffuso-elastic theory in this paper. In the generalized thermo-electro-diffuso-elastic theory it is assumed that the variation of temperature needs the extra heat which introduces the inertial entropy, and the variation of chemical potential also needs the extra heat which introduces the inertial concentration, etc. The electro-chemical Gibbs function variational principle, the electric Gibbs function variational principle and the internal energy variational principle are derived in this paper. © 2010 Springer-Verlag.

This is the first case of Graves' disease in an adolescent with lingual and prelaryngeal dual congenital ectopia and no orthotopic thyroid gland identified by technetium-99m-pertechnetate (99mTcO-4) SPET/CT imaging in a 15 years old boy. After 8 weeks treatment with methimazole, Graves' disease subsided. Fine needle aspiration cytology of the mass revealed the normal colloid and normal follicular cells without an atypia or lymphoid elements, suggesting a benign ectopic thyroid gland. In conclusion, there is no report in the literature with DETT lingual and prelaryngeal absence of orthotopic thyroid tissue and Graves' disease as in our case. This case also highlights the potential ascendancy of 99mTcO-4 SPET/CT in diagnosing the DETT.

Li Z.,Shanghai JiaoTong University | Zhang Y.,Sun Yat Sen University
Automatica | Year: 2010

Previous works for wheeled inverted pendulums usually eliminate nonholonomic constraint force in order to make the control design easier, under the assumption that the friction force from the ground is as large as needed. Nevertheless, such an assumption is unfeasible in practical applications. In this paper, adaptive robust motion/force control for wheeled inverted pendulums is investigated with parametric and functional uncertainties. The proposed robust adaptive controls based on physical properties of wheeled inverted pendulums make use of online adaptation mechanism to cancel the unmodelled dynamics. Based on Lyapunov synthesis, the proposed controls ensure that the system outputs track the given bounded reference signals within a small neighborhood of zero, and guarantee the semi-global uniform boundedness of all closed loop signals. The effectiveness of the proposed controls is verified through extensive simulations. © 2010 Elsevier Ltd. All rights reserved.

Liu J.,Shanghai JiaoTong University
International Review of Electrical Engineering | Year: 2010

To improve the accuracy of PD localization and enhance the maintenance efficiency of gas insulated switchgear (GIS), a partial discharge (PD) localization method based on Ultra High Frequency (UHF) combined with acoustic technique is proposed in this paper. The PD source is located in a rough range with UHF method firstly, which usually consists of two or three chambers. Secondly, the PD source can be located quickly and accurately by detecting the acoustic and UHF signals simultaneously. As the PD localization method detects UHF and acoustic signals of PD synchronously, it can exclude the interference and confirm PD signal more effectively. The laboratory experiment and on-site application results both show that the PD localization method using UHF combined with acoustic method can be used in online GIS PD localization effectively and precisely. © 2010 Praise Worthy Prize S.r.l.

Liu S.,Shanghai JiaoTong University
Clinical nuclear medicine | Year: 2013

A 31-year-old female patient with papillary thyroid cancer, status post-total thyroidectomy and radioablation with (131)I underwent posttherapy whole-body scan with SPECT, which revealed increased iodine activity in the cervix. The subsequent ultrasound examination demonstrated that the site of elevated iodine activity was caused by cervical Nabothian cyst.

Li Z.,Shanghai JiaoTong University | Kang Y.,Hefei University of Technology
Automatica | Year: 2010

The hybrid joints can be switched to either active (actuated) or passive (under-actuated) mode as needed (Li, Ming, Xi, & Shimojo, 2006), in this paper, dynamic coupling switching control incorporating Support Vector Machines (SVMs) is developed for wheeled mobile manipulators with hybrid joints. The hybrid actuated robot dynamics is a mixed under-actuated and actuated model. In order to approximate the high dimension unmodelled dynamics, the SVMs matrix and its operator are proposed. Considering the joint switching as an event, the event driven switching control strategy is used to ensure that the system outputs track the given bounded reference signals within a small neighborhood of zero, and guarantee semi-global uniform boundedness of all closed loop signals, and the switch stability. The effectiveness of the proposed controls is verified through extensive simulations. © 2010 Elsevier Ltd. All rights reserved.

Ji X.,Shanghai JiaoTong University | Ji X.,University of Maryland University College
Science China: Physics, Mechanics and Astronomy | Year: 2014

Parton physics, when formulated as light-front correlations, are difficult to study non-perturbatively, despite the promise of light-front quantization. Recently an alternative approach to partons have been proposed by re-visiting original Feynman picture of a hadron moving at asymptotically large momentum. Here I formulate the approach in the language of an effective field theory for a large hadron momentum P in lattice QCD, LaMET for short. I show that using this new effective theory, parton properties, including light-front parton wave functions, can be extracted from lattice observables in a systematic expansion of 1/P, much like that the parton distributions can be extracted from the hard scattering data at momentum scales of a few GeV. © 2014 Science China Press and Springer-Verlag Berlin Heidelberg.

Wang X.-W.,Rutgers Cancer Institute of New Jersey | Zhang Y.-J.,Shanghai JiaoTong University
World Journal of Gastroenterology | Year: 2014

The mechanistic target of rapamycin (mTOR) integrates growth factor signals with cellular nutrient and energy levels and coordinates cell growth, proliferation and survival. A regulatory network with multiple feedback loops has evolved to ensure the exquisite regulation of cell growth and division. Colorectal cancer is the most intensively studied cancer because of its high incidence and mortality rate. Multiple genetic alterations are involved in colorectal carcinogenesis, including oncogenic Ras activation, phosphatidylinositol 3-kinase pathway hyperactivation, p 53 mutation, and dysregulation of wnt pathway. Many oncogenic pathways activate the mTOR pathway. mTOR has emerged as an effective target for colorectal cancer therapy. In vitro and preclinical studies targeting the mTOR pathway for colorectal cancer chemotherapy have provided promising perspectives. However, the overall objective response rates in major solid tumors achieved with single-agent rapalog therapy have been modest, especially in advanced metastatic colorectal cancer. Combination regimens of mTOR inhibitor with agents such as cytotoxic chemotherapy, inhibitors of vascular endothelial growth factor, epidermal growth factor receptor and Mitogen-activated protein kinase kinase (MEK) inhibitors are being intensively studied and appear to be promising. Further understanding of the molecular mechanism in mTOR signaling network is needed to develop optimized therapeutic regimens. In this paper, oncogenic gene alterations in colorectal cancer, as well as their interaction with the mTOR pathway, are systematically summarized. The most recent preclinical and clinical anticancer therapeutic endeavors are reviewed. New players in mTOR signaling pathway, such as nonsteroidal anti-inflammatory drug and metformin with therapeutic potentials are also discussed here. © 2014 Baishideng Publishing Group Co., Limited. All rights reserved.

Shi G.,Shanghai JiaoTong University
IEEE Transactions on Circuits and Systems II: Express Briefs | Year: 2010

A determinant decision diagram (DDD) uses a binary decision diagram (BDD) to calculate a determinant symbolically, which is then applied for symbolic circuit analysis. The efficiency of such a technique is determined mainly by a symbol ordering scheme. Finding an optimal symbol order is an non-deterministic polynomial-time hard problem in the practice of BDD. So far, it is unknown what an optimal order is for a general sparse matrix. This brief shows that a row-wise (or column-wise) order is an optimal BDD order for full matrices in the sense that the DDD graph constructed has the minimum number of vertices (i.e., the DDD size). The optimal DDD size is proven to be (n. 2 n - 1) for an n × n full matrix. This size provides a DDD complexity measure that has rarely been investigated in the literature. © 2006 IEEE.

Nakata T.,Chiba University | Liu H.,Chiba University | Liu H.,Shanghai JiaoTong University
Journal of Computational Physics | Year: 2012

We present a fluid-structure interactions (FSI) model of insect flapping flight with flexible wings. This FSI-based model is established by loosely coupling a finite element method (FEM)-based computational structural dynamic (CSD) model and a computational fluid dynamic (CFD)-based insect dynamic flight simulator. The CSD model is developed specifically for insect flapping flight, which is capable to model thin shell structures of insect flexible wings by taking into account the distribution and anisotropy in both wing morphology involving veins, membranes, fibers and density, and in wing material properties of Young's modulus and Poisson's ratios. The insect dynamic flight simulator that is based on a multi-block, overset grid, fortified Navier-Stokes solver is capable to integrate modeling of realistic wing-body morphology, realistic flapping-wing and body kinematics, and unsteady aerodynamics in flapping-wing flights. Validation of the FSI-based aerodynamics and structural dynamics in flexible wings is achieved through a set of benchmark tests and comparisons with measurements, which contain a heaving spanwise flexible wing, a heaving chordwise-flexible wing with a rigid teardrop element, and a realistic hawkmoth wing rotating in air. A FSI analysis of hawkmoth hovering with flapping flexible wings is then carried out and discussed with a specific focus on the in-flight deformation of the hawkmoth wings and hovering aerodynamic performances with the flexible and rigid wings. Our results demonstrate the feasibility of the present FSI model in accurately modeling and quantitatively evaluating flexible-wing aerodynamics of insect flapping flight in terms of the aerodynamic forces, the power consumption and the efficiency. © 2011 Elsevier Inc.

Hysing S.,Shanghai JiaoTong University
Journal of Computational Physics | Year: 2012

A new realization of a finite element level set method for simulation of immiscible fluid flows is introduced and validated on numerical benchmarks. The new method involves a mixed discretization of the dependent variables, discretizing the flow variables with non-conforming Rannacher-Turek finite elements while using a simple first order conforming discretization of the level set field. A three step segregated solution approach is employed, first a discrete projection method is used to decouple and compute the velocity and pressure separately, after which the level set field can be computed independently.The developed method is tested and validated on a static bubble test case and on a numerical rising bubble test case for which a very accurate benchmark solution has been established. The new approach is also compared against two commercial simulation codes, Ansys Fluent and Comsol Multiphysics, which shows that the developed method is a magnitude or more accurate and at the same time significantly faster than state of the art commercial codes. © 2011 Elsevier Inc.

Wang B.,Shanghai JiaoTong University
International Journal of Biological Macromolecules | Year: 2011

A water-soluble polysaccharide was extracted from the fruits of Chinese jujube by boiled water extraction and ethanol precipitation. Monosaccharide composition and the structure of the polysaccharide were determined by gas spectroscopy and Fourier transform IR (FT-IR) spectroscopy. The components were glucose (23%), xylose (31.3%), mannose (12.9%) and fructose (21.6%). Six distinct-absorbance peaks, at 3290.20, 2928.66, 1616.20, 1342.96, 1254.35cm-1, 1025.43, 917, 28 and 816.57cm-1 in the infrared (IR) spectra of Chinese jujube polysaccharides were the characteristic of polysaccharide compound. Chinese jujube polysaccharides have effective reducing power, free radical scavenging, superoxide anion radical scavenging, hydrogen peroxide scavenging, and metal chelating activities. This antioxidant property depends on concentration and increases with increased amount of sample. In addition, ischemia/reperfusion could stimulate oxidative injury in rabbits' intestine. Chinese jujube polysaccharides could still effectively reduce intestine MDA level and increase antioxidant enzyme activities in rabbits with ischemia/reperfusion (I/R) of the small intestine. © 2010 Elsevier B.V.

Zhou D.,University of Warwick | Zhao C.Y.,Shanghai JiaoTong University | Tian Y.,University of Warwick
Applied Energy | Year: 2012

Thermal energy storage with phase change materials (PCMs) offers a high thermal storage density with a moderate temperature variation, and has attracted growing attention due to its important role in achieving energy conservation in buildings with thermal comfort. Various methods have been investigated by previous researchers to incorporate PCMs into the building structures, and it has been found that with the help of PCMs the indoor temperature fluctuations can be reduced significantly whilst maintaining desirable thermal comfort. This paper summarises previous works on latent thermal energy storage in building applications, covering PCMs, the impregnation methods, current building applications and their thermal performance analyses, as well as numerical simulation of buildings with PCMs. Over 100 references are included in this paper. © 2011 Elsevier Ltd.

Xu Z.,Shanghai JiaoTong University | Xu Z.,Nanjing University of Science and Technology | Yager R.R.,The College of New Rochelle
IEEE Transactions on Fuzzy Systems | Year: 2010

The power-average (PA) operator and the power-ordered-weighted-average (POWA) operator are the two nonlinear weighted-average aggregation tools whose weighting vectors depend on the input arguments. In this paper, we develop a power-geometric (PG) operator and its weighted form, which are on the basis of the PA operator and the geometric mean, and develop a power-ordered-geometric (POG) operator and a power-ordered-weighted-geometric (POWG) operator, which are on the basis of the POWA operator and the geometric mean, and study some of their properties. We also discuss the relationship between the PA and PG operators and the relationship between the POWA and POWG operators. Then, we extend the PG and POWG operators to uncertain environments, i.e., develop an uncertain PG (UPG) operator and its weighted form, and an uncertain power-ordered-weighted-geometric (UPOWG) operator to aggregate the input arguments taking the form of interval of numerical values. Furthermore, we utilize the weighted PG and POWG operators, respectively, to develop an approach to group decision making based on multiplicative preference relations and utilize the weighted UPG and UPOWG operators, respectively, to develop an approach to group decision making based on uncertain multiplicative preference relations. Finally, we apply both the developed approaches to broadband Internet-service selection. © 2006 IEEE.

Xu Z.,Shanghai JiaoTong University | Xu Z.,PLA University of Science and Technology
Information Sciences | Year: 2010

In this paper we introduce some relations and operations of interval-valued intuitionistic fuzzy numbers and define some types of matrices, including interval-valued intuitionistic fuzzy matrix, interval-valued intuitionistic fuzzy similarity matrix and interval-valued intuitionistic fuzzy equivalence matrix. We study their properties, develop a method based on distance measure for group decision making with interval-valued intuitionistic fuzzy matrices and, finally, provide an illustrative example. © 2009 Elsevier Inc. All rights reserved.

Li S.,Shanghai JiaoTong University
International Journal of Systems Science | Year: 2014

Using the well-known Arrow and Karlin (1958) dynamic production-inventory model and the model with tradable emission permits which was presented by Dobos (2005, 2007), we develop a model of the production-inventory system with deteriorating items and tradable emission permits. The objective of this paper is to apply the optimal control theory to solve the production-inventory problem with deteriorating items and tradable emission permits, and derive the optimal inventory level and the optimal production rate that minimise the total cost. The results are discussed with a numerical example and a sensitivity analysis of the optimal solution with respect to the parameters of the production-inventory system is carried out. © 2013 Taylor & Francis.

Yan-ming L.,Shanghai JiaoTong University
Clinical & developmental immunology | Year: 2012

To investigate the effects of specific immunotherapy on the NKT cells in peripheral blood and the ability of NKT cells to proliferate in response to alpha-galactosylceramide (alpha-GalCer) in house-dust-mite- (HDM-) sensitized asthma children, peripheral blood mononuclear cells were isolated from 42 asthmatic children, of whom 24 were on specific immunotherapy (SIT) for more than a year and 20 were healthy. Compared with control group, the ratio of peripheral blood NKT and CD4(+)NKT cells was significantly decreased (P < 0.01) and was elevated in SIT asthma group (P < 0.05), respectively, but it was still less than the normal control group (P < 0.01). The level of IL-4 in serum secreted by NKT cells in asthma group was significantly higher than that of control group (P < 0.01), particularly apparent after 72 hours. The level of IL-4 in SIT group decreased significantly (P < 0.01). The level of IL-10 in serum secreted by NKT cells in asthma group was decreased significantly than that of the control group (P < 0.01) especially in 48 hours, while that of SIT group was increased significantly (P < 0.01). These results suggest that the pathogenesis of asthma may be related to the ratio and dysfunction of NKT and CD4(+)NKT cells.

Liao H.,Shanghai JiaoTong University | Xu Z.,University of Sichuan
International Journal of Uncertainty, Fuzziness and Knowlege-Based Systems | Year: 2014

Multi-criteria decision making with hesitant fuzzy information is a new research topic since the hesitant fuzzy set was firstly proposed. This paper investigates a multi-criteria decision making problem where the weight information is partially known. We firstly propose the hesitant fuzzy positive ideal solution and the hesitant fuzzy negative ideal solution. Motivated by the TOPSIS (Technique for Order Preference by Similarity to an ideal Solution) method, we definite the satisfaction degree of an alternative, based on which several optimization models are derived to determinate the weights. Subsequently, in order to make a more reasonable decision, we introduce an interactive method based on some optimization models for multi-criteria decision making problems with hesitant fuzzy information. Finally, a practical example on evaluating the service quality of airlines is provided to illustrate our models and method. © 2014 World Scientific Publishing Company.

Li M.,Shanghai JiaoTong University
Genetics and molecular research : GMR | Year: 2012

Congenital insensitivity to pain with anhidrosis (CIPA; MIM 256800) is a rare autosomal recessive disorder characterized by absence of reaction to noxious stimuli, recurrent episodes of fever, anhidrosis, and mental retardation. It is caused by mutations in the gene coding for neurotrophic tyrosine kinase receptor type 1 (NTRK1; MIM# 191315). We screened two Chinese CIPA cases for mutations in the NTRK1 gene and examined their phenotype. Two novel mutations of the NTRK1 gene and two known mutations were identified. Including our two novel mutations, there are now 62 different NTRK1 gene mutations reported in patients with CIPA. We find that a combination of two null alleles usually leads to the severe phenotype, while the mild form of the CIPA disease is associated with at least one mild allele. Thirty-four among the 62 mutations (55%) are located within the tyrosine kinase domain of the NTRK1 protein. We concluded that the tyrosine kinase domain is a hot spot for mutations.