Shanghai, China

Shanghai Jiao Tong University , also referred to as SJTU, Shanghai Jiaotong University or simply Jiaotong University, is a public research university located in Shanghai, China. Established in 1896 by an imperial edict issued by the Guangxu Emperor, the university is renowned as one of the oldest and most prestigious and selective universities in China. SJTU is a member of China's C9 League and Yangtze Delta Universities Alliance.The university also annually produces the Academic Ranking of World Universities. Wikipedia.


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The invention provides novel amphiphilic drug-drug conjugates useful as cancer therapeutics, and compositions and methods thereof.


Patent
Shanghai JiaoTong University | Date: 2014-10-31

A cooling device with small structured rib-dimple hybrid structures, comprising a substrate, a cooling channel, a plurality of small structured ribs and a plurality of dimples. The cooling channel, the plurality of small structured ribs and the plurality of dimples are all disposed on the wall surface of the substrate; the plurality of dimples are in a staggered arrangement or in a longitudinal arrangement, forming a dimple array; an upstream wall surface of each dimple or a plurality of dimples is provided with the small structured ribs, thus forming an small structured rib-dimple hybrid structure.


Meng Z.,Shanghai JiaoTong University | Lin Z.,University of Virginia | Ren W.,University of California at Riverside
Systems and Control Letters | Year: 2012

In this paper, swarm tracking problems with group dispersion and cohesion behaviors are discussed for a group of Lagrange systems. The agent group is separated into two subgroups. One is called the leader group, whose members are encapsulated with the desired generalized coordinates and generalized coordinate derivatives. The other one, referred to as the follower group, is guided by the leader group. The objective is to guarantee distributed tracking of generalized coordinate derivatives for the followers and to drive the generalized coordinates of the followers close to the convex hull formed by those of the leaders. Both the case of constant leaders' generalized coordinate derivatives and the case of time-varying leaders' generalized coordinate derivatives are considered. The proposed control algorithms are shown to achieve velocity matching, connectivity maintenance and collision avoidance. In addition, the sum of the steady-state distances between the followers and the convex hull formed by the leaders is shown to be bounded and the bound is explicitly given. Simulation results are presented to validate the effectiveness of theoretical conclusions. © 2011 Elsevier B.V. All rights reserved.


Czajkowsky D.M.,Shanghai JiaoTong University | Czajkowsky D.M.,CAS Shanghai Institute of Applied Physics | Hu J.,CAS Shanghai Institute of Applied Physics | Shao Z.,Shanghai JiaoTong University
EMBO Molecular Medicine | Year: 2012

Since the first description in 1989 of CD4-Fc-fusion antagonists that inhibit human immune deficiency virus entry into T cells, Fc-fusion proteins have been intensely investigated for their effectiveness to curb a range of pathologies, with several notable recent successes coming to market. These promising outcomes have stimulated the development of novel approaches to improve their efficacy and safety, while also broadening their clinical remit to other uses such as vaccines and intravenous immunoglobulin therapy. This increased attention has also led to non-clinical applications of Fc-fusions, such as affinity reagents in microarray devices. Here we discuss recent results and more generally applicable strategies to improve Fc-fusion proteins for each application, with particular attention to the newer, less charted areas. © 2012 The Authors. Published by John Wiley and Sons, Ltd on behalf of EMBO.


Fang L.Q.,Shanghai University | Ge X.-H.,Shanghai University | Kuang X.-M.,Shanghai JiaoTong University
Nuclear Physics B | Year: 2013

We explore the properties of the holographic fermions in extremal R-charged black hole background with a running chemical potential, as well as the dipole coupling between fermions and the gauge field in the bulk. We find that although the running chemical potential effect the location of the Fermi surface, it does not change the type of fermions. We also study the onset of the Fermi gap and the gap effected by running chemical potential and the dipole coupling. The spectral function in the limit ω. →. 0 and the existence of the Fermi liquid are also investigated. The running chemical potential and the dipole coupling altogether can make a non-Fermi liquid become the Landau-Fermi type. © 2013 Elsevier B.V.


Huo F.,National University of Singapore | Xi X.-C.,Shanghai JiaoTong University | Poo A.-N.,National University of Singapore
International Journal of Machine Tools and Manufacture | Year: 2012

The model-based Taylor series expansion error compensation (TSEEC) method has been shown to be capable of eliminating contour errors in biaxial CNC machines. However, it has been developed for only linear and circular contours. In this paper, an extension of TSEEC, a generalized TSEEC or GTSEEC, is proposed which is capable of compensating for the contour errors of arbitrary two-dimensional contours. A new real-time algorithm is used to estimate the contour error so that GTSEEC can be applied even in cases where the function of the contour is unknown. Simulation results using linear, circular and parabolic contours are presented which show that, with perfect knowledge of the axial dynamics, GTSEEC can perfectly eliminate the contour errors for any contour, even when there is significant mismatch in the axes dynamics. Experiments on a small two-axis computer-controlled machine indicate the effectiveness and better performance of GTSEEC in reducing contour errors for free-form contour following tasks when compared with two other leading approaches, the zero phase error tracking control (ZPETC) and cross-coupled control (CCC). © 2011 Elsevier Ltd All rights reserved.


Fang L.Q.,Shanghai University | Ge X.-H.,Shanghai University | Kuang X.-M.,Shanghai JiaoTong University
Physical Review D - Particles, Fields, Gravitation and Cosmology | Year: 2012

We investigate the properties of holographic fermions in charged Lifshitz black holes at finite temperature through the AdS/CFT correspondence. In the charged Lifshitz background with the dynamical exponent z=2, we find that the dispersion relation is linear. The scaling behavior of the imaginal part of the Green function relative to k=k-k F is also discussed. We find, although the system has a linear dispersion relation and quadratic quasiparticle width, it does not satisfy Luttinger's theorem. We also find that the variation of the scaling parameters α and β is small as the charge q varies. Furthermore, we also discuss the effect of the dynamical exponent z by considering the cases z=4 and z=6 and show that ImG ii become smooth when the dynamical exponent z increases. © 2012 American Physical Society.


Ma R.C.W.,Hong Kong Institute of Diabetes and Obesity | Ma R.C.W.,Chinese University of Hong Kong | Lin X.,CAS Shanghai Institutes for Biological Sciences | Jia W.,Shanghai JiaoTong University
The Lancet Global Health | Year: 2014

The prevalence of diabetes in China has increased substantially over recent decades, with more than 100 million people estimated to be affected by the disease presently. During this period there has been an increase in the rates of obesity and a reduction in physical activity. Many of the changes in lifestyle and diet are a result of increased economic development and urbanisation. In addition to an increasingly westernised diet, the traditional Chinese diet also plays a part, with the quantity and quality of rice intake linked to the risk of type 2 diabetes. Familial factors including inherited genetic variants are important, although differences in the genetic architecture suggest a different combination of genetic variants could be most relevant in Chinese when compared with Europeans. Recent advances have also emphasised the role of early life factors in the epidemic of diabetes and non-communicable diseases: maternal undernutrition, maternal obesity, and gestational diabetes are all linked to increased risk of diabetes in offspring. A mismatch between developmentally programmed biology and the modern environment is relevant for countries like China where there has been rapid economic transformation. Multisectoral efforts to address the risks will be needed at different stages throughout the lifecourse to reduce the burden of diabetes. © 2014 Elsevier Ltd.


He X.-G.,Shanghai JiaoTong University | He X.-G.,National Taiwan University | Tandean J.,National Central University
Physical Review D - Particles, Fields, Gravitation and Cosmology | Year: 2011

Recent LHC searches have not found a clear signal of the Higgs boson h of the standard model (SM) with three or four families in the mass range m h=120-600GeV. If the Higgs had an unexpectedly large invisible branching ratio, the excluded mh regions would shrink. This can be realized in the simplest weakly interacting massive particle dark matter (DM) model, which is the SM plus a real gauge-singlet scalar field D as the DM, via the invisible mode h→DD. Current data allow this decay to occur for D-mass values near, but below, mh/2 and those compatible with the light DM hypothesis. For such D masses, h→DD can dominate the Higgs width depending on mh, and thus sizable portions of the mh exclusion zones in the SM with three or four families may be recovered. Increased luminosity at the LHC may even reveal a Higgs having SM-like visible decays still hiding in the presently disallowed regions. The model also accommodates well the new possible DM hints from CRESST-II and will be further tested by improved data from future DM direct searches. © 2011 American Physical Society.


Yuan X.,Shanghai JiaoTong University | Ding X.-L.,Shanghai JiaoTong University | Wang C.-Y.,Peking University | Wang C.-Y.,Pennsylvania State University | Ma Z.-F.,Shanghai JiaoTong University
Energy and Environmental Science | Year: 2013

Carbon materials, especially Vulcan XC-72 carbon black, are the most widely used catalyst support in low temperature fuel cells. Several disadvantages of these catalyst supports, however, limit the catalyst performance leading to reduced fuel cell performance and durability: low resistance to corrosion at high potentials, micropores leading to limited accessible surface, impermeability to gases and liquids, and no proton conductivity. Therefore, development of novel supports or modified carbon materials is essential to commercialization of low temperature fuel cell technology. Due to unique metallic/semiconductor characteristics along with excellent environmental stability, facile synthesis and high conductivity, polypyrrole (PPy), a member of the conjugated heterocyclic conducting polymers, has been considered the most promising alternative to carbon supports in fuel cells. Extensive research on PPy-containing catalysts has been reported in the last twenty years. This paper systematically and critically reviews the progress and main achievements of PPy use in both anode and cathode catalysts for low temperature fuel cells. Insight into the remaining challenges and future research directions is also discussed. This journal is © The Royal Society of Chemistry 2013.


Ji X.,Shanghai JiaoTong University | Ji X.,Peking University | Ji X.,University of Maryland University College | Zhang J.-H.,Shanghai JiaoTong University | Zhao Y.,University of Maryland University College
Physics Letters, Section B: Nuclear, Elementary Particle and High-Energy Physics | Year: 2015

We provide a theoretical basis for understanding the spin structure of the proton in terms of the spin and orbital angular momenta of free quarks and gluons in Feynman's parton picture. We show that each term in the Jaffe-Manohar spin sum rule can be related to the matrix element of a gauge-invariant, but frame-dependent operator through a matching formula in large-momentum effective field theory. We present all the matching conditions for the spin content at one-loop order in perturbation theory, which provide a basis to calculate parton orbital angular momentum in lattice QCD at leading logarithmic accuracy. © 2015 The Authors.


Gong B.,State University of New York at Buffalo | Gong B.,Beijing Normal University | Shao Z.,Shanghai JiaoTong University
Accounts of Chemical Research | Year: 2013

The transport of molecules and ions across nanometer-scaled pores, created by natural or artificial molecules, is a phenomenon of both fundamental and practical significance. Biological channels are the most remarkable examples of mass transport across membranes and demonstrate nearly exclusive selectivity and high efficiency with a diverse collection of molecules. These channels are critical for many basic biological functions, such as membrane potential, signal transduction, and osmotic homeostasis.If such highly specific and efficient mass transport or separa tion could be achieved with artificial nanostructures under controlled conditions, they could create revolutionary technologies in a variety of areas. For this reason, investigators from diverse disciplines have vigorously studied small nondeformable nanopores. The most exciting studies have focused on carbon nanotubes (CNTs), which have exhibited fast mass transport and high ion selectivity despite their very simple structure. However, the limitations of CNTs and the dearth of other small (≤2 nm) nanopores have severely hampered the systematic investigation of nanopore-mediated mass transport, which will be essential for designing artificial nanopores with desired functions en masse.Researchers can overcome the difficulties associated with CNT and other artificial pores by stacking macrocyclic building blocks with persistent shapes to construct tunable, self-assembling organic pores. This effort started when we discovered a highly efficient, one-pot macrocyclization process to efficiently prepare several classes of macrocycles with rigid backbones containing nondeformable cavities. Such macrocycles, if stacked atop one another, should lead to nanotubular assemblies with defined inner pores determined by their constituent macrocycles. One class of macrocycles with aromatic oligoamide backbones had a very high propensity for directional assembly, forming nanotubular structures containing nanometer and sub-nanometer hydrophilic pores. These self-assembling hydrophilic pores can form ion channels in lipid membranes with very large ion conductances.To control the assembly, we have further introduced multiple hydrogen-bonding side chains to enforce the stacking of rigid macrocycles into self-assembling nanotubes. This strategy has produced a self-assembling, sub-nanometer hydrophobic pore that not only acted as a transmembrane channel with surprisingly high ion selectivity, but also mediated a significant transmembrane water flux.The stacking of rigid macrocycles that can be chemically modified in either the lumen or the exterior surface can produce self-assembling organic nanotubes with inner pores of defined sizes. The combination of our approach with the availability and synthetic tunability of various rigid macrocycles should produce a variety of organic nanopores. Such structures would allow researchers to systematically explore mass transport in the sub-nanometer regime. Further advances should lead to novel applications such as biosensing, materials separation, and molecular purifications. © 2013 American Chemical Society.


Zeng S.X.,Shanghai JiaoTong University | Xie X.M.,Shanghai University | Tam C.M.,City University of Hong Kong
Technovation | Year: 2010

The complexity of innovation processes led to a tremendous growth in the use of external networks by small- and medium-sized enterprises (SMEs). Based on a survey to 137 Chinese manufacturing SMEs, this paper empirically explores the relationships between different cooperation networks and innovation performance of SME using the technique of structural equation modeling (SEM). The study finds that there are significant positive relationships between inter-firm cooperation, cooperation with intermediary institutions, cooperation with research organizations and innovation performance of SMEs, of which inter-firm cooperation has the most significant positive impact on the innovation performance of SMEs. Surprisingly, the result reveals that the linkage and cooperation with government agencies do not demonstrate any significant impact on the innovation performance of SMEs. In addition, these findings confirm that the vertical and horizontal cooperation with customers, suppliers and other firms plays a more distinct role in the innovation process of SMEs than horizontal cooperation with research institutions, universities or colleges, and government agencies. © 2009 Elsevier Ltd. All rights reserved.


Tsao Y.-C.,Shanghai JiaoTong University | Sheen G.-J.,National Central University
Computers and Operations Research | Year: 2012

Promotional activity has become increasingly more common in the service industry. This research considers a two-echelon multiple-retailer distribution channel under retailers' promotional efforts and the sales learning curve. The competition between retailers arises from substitution effect due to shortages. This paper incorporates the idea of the sales learning curve into the promotion cost. The objective is to solve the retailers' promotion and replenishment decisions under retailer competition and promotional effort with the sales learning curve. The current study considers promotion cost sharing as a mechanism to achieve coordination. The model shows that keeping the fractions of promotion cost sharing within an appropriate range increases profits for all parties. This work also discusses how retailer competition and the sales learning curve affect channel decisions and profits. Concepts from retailer competition and the sales learning curve, along with numerical studies on a few interesting cases help deliver several important managerial insights. These results should be a useful reference for managerial decisions and administrations. © 2011 Elsevier Ltd. All rights reserved.


Tran N.H.,National University of Singapore | Hu J.,National University of Singapore | Li J.,Shanghai JiaoTong University | Ong S.L.,National University of Singapore
Water Research | Year: 2014

There is no quantitative data on the occurrence of artificial sweeteners in the aquatic environment in Southeast Asian countries, particularly no information on their suitability as indicators of raw wastewater contamination on surface water and groundwater. This study provided the first quantitative information on the occurrence of artificial sweeteners in raw wastewater, surface water and groundwater in the urban catchment area in Singapore. Acesulfame, cyclamate, saccharin, and sucralose were ubiquitous in raw wastewater samples at concentrations in the range of ng/L-μg/L, while other sweeteners were not found or found only in a few of the raw wastewater samples. Residential and commercial effluents were demonstrated to be the two main sources of artificial sweeteners entering the municipal sewer systems. Relatively higher concentrations of the detected sweeteners were frequently found in surface waters at the sampling sites located in the residential/commercial areas. No significant difference in the concentrations of the detected sweeteners in surface water or groundwater was noted between wet and dry weather conditions (unpaired T-test, p> 0.05). Relatively higher concentrations and detection frequencies of acesulfame, cyclamate and saccharin in surface water samples were observed at the potentially impacted sampling sites, while these sweeteners were absent in most of the background surface water samples. Similarly, acesulfame, cyclamate, and saccharin were found in most groundwater samples at the monitoring well (GW6), which is located close to known leaking sewer segment; whereas these were absent in the background monitoring well, which is located in the catchment with no known wastewater sources. Taken together, the results suggest that acesulfame, cyclamate, and saccharin can be used as potential indicators of raw wastewater contamination in surface water and groundwater. © 2013 Elsevier Ltd.


Grant
Agency: Cordis | Branch: FP7 | Program: CP | Phase: ICT-2007.4.3 | Award Amount: 8.50M | Year: 2009

ROLEs cross-disciplinary innovations will deliver and test prototypes of highly responsive TEL environments, offering breakthrough levels of effectiveness, flexibility, user-control and mass-individualisation. Our work also advances the state-of-the-art in human resource management; self-regulated and social learning; psycho-pedagogical theories of adaptive education and educational psychology; service composition and orchestration; and the use of ICT in lifelong learning. Significant benefits arise for learners, their communities, employers, TEL developers and society.\nROLE offers adaptivity and personalization in terms of (1) content and navigation and (2) the entire learning environment and its functionalities. This approach permits individualization of the components, tools, and functionalities of a learning environment, and their adjustment or replacement by existing web-based software tools. Learning environment elements can be combined to generate (to mashup) new components and functionalities, which can be adapted by lone learners or collaborating learners to meet their own needs and to enhance the effectiveness of their learning. This empowers each user to generate new tools and functions according to their needs, and can help them to establish a livelier and personally more meaningful learning context and learning experience.\nROLEs generic framework uses an open source approach, interoperable across software systems and technology. Hence any tool created by an individual is available from a pool of services and tools to all learners via the internet, no matter which learning environment, operating system, or device they use, and which subject matter they learn.\nThe consortium consists of well-renown experts covering all required pedagogical and technical competencies. Respective activities have been defined to bring the results of ROLE to the targeted international markets in higher education and corporate training.


Grant
Agency: GTR | Branch: BBSRC | Program: | Phase: Research Grant | Award Amount: 26.14K | Year: 2012

Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.


Grant
Agency: Cordis | Branch: FP7 | Program: CP-TP | Phase: KBBE.2013.3.5-01 | Award Amount: 3.85M | Year: 2013

The Decathlon project will bring together a broad range of experts and expertise to jointly work on the development of new or improved methods that are needed in the field of 1) food pathogens, 2) traceability of GMOs and 3) customs issues. The project will develop advanced methods for all three application areas with method characteristics that meet the requirements of the individual areas, as will be laid down in minimal performance parameters (MPPs) for the types of methods as will be developed within the Decathlon project. Decathlon brings together all relevant molecular biological and bioinformatics expertise through the participation of expert European researchers in the respective fields of application. Besides technical experts, also field-related, application-oriented scientists will participate for the three areas of interest, which are fully aware of the user requirements for the methods to be developed, also in the light of current and future European regulations. By combining this awareness with technical expertise, user requirements will be translated into technical and bioinformatics method requirements that will form the starting-point for the molecular biological technical methods (including any related bioinformatics module, where applicable) to be developed. In this way the Decathlon project will develop focused DNA-based (on-site) methods for the identified areas of food pathogens, GMOs and customs issues, and at the same time stimulate the development of DNA methods for similar applications in numerous other fields that require high-quality, focused DNA-based detection and identification methods. Decathlon will provide the roadmap and blueprint for this broader application of all methods and modules developed in Decathlon. Furthermore, Decathlon will have the cooperation platform and network in place that will be extended effectively throughout the duration of the project as a consolidated European network of analytical experts.


Grant
Agency: Cordis | Branch: H2020 | Program: RIA | Phase: SFS-13-2015 | Award Amount: 6.43M | Year: 2016

MycoKey aims to generate innovative and integrated solutions that will support stakeholders in effective and sustainable mycotoxin management along food and feed chains. The project will contribute to reduce mycotoxin contamination mainly in Europe and China, where frequent and severe mycotoxin contaminations occur in crops, and where international trade of commodities and contaminated batches are increasing. MycoKey will address the major affected crops maize, wheat and barley, their associated toxigenic fungi and related mycotoxins (aflatoxins, deoxynivalenol, zearalenone, ochratoxin A, fumonisins). The project will integrate key information and practical solutions for mycotoxin management into a smart ICT tool (MycoKey App), providing answers to stakeholders, who require rapid, customized forecasting, descriptive information on contamination risk/levels, decision support and practical economically-sound suggestions for intervention. Tools and methodologies will be strategically targeted for cost-effective application in the field and during storage, processing and transportation. Alternative and safe ways to use contaminated batches will be also delivered. The focus of Mycokey will be: i) innovating communications of mycotoxin management by applying ICT, providing input for legislation, enhancing knowledge and networks; ii) selecting and improving a range of tools for mycotoxin monitoring; iii) assessing the use of reliable solutions, sustainable compounds/green technologies in prevention, intervention and remediation. The multi-disciplinary consortium, composed by scientific, industrial and association partners (32), includes 11 Chinese institutions and will conduct the 4 years programme in a framework of international networks.


Grant
Agency: Cordis | Branch: FP7 | Program: CP-IP | Phase: HEALTH.2013.2.2.1-1 | Award Amount: 39.56M | Year: 2013

Traumatic Brain Injury (TBI) is a major cause of death and disability, leading to great personal suffering to victim and relatives, as well as huge direct and indirect costs to society. Strong ethical, medical, social and health economic reasons therefore exist for improving treatment. The CENTER-TBI project will collect a prospective, contemporary, highly granular, observational dataset of 5400 patients, which will be used for better characterization of TBI and for Comparative Effectiveness Research (CER). The generalisability of our results will be reinforced by a contemporaneous registry level data collection in 15-25,000 patients. Our conceptual approach is to exploit the heterogeneity in biology, care, and outcome of TBI, to discover novel pathophysiology, refine disease characterization, and identify effective clinical interventions. Key elements are the use of emerging technologies (biomarkers, genomics and advanced MR imaging) in large numbers of patients, across the entire course of TBI (from injury to late outcome) and across all severities of injury (mild to severe). Improved characterization with these tools will aid Precision Medicine, a concept recently advocated by the US National Academy of Science, facilitating targeted management for individual patients. Our consortium includes leading experts and will bring outstanding biostatistical and neuroinformatics expertise to the project. Collaborations with external partners, other FP7 consortia, and international links within InTBIR, will greatly augment scientific resources and broaden the global scope of our research. We anticipate that the project could revolutionize our view of TBI, leading to more effective and efficient therapy, thus improving outcome and reducing costs. These outcomes reflect the goals of CER to assist consumers, clinicians, health care purchasers, and policy makers to make informed decisions, and will improve healthcare at both individual and population levels.


Grant
Agency: Cordis | Branch: FP7 | Program: CSA-CA | Phase: HEALTH.2010.2.1.1-2 | Award Amount: 2.29M | Year: 2011

A detailed understanding of human biology will require characterisation of the human-associated microorganisms, the human microbiome, and of the roles these microbes play in health and disease. Large projects in Europe, the United States, China and Canada target these objectives, using high throughput omics approaches. Given the complexity of our microbial communities, composed of thousands of species and differing considerably between individuals, as well as the multitude of effects they have on our biology, none of the projects can hope to achieve their comprehensive characterisation. To progress most efficiently towards this ambitious goal it is of utmost importance that the data generated in each individual project be optimally comparable across all the current projects and those yet to come. Our proposal seeks to coordinate development of standard operating procedures and protocols, which will optimize data comparisons in the human microbiome field and thus improve the synergy between all the projects. It focuses on three key aspects of data generation: (i) human sample collection, processing and identification via the associated metadata; (ii) DNA sequence quality obtained by the new generation methods from complex microbial mixtures; (iii) analysis of DNA sequence in conjunction with the metadata. Importantly, it organises public access to the standard operating procedures and protocols and enables exchanges between the users and providers of the standards. It gathers very strong international partnership that includes leaders in the field and represents the current large projects, which span three continents, Europe, Asia and America. Furthermore, it interfaces via the International Human Microbiome Consortium with additional projects from Africa and Australia. The proposal is thus highly congruent with the focus of the call, which targets omics, standards and international context.


Grant
Agency: Cordis | Branch: FP7 | Program: CP | Phase: ENERGY.2009.2.1.1 | Award Amount: 8.85M | Year: 2010

In this project we will increase the efficiency of thin-film silicon solar cells on flexible substrates by solving the issues linked to material quality, interface properties and light management, thus enabling lower production costs per Watt-peak. The general technological objectives of the project are the development of better materials and enhanced interfaces for thin film silicon solar cells, and to transfer the developed processes to an industrial production line. The most important project goals are: 1) Reduction of optical reflection and parasitic absorption losses: Design and industrial implementation of textured back contacts in flexible thin film silicon solar cells. 2) Reduction of recombination losses: Development and implementation of improved silicon absorber material. 3) Reduction of electric losses: Graded TCO layers which minimize the work function barrier between the p-layer and the TCO layer without loss of conductivity and transmission of the TCO. In addition, the top layer of the TCO stack should provide a good protection against moisture ingression. In order to achieve these objectives more in-depth knowledge is needed for several relevant key areas for thin film silicon solar cells. The main scientific objectives are: 1) Identification of the ideal texture for the back contact. This structure should maximize the light trapping in thin film silicon solar cells without deterioration of open-circuit voltage and fill factor. 2) Paradigm shift for the growth of microcrystalline silicon. In this project we want to show that it is possible to use microcrystalline silicon with high crystalline fractions leading to better current collection without voltage losses, and without crack formation when grown on nano-textured substrates. 3) Deeper understanding of moisture degradation mechanisms of common TCOs like ITO and AZO.


Grant
Agency: Cordis | Branch: H2020 | Program: RIA | Phase: INT-04-2015 | Award Amount: 3.72M | Year: 2016

This Project aims to address an increasingly pressing global challenge: How to achieve the EUs development goals and the UNs Sustainable Development Goals, while meeting the global target of staying within two degrees global warming and avoid transgressing other planetary boundaries. EU policies must align with sustainable development goals (Article 11 TFEU). The impacts of climate change and global loss of natural habitat undermine the progress achieved by pursuing the Millennium Development Goals and threaten the realisation of EU development policy goals. Our focus is the role of EUs public and private market actors. They have a high level of interaction with actors in emerging and developing economies, and are therefore crucial to achieving the EUs development goals. However, science does not yet cater for insights in how the regulatory environment influences their decision-making, nor in how we can stimulate them to make development-friendly, environmentally and socially sustainable decisions. Comprehensive, ground-breaking research is necessary into the regulatory complexity in which EU private and public market actors operate, in particular concerning their interactions with private and public actors in developing countries. Our Consortium, leading experts in law, economics, and applied environmental and social science, is able to analyse this regulatory complexity in a transdisciplinary and comprehensive perspective, both on an overarching level and in depth, in the form of specific product life-cycles: ready-made garments and mobile phones. We bring significant new evidence-based insights into the factors that enable or hinder coherence in EU development policy; we will advance the understanding of how development concerns can be successfully integrated in non-development policies and regulations concerning market actors; and we provide tools for improved PCD impact assessment as well as for better corporate sustainability assessment.


Adequate sperm motility is requisite for human fertilization, whereas the underlying causes or mechanisms of impaired sperm motility, asthenozoospermia, still remain largely unknown. RNASET2 (Ribonuclease T2) may be one of the effectors modulating human sperm motility. We determined if there is a correlation between RNASET2 expression levels in human semen from asthenozoospermia and fertile individuals. Thus, RNASET2 expression levels in spermatozoa and seminal plasma of healthy and asthenozoospermia individuals were evaluated using Western blot, laser scanning confocal microscope analysis, ELISA and flow cytometry. The results revealed that RNASET2 expression was identified in both human spermatozoa and seminal plasma. In spermatozoa from fertile individuals, it was localized to the acrosome, neck and the middle piece of tail regions. However, in spermatozoa from asthenozoospermia individuals (n = 67), RNASET2 staining was especially more frequent and evident in the neck and middle piece than that in fertile individuals (n = 59, p < 0.01). Similarly, higher RNASET2 expression was also apparent in seminal plasma from asthenozoospermia than in fertile individuals (p < 0.01). Moreover, purified RNASET2 had an inhibitory effect on sperm motility, especially on progressive motility (n = 23, p < 0.05). In conclusion, higher expression of RNASET2 in the semen of asthenozoospermia individuals may contribute to sperm motility impairment. © 2012 American Society of Andrology and European Academy of Andrology.


Zhong M.,Shanghai JiaoTong University | Bian Z.,Shanghai JiaoTong University | Wu Z.,Shanghai JiaoTong University
Cellular Physiology and Biochemistry | Year: 2013

Background/Aims: MicroRNAs (miRNAs) play key roles in tumor metastasis. The aim of this study was to determine the regulation and function of miR-30a in colorectal carcinoma (CRC) metastasis. Methods: The expression of miR-30a was detected in CRC cell lines and samples by qRT-PCR. The anti-metastatic effect of miR-30a was determined by both in vitro and in vivo assays. A luciferase reporter assay was performed to determine target association between miR-30a and phosphoinositide 3-kinase catalytic subunit delta (PIK3CD). Results: miR-30a was significantly downregulated in highly metastatic CRC cell lines and metastatic tissues. Overexpression of miR-30a suppressed CRC cell migration and invasion in vitro and liver metastasis in vivo, whereas miR-30a deletion dramatically promoted cell migration and invasion. Further studies revealed that PIK3CD is a direct target of miR-30a as miR-30a bounds directly to the 3'-UTR of PIK3CD, subsequently reducing its expression. Similar to the restoring miR-30a expression, PIK3CD downregulation inhibited cell migration and invasion, whereas PIK3CD overexpression rescued the suppressive effect of miR-30a. Moreover, significant downregulation of miR-30a in metastatic CRC tissues was found to be inversely correlated with PIK3CD expression. Mechanistic studies revealed that miR-30a down-regulated the expression of key components of the Akt/mTOR pathway, whereas PIK3CD overexpression reversed this negative effect. Conclusion: Our findings indicate that miR-30a might function as a metastasis suppressor in CRC. miR-30a may be a potential therapeutic target to block CRC metastasis. © 2013 S. Karger AG, Basel.


Zhao Y.,Shanghai JiaoTong University | Hu G.,Shanghai JiaoTong University
RSC Advances | Year: 2013

A novel flue gas desulfurization process, which applies a mixture of caprolactam tetrabutyl ammonium bromide ionic liquid ([CPL][TBAB] IL) and sodium humate (HA-Na) solution, was proposed. This study relates to the SO2 absorption efficiency and products of removing SO2 in a bubbling reactor, especially the effect of recycling the mixed aqueous solution. The experimental results indicate that the maximum absorption efficiency of SO 2 approaches almost 95%, thereby allowing this mixed solution to be used repeatedly up to 5 cycles. However, the initial pH of the mixed aqueous solution, which was prepared by recycling the mixed solution, dropped from 10 to 7.5 while the cycle number increased from 1 to 5. Meanwhile the final pH of the mixed aqueous solution remains almost a constant (2.1) after the completed absorption reaction. The desulfurization time and the absorption amount of SO2 decreased as the cycle number rises. The FT-IR spectroscopic and XPS results of desulfurization product show that humic acid (HA) can be sulfonated to some extent in this process. This finding provides a testimony that HA can react with sodium bisulfite in a Michael addition reaction, and [CPL][TBAB] IL can play a role in this reaction as a catalyst. The chief by-product is compound fertilizer consisting of sulfonated HA and sulfates. © 2013 The Royal Society of Chemistry.


Chou K.-C.,Gordon Life Science Institute | Chou K.-C.,Shanghai JiaoTong University | Shen H.-B.,Gordon Life Science Institute | Shen H.-B.,Shanghai JiaoTong University
PLoS ONE | Year: 2010

Information of subcellular locations of proteins is important for in-depth studies of cell biology. It is very useful for proteomics, system biology and drug development as well. However,most existing methods for predicting protein subcellular location can only cover 5 to 12 location sites. Also, they are limited to deal with single-location proteins and hence failed to work for multiplex proteins, which can simultaneously exist at, or move between, two or more location sites. Actually, multiplex proteins of this kind usually posses some important biological functions worthy of our special notice. A new predictor called "Euk-mPLoc 2.0" is developed by hybridizing the gene ontology information, functional domain information, and sequential evolutionary information through three different modes of pseudo amino acid composition. It can be used to identify eukaryotic proteins among the following 22 locations: (1) acrosome, (2) cell wall, (3) centriole, (4) chloroplast, (5) cyanelle, (6) cytoplasm, (7) cytoskeleton, (8) endoplasmic reticulum, (9) endosome, (10) extracell, (11) Golgi apparatus, (12) hydrogenosome, (13) lysosome, (14) melanosome, (15) microsome (16) mitochondria, (17) nucleus, (18) peroxisome, (19) plasma membrane, (20) plastid, (21) spindle pole body, and (22) vacuole. Compared with the existing methods for predicting eukaryotic protein subcellular localization, the new predictor is much more powerful and flexible, particularly in dealing with proteins with multiple locations and proteins without available accession numbers. For a newly-constructed stringent benchmark dataset which contains both single- and multiple-location proteins and in which none of proteins has ≥25% pairwise sequence identity to any other in a same location, the overall jackknife success rate achieved by Euk-mPLoc 2.0 is more than 24% higher than those by any of the existing predictors. As a user friendly web-server, Euk-mPLoc 2.0 is freely accessible at http://www.csbio.sjtu.edu.cn/bioinf/euk-multi-2/. For a query protein sequence of 400 amino acids, it will take about 15 seconds for the web-server to yield the predicted result; the longer the sequence is, the more time it may usually need. It is anticipated that the novel approach and the powerful predictor as presented in this paper will have a significant impact to Molecular Cell Biology, System Biology, Proteomics, Bioinformatics, and Drug Development. © 2010 Chou, Shen.


Chen D.,Shanghai JiaoTong University | Gyllensten U.,Uppsala University
Carcinogenesis | Year: 2014

The major histocompatibility complex class I polypeptide-related sequence A gene (MICA) encodes a membrane-bound protein acting as a ligand to stimulate an activating receptor, NKG2D, expressed on the surface of essentially all human natural killer (NK), γδ T and CD8(+) αβ T cells. MICA protein is absent from most cells but can be induced by infections and oncogenic transformation and is frequently expressed in epithelial tumors. Upon binding to MICA, NKG2D activates cytolytic responses of NK and γδ T cells against infected and tumor cells expressing MICA. Therefore, membrane-bound MICA acts as a signal during the early immune response against infection or spontaneously arising tumors. On the other hand, human tumor cells spontaneously release a soluble form of MICA, causing the downregulation of NKG2D and in turn severe impairment of the antitumor immune response of NK and CD8(+) T cells. This is considered to promote tumor immune evasion and also to compromise host resistance to infections. MICA is the most polymorphic non-classical class I gene. A possible association of MICA polymorphism with genetic predisposition to different cancer types has been investigated in candidate gene-based studies. Two genome-wide association studies have identified loci in MICA that influence susceptibility to cervical neoplasia and hepatitis C virus-induced hepatocellular carcinoma, respectively. Given the current level of interest in the field of MICA gene, we discuss the genetics and biology of the MICA gene and the role of its polymorphism in cancer. Gaps in our understanding and future research needs are also discussed. © The Author 2014. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.


Liu Y.,Shanghai JiaoTong University
The Tohoku journal of experimental medicine | Year: 2011

Lymphotoxin-alpha (LTA), a pro-inflammatory cytokine, has been implicated in the pathogenesis of coronary atherosclerosis. Meanwhile, association of some single nucleotide polymorphisms (SNPs) of LTA gene with coronary artery disease (CAD) has been evaluated; however, the results are irreproducible. We therefore investigated the relationship between four SNPs of LTA gene and CAD in Han Chinese: G+10A (rs1800683, 5'-untranslated region), A+80C (rs2239704, 5'-untranslated region), T+496C (Cys13Arg, rs2229094, exon 2), and C+804A (Thr26Asn, rs1041981, exon 3). Genotyping was performed in 438 CAD patients and 330 healthy controls. Single-locus analysis showed that the genotype and allele frequencies of G+10A polymorphism exhibited marginal differences between CAD patients and controls, although no statistical significance was observed after the Bonferroni correction. Logistic regression analysis revealed that GG genotype of G+10A polymorphism was significantly associated with the risk of CAD under the dominant mode, whereas no significant association was detected between A+80C polymorphism and CAD. In contrast, individuals carrying TT or TC genotype of T+496C polymorphism showed a decreased CAD risk relative to those with CC genotype under the recessive mode. Likewise, CC genotype of C+804A polymorphism was associated with a protective effect on CAD under the dominant mode. Further, in haplotype analysis, the haplotype G-C-T-C (in order of rs1800683, rs2239704, rs2229094 and rs1041981) was significantly associated with a decreased risk of CAD after assigning the most common haplotype A-C-T-A as a reference. In conclusion, we show a protective effect of the haplotype G-C-T-C on the occurrence of CAD, suggesting the involvement of LTA in CAD pathogenesis.


Zhang Y.X.,Shanghai JiaoTong University
International journal of nanomedicine | Year: 2011

In this paper, a new method of one-pot biosynthesizing of gold nanoparticles (GNPs), using chloroplasts as reductants and stabilizers is reported. The as-prepared GNPs were characterized by ultraviolet visible spectroscopy, transmission electron microscopy, X-ray powder diffraction, and Fourier transform infrared spectroscopy (FTIR). The cytotoxicity of the GNPs was evaluated using the 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) method against gastric mucous cell line GES-1 and gastric cancer cell line MGC-803. Rhodamine 6G as a Raman probe was used for investigating surface-enhanced Raman spectroscopy (SERS) enhancement of GNPs. The transmission electron microscopy results indicated that the GNPs were spherical in structure and almost 20 nm in diameter. Ultraviolet visible spectroscopy exhibited an absorption peak at 545 nm. The GNPs exhibited high crystallinity, with the (111) plane as the predominant orientation, clarified by X-ray powder diffraction. In addition, a potential mechanism was proposed to interpret the formation process of GNPs, mainly based on the analysis of FTIR results. The FTIR spectrum confirmed that the GNPs were carried with N-H groups. Toxicological assays of as-prepared GNPs revealed that the green GNPs were nontoxic. SERS analysis revealed that the GNPs without any treatment could substantially enhance the Raman signals of rhodamine 6G. The Raman enhancement factor was calculated to be nearly 10(10) orders of magnitude. In conclusion, the GNPs with good biocompatibility and excellent SERS effect were successfully synthesized using chloroplasts. These biogenetic GNPs have great potential for ultrasensitive detection of biomarkers in vitro and in vivo based on SERS.


Li S.,Shanghai JiaoTong University | Gu M.,Shanghai JiaoTong University
International Journal of Production Economics | Year: 2012

We investigate the effect of tradable emission permits with banking on the production-inventory strategy of a firm in this paper. The basis of the work is the well-known Arrow-Karlin dynamic production-inventory model, in which the inventory holding costs are linear, and production costs are non-decreasing and convex functions of the production level. The cost of environmental protection is taken into account in the model. We assume there is an emission trading program, with which firms are able to purchase their emission rights or sell them, and the rights are allowed to be deposited in intertemporal trading. We compare the optimal production-inventory strategies of this paper with those without emission permits. © 2012 Elsevier B.V. All rights reserved.


Peng Y.,Shanghai JiaoTong University | Dong M.,Shanghai JiaoTong University
Mechanical Systems and Signal Processing | Year: 2011

Health monitoring and prognostics of equipment is a basic requirement for condition-based maintenance (CBM) in many application domains. This paper presents an age-dependent hidden semi-Markov model (HSMM) based prognosis method to predict equipment health. By using hazard function (h.f.), CBM is based on a failure rate which is a function of both the equipment age and the equipment conditions. The state values of the equipment condition considered in CBM, however, are limited to those stochastically increasing over time and those having non-decreasing effect on the hazard rate. The previous HSMM based prognosis algorithm assumed that the transition probabilities are only state-dependent, which means that the probability of making transition to a less healthy state does not increase with the age. In the proposed method, in order to characterize the deterioration of equipment, three types of aging factors that discount the probabilities of staying at current state while increasing the probabilities of transitions to less healthy states are integrated into the HSMM. With an iteration algorithm, the original transition matrix obtained from the HSMM can be renewed with aging factors. To predict the remaining useful life (RUL) of the equipment, hazard rate is introduced to combine with the health-state transition matrix. With the classification information obtained from the HSMM, which provides the current health state of the equipment, the new RUL computation algorithm could be applied for the equipment prognostics. The performances of the HSMMs with aging factors are compared by using historical data colleted from hydraulic pumps through a case study. © 2010 Elsevier Ltd. All rights reserved.


Li Z.,Shanghai JiaoTong University | Li Z.,South China University of Technology | Yang C.,University of Plymouth
IEEE Transactions on Control Systems Technology | Year: 2012

The wheeled inverted pendulum (WIP) models have been widely applied in the transportation vehicles formed by a mobile wheeled inverted pendulum system with an operator (demonstrated in Fig.1 ). In this paper, we focus on the study of nonlinear control design for the WIP model-based vehicles, for which accurate dynamics could not be obtained beforehand due to the presence of uncertainties caused by the human operator as well as the vehicle. We develop an output feedback adaptive neural network (NN) control incorporating a linear dynamic compensator to achieve stable dynamic balance and tracking of the desired given trajectories. Comparison simulation studies demonstrate guaranteed tracking performance and stable dynamics balance in the presence of uncertainties and thus verify the efficiency of the developed nonlinear controller. © 2012 IEEE.


Shen H.-S.,Shanghai JiaoTong University
Journal of Engineering Mechanics | Year: 2013

This paper presents a study on the thermal postbuckling response of a shear deformable functionally graded cylindrical shell of finite length embedded in a large outer elastic medium. The surrounding elastic medium is modeled as a Pasternak foundation. Two kinds of micromechanics models, namely the Voigt model and Mori-Tanaka model, are considered. The governing equations are based on a higher-order shear deformation shell theory that includes shell-foundation interaction. The thermal effects are also included and the material properties of functionally graded materials (FGMs) are assumed to be temperature dependent. The governing equations are solved by a singular perturbation technique. The numerical results show that in some cases the FGM cylindrical shell with intermediate volume fraction index does not have intermediate buckling temperature and thermal postbuckling strength. The results reveal that Voigt model and Mori-Tanaka model have the same accuracy for predicting the thermal buckling and postbuckling behavior of FGM shells. The results confirm that for the case of heat conduction, the postbuckling equilibrium path for geometrically perfect FGM cylindrical shells with simply supported boundary conditions is no longer of the bifurcation type. © 2013 American Society of Civil Engineers.


Wang X.-L.,Shanghai JiaoTong University
Journal of Aircraft | Year: 2012

In this paper, an approach that can obtain the stability derivatives through the unsteady computational fluid dynamics approach and Fourier analysis is proposed. Hybrid grids composed of boundary-layer viscous structure meshes and unstructured meshes were used. The flowfield was divided into two regions: the inner region and the outer region. The dynamic deformation grid was updated through the grid move with the body in the inner region and spring analogy in the outer region. This method can keep the quality of mesh preferably than one whole region dynamic mesh method during the course of movement of body. The validity of the computational method and dynamic mesh approach was verifiedbythe calculationofthe AGARD NACA 0012 airfoil. The calculation method of stability derivatives was verified by 6:1 prolate spheroid. The effects of the presence of the fins onstability derivatives of the airship were analyzed in this paper. The method proposed in this paper can be used to calculate the stability derivatives for other aircraft and submarine vehicles. Copyright © 2012 by the American Institute of Aeronautics and Astronautics, Inc.


Li B.,Shanghai JiaoTong University | Jiang X.,Shanghai JiaoTong University | Yin J.,Shanghai JiaoTong University
Journal of Materials Chemistry | Year: 2012

We here designed and prepared a multi-responsive microgel (hPEA-mGel) fabricated through the co-assembly of hyperbranched poly(ether amine) and pentaerythritol tetra(3-mercaptopropionate) (PTMP) in aqueous solution, followed by thiol-ene photo-click crosslinking. The obtained hPEA-mGel is uniform-sized particles with 250 nm diameter and low polydispersity index (PDI = 0.15), and exhibited sharp responses to temperature and pH. The interaction between the host hPEA-mGel and a series of fluorescein dyes was investigated. hPEA-mGel exhibited strong adsorption to ETB, RB, EB, DBF and TCF, but very low affinity to FR and Cal. The big difference in the interaction between hPEA-mGel and different fluorescein dyes is indicative of the selective adsorption of hPEA-mGel to fluorescein dyes, which resulted from hydrophobic not electrostatic interactions. Based on the selective adsorption of fluorescein dyes by hPEA-mGel, we demonstrated a simple approach to separate a mixture of fluorescein dyes in aqueous solution. © 2012 The Royal Society of Chemistry.


Wang L.,Shanghai JiaoTong University | Wang X.,Shanghai JiaoTong University
Systems and Control Letters | Year: 2011

This paper investigates synchronization in a typical multi-agent system in which the communication network changes according to the system state. Through building new relationships between a matrix and its associated graph and estimating the diameter of the communication network, we prove that synchronization can be achieved if the speed of agents is bounded by O(n- β), where n is the number of agents and β is bounded by a constant independent of n, which is much better than the existing bound O(n-n). Some simulations are provided to illustrate the theoretical results. © 2011 Elsevier B.V. All rights reserved.


Huo J.,Shanghai JiaoTong University | Chen X.,Shanghai JiaoTong University
Optics Express | Year: 2012

Herein, we propose a phenomenon of "polarization-coupling (PC) cascading" generated in MgO doped periodically poled lithium niobate crystal (PPMgLN). PC cascading contributes to the effective electro-optical (EO) Kerr effect that is several orders of magnitude stronger than the classical ones. Experiment of Newton's rings demonstrates the large phase accumulation during the PC cascaded processes, and the experimental data is identical with the theoretical simulation. ©2012 Optical Society of America.


He Y.,Shanghai JiaoTong University | Xu Z.,Shanghai JiaoTong University
Waste Management and Research | Year: 2014

A large quantity of waste electrical and electronic equipment (WEEE) is being generated because technical innovation promotes the unceasing renewal of products. China's household appliances and electronic products have entered the peak of obsolescence. Due to lack of technology and equipment, recycling of WEEE is causing serious environment pollution. In order to achieve the harmless disposal and resource utilization of WEEE, researchers have performed large quantities of work, and some demonstration projects have been built recently. In this paper, the treatment techniques of typical WEEE components, including printed circuit boards, refrigerator cabinets, toner cartridges, cathode ray tubes, liquid crystal display panels, batteries (Ni-Cd and Li-ion), hard disk drives, and wires are reviewed. An integrated recycling system with environmentally friendly and highly efficient techniques for processing WEEE is proposed. The orientation of further development for WEEE recycling is also proposed. © The Author(s) 2014.


Zheng X.,Shanghai JiaoTong University | Ge T.S.,Shanghai JiaoTong University | Wang R.Z.,Shanghai JiaoTong University
Energy | Year: 2014

SDC (Solid desiccant cooling) systems have gained increasing interest as an alternative air conditioning technology. Performance of desiccant plays a crucial role in overall performance of the whole system, especially in terms of dehumidification and regeneration capacity. It is desirable to explore desiccant possessing high adsorption capacity and good regeneration ability. Thus, this review summarizes recent researches and developments on novel solid desiccant materials that can be adopted in SDC systems. The materials include composite desiccants, nanoporous inorganic materials and polymeric desiccants. Adsorption isotherms are concluded and compared. Regeneration ability is also considered for full use of low grade thermal energy. Results show that by proper selection of host matrix and immersed salts, composite desiccants have improved capacity of dehumidification and regeneration. Besides, a good balance can be reached between regeneration and adsorption capacity by tailoring textural properties of nanoporous inorganic materials. For polymeric desiccants, especially MIL type (materials of Institute Lavoisier Frameworks), further progress in adsorptive dehumidification will be anticipated. Though some novel materials approach requirements for SDC systems, no material currently available can perfectly satisfy all the required demands. In this case, more intensive researches in the field of development and evaluation of advanced materials are still required. © 2014 Elsevier Ltd.


Ge T.S.,Shanghai JiaoTong University | Dai Y.J.,Shanghai JiaoTong University | Wang R.Z.,Shanghai JiaoTong University
Renewable and Sustainable Energy Reviews | Year: 2014

Rotary desiccant wheel cooling system operates on the principle of adsorption dehumidification and evaporative cooling. The system adopts natural substance as working fluid and can be driven by low grade thermal energy such as solar energy. Due to these merits, solar powered rotary desiccant wheel cooling system has recognized as one of good alternatives to conventional vapor compression air conditioning system and has obtained increasing interests in the past years. This paper aims to summarize recent research developments related to solar powered rotary desiccant wheel cooling system and to provide information for potential application. Based on whether auxiliary refrigeration system is adopted, the systems are divided in to two categories: separate solar powered rotary desiccant wheel cooling systems and hybrid solar powered rotary desiccant wheel cooling systems. Within the first category, separate solar powered rotary desiccant wheel cooling systems are reviewed according to different types of solar collector. It can be found that these researches mainly focus on feasibility study of such system under different climates. Results show that separate solar powered rotary desiccant wheel cooling systems can be adopted in several representative cities in Europe, Asia, Australia and Africa. However, system performance in terms of solar fraction and thermal coefficient of performance varies greatly with respect to different operation conditions. For the second category, works related to hybrid solar powered rotary desiccant wheel cooling systems are grouped by types of auxiliary refrigeration systems. It can be found that vapor compression system is widely adopted in these hybrid systems. Also, due to both solar energy and electricity are consumed in hybrid systems, primary energy consumption is an important performance index. Results show that hybrid solar powered rotary desiccant wheel cooling system can obtain significant energy saving compared with conventional vapor compression system. © 2014 Elsevier Ltd.


Wu J.,Shanghai JiaoTong University | Wang Z.-X.,Shanghai JiaoTong University | Wang G.-Q.,Shanghai JiaoTong University
Renewable and Sustainable Energy Reviews | Year: 2014

China is one of the largest energy consumers in the world. Excessive consumption of coal and other primary energy causes serious environmental pollution and energy crisis. China must wean from the over-reliance on coal and needs to make great efforts to develop clean and efficient renewable energy. In recent years, offshore wind energy has been developing rapidly with the advantages of not taking up land resources and high utilization rate. By the end of 2012, the total installed capacity of offshore wind power was 389.6 MW in China. The planning capacity will be 5 GW by 2015 and 30 GW by 2020 [1,2]. Compared to onshore wind power, the development of offshore wind power is facing some new problems and challenges, for example power transmission, offshore harsh natural environments, multi-sectoral coordination and management, and so on. This paper firstly analyzes the irrationality of China's energy consumption structure and the necessity for developing offshore wind power. Secondly, an overview of offshore wind farm access, AC (Alternating Current) and DC (Direct Current) transmission technologies and offshore wind turbine control strategies are given. The development status and future plans of offshore wind power are also introduced. Finally, we analyze the existing problems and obstacles during the construction process of offshore wind farms from three aspects, including technical, economic, and national policies. And some corresponding recommendations to accelerate the development of offshore wind farm are also proposed. © 2014 Elsevier B.V. All rights reserved.


Lu J.,Shanghai JiaoTong University | Wang H.,Shanghai JiaoTong University
Optics Express | Year: 2012

Mn-doped ZnO has attracted considerable attention as an important kind of diluted magnetic semiconductors (DMSs). Here we report a new finding of lateral photovoltaic effect (LPE) in Mn-doped ZnO thin film based on DMS/SiO 2/Si structure. Remarkably the induced LPE laser can be extended to infrared region in Mn-doped ZnO film. Besides we studied the dependence of the lateral photovoltage (LPV) position sensitivity on the laser wavelength and optical power by modulating the two factors and give a complete theoretical analysis. The LPE observation adds a significant new functionality to this DMS material and suggests Mndoped ZnO a potential candidate for versatile devices. © 2012 Optical Society of America.


Liu Y.,Shanghai JiaoTong University | Wang B.,Shanghai JiaoTong University
Physical Review D - Particles, Fields, Gravitation and Cosmology | Year: 2012

We investigate the quasinormal mode of the perturbation of the scalar field interacting with the electromagnetic field in the backgrounds of neutral AdS black hole, the Reissner-Nordstrom AdS black hole, and the Born-Infeld AdS black hole. We study the influence of the electric charge Q, the coupling q between electromagnetic and scalar field, and the Born-Infeld parameter b on the quasinormal frequencies of the scalar perturbations. We observe the possible growing mode when the perturbation of the scalar field strongly couples to the electromagnetic field. When the electromagnetic field becomes nonlinear described by the Born-Infeld electrodynamics, the nonlinearity described by the Born-Infeld parameter can hinder the instability to happen in the scalar perturbation. The quasinormal behavior of the scalar field perturbation can help us further understand the physics in the holographic superconductor. © 2012 American Physical Society.


Tao J.,Shanghai JiaoTong University | Yu S.,Shanghai JiaoTong University
Applied Energy | Year: 2011

Due to the rapid economic development, living standards in China are improving fast. Chinese families are having more household electrical appliances, among which refrigerators are indispensable. Energy consumption of refrigerators is huge in China and causes environmental concerns. China has issued the national energy efficiency standards of household refrigerators, GB12021.2-2003 and GB12021.2-2008 to promote high-efficiency refrigerator production and use. This study evaluated the impacts of the standards on the environment, manufacturers and consumers over a long-term period of 2003-2023. It first evaluated the potential electricity conservation and GHG emission reduction resulting from energy efficiency improvements driven by the standards. Next, manufacturers' technological and economic concerns about complying with the standards were discussed. Some efficiency improving design options were considered and the resulting increases in manufacturing cost and retail price were estimated. The return of consumers from invest in efficiency was analyzed based on lifecycle cost saving of the improved models. The economical viability of the standards was then evaluated by national consumer costs and benefits. Results showed that the considered efficiency standards will potentially save a cumulative total of 588-1180TWh electricity, and reduce emission of 629-1260million tons of CO2, 4.00-8.04million tons of SOx and 2.37-4.76million tons of NOx by 2023, depending on sale share of models by efficiency. In a more environmentally optimal case (75% sale share of high-efficiency models), the national consumer benefits are 121billion RMB (discounted), with the benefit/cost ratio of consumer's expenditure being 1.45:1. However, the preference to high-efficiency models is substantial influenced by consumer's expectation on return from the additional cost on efficiency. © 2010 Elsevier Ltd.


Wang R.-H.,Shanghai JiaoTong University
World Journal of Gastroenterology | Year: 2015

The occurrence of gastroesophageal reflux disease is common in the human population. Almost all cases of esophageal adenocarcinoma are derived from Barrett's esophagus, which is a complication of esophageal adenocarcinoma precancerous lesions. Chronic exposure of the esophagus to gastroduodenal intestinal fluid is an important determinant factor in the development of Barrett's esophagus. The replacement of normal squamous epithelium with specific columnar epithelium in the lower esophagus induced by the chronic exposure to gastroduodenal fluid could lead to intestinal metaplasia, which is closely associated with the development of esophageal adenocarcinoma. However, the exact mechanism of injury is not completely understood. Various animal models of the developmental mechanisms of disease, and theoretical and clinical effects of drug treatment have been widely used in research. Recently, animal models employed in studies on gastroesophageal reflux injury have allowed significant progress. The advantage of using animal models lies in the ability to accurately control the experimental conditions for better evaluation of results. In this article, various modeling methods are reviewed, with discussion of the major findings on the developmental mechanism of Barrett's esophagus, which should help to develop better prevention and treatment strategies for Barrett's esophagus. © 2015 Baishideng Publishing Group Inc. All rights reserved. © 2015 The Author(s).


Li F.,Shanghai JiaoTong University
Molecular Human Reproduction | Year: 2013

In mammals, the sense of taste helps in the evaluation and consumption of nutrients, and in avoiding toxic substances and indigestible materials. Distinct cell types expressing unique receptors detect each of the five basic tastes: salty, sour, bitter, sweet and umami. The latter three tastes are detected by two distinct families of G protein-coupled receptors: T2Rs and T1Rs. Interestingly, these taste receptors have been found in tissues other than the tongue, such as the digestive system, respiratory system, brain, testis and spermatozoa. The functional implications of taste receptors distributed throughout the body are unknown. We therefore reviewed the remarkable advances in our understanding of the molecular basis of taste perception in 'taste' and 'non-taste' tissues. We also present our speculations on the direction of further research in the field of male reproduction ©The Author 2013.


Guan N.,National University of Defense Technology | Tao D.,University of Technology, Sydney | Luo Z.,National University of Defense Technology | Yuan B.,Shanghai JiaoTong University
IEEE Transactions on Neural Networks | Year: 2011

In this paper, we present a non-negative patch alignment framework (NPAF) to unify popular non-negative matrix factorization (NMF) related dimension reduction algorithms. It offers a new viewpoint to better understand the common property of different NMF algorithms. Although multiplicative update rule (MUR) can solve NPAF and is easy to implement, it converges slowly. Thus, we propose a fast gradient descent (FGD) to overcome the aforementioned problem. FGD uses the Newton method to search the optimal step size, and thus converges faster than MUR. Experiments on synthetic and real-world datasets confirm the efficiency of FGD compared with MUR for optimizing NPAF. Based on NPAF, we develop non-negative discriminative locality alignment (NDLA). Experiments on face image and handwritten datasets suggest the effectiveness of NDLA in classification tasks and its robustness to image occlusions, compared with representative NMF-related dimension reduction algorithms. © 2011 IEEE.


Wang L.,Shanghai JiaoTong University | Chen M.,Shanghai JiaoTong University
Journal of Cleaner Production | Year: 2013

In recent years, China's end-of-life vehicle (ELV) recycling industry has kept abreast with the rapidly developing automotive industry, and the laws and regulations are continuously being improved. However, no existing literature systematically introduces and analyzes such ELV policies. This paper classified such policies and regulations, which can be used to analyze China's ELV recycling industry to facilitate its development. The study referred to the experience of ELV laws and EPR (extended producer responsibility) implementation of the developed countries, and proposed strategies and perspectives to Chinese government to improve the policies and regulations for China's ELV recycling industry. © 2012 Elsevier Ltd. All rights reserved.


Kuang Z.-B.,Shanghai JiaoTong University
Acta Mechanica | Year: 2014

The physical variational principle (PVP) in a static magneto-elastic field without source current is discussed first, and then, the PVP in a general electromagnetic field is derived. It is especially useful in the plate vibration problem. Using the PVP and the pseudo total stress principle, the electro-magneto-elastic thin plate bending theory in first order and a Mindlin-type plate bending theory for a moderate thickness plate are easily obtained. This method significantly simplifies the derivation of the governing equations of the thin and moderate plates with nonlinear electromagnetic behavior. The Maxwell stress is naturally included in the governing equation. Using the governing equation of a thin plate, the analyses of the stability and vibration of a plate in an external homogeneous magnetic field are discussed. © 2014 Springer-Verlag Wien.


Han W.,Shanghai JiaoTong University | He M.,Shanghai JiaoTong University
Bioresource Technology | Year: 2010

The effects of exogenous cellulase application on straw decomposition, soil fertility, and plant growth were investigated with nylon bag and pot experiments. Cellulase application promoted straw decomposition, and the decomposition rates of rice and wheat straw increased by 6.3-26.0% and 6.8-28.0%, respectively, in the nylon bag experiments. In pot experiments soil-available N and P contents, soil cellulase activity, and growth of rice seedlings increased. Soil respiration rate and microbial population were unaffected. Seventy U g-1 was the optimal cellulase concentration for plant growth. The exogenous cellulase persisted in soil for more than 100 days. Although the data show that exogenous cellulase application can enhance soil fertility and plant growth in the short-term due to the acceleration of straw decomposition and has the potential to be an environment-friendly approach to manage straw, cellulase application to soil seems currently not economical. © 2009 Elsevier Ltd. All rights reserved.


Sun K.,Shanghai JiaoTong University | Liu J.,Shanghai JiaoTong University | Ning G.,Shanghai JiaoTong University
PLoS ONE | Year: 2012

Background: Epidemiological evidence suggests that smoking has been associated with emergence of metabolic syndrome. However, data on this issue are inconsistent and controversial. We therefore conducted a meta-analysis to examine the association between smoking and metabolic syndrome. Methodology and Principal Findings: We searched the Medline, Embase and the Cochrane Library database up to March 2012 to identify prospective cohort studies related to smoking and metabolic syndrome. Reference lists of retrieved articles were also reviewed. Summary effect estimates were derived using a random-effects model and stratified by gender, smoking dose, follow-up duration and geographical area. Primary analysis of 13 studies involving 56,691 participants and 8,688 cases detected a significant positive association between active smoking and risk of metabolic syndrome (pooled relative risk [RR] 1.26, 95% CI: 1.10-1.44). Estimates of effects were substantially consistent in the stratified analyses. In the dose-response analysis, risk of metabolic syndrome was stronger for active male smokers (pooled RR 1.34, 95% CI: 1.20-1.50) than it was for former male smokers (pooled RR 1.19, 95% CI: 1.00-1.42), and greater for heavy smokers (pooled RR 1.42, 95% CI: 1.27-1.59) compared with light smokers (pooled RR 1.10, 95% CI: 0.90-1.35). No evidence of statistical publication bias was found (Egger' s test P = 0.227, Begg' s test P = 0.113). Conclusions: Active smoking is associated with development of metabolic syndrome. Smoking cessation appears to reduce the risk of metabolic syndrome. © 2012 Sun et al.


Xu X.,Shanghai JiaoTong University | Cao X.,Shanghai JiaoTong University | Zhao L.,Shanghai JiaoTong University
Chemosphere | Year: 2013

Rice husk biochar (RHBC) and dairy manure biochar (DMBC) were prepared as sorbents for simultaneously removing Pb, Cu, Zn, and Cd from aqueous solutions. DMBC was more effective in removing all the four heavy metals than RHBC, with the removal capacities of above 486mmolkg-1 for each metal, much higher than those of RHBC (65.5-140mmolkg-1). RHBC showed stronger competition for metal removal than DMBC when the four metals coexisted, with Pb the least affected and Cd the most inhibited. When each metal was 1mM in the multi-metal system, the metal removal by RHBC was reduced by 38.4-100%, much higher than that reduced by 2-40.9% for DMBC. The stronger competition for metals removal by RHBC was due to the fact that all metals competed only for the ionized phenolic-O- groups, while the removal of metals by DMBC resulted not only from the complexation with ionized hydroxyl-O- groups but also from the precipitation of metals with CO32- and/or PO43- that were rich in DMBC, resulting in less competition. The different mechanisms for the removal of metals by the two biochars were evidenced by the instrumental analysis of XRD, FTIR, and SEM as well as chemical modeling of Visual MINTEQ. Results indicated the waste biomass can be converted into value-added biochar as sorbents for removal of heavy metals and the removal ability varies with different biochar feedstock sources where the mineral components such as CO32-, PO43- originated from the feedstock play an important role in the sorption nature of biochar. © 2013 Elsevier Ltd.


Ye Q.,Shanghai JiaoTong University | Ye Q.,CAS Shanghai Institutes for Biological Sciences | Miao Q.-L.,CAS Shanghai Institutes for Biological Sciences
Matrix Biology | Year: 2013

Perineuronal nets (PNNs) are extracellular matrix structures consisting of chondroitin sulfate proteoglycans (CSPGs), hyaluronan, link proteins and tenascin-R (Tn-R). They enwrap a subset of GABAergic inhibitory interneurons in the cerebral cortex and restrict experience-dependent cortical plasticity. While the expression profile of PNN components has been widely studied in many areas of the central nervous system of various animal species, it remains unclear how these components are expressed during the postnatal development of mouse primary visual cortex (V1). In the present study, we characterized the developmental time course of the formation of PNNs in the mouse primary visual cortex, using the specific antibodies against the two PNN component proteins aggrecan and tenascin-R, or the lectin Wisteria floribunda agglutinin (WFA) that directly binds to glycosaminoglycan chains of chondroitin sulfate proteoglycans (CSPGs). We found that the fluorescence staining signals of both the WFA staining and the antibody against aggrecan rapidly increased in cortical neurons across layers 2-6 during postnatal days (PD) 10-28 and reached a plateau around PD42, suggesting a full construction of PNNs by the end of the critical period. Co-staining with antibodies to Ca2+ binding protein parvalbumin (PV) demonstrated that the majority of PNN-surrounding cortical neurons are immunoreactive to PV. Similar expression profile of another PNN component tenascin-R was observed in the development of V1. Dark rearing of mice from birth significantly reduced the density of PNN-surrounding neurons. In addition, the expression of two recently identified CSPG receptors - Nogo receptor (NgR) and leukocyte common antigen-related phosphatase (LAR), showed significant increases from PD14 to PD70 in layer 2-6 of cortical PV-positive interneurons in normal reared mice, but decreased significantly in dark-reared ones. Taken together, these results suggest that PNNs form preferentially in cortical PV-positive interneurons in an experience-dependent manner, and reach full maturation around the end of the critical period of V1 development. © 2013 International Society of Matrix Biology.


Li X.,Shanghai JiaoTong University | Jiang C.,Shanghai JiaoTong University
IEEE Transactions on Power Systems | Year: 2011

In view of the uncertainty and intermittency of wind power, this paper proposes an optimal economical dispatch (ED) model and develops a method to estimate risk and manage hybrid power systems (traditional + wind power systems) for the short-term (24 h) operations. The model and the method have taken into account the large wind power penetration and the wind variability. The particle swarm optimization (PSO) algorithm with constraints is applied to solve the ED problem. Value at risk (VaR) and integrated risk management (IRM) are used separately to assess the risk, so that an optimal tradeoff between the profit and risk is made for the system operations. The model and the method are tested on the standard IEEE 30-bus power system and network in Shanghai. The validity of the model and the method has been approved. © 2010 IEEE.


Zhang J.,Shanghai JiaoTong University | Sun K.,Shanghai JiaoTong University
American Journal of Epidemiology | Year: 2013

Reference tools based on birth weight percentiles at a given gestational week have long been used to define fetuses or infants that are small or large for their gestational ages. However, important deficiencies of the birth weight reference are being increasingly recognized. Overwhelming evidence indicates that an ultrasonography-based fetal weight reference should be used to classify fetal and newborn sizes during pregnancy and at birth, respectively. Questions have been raised as to whether further adjustments for race/ethnicity, parity, sex, and maternal height and weight are helpful to improve the accuracy of the classification. In this issue of the Journal, Carberry et al. (Am J Epidemiol. 2013;178(8):1301-1308) show that adjustment for race/ethnicity is useful, but that additional fine tuning for other factors (i.e., full customization) in the classification may not further improve the ability to predict infant morbidity, mortality, and other fetal growth indicators. Thus, the theoretical advantage of full customization may have limited incremental value for pediatric outcomes, particularly in term births. Literature on the prediction of short-term maternal outcomes and very long-term outcomes (adult diseases) is too scarce to draw any conclusions. Given that each additional variable being incorporated in the classification scheme increases complexity and costs in practice, the clinical utility of full customization in obstetric practice requires further testing. © 2013 The Author.


Xiang W.,Shanghai JiaoTong University | Ming C.,Shanghai JiaoTong University
Journal of Cleaner Production | Year: 2011

With the rapid growth of vehicle population in China and subsequent environmental problems, remanufacturing has become the development direction of the vehicle industry for its huge environmental benefit. However, the current vehicle remanufacturing industry is still in its infancy, which makes the introduction of extended producer responsibility inevitable. This paper describes the development of China's remanufacturing policies based on EPR and discusses the recycling system in line with the country's actual conditions. This then can provide some ideas on EPR application to other developing countries. © 2010 Elsevier Ltd. All rights reserved.


Mao Y.,Shanghai Ruijin Hospital | Keller E.T.,University of Michigan | Garfield D.H.,Shanghai Ruijin Hospital | Garfield D.H.,Aurora University | And 2 more authors.
Cancer and Metastasis Reviews | Year: 2013

Cancer is a systemic disease encompassing multiple components of both tumor cells themselves and host stromal cells. It is now clear that stromal cells in the tumor microenvironment play an important role in cancer development. Molecular events through which reactive stromal cells affect cancer cells can be defined so that biomarkers and therapeutic targets can be identified. Cancer-associated fibroblasts (CAFs) make up the bulk of cancer stroma and affect the tumor microenvironment such that they promote cancer initiation, angiogenesis, invasion, and metastasis. In breast cancer, CAFs not only promote tumor progression but also induce therapeutic resistance. Accordingly, targeting CAFs provides a novel way to control tumors with therapeutic resistance. This review summarizes the current understandings of tumor stroma in breast cancer with a particular emphasis on the role of CAFs and the therapeutic implications of CAFs. In addition, the effects of other stromal components such as endothelial cells, macrophages, and adipocytes in breast cancer are also discussed. Finally, we describe the biologic markers to categorize patients into a specific and confirmed subtype for personalized treatment. © 2012 Springer Science+Business Media New York.


Zhou Y.-Y.,Shanghai JiaoTong University | Zeng F.,Shanghai JiaoTong University
Genomics, Proteomics and Bioinformatics | Year: 2013

Induced pluripotent stem (iPS) cells can be generated from mouse or human fibroblasts by exogenous expression of four factors, Oct4, Sox2, Klf4 and c-Myc, and hold great potential for transplantation therapies and regenerative medicine. However, use of retroviral vectors during iPS cell generation has limited the technique's clinical application due to the potential risks resulting from genome integration of transgenes, including insertional mutations and altered differentiation potentials of the target cells, which may lead to pathologies such as tumorigenesis. Here we review recent progress in generating safer transgene-free or integration-free iPS cells, including the use of non-integrating vectors, excision of vectors after integration, DNA-free delivery of factors and chemical induction of pluripotency. © 2013.


Hu Y.,Shanghai JiaoTong University | Meng L.,Xi'an Jiaotong University | Lu Q.,Shanghai JiaoTong University
Langmuir | Year: 2014

It is a significant issue to overcome the concentration-quenching effect of the small fluorescent probes and maintain the high fluorescent efficiency at high concentration for sensitive and selective fluorescent mark or detection. We developed a new strategy to "isolate" and "fasten" porphyrin moieties in a highly cross-linked poly(tetraphenylporphyrin-co- cyclotriphosphazene) (TPP-PZS) by the polycondensation of hexachlorocyclotriphosphazene (HCCP) and 5,10,15,20-tetrakis(4-hydroxyphenyl) porphyrin (TPP-(OH)4) in a suitable solvent. The resulting TPP-PZS particles were characterized with transmission electron microscopy (TEM), scanning electron microscopy (SEM), Fourier transform infrared (FTIR), 31P nuclear magnetic resonance (NMR), and ultraviolet and visible (UV-vis) absorption spectra. Remarkably, TPP-PZS particles obtained in acetone emitted a bright red fluorescence both in powder state and in solution because the aggregation of porphyrin moieties in "H-type" (face-to-face) and "J-type" (edge-to-edge) was effectively blocked. The fluorescent TPP-PZS particles also showed superior resistance to photobleaching, and had a high sensitivity and selectivity for the detection of Hg2+ ions. The TPP-PZS particles were therefore used as an ideal material for preparing test strips to quickly detect/monitor the Hg2+ ions in a facile way. © 2014 American Chemical Society.


He X.-Y.,Shanghai JiaoTong University | Yuan Y.-Z.,Shanghai JiaoTong University
World Journal of Gastroenterology | Year: 2014

Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal forms of cancer. Substantial progress has been made in the understanding of the biology of pancreatic cancer, and advances in patient management have been significant. However, most patients (nearly 80%) who present with locally advanced or metastatic disease have an extremely poor prognosis. Survival is better for those with malignant disease localized to the pancreas, because surgical resection at present offers the only chance of cure. Therefore, the early detection of pancreatic cancer may benefit patients with PDAC. However, its low rate of incidence and the limitations of current screening strategies make early detection difficult. Recent advances in the understanding of the pathogenesis of PDAC suggest that it is possible to detect PDAC in early stages and even identify precursor lesions. The presence of new-onset diabetes mellitus in the early phase of pancreatic cancer may provide clues for its early diagnosis. Advances in the identification of novel circulating biomarkers including serological signatures, autoantibodies, epigenetic markers, circulating tumor cells and microRNAs suggest that they can be used as potential tools for the screening of precursors and early stage PDAC in the future. However, proper screening strategies based on effective screening methodologies need to be tested for clinical application. © 2014 Baishideng Publishing Group Inc. All rights reserved.


Xiao G.,Shanghai JiaoTong University | Zhu Z.,Shanghai JiaoTong University
Tribology International | Year: 2010

A group of non-asbestos organic based friction materials containing 16 ingredients were investigated in this work using the techniques of design of experiment (2k DOE), response surface methodology (RSM), and artificial neural network (ANN). The ingredients effects on three friction characteristics including 1st fading rate, 2nd fading rate, and speed sensitivity were studied by 2k DOE. Five ingredients of phenolic resin, synthetic graphite, potassium titanate, mineral fiber, and calcium silicate were found to be statistically significant for these responses and should be studied further. In the meantime, an artificial neural network with Elman recurrent configuration was trained and tested using the data generated from dynamometer tests in 2k DOE experiments. Concerning the confounding of two-ingredient interaction effects and main effects, response surface methodology was employed to optimize the friction material formulation. The well trained and tested Elman artificial neural network was then used to predict the friction characteristics of the trials generated by RSM. Based on the ANN prediction and RSM analysis, an optimization of material formulation was obtained and validated by experiments. © 2009 Elsevier Ltd. All rights reserved.


Ruan J.,Shanghai JiaoTong University
International journal of nanomedicine | Year: 2011

Efficient preparation and labeling of human induced pluripotent stem (iPS) cells is a great challenge in stem cell research and development. With the aim of investigating the feasibility of using nanotechnology to enhance the preparation efficiency of iPS cells and to label iPS cells for long-term tracing and imaging, in this paper, four transcription factor genes, ie, Oct4, Sox2, LIN28, and Nanog, and packaging plasmids such as PSPAX2 and PMD2.G were cotransfected into 293T cells using Generation 5.0 polyamidoamine dendrimer-modified magnetic nanoparticles (dMNPs) as a delivery system. The resultant supernatant liquids were incubated with human fibroblast cells at 37°C for 21 days, then the embryonic stem (ES) cell-like clones were screened, cultured, and identified. Finally, the prepared iPS cells were labeled with fluorescent magnetic nanoparticles (FMNPs). The results showed that dMNPs can efficiently deliver all vectors into 293T cells. The resultant lentiviruses' titers were 10-fold more than those based on Lipofectamine™ 2000. Reverse transcription polymerase chain reaction analysis showed that four genes (Oct4, Sox2, LIN28, and Nanog) exhibited different expressions in iPS cells. Immunostaining analysis showed that specific surface markers of ES cells such as SSEA-3, SSEA-4, Tra-1-60, and Tra-1-81 were positive in iPS cells, and the terotomas were formed in NOD-SCID mice that were implanted with iPS cells. Red fluorescent signals could be observed in iPS cells labeled with FMNPs by fluorescent microscopy, and the magnetic signals were detected in labeled iPS cells by magnetic resonance imaging. In conclusion, human iPS cells can be efficiently generated using polyamidoamine dMNPs and lentivirus and labeled with FMNPs for long-term observation and tracking, which has great potential application in the research and development of stem cells in the near future.


Han D.,Shanghai JiaoTong University | Li J.,China Medical University at Heping
Cell and Tissue Research | Year: 2013

A large hurdle in orthopedics today is the difficulty of dealing with the non-union of fractured bones. We therefore evaluated the effects of runt-related transcription factor II (Runx II), a factor used to create gene-modified tissue-engineered bone, combined with vascular bundle implantation for repairing segmental bone defects. Adenovirus Runx II gene (Ad-Runx II)-modified rabbit adipose-derived stem cells (ADSCs) were seeded onto polylactic acid/polycaprolacton (PLA/PCL) scaffolds to construct gene-modified tissue-engineered bone. The following four methods were used for repair in rabbit radial-defect (1.5 cm long) models: gene-modified tissue-engineered bone with vascular bundle (Group A), gene-modified tissue-engineered bone (Group B), non-gene-modified tissue-engineered bone with vascular bundle (Group C), and PLA/PCL scaffolds only (Group D). X-ray, histological examination, biomechanics analysis, and micro-angiography were conducted 4, 8, and 12 weeks later to determine angiogenesis and osteogenesis. The volume and speed of production of newly formed bones in Group A were significantly superior to those in other groups, and de-novo vascular network circulation from the vessel bundle through newly formed bone tissue was observed, with the defect being completely repaired. Group B showed a slightly better effect in terms of speed and quality of bone formation than Group C, whereas the bone defect in Group D was replaced by fibrous tissue. The maximal anti-bending strength in Group A was significantly higher than that in the other groups. Runx II gene therapy combined with vascular bundle implantation thus displays excellent abilities for osteoinduction and vascularization and is a promising method for the treatment of bone non-union and defect. © 2013 Springer-Verlag Berlin Heidelberg.


Zhou L.,Shanghai JiaoTong University | Lu W.,Shanghai JiaoTong University
Organometallics | Year: 2012

Homocoupling and cross-coupling of electron-deficient arenes, including nitrobenzene, (trifluoromethyl)benzene, ethyl benzoate, etc., have been developed to afford biaryls using a catalytic system of Pd(OAc) 2/trifluoroacetic acid (TFA)/O 2 or K 2S 2O 8. The crucial step is to tune the concentrations of arenes and the loading of TFA carefully to enhance the reaction rates and the selectivity of these couplings involving dual C-H activation. © 2012 American Chemical Society.


Lv T.,Shanghai JiaoTong University | Ai Q.,Shanghai JiaoTong University
Applied Energy | Year: 2016

Recently, large-scale renewable energy resources have been widely integrated into power systems. To optimize large-scale integration of these resources and improve the operation performance of the distribution system, this paper proposes a novel dynamic energy management strategy with the cooperative interaction of an energy system: a multi-grid connected microgrids (MGs)-based active distribution system (ADS). A bi-level multi-objective optimization problem of the strategy is formulated with the active distribution network (ADN) in the upper level and MGs in the lower level. The interaction can be classified into two categories: the one between MGs and the ADN and the other one among MGs. The former is described by bi-level programming; the latter is innovatively explained by an interactive energy game matrix (IEGM) defined in this paper. The concept of the expanded energy storage system is defined and applied to the IEGM for the optimal operation of ADSs. The optimal operation includes improved technical performances in terms of power quality, energy utilization, adaptability and autonomy. The optimization problem is solved with a hybrid algorithm of Rough Set Theory-Hierarchical Genetic Algorithm-NSGA-II. Case studies of an ADS with different MGs and a real system would validate the efficiency of the proposed methodology. Results show that the proposed EM strategy can accurately quantify and guide the energy interaction among MGs and that between MGs and the ADN. Moreover, those technical performances of the ADS are improved. © 2015 Elsevier Ltd.


Xu Y.,Shanghai JiaoTong University | Chen G.,Shanghai JiaoTong University
Mediators of Inflammation | Year: 2015

Mast cells are important in innate immune system. They have been appreciated as potent contributors to allergic reaction. However, increasing evidence implicates the important role of mast cells in autoimmune disease like rheumatoid arthritis and multiple sclerosis. Here we review the current stage of knowledge about mast cells in autoimmune diseases. © 2015 Yunzhi Xu and Guangjie Chen.


Li M.,Shanghai JiaoTong University
Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery | Year: 2011

Platelet-rich plasma (PRP) can enhance the chondrocyte proliferation and repair of cartilage defects. To explore the safety and efficacy of intra-knee-articular injection of PRP to treat knee articular cartilage degeneration by comparing with injecting sodium hyaluronate (SH). Thirty consecutive patients (30 knees) with knee articular cartilage degeneration were selected between January 2010 and June 2010. According to different injections, 30 patients were randomly divided into PRP group (test group, n = 15) and SH group (control group, n = 15). There was no significant difference in gender, age, body mass index, and Kellgren-Lawrence grade between 2 groups (P > 0.05). Test group received 3.5 mL of PRP intra-knee-articular injections while control group received 2 mL of SH during the same time period. Both treatments were administered in series of 3 intra-knee-articular injections at 3-week intervals. Then, adverse reactions were recorded. International Knee Documentation Committee (IKDC) score, Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) score, and Lequesne index were used for evaluation of treatment results. The patients of 2 groups were followed up 6 months. There were significant differences in IKDC score, WOMAC score, and Lequesne index between pre- and post-injection in 2 groups (P < 0.05); no significant difference was found between different time points (3, 4, and 6 months) in test group (P > 0.05), while significant differences were found between the postoperative 6th month and the postoperative 3rd and 4th months in control group (P < 0.05). There was no significant difference in IKDC score, WOMAC score, and Lequesne index between 2 groups within 4 months (P > 0.05), but the effectiveness of test group was significantly better than that of control group at 6 months after injection (P < 0.05). Adverse reactions occurred in 12 patients (31 injections) of test group and in 12 patients (30 injections) of control group. No significant difference in onset time, termination time, and duration of adverse reactions were found between 2 groups (P > 0.05). Intra-knee-articular injection of PRP to treat knee articular cartilage degeneration is safe, which can alleviate symptoms of pain and swelling and improve the quality of life of patients; however, further data of large samples and long-term follow-up are needed to confirm the safety and effectiveness.


Rong Y.,Shanghai JiaoTong University
Jinshu Xuebao/Acta Metallurgica Sinica | Year: 2011

The quenching-partitioning-tempering (Q-P-T) process was developed from quenching & partitioning (Q&P) process and their difference are first described in this paper. The development of Q-P-T steels from ultrahigh strength to high strength-ductility is summarized. Novel Q-P-T process and conventional quenching-tempering (Q-T) process and their different effects on mechanical properties are compared. The micro-mechanism of the ductility enhancement from retained austenite in unltrahigh strength steels during deformation is emphasized in discussion, which provides guidance for microstructural design and control on the further development of advanced high strength steels. © Right.


Li Y.,China Jiliang University | Ding H.,Shanghai JiaoTong University
Tribology International | Year: 2012

This paper describes a simplified performance calculation method of aerostatic thrust bearing with multiple pocketed orifice-type restrictors. It also explains theoretically the influence of film thickness, orifice diameter, gas property, supply pressure, and structural parameters on the bearing's performance. Compared to finite element method (FEM) and computational fluid dynamics (CFD), this method is much easier. Furthermore, it simplifies the performance prediction and parameters optimization, and facilitates the application of this kind of bearing. © 2012 Elsevier Ltd. All rights reserved.


Nakata T.,Chiba University | Liu H.,Chiba University | Liu H.,Shanghai JiaoTong University
Proceedings of the Royal Society B: Biological Sciences | Year: 2012

Insect wings are deformable structures that change shape passively and dynamically owing to inertial and aerodynamic forces during flight. It is still unclear how the three-dimensional and passive change of wing kinematics owing to inherent wing flexibility contributes to unsteady aerodynamics and energetics in insect flapping flight. Here, we perform a systematic fluid-structure interaction based analysis on the aerodynamic performance of a hovering hawkmoth, Manduca, with an integrated computational model of a hovering insect with rigid and flexible wings. Aerodynamic performance of flapping wings with passive deformation or prescribed deformation is evaluated in terms of aerodynamic force, power and efficiency. Our results reveal that wing flexibility can increase downwash in wake and hence aerodynamic force: first, a dynamic wing bending is observed, which delays the breakdown of leading edge vortex near the wing tip, responsible for augmenting the aerodynamic force-production; second, a combination of the dynamic change of wing bending and twist favourably modifies the wing kinematics in the distal area, which leads to the aerodynamic force enhancement immediately before stroke reversal. Moreover, an increase in hovering efficiency of the flexible wing is achieved as a result of the wing twist. An extensive study of wing stiffness effect on aerodynamic performance is further conducted through a tuning of Young's modulus and thickness, indicating that insect wing structures may be optimized not only in terms of aerodynamic performance but also dependent on many factors, such as the wing strength, the circulation capability of wing veins and the control of wing movements. © 2011 The Royal Society.


Chen K.,Shanghai JiaoTong University | Zhang J.,Shanghai JiaoTong University | Gu H.,Shanghai JiaoTong University
Journal of Materials Chemistry | Year: 2012

The degradation of composite mesoporous silica nanoparticles is quite important for the in vivo use of this delivery carrier. We investigated the dynamic silica degradation of core-shell structured magnetic mesoporous silica nanoparticles (M-MSNs) and its counterpart with polyethyleneimine coating (M-MSN@PEI) in PBS. It is confirmed for the first time that M-MSNs unexpectedly experienced a preferential dissolution from the inside part of the mesoporous shell, leading to a rattle-type degradation structure. Additionally, the presence of polyethylenimine (PEI) can maintain this transition state of rattle-type structure for more than 50 h of immersion in PBS, whereas the same structure was disintegrated after 2 h for bare M-MSNs. We then tried to put forward a possible degradation mechanism for this type of core-shell M-MSNs by studying and comparing with the dissolution behaviour of pristine mesoporous silica nanoparticles (MSNs). It is discovered that two pivotal factors governed this unique process: (a) the unique shell structure with lower interior pore order and (b) the role of PEI chains in affecting silicate condensation. There is no doubt that the present study will provide guidance for the design and in vivo bio-applications of an M-MSN-based delivery system. © 2012 The Royal Society of Chemistry.


Background: Glutamine (Gln) is the most abundant amino acid in blood and tissue fluids and is considered to be essential in certain catabolic conditions. A series of studies has shown that glutamine can attenuate cytokine release, reduce organ damage and improve survival in a rat model of endotoxaemia. The hypothesis for this rat model study is that pre-treatment with Gln reduces the expression of ICAM-1 and attenuates lung injury induced by intestinal ischaemia-reperfusion (I/R). Methods: Sprague-Dawley rats were randomised into five groups, namely sham group (sham surgery), Gln groups (three different doses) and control group. Lung injury caused by intestinal I/R was evaluated using Evans blue dye concentration and histopathologic examination. The level of myeloperoxidase (MPO) was measured using biochemistry method. The expression of heat shock protein 70 (HSP 70) and ICAM-1 were detected using Western blot and real-time polymerase chain reaction (PCR) methods, respectively. Results: Compared with the control group, rats pre-treated with Gln before intestinal I/R demonstrated decreased Evans Blue content and MPO activities in lung tissue, reduced the expression of ICAM-1, attenuated lung injury evidenced by pathological change compared with lactated Ringer pre-treated rats. Gln administration increased HSP 70 mRNA and protein expression in lung tissue compared with control group. Conclusion: Ischaemia-reperfusion injury increases the expression of ICAM-1 in the lung. This may contribute to the migration, accumulation and activation of neutrophils. Pre-treatment with Gln attenuates rat lung injury and reduces ICAM-1 expression. © 2009 Elsevier Ltd.


Xu W.,Pacific Northwest National Laboratory | Wang J.,Pacific Northwest National Laboratory | Wang J.,Shanghai JiaoTong University | Ding F.,Tianjin Institute of Power Sources | And 5 more authors.
Energy and Environmental Science | Year: 2014

Lithium (Li) metal is an ideal anode material for rechargeable batteries due to its extremely high theoretical specific capacity (3860 mA h g -1), low density (0.59 g cm-3) and the lowest negative electrochemical potential (-3.040 V vs. the standard hydrogen electrode). Unfortunately, uncontrollable dendritic Li growth and limited Coulombic efficiency during Li deposition/stripping inherent in these batteries have prevented their practical applications over the past 40 years. With the emergence of post-Li-ion batteries, safe and efficient operation of Li metal anodes has become an enabling technology which may determine the fate of several promising candidates for the next generation energy storage systems, including rechargeable Li-air batteries, Li-S batteries, and Li metal batteries which utilize intercalation compounds as cathodes. In this paper, various factors that affect the morphology and Coulombic efficiency of Li metal anodes have been analyzed. Technologies utilized to characterize the morphology of Li deposition and the results obtained by modelling of Li dendrite growth have also been reviewed. Finally, recent development and urgent need in this field are discussed. © The Royal Society of Chemistry.


Chen R.,CAS Shanghai Institute of Applied Physics | Liu P.,Shanghai JiaoTong University | Xiao T.,CAS Shanghai Institute of Applied Physics | Xu L.X.,Shanghai JiaoTong University
Advanced Materials | Year: 2014

X-ray imaging has become an essential detection technique in a wide range of research fi elds since its discovery by Röntgen in 1895. Up to now, X-ray tube source based imaging systems have been widely used. However, limitations arise from insuffi - cient spatial and temporal resolution, and low contrast of these systems, which are unavoidable drawbacks. The availability of third generation synchrotron radiation (SR) facilities since the 1990s sheds light on the advancement of X-ray imaging. The high intensity, high coherence, quasi-parallel, and monochromatic characteristics of SR beams have enabled the development of SR-based high spatial and temporal X-ray imaging techniques. In the past decades, experiments have demonstrated the advantage of SR X-ray imaging in the fi elds of material sciences [ 1 ] and biomedicine. [ 2 ] The Shanghai Synchrotron Radiation Facility (SSRF) is a third-generation synchrotron radiation light source, and it provides a powerful technical platform for scientifi c research and industrial applications for scientists in China and overseas. The X-ray imaging beamline (BL13W1) is one of the seven initial beamlines at SSRF, and was formally opened to users in May 2009. The double crystal monochromator at BL13W1 provides photon energies ranging from 8 to 72.5 keV with a beam size of ca. 45 mm × 5 mm. The beamline aims at developing and evaluating the effectiveness of SR-based imaging techniques in planar or computed tomography (CT) modalities. [ 3 ] Several X-ray imaging methods, such as micro-tomography and quantitative imaging, [ 4 ] have been developed and they have found extensive applications in biomedicine, [ 5,6 ] materials science, [ 7,8 ] and so on. The X-ray imaging methods and the statistics for user research fi elds at BL13W1 are shown in Figure 1 , in which it is obvious that the beamline is mainly devoted to the materials science and biomedical fi elds. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.


Qi Z.,Shanghai JiaoTong University
Renewable and Sustainable Energy Reviews | Year: 2014

There is a rising interest in electric vehicle's climate control system including cooling and heating. Electric vehicles (EVs, including hybrid electric vehicles and full electric vehicles) have inadequate waste heat to warm up the cabin and the climate control system has a very significant effect on the energy consumption efficiency and operating mileage. Heat pump (HP) is one approach for energy consumption efficiency improvement in EVs which can supply cooling and heating capacity. A literature review was performed on the vapor compression HP cycle design, performance characteristics, and challenges for variable working fluids for electric vehicles. The non-vapor compressor HP systems were also analyzed including the applications of magnetocaloric effect and thermoelectric effect. It seems heat pump system is a reasonable and feasible option in EV's climate control system if some essential issues could be solved. The mobile climate control systems based on magnetocaloric effect and thermoelectric effect could be the supplementary methods in future applications. © 2014 Elsevier Ltd.


Zhao Y.,Shanghai JiaoTong University | Zhu K.,National Renewable Energy Laboratory
Journal of Physical Chemistry Letters | Year: 2014

Organic and inorganic hybrid perovskites (e.g., CH3NH3PbI3) have emerged as a revolutionary class of light-absorbing semiconductors that has demonstrated a rapid increase in efficiency within a few years of active research. Controlling perovskite morphology and composition has been found critical to developing high-performance perovskite solar cells. The recent development of solution chemistry engineering has led to fabrication of greater than 15-17%-efficiency solar cells by multiple groups, with the highest certified 17.9% efficiency that has significantly surpassed the best-reported perovskite solar cell by vapor-phase growth. In this Perspective, we review recent progress on solution chemistry engineering processes and various control parameters that are critical to the success of solution growth of high-quality perovskite films. We discuss the importance of understanding the impact of solution-processing parameters and perovskite film architectures on the fundamental charge carrier dynamics in perovskite solar cells. The cost and stability issues of perovskite solar cells will also be discussed. © 2014 American Chemical Society.


Jannati M.,Amirkabir University of Technology | Hosseinian S.H.,Amirkabir University of Technology | Vahidi B.,Amirkabir University of Technology | Li G.-J.,Shanghai JiaoTong University
Renewable and Sustainable Energy Reviews | Year: 2014

As the wind power capacity increases, the effect of wind power fluctuations on the system stability becomes more significant. Despite its high costs, utilizing energy storage resources such as batteries is inevitable in the smoothing process of wind power fluctuations. In a wind power plant, the place where batteries are located has considerable direct effect on their required capacity and thus on the initial investment cost. Therefore, in this paper a suitable configuration which significantly reduces the batteries investment cost is proposed and then the wind power fluctuation of a large wind power plant connected to a smart distribution grid is smoothed. Additionally, existing configurations for installing batteries in large wind power plants are investigated. The proposed configuration utilizes smart parks as aggregated storage resources in load side and an aggregated battery energy storage system with limited capacity in plant side as well. Therefore, in addition to accurate smoothing of wind power fluctuations, the energy storage investment cost is reduced significantly utilizing the proposed configuration. Simulation studies in MATLAB software package are carried out to verify the performance of the proposed approach. © 2013 Published by Elsevier Ltd.


Li T.X.,Shanghai JiaoTong University | Wang R.Z.,Shanghai JiaoTong University | Li H.,China Shipbuilding Industry Corporation CSIC
Progress in Energy and Combustion Science | Year: 2014

Heat-powered solid-gas sorption refrigeration technology has been regarded as one of the effective methods for reutilization of low-grade thermal energy such as industrial waste heat, renewable energy, and exhaust gases from engines. A number of advanced solid sorption refrigeration systems have been developed to improve energy efficiency by reducing the primary energy consumption as the recognition of energy saving. These advanced solid sorption refrigeration cycles mainly include heat recovery sorption cycle, mass recovery sorption cycle, mass and heat recovery sorption cycle, double/multi-effect sorption cycle, combined double-way sorption cycle, double-effect and double-way sorption cycle, two/multi-stage sorption cycle, etc. In this paper, the progress in the development of solid-gas sorption refrigeration thermodynamic cycle is reviewed. The operating principles of these advanced solid-gas sorption refrigeration cycles are introduced in detail, and the representative working performances of different sorption refrigeration cycles are presented and compared. Moreover, the key problems of advanced sorption refrigeration cycles are described and discussed. Finally, the future development of solid-gas sorption refrigeration cycle is also proposed. © 2013 Elsevier Ltd. All rights reserved.


Cai J.,Shanghai JiaoTong University | Cai J.,China University of Petroleum - Beijing | Wu W.,Shanghai JiaoTong University | Liu R.,Shanghai JiaoTong University
Renewable and Sustainable Energy Reviews | Year: 2014

Research interest in the conversion of lignocellulosic biomass into energy and fuels through the pyrolysis process has increased significantly in the last decade as the necessity for a renewable source of carbon has become more evident. For optimal design of pyrolysis reactors, an understanding of the pyrolysis kinetics of lignocellulosic biomass is of fundamental importance. The distributed activation energy model (DAEM) has been usually used to describe the pyrolysis kinetics of lignocellulosic biomass. In this review, we start with the derivation of the DAEM. After an overview of the activation energy distribution and frequency factor in the DAEM, we focus on the numerical calculation and parameter estimation methods of the DAEM. Finally, this review summarizes recent results published in the literature for the application of the DAEM to the pyrolysis kinetics of lignocellulosic biomass. © 2014 Elsevier Ltd.


Wang X.,Shanghai JiaoTong University | Su H.,Huazhong University of Science and Technology
Annual Reviews in Control | Year: 2014

In practice, directly control every node in a dynamical networked system with a huge number of nodes might be impossible or unnecessary; therefore, pinning control is a desirable approach. This paper surveys advances in pinning control approaches to making a dynamical networked system have a desired behavior. For a network with fixed topology, we review the feasibility, stability and effectiveness of pinning control. We then focus on pinning-based consensus and flocking control of mobile multi-agent networked systems. One of the main challenges with consensus and flocking control is that the topology of the corresponding dynamical network is time-varying, which depends on the states of all the agents in the network. Looking forward to the next decade, we expect to have a much deeper understanding of the relationship between the effectiveness of pinning control and the structural properties of a complex network, which may result in better control of large scale networked systems. © 2014 Elsevier Ltd. All rights reserved.


Yuan Y.,Shanghai JiaoTong University | Du W.,Anyang University, China | Qian X.,Shanghai JiaoTong University
Journal of Materials Chemistry | Year: 2012

Homogenous Zn xGa 2O 3+x (0 ≤ x ≤ 1) solid solution nanocrystals were successfully prepared by a solvothermal approach and characterized by X-ray powder diffraction (XRD), X-ray spectra in fluorescence (XRF), transmission electron microscopy (TEM), UV-vis spectroscopy, and X-ray photoelectron spectrum (XPS). XRD pattern analysis revealed that the lattice parameters of Zn xGa 2O 3+x (0 ≤ x ≤ 1) solid solution nanocrystals increased linearly with the increase of ZnGa 2O 4 ratio according to Vegard's law, which confirmed the homogenous structures of these solid solution nanocrystals. UV-vis absorption spectra demonstrated that the band gap of the obtained Zn xGa 2O 3+x solid solution nanocrystals could be precisely tuned in the range of 4.43 to 3.70 eV by elaborately controlling the content of zinc. The emission of Zn xGa 2O 3+x solid solution nanocrystals strengthened and red-shifted gradually with the increase of x value, and ZnGa 2O 4 nanocrystals showed an intense blue emission. XPS results revealed that Zn xGa 2O 3+x binding energy of O 2- 1s increased with the increase of the x value, indicating the decrease of the oxygen vacancies (V o*) of O h sites and the increase of the symmetry of the Ga-O octahedron, which resulted in the emission red-shift of Zn xGa 2O 3+x solid solution. © 2012 The Royal Society of Chemistry.


Dong R.,Shanghai JiaoTong University | Zhou Y.,Shanghai JiaoTong University | Zhu X.,Shanghai JiaoTong University
Accounts of Chemical Research | Year: 2014

ConspectusSupramolecular dendritic polymers (SDPs), which perfectly combine the advantages of dendritic polymers with those of supramolecular polymers, are a novel class of non-covalently bonded, highly branched macromolecules with three-dimensional globular topology. Because of their dynamic/reversible nature, unique topological structure, and exceptional physical/chemical properties (e.g., low viscosity, high solubility, and a large number of functional terminal groups), SDPs have attracted increasing attention in recent years in both academic and industrial fields. In particular, the reversibility of non-covalent interactions endows SDPs with the ability to undergo dynamic switching of structure, morphology, and function in response to various external stimuli, such as pH, temperature, light, stress, and redox agents, which further provides a flexible and robust platform for designing and developing smart supramolecular polymeric materials and functional supramolecular devices.The existing SDPs can be systematically classified into the following six major types according to their topological features: supramolecular dendrimers, supramolecular dendronized polymers, supramolecular hyperbranched polymers, supramolecular linear-dendritic block copolymers, supramolecular dendritic-dendritic block copolymers, and supramolecular dendritic multiarm copolymers. These different types of SDPs possess distinct morphologies, unique architectures, and specific functions. Benefiting from their versatile topological structures as well as stimuli-responsive properties, SDPs have displayed not only unique characteristics or advantages in supramolecular self-assembly behaviors (e.g., controllable morphologies, specific performance, and facile functionalization) but also great potential to be promising candidates in various fields.In this Account, we summarize the recent progress in the synthesis, functionalization, and self-assembly of SDPs as well as their potential applications in a wide range of fields. A variety of synthetic methods using non-covalent interactions have been established to prepare different types of SDPs based on varied mono- or multifunctionalized building blocks (e.g., monomer, dendron, dendrimer, and hyperbranched polymer) with homo- or heterocomplementary units. In addition, SDPs can be further endowed with excellent functionalities by employing different modification approaches involving terminal, focal-point, and backbone modification. Similar to conventional dendritic polymers, SDPs can self-assemble into diverse supramolecular structures such as micelles, vesicles, fibers, nanorings, tubes, and many hierarchical structures. Finally, we highlight some typical examples of recent applications of SDP-based systems in biomedical fields (e.g., controlled drug/gene/protein delivery, bioimaging, and biomimetic chemistry), nanotechnology (e.g., nanoreactors, catalysis, and molecular imprinting), and functional materials. The current research on SDPs is still at the very early stage, and much more work needs to be done. We anticipate that future studies of SDPs will focus on developing multifunctional, hierarchical supramolecular materials toward their practical applications by utilization of cooperative non-covalent interactions. © 2014 American Chemical Society.


In this study, we synthesized poly(ethylene oxide)-block-poly(ε- caprolactone)-block-polystyrene (PEO-b-PCL-b-PS) triblock copolymer via the combination of ring-opening polymerization (ROP) and atomic transfer radical polymerization (ATRP). The ABC triblock copolymer was incorporated into epoxy to access the nanostructured thermosets. It is found that the nanophases of the epoxy thermosets can be modulated by using different hardeners. While cured with 4,4′-methylenebis(2-chloroaniline), the thermosets displayed the long-ranged ordered nanostructures in which the spherical nanophases were arranged into body-centered cubic (bcc) lattice at the compositions investigated. While 4,4′-diaminodiphenylsulfone was used as the hardener, the thermosets displayed the lamellar nanostructure. The formation of nanostructures in the thermosets has been evidenced by atomic force microscopy and small-angle X-ray scattering. The morphological transition from spherical to lamellar nanophases has been interpreted in terms of the microphase separation of different subchains of the ABC triblock copolymer out of the epoxy-amine matrix during the curing reactions owing to the dependence of miscibility of epoxy networks with PCL subchain of the triblock copolymer on types of hardeners. The kinetics of curing and microphase separation shows the tandem reaction-induced microphase separation occurred while DDS was used as the hardener, which gave rise to the formation of lamellar nanostructures in the epoxy thermosets containing the ABC triblock copolymer. © 2011 American Chemical Society.


A versatile strategy is provided for the fabrication of pH-sensitive polypeptide-based normal micelles and reverse micelles from the same polypeptide-based copolymers via hydrogen-bonding interactions or host-guest chemistry. The pH-sensitive self-assembly of both linear and dendron-like/linear poly(l-glutamic acid)-b-poly(ethylene oxide) (Dm-PLG-b-PEO) block copolymers was investigated in detail by means of UV-vis, dynamic light scattering, NMR, fluorescence spectroscopy, and transmission electron microscopy. It was demonstrated that both the copolymer topology and the composition controlled the morphology of the polypeptide-cored normal micelles. Importantly, a novel class of polypeptide-shelled reverse micelles was for the first time generated by host-guest-chemistry-mediated self-assembly of these copolymers and α-cyclodextrin (α-CD) in alkaline solution. The supramolecular inclusion complexation between PEO and α-CD was confirmed by wide-angle X-ray diffraction, differential scanning calorimetry, and NMR. Moreover, the potential of the reverse micelles ranged from -20.2 to -24.2 mV, convincingly demonstrating that the reverse micelles had an anionic PLG shell. Furthermore, the anticancer doxorubicin (DOX)-loaded micelles fabricated from the dendron-like/linear copolymer showed a higher DOX loading efficiency (38%) and capacity (24%) and sustained a longer drug-release period (∼70 days) than the linear counterpart. Consequently, this will provide a platform for the fabrication of supramolecular polypeptide-cored and polypeptide-shelled micelles for the anticancer drug delivery systems. © 2010 American Chemical Society.


Fan S.,Shanghai JiaoTong University | Chen B.,Shanghai JiaoTong University
Construction and Building Materials | Year: 2014

Magnesium phosphate cement (MPC) was prepared with dead burned magnesia oxide and phosphate salts, such as ammonium dihydrogen phosphate (NH 4H2PO4) and potassium dihydrogen phosphate (KH2PO4). The properties of MPC prepared with varied phosphate salts were of much difference. In this paper the exothermia kinetics, mechanical properties and phase compositions of MPC prepared by mixing MgO with either ammonium dihydrogen phosphate or potassium dihydrogen phosphate, or a combination of both were studied. Besides, the effects of sodium triphosphate (Na5P3O10) on the microstructure and mechanical properties of MPC were also investigated. The results revealed that MPC prepared with ammonium dihydrogen phosphate exhibited substantially higher early strength and hydration temperature than that of magnesium potassium phosphate, while the later demonstrated better strength development. The strength of MPC prepared with equivalent mixture of ammonium dihydrogen phosphate and potassium dihydrogen phosphate was higher than that of MPC containing magnesium ammonium phosphate or magnesium potassium phosphate only. Moreover, the testing presented that the addition of sodium triphosphate improved the mechanical properties of MPC significantly. It also prolongs the setting time. Finally, the reaction products and their micro-morphology of MPC paste were examined and analyzed by X-ray diffraction (XRD) and Scanning Electronic Microscopic (SEM). © 2014 Elsevier Ltd. All rights reserved.


Peng Y.,Shanghai JiaoTong University | Gong T.,Shanghai JiaoTong University | Cui Y.,Shanghai JiaoTong University
Chemical Communications | Year: 2013

A chiral porous metal-organic framework of an axially C2- symmetric 1,1′-biphenol ligand is constructed and can be used as a solid-state host to enanioselectively adsorb mandelates with up to 93.1% ee and to entrap achiral tropolone ethers and induce their asymmetric photocyclization with up to 98.5% ee. © 2013 The Royal Society of Chemistry.


Liang H.-W.,Max Planck Institute for Polymer Research | Wei W.,Max Planck Institute for Polymer Research | Wu Z.-S.,Max Planck Institute for Polymer Research | Feng X.,Max Planck Institute for Polymer Research | And 2 more authors.
Journal of the American Chemical Society | Year: 2013

A family of mesoporous nonprecious metal (NPM) catalysts for oxygen reduction reaction (ORR) in acidic media, including cobalt-nitrogen-doped carbon (C-N-Co) and iron-nitrogen-doped carbon (C-N-Fe), was prepared from vitamin B12 (VB12) and the polyaniline-Fe (PANI-Fe) complex, respectively. Silica nanoparticles, ordered mesoporous silica SBA-15, and montmorillonite were used as templates for achieving mesoporous structures. The most active mesoporous catalyst was fabricated from VB12 and silica nanoparticles and exhibited a remarkable ORR activity in acidic medium (half-wave potential of 0.79 V, only ∼58 mV deviation from Pt/C), high selectivity (electron-transfer number >3.95), and excellent electrochemical stability (only 9 mV negative shift of half-wave potential after 10 000 potential cycles). The unprecedented performance of these NPM catalysts in ORR was attributed to their well-defined porous structures with a narrow mesopore size distribution, high Brunauer-Emmett-Teller surface area (up to 572 m2/g), and homogeneous distribution of abundant metal-Nx active sites. © 2013 American Chemical Society.


Liu D.-L.,Shanghai JiaoTong University | Chang X.,Shanghai JiaoTong University | Dong C.-M.,Shanghai JiaoTong University
Chemical Communications | Year: 2013

Dual stimuli-sensitive star polypeptide was for the first time synthesized and self-assembled into reduction- and thermo-sensitive micelles and hydrogels, demonstrating tunable size, mechanical and triggered drug-release properties useful for on-demand drug delivery. This journal is © 2013 The Royal Society of Chemistry.


Ye N.,Shanghai JiaoTong University | Zhang P.,Shanghai JiaoTong University
Journal of Chemical and Engineering Data | Year: 2012

Tetra-n-butyl ammonium bromide (TBAB) is an attractive additive to form hydrates that can incorporate specific guest molecules, such as CO 2, and the phase diagram of CO 2 + TBAB double hydrate is important to the formation and dissociation of hydrate. In this work, experimental equilibrium data of CO 2 + TBAB hydrate are presented in the pressure range of (0.3 to 4.4) MPa and in the temperature range of (279 to 292) K at mass fraction w = 0.05, 0.10, 0.19, 0.32, and 0.55. Meanwhile, the visualization of TBAB hydrates with and without CO 2 is also presented and discussed. © 2012 American Chemical Society.


Xu Z.,Shanghai JiaoTong University | Wang T.,Shanghai JiaoTong University
Biochemical and Biophysical Research Communications | Year: 2014

Previous studies have shown that miR-214 functions either as an oncogene or a tumor suppressor in various human cancer types. The role of this microRNA in osteosarcoma (OS) is presently unclear. Here, we demonstrated that miR-214 is frequently upregulated in OS specimens, compared with noncancerous bone tissues. Bioinformatics analysis further revealed leucine zipper, putative tumor suppressor 1 (LZTS1) as a potential target of miR-214. Expression patterns of miR-214 were inversely correlated with those of LZTS1 mRNA and protein in OS tissues. Data from reporter assays showed that miR-214 directly binds to the 3′-untranslated region (3′-UTR) of LZTS1 mRNA and suppresses expression at both transcriptional and translational levels. In functional assays, miR-214 promoted OS cell proliferation, invasion and tumor growth in nude mice, which could be reversed by overexpression of LZTS1. Taken together, our data provide compelling evidence that miR-214 functions as an onco-miRNA in OS, and its oncogenic effects are mediated chiefly through downregulation of LZTS1. © 2014 Elsevier Inc. All rights reserved.


Zhang G.,Shanghai JiaoTong University | Fu Y.,CAS Changchun Institute of Applied Chemistry | Xie Z.,CAS Changchun Institute of Applied Chemistry | Zhang Q.,Shanghai JiaoTong University
Macromolecules | Year: 2011

A series of new isoindigo-based low banbap polymers, containing thiophene, thieno[3,2-b]thiophene and benzo[1,2-b:4,5-b′]dithiophene as donors, have been synthesized by Stille cross-coupling reaction. Their photophysical, electrochemical and photovoltaic properties have been investigated. These new polymers exhibit broad and strong absorption between 400 and 800 nm with absorption maxima around 700 nm. The HOMO energy levels of polymers vary between -5.20 and -5.49 eV and the LUMO energy levels range from -3.66 to -3.91 eV. The optical bandgaps of the polymers are optimized for solar cell applications and they are at about 1.5 eV. Polymer solar cells (PSC) based on these new polymers were fabricated with device structures of ITO/PEDOT:PSS/polymers: PC 71BM (1:2, w/w)/LiF/Al. The photovoltaic properties of the polymers have been evaluated under AM 1.5G illumination at 100 mW/cm2 with a solar simulator. The combination of broad absorption, optimal bandgap and well matched energy levels with those of PCBMs makes these isoindigo-based low bandbap polymers promising materials for photovoltaic applications. © 2011 American Chemical Society.


Liu X.,Shanghai JiaoTong University | Sun J.,Shanghai JiaoTong University
Biomaterials | Year: 2010

Drug carriers are generally introduced into the body intravenously and directly exposed to endothelial cells. Silica nanoparticles could be promising delivery vehicles for drug targeting or gene therapy. However, few studies have been undertaken to determine the biological behavior of silica nanoparticles on endothelial cells. Here we measured reactive oxygen species (ROS) generation, apoptosis and necrosis, proinflammatory and prothrombic properties and the levels of the apoptotic signaling proteins and the transcription factors in human umbilical vein endothelial cells (HUVECs) after exposure to silica nanoparticles of different concentrations (25, 50, 100, and 200 μg/mL) for 24. h. The results showed that silica nanoparticles, ranging from 50 μg/mL to 200 μg/mL, markedly induced ROS production, mitochondrial depolarization and apoptosis in HUVECs. At the highest concentration, the necrotic rate, LDH leakage, the expression of CD54 and CD62E, and the release of TF, IL-6, IL-8 and MCP-1 were significantly increased. Silica nanoparticles also activated c-Jun N-terminal kinase (JNK), c-Jun, p53, caspase-3 and NF-κB, increased Bax expression and suppressed Bcl-2 protein. Moreover, inhibition of ROS attenuated silica nanoparticles-induced apoptosis and inflammation and the activation of JNK, c-Jun, p53 and NF-κB. In summary, our findings demonstrated that silica nanoparticles could induce dysfunction of endothelial cells through oxidative stress via JNK, p53 and NF-κB pathways, suggesting that exposure to silica nanoparticles may be a significant risk for the development of cardiovascular diseases such as atherosclerosis and thrombus. © 2010 Elsevier Ltd.


Zhu S.,Shanghai JiaoTong University | Deng K.,Shanghai JiaoTong University | Qu S.,China North Engine Research Institute
Energy | Year: 2013

In this paper, a theoretical study on the thermodynamic processes of a bottoming Rankine cycle for engine waste heat recovery is conducted from the viewpoints of energy balance and exergy balance. A theoretical formula and an exergy distribution map for qualitative analyses of the main operating parameters are presented under simplified conditions when exhaust gas is selected as the only heat source. Five typical working fluids, which are always selected by manufacturers for different types of engines, are compared under various operating conditions in Matlab software. The results show that working fluid properties, evaporating pressure and superheating temperature are the main factors influencing the system design and performances. The global recovery efficiency does not exceed 0.14 under typical operating conditions. Ethanol and R113 show better thermodynamic performances in the whole exhaust gas temperature range. In addition, the optimal evaporating pressure usually does not exist in engine exhaust heat recovery, and the distributions of exergy destruction are varied with working fluid categories and system design constraints. © 2013 Elsevier Ltd.


Bao W.,Shanghai JiaoTong University
Respirology (Carlton, Vic.) | Year: 2013

Procaterol, a selective, short-acting beta-2 adrenoceptor agonist, is effective in treating 'classical' asthma, but its efficacy for cough-variant asthma (CVA) is unknown. We evaluated the efficacy and safety of procaterol combined with budesonide for CVA. A prospective, randomized, double-blind, placebo-controlled, multicenter trial in China was conducted. One hundred and fifty-nine patients diagnosed with CVA (aged 18-75 years) were randomly divided into two groups to receive twice daily for 8 weeks, inhaled budesonide 100 μg plus either oral procaterol 25 μg or placebo. Primary and secondary efficacy variables were cough symptom severity scores and Leicester Cough Questionnaire (LCQ) life quality scores. Adverse events were also assessed. The budesonide/placebo and budesonide/procaterol groups contained 80 and 78 participants (one excluded for later diagnosis of eosinophilic bronchitis), respectively, with similar baseline characteristics. Daily cough score declined during treatment in both groups and was lower in the budesonide/procaterol group at 8 (0.44 vs 0.73) and 10 (0.36 vs 0.69) weeks (P < 0.05). Compared with the budesonide/placebo group, the proportion of patients with a reduction of 3 points or greater (66% vs 42%) and that of patients scoring 0 points (63% vs 51%) was higher in the budesonide/procaterol group for daily cough scores (P < 0.05). At 8 weeks, LCQ score improvement was superior in the budesonide/procaterol group (38.94 ± 19.24 vs 32.71 ± 18.92; P < 0.05). Procaterol combined with budesonide was well tolerated and effective at improving cough symptoms and quality of life in patients with CVA. © 2013 The Authors. Respirology © 2013 Asian Pacific Society of Respirology.


Liao H.,Shanghai JiaoTong University | Liao H.,University of Manchester | Xu Z.,University of Sichuan | Zeng X.-J.,University of Manchester
Information Sciences | Year: 2014

The hesitant fuzzy linguistic term sets (HFLTSs), which can be used to represent an expert's hesitant preferences when assessing a linguistic variable, increase the flexibility of eliciting and representing linguistic information. The HFLTSs have attracted a lot of attention recently due to their distinguished power and efficiency in representing uncertainty and vagueness within the process of decision making. To enhance and extend the applicability of HFLTSs, this paper investigates and develops different types of distance and similarity measures for HFLTSs. The paper first proposes a family of distance and similarity measures between two HFLTSs. Then a variety of weighted or ordered weighted distance and similarity measures between two collections of HFLTSs are proposed and analyzed for discrete and continuous cases respectively. After that, the application of these measures to multi-criteria decision making problems is given. Based on the proposed distance and similarity measures, the satisfaction degrees for different alternatives are established and are then used to rank alternatives in multi-criteria decision making. Finally a practical example concerning the evaluation of the quality of movies is given to illustrate the applicability and advantage of the proposed approach and the differences between the proposed distance and similarity measures. © 2014 Elsevier Inc. All rights reserved.


Xi Y.-G.,Shanghai JiaoTong University
Zidonghua Xuebao/Acta Automatica Sinica | Year: 2013

With the rapid development of communication and network technology, more and more complex dynamic networks appear in the fields of social, economic and human's daily life. Network science as a new interdisciplinary subject has gained great achievements in the research on performance characteristic, evolution process and control method of complex dynamic networks. The control theory and methodology of large scale systems, aiming at the behavior analysis, control and optimization for high dimensional dynamic systems, should be able to provide a helpful reference for the study of complex networks. In this paper, against some hotspot problems in the research of complex dynamic networks, we explore the possibility of using the control theory and methodology of large scale systems to solve the structural analysis and control problems of complex networks, analyze the facing difficulties and the possible coping ways. For control and optimization of large scale complex dynamic networks, a multi-layer hierarchical structure is proposed which integrates the macroscope analysis methods of network science, the quantitative design methods of control science and the intelligent processing methods of information science. Copyright © 2013 Acta Automatica Sinica. All rights reserved.


Qin J.,Shanghai JiaoTong University | Luo M.,Shanghai JiaoTong University
FEBS Letters | Year: 2014

MicroRNAs (miRNAs) have recently emerged as regulators of metastasis. We provide insight into the behavior of miR-221 in colorectal cancer (CRC) metastasis by showing that miR-221 is significantly upregulated in metastatic CRC cell lines and tissues. miR-221 overexpression enhances, whereas miR-221 depletion reduces CRC cell migration and invasion in vitro and metastasis in vivo. We identify RECK as a direct target of miR-221, reveal its expression to be inversely correlated with miR-221 in CRC samples and show that its re-introduction reverses miR-221-induced CRC invasiveness. Collectively, miR-221 is an oncogenic miRNA which may regulate CRC migration and invasion through targeting RECK. © 2013 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.


Zhang D.-G.,Shanghai JiaoTong University
International Journal of Non-Linear Mechanics | Year: 2013

In this paper, non-linear bending analysis is first presented for super elliptical thin plates with simply supported edge and clamped edge based on classical plate theory. Approximate solutions of super elliptical thin plates are obtained by Ritz method, convergence studies are discussed, and the validity can be confirmed by comparison with related researchers' results. It can be observed that the characteristics of non-linear bending are significantly influenced by different boundary conditions, ratio of major to minor axis, as well as the power of the super ellipse. © 2013 Elsevier Ltd.


OBJECTIVE:: We assessed the prognostic value of ECG left ventricular hypertrophy (LVH) using Sokolow–Lyon (SL-LVH), Cornell voltage (CV-LVH) or Cornell product (CP-LVH) criteria in 3043 hypertensive people aged 80 years and over enrolled in the Hypertension in the Very Elderly Trial. METHODS:: Multivariate Cox proportional hazard models were used to estimate hazard ratios with 95% confidence intervals (CIs) for all-cause mortality, cardiovascular diseases, stroke and heart failure in participants with and without LVH at baseline. The mean follow-up was 2.1 years. RESULTS:: LVH identified by CV-LVH or CP-LVH criteria was associated with a 1.6–1.9-fold risk of cardiovascular disease and stroke. The presence of CP-LVH was associated with an increased risk of heart failure (hazard ratio 2.38, 95% CI 1.16–4.86). In sex-specific analyses, CV-LVH (hazard ratio 1.94, 95% CI 1.06–3.55) and CP-LVH (hazard ratio 2.36, 95% CI 1.25–4.45) were associated with an increased risk of stroke in women and of heart failure in men, CV-LVH (hazard ratio 6.47, 95% CI 1.41–29.79) and CP-LVH (10.63, 95% CI 3.58–31.57), respectively. There was no significant increase in the risk of any outcomes associated with Sokolow–Lyon-LVH. LVH identified by these three methods was not a significant predictor of all-cause mortality. CONCLUSION:: Use of Cornell voltage and Cornell product criteria for LVH predicted the risk of cardiovascular disease and stroke. Only Cornell product was associated with an increased risk of heart failure. This was particularly the case in men. The identification of ECG LVH proved to be important in very elderly hypertensive people. Copyright © 2016 Wolters Kluwer Health, Inc. All rights reserved.


Fang Y.,Fudan University | Xue J.-L.,Fudan University | Shen Q.,Fudan University | Chen J.,Fudan University | And 2 more authors.
Hepatology | Year: 2012

MicroRNAs (miRNAs) are known to be involved in carcinogenesis and tumor progression in hepatocellular carcinoma (HCC). Recently, microRNA-7 (miR-7) has been proven to play a substantial role in glioblastoma and breast cancer, but its functions in the context of HCC remain unknown. Here, we demonstrate that miR-7 inhibits HCC cell growth and metastasis invitro and in vivo. We first screened and identified a novel miR-7 target, phosphoinositide 3-kinase catalytic subunit delta (PIK3CD). Overexpression of miR-7 would specifically and markedly down-regulate its expression. miR-7-overexpressing subclones showed significant cell growth inhibition by G 0/G 1-phase cell-cycle arrest and significant impairment of cell migration in vitro. To identify the mechanisms, we investigated the phosphoinositide 3-kinase (PI3K)/Akt pathway and found that Akt, mammalian target of rapamycin (mTOR), and p70S6K were down-regulated, whereas 4EBP1 was up-regulated in miR-7-overexpressing subclones. We also identified two novel, putative miR-7 target genes, mTOR and p70S6K, which further suggests that miR-7 may be a key regulator of the PI3K/Akt pathway. In xenograft animal experiments, we found that overexpressed miR-7 effectively repressed tumor growth (3.5-fold decrease in mean tumor volume; n = 5) and abolished extrahepatic migration from liver to lung in a nude mouse model of metastasis (n = 5). The number of visible nodules on the lung surface was reduced by 32-fold. A correlation between miR-7 and PIK3CD expression was also confirmed in clinical samples of HCC. Conclusion: These findings indicate that miR-7 functions as a tumor suppressor and plays a substantial role in inhibiting the tumorigenesis and reversing the metastasis of HCC through the PI3K/Akt/mTOR-signaling pathway in vitro and in vivo. By targeting PIK3CD, mTOR, and p70S6K, miR-7 efficiently regulates the PI3K/Akt pathway. Given these results, miR-7 may be a potential therapeutic or diagnostic/prognostic target for treating HCC. © 2012 American Association for the Study of Liver Diseases.


Wang Y.-G.,Shanghai JiaoTong University | Yu F.,Shanghai JiaoTong University
Archive for Rational Mechanics and Analysis | Year: 2013

We analyze the linear stability of rectilinear compressible current-vortex sheets in two-dimensional isentropic magnetohydrodynamics, which is a free boundary problem with the boundary being characteristic. In the case when the magnitude of the magnetic field has no jump on the current-vortex sheets, we find a necessary and sufficient condition of linear stability for the rectilinear current-vortex sheets, showing that magnetic fields exert a stabilization effect on compressible vortex sheets. In addition, a loss of regularity with respect to the source terms, both in the interior domain and on the boundary, occurs in a priori estimates of solutions to the linearized problem for a rectilinear current-vortex sheet, as the Kreiss-Lopatinskii determinant associated with this linearized boundary value problem has roots on the boundary of frequency spaces. In this study, the construction of symmetrizers for a reduced differential system, which has poles at which the Kreiss-Lopatinskii condition may fail simultaneously, plays a crucial role in the a priori estimates. © 2013 Springer-Verlag Berlin Heidelberg.


Yao J.,Shanghai JiaoTong University | Liu X.,McGill University | Zhang C.,American Express
IEEE Transactions on Smart Grid | Year: 2014

More and more cloud computing services are handled by different Internet operators in distributed Internet data centers (IDCs), which incurs massive electricity costs. Today, the power usage of data centers contributes to more than 1.5% market share of electricity consumption across the United States. Minimization of these costs benefits cloud computing operators, and attracts increasing attentions from many research groups and industrial sectors. Along with the deployment of smart grid, the electrical real-time pricing policy promotes power consumers to adaptively schedule their electricity utilization for lower operational costs. This paper proposes a novel approach to enable electrical energy buffering in batteries to predictively minimize IDC electricity costs in smart grid. Batteries are charged when electricity price is low and discharged to power servers when electricity price is high. A power management controller is used per battery to arbitrate the charging and discharging actions of the battery. The controller is designed as a MPC-based (model predictive control) controller. To this end, an MPC power minimization problem is formulated based on a discrete state-space model with states of battery power level and cost. Extensive simulation results demonstrate the effectiveness of our approach based on real-life electricity prices in smart grid. © 2010-2012 IEEE.


Xie L.,Shanghai JiaoTong University | Huang X.,Shanghai JiaoTong University | Wu C.,Shanghai JiaoTong University | Jiang P.,Shanghai JiaoTong University
Journal of Materials Chemistry | Year: 2011

Core-shell structured BaTiO3/poly(methyl methacrylate) (PMMA) nanocomposites were successfully prepared by in situ atom transfer radical polymerization (ATRP) of methyl methacrylate (MMA) from the surface of BaTiO3 nanoparticles. A broadband dielectric spectrometer was used to investigate the temperature dependence of the dielectric properties of the nanocomposites in a frequency range from 0.1 Hz to 1 MHz. It was found that the nanocomposites not only showed a significantly increased dielectric constant when compared with pure PMMA, but also showed the inherent low loss of the base polymer in a wide range of frequencies. Only in the very low frequency/high temperature range, can a higher dielectric loss can be observed in the nanocomposites. It was also found that the effective dielectric constant of the core-shell structured hybrid nanoparticles can be tailored by varying the polymer shell thickness. The dielectric response of beta relaxation of PMMA was also studied and the results showed that the nanoparticles had no influence upon the relaxation activation energy. Fourier-transform infrared spectroscopy (FTIR) and 1H NMR spectra confirmed the chemical structure of the PMMA shell on the surface of the BaTiO3 nanoparticles. Transmission electron microscopy (TEM) and thermogravimetric analysis (TGA) results revealed that the PMMA shell thickness could be well controlled by tuning the feed ratio of MMA to BaTiO3. © 2011 The Royal Society of Chemistry.


Yu F.,Shanghai JiaoTong University | Ma J.,Tongji University | Wu Y.,Shanghai JiaoTong University
Journal of Hazardous Materials | Year: 2011

The purified and oxidized multi-walled carbon nanotubes (MWCNTs) with different oxygen contents are employed as adsorbents to study their physicochemical properties and adsorption behaviors of toluene, ethylbenzene and m-xylene (TEX) in aqueous solutions. The results demonstrate that adsorption capacity is significantly enhanced for 3.2% surface oxygen, but is dramatically reduced for 5.9% oxygen concentration. The adsorption kinetics is investigated and fitted with pseudo-second-order model. The adsorption isotherms are found to be fitted with Langmuir model. More interestingly, with the increasing of surface oxygen content, maximum adsorption capacities firstly increased, and then, began to decrease. In the first stage, dispersion is the most important factor. A better dispersive interaction increases the available adsorption sites, which consequently can be favorable for the aqueous phase adsorption. Therefore, maximum adsorption capacity is remarkably enhanced with the increasing of oxygen content, which is according with our results. However, in the second stage, when oxygen content increases to a certain extent, hydroxyl groups cause water clusters formation on the surface or tube end of MWCNTs, which hinder the interaction between TEX and MWCNTs. Consequently, more oxygen content leads to the decrease in maximum adsorption capacity. The decrease indicates that the formation of water clusters plays a more important role than the better dispersion of MWCNTs for TEX adsorption. © 2011 Elsevier B.V.


Mo K.,Shanghai JiaoTong University | Yang Y.,Shanghai JiaoTong University | Cui Y.,Shanghai JiaoTong University
Journal of the American Chemical Society | Year: 2014

A homochiral metal-organic framework (MOF) of an enantiopure 2,2′-dihydroxy-1,1′-biphenyl ligand was constructed. After exchanging one proton of the dihydroxyl group for Li(I) ions, the framework is shown to be a highly efficient and recyclable heterogeneous catalyst for asymmetric cyanation of aldehydes with up to >99% ee. Compared with the homogeneous counterpart, the MOF catalyst exhibits significantly enhanced catalytic activity and enantioselectivity, especially at a low catalyst/substrate ratio, due to that the rigid framework could stabilize the catalytically active monolithium salt of biphenol against its free transformation to catalytically inactive and/or less active assemblies in reactions. The synthetic utility of the cyanation was demonstrated in the synthesis of (S)-bufuralol (a nonselective β-adrenoceptor blocking agent) with 98% ee. © 2014 American Chemical Society.


Modeling and analysis for the postbuckling of carbon nanotube-reinforced composite (CNTRC) cylindrical panels resting on elastic foundations subjected to lateral pressure in thermal environments are presented. Various profiles of single walled carbon nanotubes (SWCNTs) which are assumed to be uniformly distributed (UD) or functionally graded (FG) distribution along the thickness are taken into consideration. The temperature dependent material properties of FG-CNTRC panels are estimated through a micromechanical model. The formulations are developed based on a higher order shear deformation theory. To capture the large deflections, geometrical nonlinearity in von Kármán sense is taken into account. The panel-foundation interaction and thermal effects are also included. The initial deflections caused by lateral pressure and thermal bending stresses are both taken into account. The governing equations are first deduced to a boundary layer type that includes nonlinear prebuckling deformations and initial geometric imperfections of the panel. These equations are then solved by means of a singular perturbation technique along with a two-step perturbation approach. The influences of CNT volume fraction, temperature variation, panel geometric parameters as well as foundation stiffness on the postbuckling behavior of FG-CNTRC cylindrical panels are investigated. © 2016 Elsevier Ltd


Abdalla E.,University of Sao Paulo | Graef L.L.,University of Sao Paulo | Wang B.,Shanghai JiaoTong University
Physics Letters, Section B: Nuclear, Elementary Particle and High-Energy Physics | Year: 2013

We discuss a model of nonperturbative decay of dark energy. We suggest the possibility that this model can provide a mechanism from the field theory to realize the energy transfer from dark energy into dark matter, which is the requirement to alleviate the coincidence problem. The advantage of the model is the fact that it accommodates a mean life compatible with the age of the universe. We also argue that supersymmetry is a natural set up, though not essential. © 2013 Elsevier B.V.


Chen G.,Shanghai JiaoTong University
Archivum Immunologiae et Therapiae Experimentalis | Year: 2010

Rheumatoid arthritis is a chronic disorder for which there is no known cure. Concentrating on specific elements of the abnormal immune response that characterizes the disease, scientists are reaching into biotechnology's bag of tricks to develop immunotherapeutic techniques. This paper will present some advances in the immunotherapy of rheumatoid arthritis targeting inflammatory cytokines and autoreactive T cells. © 2009 L. Hirszfeld Institute of Immunology and Experimental Therapy, Wroclaw, Poland.


Zhang Z.,Shanghai JiaoTong University | Chen L.-W.,Shanghai JiaoTong University | Chen L.-W.,Accelerator Centre
Physics Letters, Section B: Nuclear, Elementary Particle and High-Energy Physics | Year: 2013

We show that the neutron skin thickness δrnp of heavy nuclei is uniquely fixed by the symmetry energy density slope L(ρ) at a subsaturation cross density ρc≈0.11 fm-3 rather than at saturation density ρ0, while the binding energy difference δE between a heavy isotope pair is essentially determined by the magnitude of the symmetry energy Esym(ρ) at the same ρc. Furthermore, we find a value of L(ρc) leads to a negative Esym(ρ0)-L(ρ0) correlation while a value of Esym(ρc) leads to a positive one. Using data on δrnp of Sn isotopes and δE of a number of heavy isotope pairs, we obtain simultaneously Esym(ρc)=26.65±0.20 MeV and L(ρc)=46.0±4.5 MeV at 95% confidence level, whose extrapolation gives Esym(ρ0)=32.3±1.0 MeV and L(ρ0)=45.2±10.0 MeV. The implication of these new constraints on the δrnp of 208Pb and the core-crust transition density in neutron stars is discussed. © 2013 Elsevier B.V.


Tang Y.,Shanghai JiaoTong University | Xu J.,Shanghai JiaoTong University
Applied Physics Express | Year: 2012

A hybrid-pumped gain-switched Tm 3+ fiber laser with an all-fiber configuration is demonstrated to achieve over 10W 2 μm pulsed laser beams. This laser system is complementarily pumped by a 790nm diode laser and a 1 μm pulsed Yb 3+ fiber laser. Based on the triggering effect of a 1 μm pulse pump, most of the stored energy is efficiently transformed into the 2 μm laser pulse. The laser wavelength is centered at 2018.3nm with a spectral bandwidth of 0.08 nm. The maximum pulse energy is 2mJ with a pulse width of 500 ns, corresponding to a peak power of 4 kW. © 2012 The Japan Society of Applied Physics.


Shao X.-F.,Shanghai JiaoTong University
IEEE Transactions on Engineering Management | Year: 2013

This paper explores the effectiveness of mass customization strategies in a manufacturing firm. The manufacturing firm produces standard products in a flexible factory where mass customization is technologically feasible. We integrate product strategy and channel design to explore whether the firm should adopt mass customization and how the distribution channel should be configured for custom products. We find that the mixed mass customization strategy dominates the pure standard product strategy in the centralized system. For the decentralized system, we identify the parameters that would impact superiority of each product strategy. We further discuss two channel structures for mass customization: single-channel strategy and dual-channel strategy, and find that the dual-channel strategy is always superior to the single-channel strategy when mixed mass customization is adopted. © 1988-2012 IEEE.


Zhao H.,Shanghai JiaoTong University | Zhu L.,Shanghai JiaoTong University | Ding H.,Shanghai JiaoTong University
International Journal of Machine Tools and Manufacture | Year: 2013

Straight lines, or GOl blocks, are the most widespread representation form for the tool path in CNC machining. At the junctions between consecutive segments, the tangency and curvature discontinuities may lead to feedrate fluctuation and acceleration oscillation, which would deteriorate the machining efficiency and quality. To solve this problem, a real-time path-smoothing method is proposed, which adopts a curvature-continuous B-spline with five control points to blend the adjacent straight lines. The advantage of the transition scheme is that, G2 continuity, analytical calculation of the curvature extrema, approximation error control and real-time performance are considered simultaneously. Then, a bidirectional scanning algorithm for jerk limited S-shape feedrate profile is proposed to evaluate the feedrate constraints. On this basis, a real-time look-ahead scheme, which comprises of path-smoothing, bidirectional scanning and feedrate scheduling, is developed to acquire a feedrate profile with smooth acceleration. Also, an arc-length based interpolation algorithm for mixed linear and parametric segments is proposed to overcome the difficulty of crossing different segments. With these schemes, the smoothness of both tool path and feedrate is guaranteed. Simulation and experiments on anX-Y-Z platform are conducted. The results demonstrate the feasibility and efficiency of the present algorithms. © 2012 Elsevier Ltd. All rights reserved.


Du S.,Shanghai JiaoTong University | Lv J.,East China Normal University
International Journal of Production Economics | Year: 2013

Though traditional control charts have been widely used as effective tools in statistical process control (SPC), they are not applicable in many industrial applications where the process variables are highly auto-correlated. In this study, one new minimal Euclidean distance (MED) based monitoring approach is proposed for enhancing the monitoring mean shifts of auto-correlated processes. Support vector regression (SVR) is used to predict the values of a variable in time series. Through calculating minimal Euclidean distance (MED) values over time series, a novel MED chart is developed for monitoring mean shifts, and it can provide a comprehensive and quantitative assessment for the current process state. The performance of the proposed MED control chart is evaluated based on average run length (ARL). Simulation experiments are conducted and one industrial case is illustrated to validate the effectiveness of the developed MED control chart. The analysis results indicate that the developed MED control chart is more effective than other control charts for small process mean shifts in auto-correlated processes, and it can be used as a promising tool for SPC. © 2012 Elsevier B.V. All rights reserved.


Zhu L.,Shanghai JiaoTong University | Zhao H.,Shanghai JiaoTong University | Ding H.,Shanghai JiaoTong University
International Journal of Machine Tools and Manufacture | Year: 2013

To reduce contour error in contour-following tasks, a common approach is to design a controller based on the contour error information. Hence, real-time contouring error estimation plays an important role in contour-following control. However, the available second-order estimation formulas only apply to biaxial motion systems, and cannot be generalized to handle arbitrary contours tracked by multi-axis motion systems. In this paper, a point-to-curve distance function is defined, and its properties are investigated, especially, its second-order Taylor approximant is derived. On this basis, a novel second-order approach for calculating contour errors of arbitrary contours in real time is proposed. The inter-correlations between the present approach and four commonly used ones are classified. Simulation and experimental results demonstrate the effectiveness of the proposed contour error estimation algorithm. © 2013 Elsevier Ltd.


Li Y.,Shanghai JiaoTong University | Lin Z.,Shanghai JiaoTong University | Lin Z.,University of Virginia
Automatica | Year: 2013

Ellipsoids, as level sets of quadratic Lyapunov functions, and the convex hull of ellipsoids, as a level set of a certain composite quadratic Lyapunov function, have both been extensively used as estimates of the domain of attraction of a linear system under saturated linear feedback. By expressing the saturated linear feedback law on the convex hull of a group of linear feedback laws, which in turn expresses the linear system under this saturated linear feedback in a linear differential inclusion, conditions have been established under which an ellipsoid or the convex hull of a group of ellipsoids are contractively invariant sets and are thus estimates of the domain of attraction. These conditions are usually less conservative for single input systems than for multiple input systems. In this paper, we consider multiple input systems and establish conditions for contractive invariance of the convex hull of ellipsoids that are less conservative than the existing conditions. © 2012 Elsevier Ltd. All rights reserved.


Song J.,Nanyang Technological University | Guo F.,Shanghai JiaoTong University
Thin-Walled Structures | Year: 2013

The collapse of thin-walled tubes under axial and oblique loading is frequently encountered in real crash events. The windowing and multi-cell methods are effective in improving tubes' energy absorbing performance. In this paper, a comparative study on the performance of windowed and multi-cell square tubes of the same weight under axial and oblique loading is conducted numerically. The results show that the multi-cell tube can achieve higher mean crushing force than the windowed tube but the windowed tube has lower initial peak force. The effectiveness of both methods reduces as the load angle increases. Moreover, the multi-cell and windowed tubes may have worse performance than the conventional tube if the former two collapse in global bending and the later in axial mode. © 2013 Elsevier Ltd.


Wang H.,Shanghai JiaoTong University
International Journal of Production Research | Year: 2013

One of the most important quality control tools for mass customisation production (MCP) is defects tracking. Classical statistical process control and design of experiment technologies are not useful for MCP quality control due to the extensive difference in organisational structures, values, management roles and systems, learning and training techniques and customer relations with the traditional mass production. Defects tracking work is often affected by the frequent reconfiguration of the production line and the interruption of the quality information flow. The purpose of this research is to develop an effective and efficient tool for defects tracking in MCP. A defect tracking matrix (DTM) based on house of quality is constructed to directly connect manufacturing technologies with quality defects within a production module. An AHP method is employed and a new correlation coefficients calculation algorithm is proposed to build the 'house'. The matrix, which is called 'defect-gene matrix', contains core defects and manufacturing technologies extracted from DTM by using principle component analysis. The defect-gene matrix can identify and track defects in mass customisation production without being affected by the frequent reconfiguration of the production line and the interruption of the quality information flow. The application revealed that the proposed DTM and defect-gene matrix was an effective and efficient tool for defects tracking in MCP. The defect-gene matrix brings a novel idea to defects tracking. The results of this research will help systematically in defects tracking in MCP. © 2013 Copyright Taylor and Francis Group, LLC.


Shen H.-S.,Shanghai JiaoTong University | Xiang Y.,University of Western Sydney
Engineering Structures | Year: 2013

This paper studies the behaviors of large amplitude vibration, nonlinear bending and thermal postbuckling of nanocomposite beams reinforced by single-walled carbon nanotubes (SWCNTs) resting on an elastic foundation in thermal environments. Two types of carbon nanotube-reinforced composite (CNTRC) beams, namely, uniformly distributed (UD) and functionally graded (FG) reinforcements, are considered. The material properties of FG-CNTRCs are assumed to be graded in the beam thickness direction, and are estimated through a micromechanical model. The motion equations of a CNTRC beam on an elastic foundation are derived based on a higher order shear deformation beam theory. The thermal effects are also included in the motion equations and the material properties of CNTRCs are assumed to be temperature-dependent. Numerical studies are carried out for the nonlinear vibration, nonlinear bending and thermal postbuckling of CNTRC beams resting on Pasternak elastic foundations under different thermal environmental conditions. It is found that a CNTRC beam with intermediate CNT volume fraction does not necessarily have intermediate nonlinear frequencies, buckling temperatures and thermal postbuckling strengths. Thermal postbuckling path of unsymmetric FG-CNTRC beams is no longer the bifurcation type. © 2013 Elsevier Ltd.


Wang Y.,Shanghai JiaoTong University | Wang F.,Shanghai JiaoTong University
IEEE Transactions on Power Electronics | Year: 2013

Characterized by the low leakage current and high efficiency, a three-level neutral point clamped (3L-NPC) inverter becomes more popular for a transformerless photovoltaic grid connected system. The three-level-stacked neutral point clamped (3L-SNPC) structure is a derivative of 3L-NPC providing more advantages such as a double apparent switching frequency and parallel load current paths. In this paper, the power loss distribution and features of 3L-SNPC are analyzed first when applied to solar inverters. Based on the analysis, a novel 3L-SNPC leg structure is proposed for solar applications in order to reduce the power loss particularly for the low power range, given the fact that solar inverters generally operate in the low power range during most of the daytime. Then, a two-stage solar inverter topology, applying the proposed structure to the phase leg, is described. Further, a split phase controller is applied for the two-stage solar inverter, consisting of the maximum power point tracking control, optimized dc-link voltage control, and grid current control. Finally, a new dead-time elimination pulsewidth modulation strategy is proposed and conveniently implemented to each phase based on the split phase controller. Experimental results are illustrated to demonstrate the applicability of the proposed topology and controller. © 2012 IEEE.


Wei L.,Shanghai JiaoTong University | Chen W.,Shanghai JiaoTong University | Chen W.,Xidian University
IEEE Transactions on Wireless Communications | Year: 2012

Network coding is a new and promising paradigm for modern communication networks by allowing intermediate nodes to mix messages received from multiple sources. Compute-and-forward strategy is one category of network coding in which a relay will decode and forward a linear combination of source messages according to the observed channel coefficients, based on the algebraic structure of lattice codes. The destination will recover all transmitted messages if enough linear equations are received. In this work, we design in a system level, the compute-and-forward network coding coefficients by Fincke-Pohst based candidate set searching algorithm and network coding system matrix constructing algorithm, such that by those proposed algorithms, the transmission rate of the multi-source multi-relay system is maximized. Numerical results demonstrate the effectiveness of our proposed algorithms. © 2012 IEEE.


Min Z.,Shanghai JiaoTong University
The American journal of drug and alcohol abuse | Year: 2011

To conduct a pilot assessment of relapse prevention (RP) group therapy for heroin-dependent patients in a drug rehabilitation center in China. A randomized case-control study was conducted to assess the efficacy of RP delivered over a 2-month period to male heroin addicts (n = 50, RP group) in the Shanghai Labor Drug Rehabilitation Center (LDRC) compared with an equal number of participants (n = 50, labor rehabilitation (LR) group) in the LDRC program receiving standard-of-care treatment. Outcomes were assessed by the Beck Depression Inventory (BDI), the Self-Rating Anxiety Scale (SAS), the Self-Efficacy Scale (SE), and the Self-Esteem Scale (SES) after completion of RP, and by the Addiction Severity Index (ASI) and abstinence rates of heroin use at 3-month follow-up post release from the LDRC for both groups. Significant improvements in scores on SAS, SE, and SES were found in the RP group after completion of the 2-month RP group therapy compared with the LR group (SAS 7.85 ± 6.20 vs 1.07 ± 5.42, SE 3.88 ± 3.60 vs .08 ± 2.89, and SES 3.83 ± 3.31 vs .78 ± 2.55). At 3-month follow-up, the RP group participants had more improvements on ASI scores in most domains and had higher abstinence rates than that in the LR group (37.2% vs 16.7%). An RP component can be effective in increasing abstinence rates among post-program heroin-dependent individuals and may help reduce anxiety and improve self-esteem and self-efficacy during and following treatment. SCIENTIFIC SIGNIFICANCE: This study suggests RP as a potentially effective component of treatment for heroin addicts.


Liu H.,Shanghai JiaoTong University | Dong C.,Shanghai JiaoTong University | Ren J.,Shanghai JiaoTong University
Journal of the American Chemical Society | Year: 2014

In this study, a new tempo-spatially resolved fluctuation spectroscopy under dark-field illumination is described, named dark-field illumination-based scattering correlation spectroscopy (DFSCS). DFSCS is a single-particle method, whose principle is similar to that of fluorescence correlation spectroscopy (FCS). DFSCS correlates the fluctuations of the scattered light from single nanoparticle under dark-field illumination. We developed a theoretical model for translational diffusion of nanoparticles in DFSCS system. The results of computer simulations documented that this model was able to well describe the diffusion behaviors of nanoparticles in uniformly illuminated field. The experimental setup of DFSCS was achieved by introducing a dark-field condenser to the frequently used bright-field microscope and an electron multiplying charge-coupled device (EMCCD) as the array detector. In the optimal condition, a stack of 500 000 frames were collected simultaneously on 64 detection channels for a single measurement with acquisition rate of 0.5 ms per frame. We systematically investigated the effect of certain factors such as particle concentration, viscosity of the solution, and heterogeneity of gold nanoparticles (GNPs) samples on DFSCS measurements. The experiment data confirmed theoretical model proposed. Furthermore, this new method was successfully used for investigating dynamic behaviors of GNPs in live cells. Our preliminary results demonstrate that DFSCS is a practical and affordable tool for ordinary laboratories to investigate the dynamic information of nanoparticles in vitro as well as in vivo. © 2014 American Chemical Society.


Zheng Y.X.,Shanghai JiaoTong University
World journal of gastroenterology : WJG | Year: 2012

To investigate the relationship and molecular features of CD74/macrophage migration inhibitory factor (MIF)/Toll-like receptor 4 (TLR4) in gastric cancer. CD74, MIF and TLR4 expression in the paraffin-embedded sections of gastric cancer from 120 patients were detected by immunohistochemical staining. Knock down of CD74 expression in gastric cancer cell line MKN-45 was performed by lentivirus transduction and detected by Western blotting. MKN-45 cell proliferation assay under the stimulants was measured by the cell counting kit 8 (CCK8) assay and MIF concentration in the culture medium was detected by enzyme-linked immunosorbent assay. Surface staining of CD74 in the MKN-45 cell line under the stimulation of lipopolysaccharide (LPS) was measured by flow cytometry. MIF, CD74 and TLR4 co-localization in the MKN-45 cell line was performed by the immunoprecipitation. CD74, MIF and TLR4 were found to be expressed in gastric cancer and increased significantly in the advanced stage, and were also associated with lymph node metastasis. Correlation analysis revealed that CD74 was positively correlated with MIF (r = 0.2367, P < 0.01) and both proteins were also associated with TLR4 (r = 0.4414, r = 0.5001, respectively, P < 0.01). LPS can significantly promote MKN-45 cell proliferation (3.027 ± 0.388 vs 4.201 ± 0.092, P < 0.05), induce MIF production (54.333 ± 2.906 pg/mL vs 29.667 ± 3.180 pg/mL, P < 0.01) and cell surface expression of CD74 (75.6% ± 4.046% vs 9.4% ± 0.964%, P < 0.01) at LPS concentration of 1 μg/mL compared to medium control. Knockdown of CD74 or using anti-CD74 and MIF antagonist ISO-1 significantly reduced LPS-induced MKN-45 cell proliferation (4.201 ± 0.092 vs 3.337 ± 0.087, 4.534 ± 0.222 vs 3.368 ± 0.290, 4.058 ± 0.292 vs 2.934 ± 0.197, respectively, P < 0.01). MIF, CD74 and TLR4 could co-localize in the MKN-45 cell line. Upregulation of MIF, CD74 and TLR4 are associated with increasing clinical stage and provide an opportunity as novel gastric cancer chemoprevention and/or treatment strategy.


Li D.,Shanghai JiaoTong University | Mao J.-F.,Shanghai JiaoTong University
IEEE Transactions on Antennas and Propagation | Year: 2012

A novel Koch-like fractal curve is proposed to transform ultra-wideband (UWB) bow-tie into so called Koch-like sided fractal bow-tie dipole. A small isosceles triangle is cut off from center of each side of the initial isosceles triangle, then the procedure iterates along the sides like Koch curve does, forming the Koch-like fractal bow-tie geometry. The fractal bow-tie of each iterative is investigated without feedline in free space for fractal trait unveiling first, followed by detailed expansion upon the four-iterated pragmatic fractal bow-tie dipole fed by 50-Ω coaxial SMA connector through coplanar stripline (CPS) and comparison with Sierpinski gasket. The fractal bow-tie dipole can operate in multiband with moderate gain (3.5-7 dBi) and high efficiency (60%-80%), which is corresponding to certain shape parameters, such as notch ratio α, notch angle ψ, and base angles θ of the isosceles triangle. Compared with conventional bow-tie dipole and Sierpinski gasket with the same size, this fractal-like antenna has almost the same operating properties in low frequency and better radiation pattern in high frequency in multi-band operation, which makes it a better candidate for applications of PCS, WLAN, WiFi, WiMAX, and other communication systems. © 2012 IEEE.


Wang R.,Shanghai JiaoTong University | Xu Z.,Shanghai JiaoTong University
Waste Management | Year: 2014

The world's waste electrical and electronic equipment (WEEE) consumption has increased incredibly in recent decades, which have drawn much attention from the public. However, the major economic driving force for recycling of WEEE is the value of the metallic fractions (MFs). The non-metallic fractions (NMFs), which take up a large proportion of E-wastes, were treated by incineration or landfill in the past. NMFs from WEEE contain heavy metals, brominated flame retardant (BFRs) and other toxic and hazardous substances. Combustion as well as landfill may cause serious environmental problems. Therefore, research on resource reutilization and safe disposal of the NMFs from WEEE has a great significance from the viewpoint of environmental protection. Among the enormous variety of NMFs from WEEE, some of them are quite easy to recycle while others are difficult, such as plastics, glass and NMFs from waste printed circuit boards (WPCBs). In this paper, we mainly focus on the intractable NMFs from WEEE. Methods and technologies of recycling the two types of NMFs from WEEE, plastics, glass are reviewed in this paper. For WEEE plastics, the pyrolysis technology has the lowest energy consumption and the pyrolysis oil could be obtained, but the containing of BFRs makes the pyrolysis recycling process problematic. Supercritical fluids (SCF) and gasification technology have a potentially smaller environmental impact than pyrolysis process, but the energy consumption is higher. With regard to WEEE glass, lead removing is requisite before the reutilization of the cathode ray tube (CRT) funnel glass, and the recycling of liquid crystal display (LCD) glass is economically viable for the containing of precious metals (indium and tin). However, the environmental assessment of the recycling process is essential and important before the industrialized production stage. For example, noise and dust should be evaluated during the glass cutting process. This study could contribute significantly to understanding the recycling methods of NMFs from WEEE and serve as guidance for the future technology research and development. © 2014 Elsevier Ltd.


Zhang P.,Shanghai JiaoTong University | Gao L.,Shanghai JiaoTong University | Song X.,Shanghai JiaoTong University | Sun J.,CAS Shanghai Institute of Ceramics
Advanced Materials | Year: 2015

Artificial photosynthesis of clean fuels has aroused great interest to meet the great demand for clean and renewable energy. Great advances have recently been made in various photoelectrodes with their efficiencies and stabilities significantly improved by the design and implementation of novel structures, which are determinative for the optical absorption, charge-transport path, surface area, and electronic conductivity. This Research News article discusses perspectives of the synthetic methods and micro- and nanostructures (planar structures, 1D structures, and mesoporous structures) of photoelectrodes, and their relationships with the photo-electrochemical performance. Structural features, such as particle size, crystallinity, morphology, and film thickness, as well as the trade-offsamong them are also evaluated and discussed for each category of structure. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.


Wang Y.,Shanghai JiaoTong University | Gu H.,Shanghai JiaoTong University
Advanced Materials | Year: 2015

Advances in nanotechnology and nanomedicine offer great opportunities for the development of nanoscaled theranostic platforms. Among various multifunctional nanocarriers, magnetic mesoporous silica nanocomposites (M-MSNs) attract prominent research interest for their outstanding properties and potential biomedical applications. This Research News article highlights recent progress in the design of core-shell-type M-MSNs for both diagnostic and therapeutic applications. First, an overview of synthetic strategies for three representative core-shell-type M-MSNs with different morphologies and structures is presented. Then, the diagnostic functions of M-MSNs is illustrated for magnetic resonance imaging (MRI) applications. Next, magnetic targeted delivery and stimuli-responsive release of drugs, and effective package of DNA/siRNA inside mesopores using M-MSNs as therapeutic agent carriers are discussed. The article concludes with some import ant challenges that need to be overcome for further practical applications of M-MSNs in nanomedicine. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.


Duan H.,Shanghai JiaoTong University | Hueste M.B.D.,Texas A&M University
Engineering Structures | Year: 2012

This paper investigates the seismic performance of a multi-story reinforced concrete frame building designed according to the provisions of the current Chinese seismic code (GB50011-2010). A typical five-story reinforced concrete frame building is designed. Seven natural earthquake acceleration records, selected and adjusted for compatibility with the adopted design spectrum, are used. The frame structure is evaluated using both a nonlinear static (push-over) analysis and nonlinear dynamic time-history analysis. The assessment of seismic performance is based on both global and member level criteria. According to the numerical results, the building frame designed by GB50011-2010 provides the inelastic behavior and response intended by the code and satisfies the interstory drift and maximum plastic rotation limits suggested by ASCE/SEI 41-06. However, the push-over analysis indicated the potential for a soft first story mechanism under significant lateral demands. Design recommendations are provided to help ensure the preferred strong-column, weak-beam damage mechanism. © 2012 Elsevier Ltd.


Long M.,Shanghai JiaoTong University | Cai W.,Shanghai JiaoTong University
Nanoscale | Year: 2014

Silver/silver compound (SSC) composites have received much attention as a type of potential materials in photochemical reactions due to their high efficiency, facile syntheses and availability of raw materials. This article reviews the state-of-the-art progress on the advanced nanoarchitectures of SSC composites. We begin with a survey on the general synthetic strategies for SSC composites, and then step into relatively detailed methods for size and morphology tunable two-component and more delicate multi-component SSC nanostructures. In addition, the electronic structure-related mechanisms of such materials and the recent studies on their stability are summarized. This review also highlights some perspectives on challenges related to the SSC composites and the possible research in the future. © 2014 the Partner Organisations.


Lou Y.,Nanjing Southeast University | Zhao Y.,Shanghai JiaoTong University | Chen J.,Nanjing Southeast University | Zhu J.-J.,Nanjing University
Journal of Materials Chemistry C | Year: 2014

Colloidal semiconductor nanocrystals or quantum dots (QDs) have been facilitating the development of sensitive fluorescence sensors over the past decade, due to their unique photophysical properties, versatile surface chemistry and ligand binding ability, and the possibility of the encapsulation in different materials or attachment to different functional materials, while retaining their native luminescence property. The optical metal ion chemosensors with high sensitivity and selectivity have been developed due to the importance of the metal ions' fundamental roles, possessed in a wide range of biological processes and the aquatic environment. This review addresses the different sensing strategies with chemically modified QD hybrid structures for the sensing of metal ions in aqueous solution or an in vivo environment, and discusses the photophysical mechanisms in the different sensor systems while comparing their detecting/sensing selectivity. The perspectives for the future potential developments in QD based optical sensing for metal ions are discussed. © 2013 The Royal Society of Chemistry.


Zhou L.,Shanghai JiaoTong University | Lu W.,Shanghai JiaoTong University
Chemistry - A European Journal | Year: 2014

An overview of recent progress in the Fujiwara-Moritani reaction, which is the palladium-catalyzed oxidative coupling of arenes with olefins to afford alkenyl arenes, is described. It is emphasized that regioselectivity on aryl ortho- or meta-C-H activation could be controlled very well in the presence of Pd, Rh, or Ru catalysts with the assistance of various chelation groups on aromatic rings in this coupling reaction. Catalytic alkenylation of aryl C-H bonds from simple arenes is also discussed, especially from electron-deficient arenes. These advanced protocols would not only make the Fujiwara-Moritani reaction more useful and applicable in organic synthesis but also light the way for the further development of the functionalization of normal C-H bonds. Copyright © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.


Liao S.,Shanghai JiaoTong University
Science China: Physics, Mechanics and Astronomy | Year: 2012

It is well-known that the celebrated Camassa-Holm equation has the peaked solitary waves, which have been not reported for other mainstream models of shallow water waves. In this letter, the closed-form solutions of peaked solitary waves of the KdV equation, the BBM equation and the Boussinesq equation are given for the first time. All of them have either a peakon or an anti-peakon. Each of them exactly satisfies the corresponding Rankine-Hogoniot jump condition and could be understood as weak solution. Therefore, the peaked solitary waves might be common for most of shallow water wave models, no matter whether or not they are integrable and/or admit breaking-wave solutions. © 2012 Science China Press and Springer-Verlag Berlin Heidelberg.


Wang Y.,Shanghai JiaoTong University | Gao Q.,Shanghai JiaoTong University | Cai X.,Shanghai JiaoTong University
IEEE Transactions on Industrial Electronics | Year: 2011

Numerous studies have been carried out to compensate or eliminate the dead-time effect. This paper analyzes the limitations of the previous compensation or elimination schemes. Then, a novel mixed pulsewidth-modulation scheme for dead-time elimination and compensation is proposed for the grid-tied inverter. The proposed scheme implements the dead-time elimination in most of the grid current fundamental period but switches to the conventional dead-time compensation around the zero-crossing point. In this way, a safe and efficient dead-time effect elimination method is achieved. Furthermore, this paper proposes to determine the switching point and the compensation direction by the grid current modulation function. Experimental results are given to demonstrate the validity and features of the proposed method. © 2011 IEEE.


Peng Y.,Shanghai JiaoTong University | Dong M.,Shanghai JiaoTong University
Expert Systems with Applications | Year: 2011

This paper presents a hybrid prognosis approach of age-dependent hidden Markov model (HMM) and grey model (GM) for prediction of engineering asset health. Age-dependent HMM allows modeling the time duration of the hidden states and therefore is capable of prognosis. The estimated state duration probability distributions can be used to predict the remaining useful life (RUL) of the assets. The previous HMM based prognosis method assumed that the transition probabilities are only state-dependent. That is, the probability of making transition to a less healthy state does not increase with the age. In the proposed method, in order to characterize a deteriorating asset, an aging factor that discounts the probabilities of staying at current state while increasing the probabilities of transitions to less healthy states will be introduced. After the estimation of the aging factor, a grey model is used to compute the expected residual life (ERL) by redefining the hazard rate. With the asset health prognosis, the behavior of the asset condition can be predicted. © 2010 Elsevier Ltd. All rights reserved.


Fei N.,Shanghai JiaoTong University | Zhao L.,Shanghai JiaoTong University
ISME Journal | Year: 2013

Lipopolysaccharide endotoxin is the only known bacterial product which, when subcutaneously infused into mice in its purified form, can induce obesity and insulin resistance via an inflammation-mediated pathway. Here we show that one endotoxin-producing bacterium isolated from a morbidly obese human's gut induced obesity and insulin resistance in germfree mice. The endotoxin-producing Enterobacter decreased in relative abundance from 35% of the volunteer's gut bacteria to non-detectable, during which time the volunteer lost 51.4 kg of 174.8 kg initial weight and recovered from hyperglycemia and hypertension after 23 weeks on a diet of whole grains, traditional Chinese medicinal foods and prebiotics. A decreased abundance of endotoxin biosynthetic genes in the gut of the volunteer was correlated with a decreased circulating endotoxin load and alleviated inflammation. Mono-association of germfree C57BL-6J mice with strain Enterobacter cloacae B29 isolated from the volunteer's gut induced fully developed obesity and insulin resistance on a high-fat diet but not on normal chow diet, whereas the germfree control mice on a high-fat diet did not exhibit the same disease phenotypes. The Enterobacter-induced obese mice showed increased serum endotoxin load and aggravated inflammatory conditions. The obesity-inducing capacity of this human-derived endotoxin producer in gnotobiotic mice suggests that it may causatively contribute to the development of obesity in its human host.


Gu Y.X.,Shanghai JiaoTong University
Journal of biomedical materials research. Part B, Applied biomaterials | Year: 2012

The modification on the titanium (Ti) implant surface is an effective method to improve the bioactivity of Ti. In this study, a hydroxyapatite (HA)-deposited nanotubular Ti surface was prepared by anodization coupled with an alternative immersion method (AIM). Surface physicochemical characteristics including morphology, microstructure, composition, roughness were evaluated by field-emission scanning electron microscopy (FE-SEM), X-ray diffraction (XRD), Fourier-transformed infrared spectroscopy (FTIR), X-ray photoelectron spectroscopy (XPS) and atomic force microscopy (AFM). Preosteoblast cell (MC3T3-E1) behavior on the HA-deposited nanotube surface, including cell morphology, proliferation, alkaline phosphatase (ALP) activity, osteocalcin secretion, and mineralization, were also investigated. The untreated nanotube surface and bare Ti were used as controls. The results showed that synthetic HA crystals could be efficiently grown on/inside the nanotubes after AIM treatment in saturated Ca(OH)(2) and 0.02M (NH(4))(2) HPO(4). The amount of synthetic HA on nanotube layer was dependent on the number of dipping cycles. Significant increases in ALP activity and osteocalcin production on day 7 and 14 and calcium deposition on day 21 (P < 0.05) were observed for HA-deposited nanotubular Ti surface when compared with untreated nanotube layer and bare Ti. However, the cell proliferation rate on HA-deposited nanotube surfaces was slowed down significantly (P < 0.05). All these results indicated that this HA-deposited nanotube surface might have the potential benefit to enhance implant osseointegration. The synthetic HA TiO(2) nanotube loading might be a highly promising path to improve the bioactivity of Ti-based implants. Copyright © 2012 Wiley Periodicals, Inc.


Fu Q.,Shanghai JiaoTong University | Cao Y.-L.,Shanghai 9th Peoples Hospital
Urology | Year: 2012

Objective: To review the advances in the basic research and clinical application of tissue engineering and stem cell technology in urethral reconstruction. Urethral defects resulting from congenital malformations, trauma, inflammation, or cancer are a common urologic issue. Traditional urethral reconstruction is associated with various complications. Tissue engineering and stem cell technology hold novel therapeutic promise for urethral reconstruction. Methods: One of us searched the PubMed database (January 1999 to January 2011) using the English search terms "tissue engineering," "stem cells," "urethral reconstruction," and "urethra." A total of 86 reports were retrieved. After the repetitive and irrelevant reports were excluded, 40 were included in the final analysis. The review outlined and evaluated the advances in basic research and clinical application and the current status and prospects of tissue engineering and stem cell technology in urinary reconstruction. Results: Two therapeutic strategies are available for urethral reconstruction using tissue engineering: the acellular matrix bioscaffold model and the cell-seeded bioscaffold model. The acellular matrix bioscaffold model has been successfully used in the clinic and the cell-seeded bioscaffold model is making its transition from bench to bedside. Conclusion: Stem cells can provide the seed cells for urologic tissue engineering, but much basic research is still needed before their clinical use is possible. © 2012 Elsevier Inc. All Rights Reserved.


Ni Y.,Shanghai JiaoTong University | Fan F.,Shanghai JiaoTong University
Expert Systems with Applications | Year: 2011

The difficulty with fashion retail forecasting is due to a number of factors such as the season, region and fashion effect and causes a nonlinear change in the original sales rules. To improve the accuracy of fashion retail forecasting, a two-stage dynamic forecasting model is proposed, which is combined with both long-term and short-term predictions. The model introduces the improved adjustment methods, the main adjustment model and error forecasting model in the adjustment system collaborated with each other. The real-time data are demonstrated by applying the model in wireless mobile environment. The experiment shows that the model provides good results for fashion retail forecasting. © 2010 Elsevier Ltd. All rights reserved.


Su J.,Shanghai JiaoTong University | Xie W.,China Aerospace Science and Technology Corporation
IEEE Transactions on Systems, Man, and Cybernetics, Part B: Cybernetics | Year: 2011

This paper proposes a general motion planning and coordination strategy for robot systems. The representation space (RS) of a robot system is constructed to describe the distributions of system attributes. The reachable area in the RS, denoting the attribute set that the system can be of, indicates the system's ability to accomplish tasks. Moreover, it also describes the influences of the internal and external constraints on the system's capability. Task realization is transformed to finding a trajectory in the RS for the system attributes to transit along under constraints. Meanwhile, the realizable conditions of a prescribed task by the robot system of specific configurations are discussed. If the task is realizable, the optimal strategy for task execution could further be figured out. Otherwise, it could be transformed to be realizable via task reassignment or system reconfigurations so that a connected path could be found for the transition of the system attributes from the starting point to the goal in the RS. The proposed scheme contributes to designing, planning, and coordination of the robotic tasks. Experiments on path planning of a robot manipulator and formation movement of a multirobot system, as well as coordination of a mobile manipulator system, are conducted to show the validity and generalization of the proposed method. © 2010 IEEE.


Fu L.,Shanghai JiaoTong University | Xiao G.,Shanghai JiaoTong University | Yan D.,Shanghai JiaoTong University
Journal of Materials Chemistry | Year: 2012

This work investigated the thermal treatment of sulfonated poly(arylene ether phosphine oxide) membranes under vacuum without using any cross-linking agents or additives. During the thermal treatment, the sulfonic acid groups of the membranes acted as cross-linkable groups and reacted with the activated benzene rings in the membranes, resulting in self-cross-linking. Interestingly, the available degree of cross-linking of the membranes almost no longer increased with increasing time and temperature after the required thermal treatment because many sulfonic acid groups of the membranes could not be cross-linked due to steric hindrance and only functioned as a conducting group of protons. Meanwhile, this approach facilitated the cross-linked membranes to exhibit excellent dimensional stability, as well as high proton conductivity. This is a self-protected cross-linking to some extent. Through such a cross-linking, phosphine oxide-containing membranes with excellent overall properties were achieved. In addition, this effect of steric hindrance could be employed to design cross-linked proton exchange membranes with high performance. © 2012 The Royal Society of Chemistry.


Yang S.,Shanghai JiaoTong University | Song X.,Shanghai JiaoTong University | Zhang P.,Shanghai JiaoTong University | Gao L.,Shanghai JiaoTong University
ACS Applied Materials and Interfaces | Year: 2013

Nitrogen-doped graphene-ultrathin MnO2 sheet composites (NGMCs) were prepared through a one-step hydrothermal method at low temperature (120 C). Ultrathin MnO2 sheets were well-dispersed and tightly anchored on graphene sheets, which were doped with nitrogen simultaneously. NGMCs electrode exhibited enhanced capacitive performances relative to those of undoped graphene-ultrathin MnO2 sheets composites (GMCs). As the current density increased from 0.2 to 2 A/g, the capacitance of NGMCs still retained ∼74.9%, which was considerablely higher than that of GMCs (27%). Moreover, over 94.2% of the original capacitance was maintained after 2000 cycles, indicating a good cycle stability of NGMCs electrode materials. © 2013 American Chemical Society.


Kong L.T.,Shanghai JiaoTong University
Computer Physics Communications | Year: 2011

A method to measure the phonon dispersion of a crystal based on molecular dynamics simulation is proposed and implemented as an extension to an open source classical molecular dynamics simulation code LAMMPS. In the proposed method, the dynamical matrix is constructed by observing the displacements of atoms during molecular dynamics simulation, making use of the fluctuation-dissipation theory. The dynamical matrix can then be employed to compute the phonon spectra by evaluating its eigenvalues. It is found that the proposed method is capable of yielding the phonon dispersion accurately, while taking into account the anharmonic effect on phonons simultaneously. The implementation is done in the style of fix of LAMMPS, which is designed to run in parallel and to exploit the functions provided by LAMMPS; the measured dynamical matrices could be passed to an auxiliary postprocessing code to evaluate the phonons. Program summary: Program title: FixPhonon, version 1.0 Catalogue identifier: AEJB-v1-0 Program summary URL: http://cpc.cs.qub.ac.uk/ summaries/AEJB-v1-0.html Program obtainable from: CPC Program Library, Queens University, Belfast, N. Ireland Licensing provisions: GNU General Public license No. of lines in distributed program, including test data, etc.: 105 393 No. of bytes in distributed program, including test data, etc.: 3 231 800 Distribution format: tar.gz Programming language: C++ Computer: All Operating system: Linux Has the code been vectorized or parallelized?: Yes. 1 to N processors may be used RAM: Depends on problem, ≈1 kB to several MB Classification: 7.8 External routines: MPI, FFT, LAMMPS version 15, January 2010 (http://lammps.sandia.gov/) Nature of problem: Atoms in solids make ceaseless vibrations about their equilibrium positions, and a collective vibration forms a wave of allowed wavelength and amplitude. The quantum of such lattice vibration is called the phonon, and the so-called "lattice dynamics" is the field of study to find the normal modes of these vibrations. In other words, lattice dynamics examines the relationship between the frequencies of phonons and the wave vectors, i.e., the phonon dispersion. The evaluation of the phonon dispersion requires the construction of the dynamical matrix. In atomic scale modeling, the dynamical matrices are usually constructed by deriving the derivatives of the force field employed, which cannot account for the effect of temperature on phonons, with an exception of the tedious "quasi- harmonic" procedure. Solution method: We propose here a method to construct the dynamical matrix directly from molecular dynamics simulations, simply by observing the displacements of atoms in the system thus making the constructing of the dynamical matrix a straightforward task. Moreover, the anharmonic effect was taken into account in molecular dynamics simulations naturally, the resultant phonons therefore reflect the finite temperature effect simultaneously. Restrictions: A well defined lattice is necessary to employ the proposed method as well as the implemented code to evaluate the phonon dispersion. In other words, the system under study should be in solid state where atoms vibrate about their equilibrium positions. Besides, no drifting of the lattice is expected. The method is best suited for periodic systems, although non-periodic system with a supercell approach is also possible, it will however become inefficient when the unit cell contains too many atoms. Additional comments: The readers are encouraged to visit http://code.google.com/ p/fix-phonon for subsequent update of the code as well as the associated postprocessing code, so as to keep up with the latest version of LAMMPS. Running time: Running time depends on the system size, the numbers of processors used, and the complexity of the force field, like a typical molecular dynamics simulation. For the third example shown in this paper, it took about 2.5 hours on an Intel Xeon X3220 architecture (2.4G, quadcore). References: C. Campañá, M.H. Müser, Phys. Rev. B 74 (2006) 075420.L.T. Kong, G. Bartels, C. Campañá, C. Denniston, M.H. Müser, Comp. Phys. Commun. 180 (6) (2009) 1004-1010. © 2011 Elsevier B.V. All rights reserved.


Zheng J.,Shanghai JiaoTong University | Lu Bao-Liang B.-L.,Shanghai JiaoTong University
Neurocomputing | Year: 2011

In this paper, we propose a support vector machine with automatic confidence (SVMAC) for pattern classification. The main contributions of this work to learning machines are twofold. One is that we develop an algorithm for calculating the label confidence value of each training sample. Thus, the label confidence values of all of the training samples can be considered in training support vector machines. The other one is that we propose a method for incorporating the label confidence value of each training sample into learning and derive the corresponding quadratic programming problems. To demonstrate the effectiveness of the proposed SVMACs, a series of experiments are performed on three benchmarking pattern classification problems and a challenging gender classification problem. Experimental results show that the generalization performance of our SVMACs is superior to that of traditional SVMs. © 2011 Elsevier B.V.


Zhang D.,Shanghai JiaoTong University | Yang L.,Shanghai JiaoTong University
Current Opinion in Plant Biology | Year: 2014

Flowering plants form male reproductive cells (microsporocytes) during sporophytic generation, which subsequently differentiate into multicellular male gametes in the gametophytic generation. The tapetum is a somatic helper tissue neighboring microsporocytes and supporting gametogenesis. The mechanism controlling the specification of the tapetum and microsporocyte cell fate within the anther has long been a mystery in biology. Recent investigations have revealed molecular switches and signaling pathways underlying the establishment of somatic and reproductive cells in plants. In this review we discuss common and diversified signaling molecules and regulatory pathways including receptor-like protein kinases, redox status, glycoprotein, transcription factors, hormones and microRNA implicated in the specification of tapetum and microsporocytes in plants. © 2013.


Hu G.,Shanghai JiaoTong University | Tang B.,Shanghai JiaoTong University
Materials Chemistry and Physics | Year: 2013

Graphene modified semiconductor photocatalysts (GMSP) have attracted extensive attention due to their great photoactivities and promising prospect in environmental area. Although several GMSP samples have been prepared, the photocatalytic mechanism of these composites under visible-light illumination is still misty. Based on their energy band structures electron transport model of graphene/titanate nanotubes (TNTs) photocatalyst under visible-light illumination is proposed in this study. Graphene and TNTs make a metal-semiconductor junction, and graphene can play as a sensitizer to endow the photocatalyst with an excellent visible-light response. Quantum tunneling is the major way to achieve the electron transport between graphene and TNTs, and the tunneling probability was calculated in the theory. Moreover, by using scanning tunneling microscope, electron paramagnetic resonance and photoluminescence spectra, the electron transport from graphene to TNTs under visible-light irradiation is confirmed unambiguously. © 2013 Elsevier B.V. All rights reserved.


Yin Z.W.,Shanghai JiaoTong University
CAD Computer Aided Design | Year: 2011

An extended STL file format is presented in this paper. Differing with existing solutions, it proposes a new format to produce and store triangles. The format uses a cluster unit composed of several triangles. The main advantages of the format are that it contains both geometry and topological information and has improved storage capability. Direct generation of the extended STL from the scanned data has a great advantage in that it can reduce the time and error in modeling process. In order to obtain the format from unorganized point cloud, a new triangulation algorithm was introduced. The algorithm is based on reconstructing the relative Delaunay triangulation of the sample points on the surface. Other advantages of the extended STL format were also presented in this paper. © 2011 Elsevier Ltd. All rights reserved.


Wu K.,Shanghai JiaoTong University | Zhang X.,CAS Shanghai Institute of Optics and fine Mechanics | Wang J.,CAS Shanghai Institute of Optics and fine Mechanics | Chen J.,Shanghai JiaoTong University
Optics Letters | Year: 2015

We report on the passive-mode-locking operation of a fiber laser with a fundamental repetition rate of 463MHz based on molybdenum disulfide (MoS2) saturable absorber (SA). By embedding MoS2 into polyvinyl alcohol (PVA) thin film, MoS2-PVA SA was prepared with a modulation depth of 2.7% and a saturation intensity of 137 MW/cm2. The mode-locked fiber laser-employed MoS2-PVA SA was achieved with center wavelength of 1556.3 nm, 3-dB bandwidth of 6.1 nm, output power of 5.9 mW, and an extinction ratio of up to 97 dB in the RF spectrum. The demonstration of mode-locking operation with high fundamental repetition rate and high spectral purity indicates that MoS2-PVA SA can be a good candidate for high-precision ultrafast applications. © 2015 Optical Society of America.


Ruan J.,Shanghai JiaoTong University | Xu Z.,Shanghai JiaoTong University
Waste Management | Year: 2011

A large amount of hazardous trichloromonofluoromethane (CFC-11) is contained in the polyurethane (PUR) foam of refrigerator cabinet. How to recover the cabinet of waste refrigerator with environmental awareness has been the pressing problem in the treatment of waste refrigerator. The published literature of waste refrigerator cabinets recovering mainly focuses on policy making and conceptual design. Little information relates to the production line of waste refrigerator cabinet recovering and its detailed operation, which is the urgent needed literature. In this paper, an environmental friendly production line for recovering the cabinet of waste refrigerators was reported for helping enterprise or government to construct line to recover the obsolete refrigerators. It included closed shearing process, activated carbon fiber absorption (ACFA) process, air current separation, and magnetic/eddy current separation. The optimized operating parameters of every process were obtained from the experiments. Then, experiment of recovering 50 waste refrigerator cabinets by the production line was performed in factory. Mass balances of the recovered materials were carried out. The result shown the recovery rate of waste refrigerator cabinet could reach 97.6%. Finally, comparison between the production line and other recovery technologies was made. The results indicated that the proposed line provided environment-friendly recovery of waste refrigerator cabinets while achieving low cost of production. © 2011 Elsevier Ltd.


Shi Q.,Alcatel - Lucent | Razaviyayn M.,University of Minnesota | Luo Z.-Q.,University of Minnesota | He C.,Shanghai JiaoTong University
IEEE Transactions on Signal Processing | Year: 2011

Consider the multiple-input multiple-output (MIMO) interfering broadcast channel whereby multiple base stations in a cellular network simultaneously transmit signals to a group of users in their own cells while causing interference to each other. The basic problem is to design linear beamformers that can maximize the system throughput. In this paper, we propose a linear transceiver design algorithm for weighted sum-rate maximization that is based on iterative minimization of weighted mean-square error (MSE). The proposed algorithm only needs local channel knowledge and converges to a stationary point of the weighted sum-rate maximization problem. Furthermore, the algorithm and its convergence can be extended to a general class of sum-utility maximization problem. The effectiveness of the proposed algorithm is validated by numerical experiments. © 2011 IEEE.


Zou W.,Shanghai JiaoTong University | Yang S.,Shanghai JiaoTong University | Long X.,Shanghai JiaoTong University | Chen J.,Shanghai JiaoTong University
Optics Express | Year: 2015

This paper proposes a novel reflectometry based on the frequency modulation pulse-compression technology, called optical pulse compression reflectometry (OPCR). Linear frequency modulation (LFM) pulse is taken as an example to implement the OPCR. Its working principle and theoretical analysis are demonstrated. The spatial resolution is determined by the sweeping range of the LFM rather than the pulse width, which overcomes the tradeoff between spatial resolution and measurement range in the conventional pulse-based optical time domain reflectometry. The influence of the laser's phase noise on the integrated side lobe ratio and peak side lobe ratio is theoretically studied. Thanks to the continuous acquisition nature of the OPCR, time averaging is valid to eliminate the influence and results in the measurement range of the OPCR beyond a few times of the source coherent length. A proof-of-concept experiment of the OPCR is carried out to verify the spatial resolution and measurement range. © 2014 Optical Society of America.


Dong C.-M.,Shanghai JiaoTong University
Combinatorial Chemistry and High Throughput Screening | Year: 2011

Over the past two decades, glycosylated nanoparticles (i.e., glyconanoparticles having sugar residues on the surface) received much attention for biomedical applications such as bioassays and targeted drug delivery. This minireview focuses on three aspects: (1) glycosylated gold nanoparticles, (2) glycosylated quantum dots, and (3) glyconanoparticles self-assembled from amphiphilic glycopolymers. The synthetic methods and the multivalent interactions between glyconanoparticles and lectins is shortly illustrated. ©2011 Bentham Science Publishers Ltd.


Liu Y.,Shanghai JiaoTong University
Lixue Xuebao/Chinese Journal of Theoretical and Applied Mechanics | Year: 2012

The lateral vibration of an axially moving beam is a dynamics problem with practical engineering background. In this paper the Cosserat's model of elastic rod was applied to discuss the dynamics modeling and stability of an axially moving beam with circular cross section. The arc-coordinate along the center line of the beam was used instead of the fixed coordinate. The deformation process of the beam was expressed by the attitude motion of the cross section with the variation of the arc-coordinate and time. Considering the inertial effect and shear strain of the cross section, the dynamics equations of the beam with large deformation were established from the view point of the concept of velocity field of Euler. The three-dimensional motion of an axially moving Timoshenko's beam can be regarded as a special case of small deformation. The stability problem of quasi-stationary state of the axially moving beam was discussed in the static and dynamic states, and the critical axial velocity before buckling was derived. It was proved that the Euler's stability conditions of the moving beam in the space domain are the necessary conditions of Lyapunov's stability in the time domain.


Chen L.,Shanghai JiaoTong University | Lu Z.,Shanghai JiaoTong University
International Journal of Production Economics | Year: 2012

This paper addresses the storage location assignment problem for outbound containers. The problem is decomposed into two stages. The yard bays and the amount of locations in each yard bay, which will be assigned to the containers bounded for different ships, are determined in the first stage. The exact storage location for each container is determined in the second stage. The problem in the first stage is solved by a mixed integer programming model, while a hybrid sequence stacking algorithm is applied to solve the problem in the second stage. Experimental results show that the proposed approach is effective and efficient in solving the storage location assignment problem for outbound containers. © 2010 Elsevier B.V. All rights reserved.


Li Z.-M.,Shanghai JiaoTong University
Journal of Thermal Stresses | Year: 2011

Thermal postbuckling characteristics of 3D braided rectangular plates are investigated. A 3D braided composite may be treated as a cell system and the geometry of each cell is deeply dependent on its position in the cross-section of the plate. Based on Reddy's higher-order shear deformation plate theory, a perturbation technique is employed to determine buckling temperatures and postbuckling equilibrium paths of simply supported 3D braided rectangular plates. The results reveal that the temperature-dependent properties, geometric parameter, fiber volume fraction and braiding angle have a significant effect on thermal postbuckling behavior of braided composite plates. Copyright © Taylor & Francis Group, LLC.


Shao X.-F.,Shanghai JiaoTong University
International Journal of Production Economics | Year: 2012

This research examines demand-side reactive strategies for supply disruption in a multiple assemble-to-order system. We consider an assemble-to-order system with two substitute products where the demand is price-sensitive and disruption-sensitive. Two different supply disruption situations are examined: disruption of the low-value component and disruption of the high-value component. We propose and compare the performance of four reactive strategies for managing supply disruptions, namely, the backordering strategy, the upgrading/downgrading strategy, the compensation strategy, and the mixed strategy. We find that the compensation strategy and the mixed strategy can keep more customers than the backordering strategy and the upgrading strategy during the supply disruption of the low-value product. For the disruption of the high-value product, the total number of customers keeps constant. But it does lead to the reallocation of customers among the products. We find that the mixed strategy is the best reactive strategy and the backordering strategy is the worst one among the four reactive strategies. © 2011 Elsevier B.V.


Yin Y.,Nanjing University | Zhang C.,Shanghai JiaoTong University
Proceedings of the Annual ACM-SIAM Symposium on Discrete Algorithms | Year: 2013

We show for a broad class of counting problems, correlation decay (strong spatial mixing) implies FPTAS on planar graphs. The framework for the counting problems considered by us is the Holant problems with arbitrary constant-size domain and symmetric constraint functions. We define a notion of regularity on the constraint functions, which covers a wide range of natural and important counting problems, including all multi-state spin systems, counting graph homomorphisms, counting weighted matchings or perfect matchings, and all counting CSPs and Holant problems with symmetric constraint functions of constant arity. The core of our algorithm is a fixed-parameter tractable algorithm which computes the exact values of the Holant problems with regular constraint functions on graphs of bounded treewidth. By utilizing the locally tree-like property of apex-minor-free families of graphs, the parameterized exact algorithm implies an FPTAS for the Holant problem on these graph families whenever the Gibbs measure defined by the problem exhibits strong spatial mixing. We further extend the recursive coupling technique to establish the strong spatial mixing on Holant problems. As consequences, we have new deterministic approximation algorithms on planar graphs for several counting problems. Copyright © SIAM.


Wang X.,Shanghai JiaoTong University | Chen W.,Shanghai JiaoTong University
Anti-Cancer Agents in Medicinal Chemistry | Year: 2012

Gambogic acid (GA) is a caged xanthone that is derived from Garcinia hanburyi and functions as a strong apoptotic inducer in many types of cancer cells. The distinct effectiveness of GA has led to its characterization as a novel anti-cancer agent. There is an increasing number of research studies focused on elucidating the molecular mechanisms of GA-induced anti-cancer effects, and several critical signaling pathways have been reported to be influenced by GA treatment. In this review, we summarize the multiple functional effects of GA administration in cancer cells including the induction of apoptosis, the inhibition of proliferation and the prevention of cancer metastasis and tumor angiogenesis. © 2012 Bentham Science Publisher.


Zhang Y.,Shanghai JiaoTong University
European journal of histochemistry : EJH | Year: 2013

Nucleoside triphosphate pyrophosphohydrolase (NTP-PPase) functions as one of the mechanisms to guarantee the fidelity of DNA replication through the cleavage of non-canonical nucleotides into di- or monophosphates. Human NTP-PPase is poorly understood and investigated. In the present study, by using tissue microassays with the paired cancer and adjacent regions, we found that with the prevalent expression of dCTP pyrophosphohydrase (DCTPP1) in the cytosol and nucleus in tumors investigated, DCTPP1 was inclined to accumulate in the nucleus of cancer cells compared to the paired adjacent tissue cells in multiple carcinoma including lung, breast, liver, cervical, gastric and esophagus cancer. More significantly, the higher DCTPP1 expression in the nucleus of lung, gastric and esophagus cancer cells was associated with histological subtypes. The nucleic accumulation of DCTPP1 was apparently observed as well when cancer cell line MCF-7 was treated with H2O2 in vitro. Considering the roles of DCTPP1 on restricting the concentration of non-canonical nucleotides in the nucleotide pool, accumulation of DCTPP1 in the nucleus of cancer cells might suffice for maintaining the proper DNA replication in order to fulfill the requirement for the survival and proliferation of tumor cells.


OBJECTIVE: To assess the activity of mTOR and downstream effector proteins in the mTOR pathway after treatment with a dual mTOR complex 1 and 2 (mTORC1/2) inhibitor (PP242) compared with that of mTOR complex 1 (mTORC1) inhibitor (rapamycin) using a xenograft tumor model.METHODS: Pheochromocytoma PC12 cell were xenografted into nude mice. Animals were treated with PP242 and rapamycin. Mean tumor volume was compared across groups. Terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling staining was used to detect apoptosis. Immunoblot analysis was performed to assess mTORC1/2 activity using p-Akt, p-S6, and p-4E-BP1. The expression of the antiapoptotic protein Bcl-2, pro-apoptotic protein Bax, and the mediator of angiogenesis vascular endothelial growth factor were also investigated.RESULTS: The mean tumor volume of PP242 was significantly lower than in other groups. The terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling results showed that PP242 markedly increased cell apoptosis compared with other groups. Immunoblot analysis of tumor lysates treated with PP242 demonstrated inhibition of activated p-Akt. We also observed that only PP242, but not rapamycin, significantly reduced Bcl-2 expression and markedly increased Bax expression. Rapamycin decreased vascular endothelial growth factor expression, but not nearly as striking as seen in the PP242 group.CONCLUSION: Our study showed that PP242 showed strong antitumor activity in a pheochromocytoma PC12 cell tumor model. Based on our study, dual mTORC1/2 kinase inhibitors warrant further investigation as a potential treatment for malignant pheochromocytomas or paragangliomas. Copyright © 2015 Elsevier Inc. All rights reserved.


Song Q.,Shanghai JiaoTong University | Wang X.,Shanghai JiaoTong University
IEEE Transactions on Intelligent Transportation Systems | Year: 2011

Efficient routing is essential in everyday life. Although various hierarchical algorithms exist for computing shortest paths, their heavy precomputation/storage costs and/or query costs hinder their application to large road networks. By detecting a hierarchical community structure in road networks, we develop a community-based hierarchical graph model that supports efficient route computation on large road networks. We then propose a new hierarchical routing algorithm that can significantly reduce the search space over the conventional algorithms with acceptable loss of accuracy. Experimental results on a New York road network demonstrate the performance of the algorithm. © 2010 IEEE.


Wu K.,Shanghai JiaoTong University | Zhang X.,CAS Shanghai Institute of Optics and fine Mechanics | Wang J.,CAS Shanghai Institute of Optics and fine Mechanics | Li X.,Shanghai JiaoTong University | Chen J.,Shanghai JiaoTong University
Optics Express | Year: 2015

Two-dimensional (2D) nanomaterials, especially the transition metal sulfide semiconductors, have drawn great interests due to their potential applications in viable photonic and optoelectronic devices. In this work, 2D tungsten disulfide (WS2) based saturable absorber (SA) for ultrafast photonic applications was demonstrated. WS2 nanosheets were prepared using liquid-phase exfoliation method and embedded in polyvinyl alcohol (PVA) thin film for the practical usage. Saturable absorption was discovered in the WS2-PVA SA at the telecommunication wavelength near 1550 nm. By incorporating WS2-PVA SA into a fiber laser cavity, both stable mode locking operation and Q-switching operation were achieved. In the mode locking operation, the laser obtained femtosecond output pulse width and high spectral purity in the radio frequency spectrum. In the Qswitching operation, the laser had tunable repetition rate and output pulse energy of a few tens of nano joule. Our findings suggest that few-layer WS2 nanosheets embedded in PVA thin film are promising nonlinear optical materials for ultrafast photonic applications as a mode locker or Q-switcher. © 2015 Optical Society of America.


Wu C.,Shanghai JiaoTong University | Huang X.,Shanghai JiaoTong University | Wu X.,Shanghai JiaoTong University | Qian R.,Shanghai JiaoTong University | Jiang P.,Shanghai JiaoTong University
Advanced Materials | Year: 2013

We present a novel strategy for the fabrication of ordered and flexible polymer-based graphene foams by self-assembly of graphene sheets on a 3D polymer skeleton. The obtained graphene foams show excellent mechanical, electrical, and hydrophobic properties, thus holding great potential as elastic conductors and oil-water separators. © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.


Peng C.,Shanghai JiaoTong University
Biophysical journal | Year: 2010

We present a novel sampling approach to explore large protein conformational transitions by determining unique substates from instantaneous normal modes calculated from an elastic network model, and applied to a progression of atomistic molecular dynamics snapshots. This unbiased sampling scheme allows us to direct the path sampling between the conformational end states over simulation timescales that are greatly reduced relative to the known experimental timescales. We use adenylate kinase as a test system to show that instantaneous normal modes can be used to identify substates that drive the structural fluctuations of adenylate kinase from its closed to open conformations, in which we observe 16 complete transitions in 4 mus of simulation time, reducing the timescale over conventional simulation timescales by two orders of magnitude. Analysis shows that the unbiased determination of substates is consistent with known pathways determined experimentally. Copyright 2010 Biophysical Society. Published by Elsevier Inc. All rights reserved.


Zhang D.,Shanghai JiaoTong University | Yuan Z.,Shanghai JiaoTong University
Annual Review of Plant Biology | Year: 2014

The grass family is one of the largest families in angiosperms and has evolved a characteristic inflorescence morphology, with complex branches and specialized spikelets. The origin and development of the highly divergent inflorescence architecture in grasses have recently received much attention. Increasing evidence has revealed that numerous factors, such as transcription factors and plant hormones, play key roles in determining reproductive meristem fate and inflorescence patterning in grasses. Moreover, some molecular switches that have been implicated in specifying inflorescence shapes contribute significantly to grain yields in cereals. Here, we review key genetic and molecular switches recently identified from two model grass species, rice (Oryza sativa) and maize (Zea mays), that regulate inflorescence morphology specification, including meristem identity, meristem size and maintenance, initiation and outgrowth of axillary meristems, and organogenesis. Furthermore, we summarize emerging networks of genes and pathways in grass inflorescence morphogenesis and emphasize their evolutionary divergence in comparison with the model eudicot Arabidopsis thaliana. We also discuss the agricultural application of genes controlling grass inflorescence development. Copyright © 2014 by Annual Reviews.


Wu F.,Shanghai JiaoTong University | Vaidya N.,University of Illinois at Urbana - Champaign
IEEE Transactions on Mobile Computing | Year: 2013

With the growing deployment of wireless communication technologies, radio spectrum is becoming a scarce resource. Thus, mechanisms to efficiently allocate the available spectrum are of interest. In this paper, we model the radio spectrum allocation problem as a sealed-bid reserve auction, and propose SMALL, which is a Strategy-proof Mechanism for radio spectrum ALLocation. Furthermore, we extend SMALL to adapt to multiradio spectrum buyers, which can bid for more than one radio. We evaluate SMALL with simulations. Simulation results show that SMALL has good performance in median to large scale spectrum auctions. © 2002-2012 IEEE.


Han Z.-G.,Shanghai JiaoTong University | Han Z.-G.,Chinese National Human Genome Center at Shanghai
Annual Review of Genomics and Human Genetics | Year: 2012

Liver cancer is the sixth-most-common cancer overall but the third-most-frequent cause of cancer death. Among primary liver cancers, hepatocellular carcinoma (HCC), the major histological subtype, is associated with multiple risk factors, including hepatitis B and C virus infection, alcohol consumption, obesity, and diet contamination. Although previous studies have revealed that certain genetic and epigenetic changes, such as TP53 and β-catenin mutations, occur in HCC cells, the pathogenesis of this cancer remains obscure. Functional genomic approaches-including genome-wide association studies, whole-genome and whole-exome sequencing, array-based comparative genomic hybridization, global DNA methylome mapping, and gene or noncoding RNA expression profiling-have recently been applied to HCC patients with different clinical features to uncover the genetic risk factors and underlying molecular mechanisms involved in this cancer's initiation and progression. The genome-wide analysis of germline and somatic genetic and epigenetic events facilitates understanding of the pathogenesis and molecular classification of liver cancer as well as the identification of novel diagnostic biomarkers and therapeutic targets for cancer. © 2012 by Annual Reviews. All rights reserved.


Wang Y.,Shanghai JiaoTong University | Yang J.,Shanghai JiaoTong University | Yi J.,Shanghai JiaoTong University
Antioxidants and Redox Signaling | Year: 2012

Significance: Reactive oxygen species (ROS) are not only essential for the cell's normal functions, but also mediate many pathological effects. When cells experience oxidative stress, proteins are modulated by redox changes and ultimately generate novel signaling patterns. It remains elusive how proteins are modulated, rather than simply damaged, by ROS and then mediate the diverse cellular responses. Recent Advances: During the past decade, researchers frequently used "redox sensor" for proteins. However, the term "redox sensing" has not been clearly defined to date. Thiols of cysteines are subjected to oxidative modifications. The conformation changes and the various types of post-translational modifications (PTMs) may result from thiol oxidation of the same protein or other proteins. The molecular effects of redox sensing include changes in protein activity, abundance, localization, and interaction with other biomacromolecules. Critical Issues: We discuss the emerging concept of cysteine-based redox sensing, emphasizing "sensing redox changes by proteins using their thiols." ROS are an input, and the conformation changes and/or the other PTMs after thiol oxidation are the output of redox sensing. Among dozens of redox sensing proteins listed in this article, SENP3 and caspase-9, which have been investigated in our work, are given particular attention. We also introduce the notion of biphasic and compartment-specific redox sensing by nuclear factor kappa B. Future Directions: Understanding chemical modifications and conformational changes following protein redox sensing requires more studies in mass spectrometry and crystallography. Redox-indicative probes in live cells and tissues will help monitor redox-related biological and pathological progresses. © 2012, Mary Ann Liebert, Inc.


Yang X.,Japan National Institute of Materials Science | Yanagida M.,Japan National Institute of Materials Science | Han L.,Japan National Institute of Materials Science | Han L.,Shanghai JiaoTong University
Energy and Environmental Science | Year: 2013

Dye-sensitized solar cells (DSCs) have attracted great interest as potential candidates of "low cost solar cells" in the solution of global energy demand. To accelerate the progress of DSCs, it is important to evaluate device performance with reliable measurements that will enable more effective comparison and application of new findings in materials and technologies by different research groups. In this perspective, we review existing measurement methods and summarize the appropriate techniques for the evaluation of DSCs based mainly on our experience, which helped us to obtain reliable results close to those certified by public test centres. The key factors in the measurements that correlate to device performance are discussed, including the calibration of the solar simulator using reference cells, the measurement time of the current-voltage characteristics and the incident photon-to-current conversion efficiency, and the area for determination with a proper shading mask. We demonstrate the causes and solutions of measurement errors in the results of device performance, such as short circuit photocurrent density, open circuit voltage, fill factor, and energy conversion efficiency. Finally, a list of appropriate measurements for a more reliable evaluation of DSCs is proposed. © The Royal Society of Chemistry 2013.


Yang B.,Shanghai JiaoTong University | Shu X.W.,Shanghai JiaoTong University
Ocean Engineering | Year: 2012

A kind of hydrofoil, which is especially for use by helical vertical axis turbine for power generation from marine current, has been optimized by means of traditional genetic algorithms combined with hierarchical fair competition model. Bezier curve is used to parameterize the hydrofoils and numerical analysis is also introduced to evaluate hydrodynamic performance. Special fitness function as well as modified total liftdrag ratio is discussed in detail. Turbine performance tests and flow visualization experiments by PIV are conducted in order to draw a comparison between the optimized and two other competitive hydrofoils. The experimental results demonstrate that the optimized is more suitable to marine condition and beneficial to turbine efficiency improvement, and can be expected to act as a prospective hydrofoil for helical vertical axis turbine. © 2012 Elsevier Ltd. All rights reserved.


Zhao Y.,Shanghai JiaoTong University | Zhu K.,National Renewable Energy Laboratory
Journal of the American Chemical Society | Year: 2014

Hybrid organometallic halide perovskite CH3NH 3PbI2Br (or MAPbI2Br) nanosheets with a 1.8 eV band gap were prepared via a thermal decomposition process from a precursor containing PbI2, MABr, and MACl. The planar solar cell based on the compact layer of MAPbI2Br nanosheets exhibited 10% efficiency and a single-wavelength conversion efficiency of up to 86%. The crystal phase, optical absorption, film morphology, and thermogravimetric analysis studies indicate that the thermal decomposition process strongly depends on the composition of precursors. We find that MACl functions as a glue or soft template to control the initial formation of a solid solution with the main MAPbI2Br precursor components (i.e., PbI2 and MABr). The subsequent thermal decomposition process controls the morphology/surface coverage of perovskite films on the planar substrate and strongly affects the device characteristics. © 2014 American Chemical Society.


Wang L.,Case Western Reserve University | McCleese C.,Case Western Reserve University | Kovalsky A.,Case Western Reserve University | Zhao Y.,Shanghai JiaoTong University | Burda C.,Case Western Reserve University
Journal of the American Chemical Society | Year: 2014

CH3NH3PbI3 perovskite layered films deposited on substrates with and without a titania support structure have been prepared and studied using time-resolved femtosecond transient absorption (fs-TA) spectroscopy in the visible light range (450-800 nm). The electron injection dynamics from the photoexcited perovskite layers to the neighboring film structures could be directly monitored via the transient bleaching dynamics of the perovskite at ∼750 nm and thus systematically studied as a function of the layer-by-layer architecture. In addition, for the first time we could spectrally distinguish transient bleaching at ∼750 nm from laser-induced fluorescence that occurs red-shifted at ∼780 nm. We show that an additional bleach feature at ∼510 nm appears when PbI2 is present in the perovskite film. The amplitudes of the PbI2 and perovskite TA peaks were compared to estimate relative amounts of PbI2 in the samples. Kinetic analysis reveals that perovskite films with less PbI2 show faster relaxation rates than those containing more PbI2. These fast dynamics are attributed to charge carrier trapping at perovskite grain boundaries, and the slower dynamics in samples containing PbI2 are due to a passivation effect, in line with other recently reported work. © 2014 American Chemical Society.


Ji X.,Shanghai JiaoTong University | Ji X.,University of Maryland University College
Physical Review Letters | Year: 2013

I show that the parton physics related to correlations of quarks and gluons on the light cone can be studied through the matrix elements of frame-dependent, equal-time correlators in the large momentum limit. This observation allows practical calculations of parton properties on a Euclidean lattice. As an example, I demonstrate how to recover the leading-twist quark distribution by boosting an equal-time correlator to a large momentum. © 2013 American Physical Society.


Zheng H.,Shanghai JiaoTong University | Che S.,Shanghai JiaoTong University
RSC Advances | Year: 2012

Mesoporous nanoparticles functionalized with amino groups on the pore surface and quaternary ammonium groups on the particle surface with particle sizes of 500-800 nm in length and 300-500 nm in diameter and a pore size of 7.2-7.4 nm, have been obtained through a post-synthesis and co-condensation method. Bleomycin (BLM) has been chosen as a model anti-cancer drug with a large molecular size, and the iron essential for organisms has been utilized for constructing NH 2-Fe-BLM coordination bond architecture in the pore surface. The BLM was released under mildly acidic pH conditions by cleavage of the Fe-BLM coordination bond triggered by pH reduction. Cell assays show that mesoporous nanoparticles have good dispersity and good cell penetrating properties due to the positively charged quaternary ammonium groups on the outer surface of the nanoparticles. These organic functionalized large pore mesoporous materials can be utilized as carriers in the pH-responsive delivery of an anti-cancer drug with a large molecular size, opening up new opportunities for their further application in controlled release of biomacromolecules. © The Royal Society of Chemistry 2012.


Liu L.,Shanghai JiaoTong University
Qualitative health research | Year: 2012

In this study we explored the perceptions of Chinese patients with schizophrenia about their treatment, mental state, social relationships, and daily life throughout the psychotic episodes. A purposive sample of 16 schizophrenia patients with heterogeneous demographic backgrounds was recruited. We collected data through face-to-face semistructured interviews. We conducted a qualitative data analysis and identified three central themes inductively: (a) negative experiences, (b) sense of powerlessness, and (c) ambivalent therapeutic relationship. Several subthemes were derived under each central theme. The participants' narratives revealed a complex picture of disadvantage and difficulties throughout their psychotic episodes and rehabilitation processes. The themes identified are explored in detail, and their links with existing research and potential clinical implications are considered.


Cao L.,Shanghai JiaoTong University
Movement disorders : official journal of the Movement Disorder Society | Year: 2010

Mutation detection in the guanosine triphosphate cyclohydrolase I gene (GCH1) was performed from 4 female patients with dopa-responsive dystonia (DRD). DNA sequencing revealed the presence of four novel mutations including c.2T>C(M1T), c.239G>A(S80N), c.245T>C(L82P), and IVS5+3 del AAGT. These four mutations were not found in 100 genetically unrelated healthy controls with the same ethnic background band. In all 3 childhood-onset patients, DRD started in the legs, and missense mutations were located in the coding region of GCH1. Deletion mutation in the fifth exon-intron boundary of GCH1 was detected in the adult-onset patient. Although the data presented here do not provide sufficient evidence to establish a genotype-phenotype correlation of DRD, it is important to know the clinic features and genetic defects of DRD patients, which will help prenatal diagnosis, early diagnosis, evaluate the prognosis, and facilitate causal therapy with levodopa. 2010 Movement Disorder Society


Wu C.,Shanghai JiaoTong University | Liu R.,Shanghai JiaoTong University
International Journal of Hydrogen Energy | Year: 2010

Catalyst deactivation caused by coke formation is a bottleneck in steam reforming of bio-oil for hydrogen production. The investigation of carbon deposition behavior can make a contribution to the improvement of catalyst and the knowledge of reaction mechanism. In this paper, m-cresol (C7H8O, one of the organic compounds present in bio-oil) was chosen as model compound. The experiment was carried out on a commercial Ni/MgO catalyst. As a comparative test, m-cresol decomposition showed carbon deposition can be formed more easily under higher temperature. In steam reforming process, for the competition of carbon deposition and carbon elimination, a peak value of coking formation rate was obtained in a broad range of temperature (575-900 °C). The increase of steam to carbon ratio can favor the carbon elimination. Final coking formation rate curve was determined under optimal reaction conditions and the results showed the severity of carbon deposition maintained a very low level during the entire reaction time. Based on the distribution of reforming products, high temperature and sufficient water feeding can favor the carbon conversion from solid and liquid phase to gaseous phase. Unreacted m-cresol is the main organic compound detected in liquid condensate. Some secondary reactions can be deduced through the other compounds detected. The carbon deposition state on catalyst surface can be in the form of nanofiber, but their concrete shapes can be different due to different reaction conditions. © 2010 Professor T. Nejat Veziroglu.


Wu S.F.,Shanghai JiaoTong University
European review for medical and pharmacological sciences | Year: 2012

To evaluate the expression of apoptosis-related genes and their correlation with prognosis in cervical cancer patients. The expressions of Survivin, Fas and FasL in tissues of cervical cancer, cervical intraepithelial neoplasia (CIN), chronic cervicitis and normal cervix wer detected by immunohistochemical staining, and the relationship between the expression of Survivin, Fas and FasL and clinical pathologic characteristics of cervical cancer was correlation analysis. The positive expression rates of Survivin and FasL in cervical cancer tissues were significantly higher than those in tissues of normal cervix, chronic cervicitis and CIN (p < 0.05), but lower positive expression rate of Fas was observed in cervical cancer tissues when compared with that in normal cervix, chronic cervicitis and CIN tissues (p < 0.05). The expression of Survivin was significantly correlated with clinical staging and lymph node metastases of cervical cancer (p < 0.05). The expression of FasL was correlated with lymph node metastases, clinical staging and pathological grading of cervical cancer (p < 0.05). The expression of Survivin was negatively correlated with that of Fas (r = -0.517, p < 0.01), but positively correlated with that of FasL (r = 0.381, p < 0.01) in tissues of cervical cancer. The up-regulated expression of Survivin and FasL and down-regulated expression of Fas may be involved in the carcinogenesis and development of cervical cancer. The expression of FasL may be one of the prediction indexes for disease progression and prognosis in cervical cancer.


Fan J.-G.,Shanghai JiaoTong University
Journal of Gastroenterology and Hepatology (Australia) | Year: 2013

The prevalence of patients presenting with fatty liver disease (FLD) in China has approximately doubled over the past two decades. At present, FLD, which is typically diagnosed by imaging, is highly prevalent (~27% urban population) in China and is mainly related to obesity and metabolic syndrome (MetS). However, the percentage of alcoholic liver disease (ALD) among patients with chronic liver diseases in clinic is increasing as well, and a synergetic effect exists between heavy alcohol drinking and obesity in ALD. Prevalence figures reveal regional variations, with a median prevalence of ALD and nonalcoholic FLD (NAFLD) of 4.5% and 15.0%, respectively. The prevalence of NAFLD in children is 2.1%, although the prevalence increases to 68.2% among obese children. With the increasing pandemic of obesity and MetS in the general population, China is likely to harbor an increasing reservoir of patients with FLD. The risk factors for FLD resemble to those of Caucasian counterparts, but the ethnic-specific definitions of obesity and MetS are more useful in assessment of Chinese people. Therefore, FLD/NAFLD has become a most common chronic liver disease in China. Public health interventions are needed to halt the worldwide trend of obesity and alcohol abuse to ameliorate liver injury and to improve metabolic health. © 2013 Journal of Gastroenterology and Hepatology Foundation and Wiley Publishing Asia Pty Ltd.


Wang R.,Shanghai JiaoTong University | Tao M.,Shanghai JiaoTong University | Liu Y.,Shanghai JiaoTong University
IEEE Transactions on Signal Processing | Year: 2013

This paper studies a cooperative cognitive radio network where two primary users (PUs) exchange information with the help of a secondary user (SU) that is equipped with multiple antennas and in return, the SU superimposes its own messages along with the primary transmission. The fundamental problem in the considered network is the design of transmission strategies at the secondary node. It involves three basic elements: first, how to split the power for relaying the primary signals and for transmitting the secondary signals; second, what two-way relay strategy should be used to assist the bidirectional communication between the two PUs; third, how to jointly design the primary and secondary transmit precoders. This work aims to address this problem by proposing a transmission framework of maximizing the achievable rate of the SU while maintaining the rate requirements of the two PUs. Three well-known and practical two-way relay strategies are considered: amplify-and-forward (AF), bit level XOR based decode-and-forward (DF-XOR) and symbol level superposition coding based DF (DF-SUP). For each relay strategy, although the design problem is non-convex, we find the optimal solution by using certain transformation techniques and optimization tools such as semidefinite programming (SDP) and second-order cone programming (SOCP). Closed-form solutions are also obtained under certain conditions. Simulation results show that when the rate requirements of the two PUs are symmetric, by using the DF-XOR strategy and applying the proposed optimal precoding, the SU requires the least power for relaying and thus reserves the most power to transmit its own signal. In the asymmetric scenario, on the other hand, the DF-SUP strategy with the corresponding optimal precoding is the best. © 1991-2012 IEEE.


Gliomas are highly malignant brain tumors that are highly invasive and resistant to conventional therapy. Receptor tyrosine kinases (RTKs) such as PDGFRα (platelet-derived growth factor receptor-α), which show frequent aberrant activation in gliomas, are associated with a process of epithelial–mesenchymal transition (EMT), a cellular alteration that confers a more invasive and drug-resistant phenotype. Although this phenomenon is well documented in human cancers, the processes by which RTKs including PDGFRα mediate EMT are largely unknown. Here, we report that SHP-2 (encoded by PTPN11) upregulates an EMT inducer, ZEB1, to mediate PDGFRα-driven glioma EMT, invasion and growth in glioma cell lines and patient-derived glioma stem cells (GSCs) using cell culture and orthotopic xenograft models. ZEB1 and activated PDGFRα were coexpressed in invasive regions of mouse glioma xenografts and clinical glioma specimens. Glioma patients with high levels of both phospho-PDGFRα (p-PDGFRα) and ZEB1 had significantly shorter overall survival compared with those with low expression of p-PDGFRα and ZEB1. Knockdown of ZEB1 inhibited PDGFA/PDGFRα-stimulated glioma EMT, tumor growth and invasion in glioma cell lines and patient-derived GSCs. PDGFRα mutant deficient of SHP2 binding (PDGFRα-F720) or phosphoinositide 3-kinase (PI3K) binding (PDGFRα-F731/42), knockdown of SHP2 or treatments of pharmacological inhibitor for PDGFRα-signaling effectors attenuated PDGFA/PDGFRα-stimulated ZEB1 expression, cell migration and GSC proliferation. Importantly, SHP-2 acts together with PI3K/AKT to regulate a ZEB1-miR-200 feedback loop in PDGFRα-driven gliomas. Taken together, our findings uncover a new pathway in which ZEB1 functions as a key regulator for PDGFRα-driven glioma EMT, invasiveness and growth, suggesting that ZEB1 is a promising therapeutic target for treating gliomas with high PDGFRα activation.Oncogene advance online publication, 4 April 2016; doi:10.1038/onc.2016.100. © 2016 Macmillan Publishers Limited


Background: The HIV prevalence and incidence among men who have sex with men (MSM) are high. Unprotected anal intercourse (UAI) with male regular partners (RP) is an important but under-emphasized risk behavior. The current study aimed to describe the prevalence of UAI with regular partner and the associated multi-dimensional factors with UAI among MSM in Hong Kong, China.Methods: Respondent Driven Sampling method was used to recruit participants. A total of 285 participants were recruited, of whom 211 (75.1%) had had anal sex with RP in the last six months and their data were analyzed in this report. Weighed data were presented and logistic regression methods were fit.Results: Participants' high risk behaviors in the last six months included high prevalence of having had UAI with RP (45.8%), having had non-regular male sex partners (NRP: 27.3%) and UAI with such partners (18.9%). Adjusted for socio-demographic variables, factors associated with UAI with RP included: 1) substances use prior to having anal sex (65.7% versus 43.8%; AOR =2.36; 95% CI =1.07-5.18), 2) worry that condom use symbolizes mistrust (67.9% versus 44.3%; AOR = 2.91; 95% CI =1.19-7.10), 3) a lower perceived degree of the RP's acceptance of condom use (91.7% versus 38.3%; AOR = 22.70; 95% CI =6.20-83.10), and 4) a higher level of impulsivity (61.1% versus 35.0%; AOR =4.02; 95% CI = 1.62-9.97). Two of these four variables, substances use (ORm = 2.28, 95% CI = 1.01-5.16) and perceived lower level of RP's acceptance of condom use (ORm = 17.22; 95% CI = 5.06-58.62) were selected by the forward stepwise logistic regression model.Conclusions: MSM with RP in Hong Kong is subjected to high risk of HIV transmission. Risk factors of UAI are multi-dimensional and interventions need to take into account factors of structural, interpersonal and individual levels. © 2014 Cai and Lau; licensee BioMed Central Ltd.


Kuang Z.-B.,Shanghai JiaoTong University
Acta Mechanica | Year: 2013

Two fundamental theories are discussed in this paper. In the nonlinear electro-magneto-elastic analysis, different authors give different formulas. It means that the fundamental theory should still be studied. In this paper, we give a review of different theories and extend the physical variational principle to the material with electromagnetic body couple. For the temperature wave, we compare the inertial entropy theory and the Cattaneo-Vernotte's theory in detail and show that the former is more appropriate. These theories may be interesting and need further research. © 2013 Springer-Verlag Wien.


Shen C.,Shanghai JiaoTong University | Yang G.,Shanghai JiaoTong University | Zhang W.,Shanghai JiaoTong University
Organic and Biomolecular Chemistry | Year: 2012

A method was developed for the nickel-catalyzed phosphonylation of aryl mesylates and tosylates with H(O)PR 1R 2. To the best of our knowledge, this is the first example of nickel-catalyzed C-P coupling of aryl mesylates and tosylates. Most of the substrates gave moderate to good yields under our catalytic system. © 2012 The Royal Society of Chemistry.


Gao C.,Shanghai JiaoTong University | Che S.,Shanghai JiaoTong University
Advanced Functional Materials | Year: 2010

This article provides a brief overview of functional mesoporous silica materials synthesized by the co-structure-directing route, which is distinct from conventional synthesis strategies. In these systems, organosilane serves as the co-structure-directing agent (CSDA), which provides critical interactions between the template and organic part of the organosilane to form mesostructures, thus retaining the organic groups on the pore surface after removal of the template by extraction. i) The formation of anionic- surfactanttemplated mesoporous silicas (AMSs) has been achieved by the co-structuredirecting route, which leads to a variety of mesostructures, porous properties and morphologies. ii) Other co-structure-directing systems for synthesizing mesoporous silicas have also been achieved, including systems using cationic surfactants and non-surfactants, and systems using DNA for constructing nanofibers and DNA-silica liquid crystalline complexes. iii) Evidence for the regular arrangement of functional groups on the pore surface resulted from the co-structure-directing effect has been discussed. Also included is a brief description of the application, future requirements, and trends in the development of mesoporous materials by the co-structure-directing route. © 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.


Chen H.,Shanghai JiaoTong University | Ren J.,Shanghai JiaoTong University
Talanta | Year: 2012

A new method was developed for selective and sensitive determination of trace chromium (VI) based on the inner filter effect (IFE) of upconversion luminescent nanoparticles (NaYF 4:Yb 3, Er 3) as fluorescence probes. In this study, water-soluble and well dispersible upconversion luminescent nanoparticles (NaYF 4:Yb 3, Er 3) were firstly synthesized by hydrothermal method, and characterized by transmission electron microscopy (TEM) and luminescence spectroscopy. And then, the IFE method was established for determination of chromium (VI). The principle of this assay is based on the complementary overlap of the green emission band of nanoparticles (NaYF 4:Yb 3, Er 3) with the absorption spectrum of a pink chelate complex (Cr(III)- diphenylcarbazone), which was generated by the quantitative reaction between diphenylcarbazide (DPC) and Cr(VI) in mineral acid solution. Under the optimal condition, the decrease in the upconversion luminescent nanoparticles was proportional to the concentration of chromium (VI) due to IFE. The linear range is 0.070-10.0×10 -6 mol L -1 Cr(VI), and the limit of detection (3σ) is 2.40×10 -8 mol L -1 Cr(VI). The method described here is sensitive than the method of spectrophotometry. This assay was used in the determination of Cr(VI) in water samples. © 2012 Elsevier B.V.


Yang G.,Shanghai JiaoTong University | Zhang W.,Shanghai JiaoTong University
Organic Letters | Year: 2012

A switchable regioselective intramolecular aerobic aza-Wacker cyclization catalyzed by palladium is presented. Isoindolinones or isoquinolin-1(2H)-ones could be prepared selectively from the same substrates using different catalysts. The type and steric hindrance of the ligands may be the variables most significant for regiocontrol. © 2011 American Chemical Society.


Zang X.,Shanghai JiaoTong University | Jiang C.,Shanghai JiaoTong University
Optics Express | Year: 2010

Using coordinate transformation stated earlier by Pendry et al. [Science 312, 1780 (2006)], we investigate the two-dimensional elliptical electromagnetic superscatterer and superabsorber, based on the concept of complementary media. Such an elliptical electromagnetic superscatterer (or superabsorber) is realized by coating an elliptical negative refractive material shell. The effectiveness of the elliptical electromagnetic superscatterer and superabsorber designs is verified by finite element simulations. The proposed design provides a more practical superscatterer (or superabsorber) geometry when compared to previous designs with axial and radial symmetries. Our results can be extended to an arbitrarily shaped electromagnetic superscatterer and superabsorber. ©2010 Optical Society of America.


Shen H.-S.,Shanghai JiaoTong University | Zhang C.-L.,Shanghai JiaoTong University
Composite Structures | Year: 2010

This paper presents an investigation on the buckling and postbuckling of double-walled carbon nanotubes (CNTs) subjected to torsion in thermal environments. The double-walled carbon nanotube is modeled as a nonlocal shear deformable cylindrical shell which contains small scale effects and van der Waals interaction forces. The governing equations are based on higher order shear deformation shell theory with a von Kármán-Donnell-type of kinematic nonlinearity and include the extension-twist and flexural-twist couplings. The thermal effects are also included and the material properties are assumed to be temperature-dependent and are obtained from molecular dynamics (MD) simulations. The small scale parameter e0 a is estimated by matching the buckling torque of CNTs observed from the MD simulation results with the numerical results obtained from the nonlocal shear deformable shell model. The results show that buckling torque and postbuckling behavior of CNTs are very sensitive to the small scale parameter e0 a. The results reveal that the size-dependent and temperature-dependent material properties have a significant effect on the torsional buckling and postbuckling behavior of both single-walled and double-walled CNTs. © 2009 Elsevier Ltd. All rights reserved.


Shen H.-S.,Shanghai JiaoTong University
Journal of Theoretical Biology | Year: 2010

This paper presents an investigation on the buckling and postbuckling of microtubules (MTs) subjected to a uniform external radial pressure in thermal environments. The microtubule is modeled as a nonlocal shear deformable cylindrical shell which contains small scale effects. The governing equations are based on higher order shear deformation shell theory with a von Kármán-Donnell-type of kinematic nonlinearity and include the extension-twist and flexural-twist couplings. The thermal effects are also included and the material properties are assumed to be temperature-dependent. A singular perturbation technique is employed to determine the buckling pressure and postbuckling equilibrium paths. The small scale parameter e0a is estimated by matching the buckling pressure of MTs measured from the experiments with the numerical results obtained from the nonlocal shear deformable shell model. The numerical results show that buckling pressure and postbuckling behavior of MTs are very sensitive to the small scale parameter e0a. The results reveal that the 13_3 microtubule has a stable postbuckling path, whereas the 13_2 microtubule has an unstable postbuckling behavior due to the presence of skew angles. © 2010 Elsevier Ltd.


Kang Q.,Shanghai JiaoTong University | Shen Y.,Shandong University | Bai L.,Shanghai JiaoTong University
Natural Product Reports | Year: 2012

Covering: 1957 to 2011 3-Amino-5-hydroxy benzoic acid (3,5-AHBA) is a precursor for a large group of natural products, including the family of naphthalenic and benzenic ansamycins, the unique saliniketals, and the family of mitomycins. This review covers the biosynthesis of AHBA-derived natural products from a molecular genetics, chemical, and biochemical perspectives, and 174 references are cited. © 2012 The Royal Society of Chemistry.


Li Z.-M.,Shanghai JiaoTong University | Lin Z.-Q.,Shanghai JiaoTong University
Composite Structures | Year: 2010

Non-linear buckling and postbuckling of a moderately thick anisotropic laminated cylindrical shell of finite length subjected to lateral pressure, hydrostatic pressure and external liquid pressure has been presented in the paper. The material of each layer of the shell is assumed to be linearly elastic, anisotropic and fiber-reinforced. The governing equations are based on a higher order shear deformation shell theory with von Kármán-Donnell-type of kinematic non-linearity and including the extension/twist, extension/flexural and flexural/twist couplings. The non-linear prebuckling deformations and initial geometric imperfections of the shell are both taken into account. A singular perturbation technique is employed to determine the buckling pressure and postbuckling equilibrium paths. The numerical illustrations concern the postbuckling response of perfect and imperfect, moderately thick, anisotropic laminated cylindrical shells with different values of shell parameters and stacking sequence. The results confirm that there exists a circumferential stress along with an associate shear stress when the shell is subjected to external pressure. © 2009 Elsevier Ltd. All rights reserved.


Chou K.-C.,Shanghai JiaoTong University | Chou K.-C.,Gordon Life Science Institute | Shen H.-B.,Shanghai JiaoTong University | Shen H.-B.,Gordon Life Science Institute
PLoS ONE | Year: 2010

One of the fundamental goals in proteomics and cell biology is to identify the functions of proteins in various cellular organelles and pathways. Information of subcellular locations of proteins can provide useful insights for revealing their functions and understanding how they interact with each other in cellular network systems. Most of the existing methods in predicting plant protein subcellular localization can only cover three or four location sites, and none of them can be used to deal with multiplex plant proteins that can simultaneously exist at two, or move between, two or more different location sites. Actually, such multiplex proteins might have special biological functions worthy of particular notice. The present study was devoted to improve the existing plant protein subcellular location predictors from the aforementioned two aspects. A new predictor called "Plant-mPLoc" is developed by integrating the gene ontology information, functional domain information, and sequential evolutionary information through three different modes of pseudo amino acid composition. It can be used to identify plant proteins among the following 12 location sites: (1) cell membrane, (2) cell wall, (3) chloroplast, (4) cytoplasm, (5) endoplasmic reticulum, (6) extracellular, (7) Golgi apparatus, (8) mitochondrion, (9) nucleus, (10) peroxisome, (11) plastid, and (12) vacuole. Compared with the existing methods for predicting plant protein subcellular localization, the new predictor is much more powerful and flexible. Particularly, it also has the capacity to deal with multiple-location proteins, which is beyond the reach of any existing predictors specialized for identifying plant protein subcellular localization. As a user-friendly web-server, Plant-mPLoc is freely accessible at http://www.csbio.sjtu.edu.cn/bioinf/plan-multi/. Moreover, for the convenience of the vast majority of experimental scientists, a step-by-step guide is provided on how to use the web-server to get the desired results. It is anticipated that the Plant-mPLoc predictor as presented in this paper will become a very useful tool in plant science as well as all the relevant areas. © 2010 Chou, Shen.


Sun Q.J.,Shanghai JiaoTong University
World journal of gastroenterology : WJG | Year: 2010

To investigate the resistance of Helicobacter pylori (H. pylori) to 6 commonly used antibiotics from 2000 to 2009 in Shanghai. A total of 293 H. pylori strains were collected from 2000 to 2009 in Shanghai and tested for their susceptibility to metronidazole, clarithromycin, amoxicillin, furazolidone, levofloxacin and tetracycline using agar dilution. The resistant rates of H. pylori to clarithromycin (8.6%, 9.0% and 20.7%) and levofloxacin (10.3%, 24.0% and 32.5%) increased from 2000 to 2009 in Shanghai. The resistant rate of H. pylori to metronidazole remained stable (40%-50%). Only one strain of H. pylori isolated in 2005 was resistant to tetracycline. All strains were sensitive to amoxicillin and furazolidone. The resistant rate of H. pylori to antibiotics was not related with the sex, age and clinical outcome of patients. Resistance of H. pylori to antibiotics plays an important role in making treatment strategies against H. pylori-associated diseases.


Li J.,Shanghai JiaoTong University | Jiang J.-Y.,Shanghai JiaoTong University
Journal of Neurotrauma | Year: 2012

Hyperthermia may accentuate the detrimental consequences of brain injury and worsen the outcome of patients with acute head trauma, especially severe traumatic brain injury (TBI). We explored the effect of different magnitudes and durations of hyperthermia in the first 3 days after injury on the outcome of 7145 patients with acute head trauma, including 1626 with severe TBI. The differences in mortality and unfavorable outcome between the normothermia group, mild fever group, moderate fever group, and high fever group were statistically significant (p<0.001). The mortality and unfavorable outcome of severe TBI patients in the groups also differed significantly (p<0.001). The mortality and unfavorable outcome of patients with 1 day, 2 days, and 3 days of high fever were significantly increased (p<0.01). Our data strongly indicate that both degree and duration of early post-trauma hyperthermia are closely correlated with the outcome of acute TBI patients, especially severely injured ones, which indicates that hyperthermia may play a detrimental role in the delayed mechanisms of damage after acute TBI. Prevention of early hyperthermia after acute head trauma is therefore essential to the management of TBI patients. © 2012, Mary Ann Liebert, Inc.


Yang G.,Shanghai JiaoTong University | Shen C.,Shanghai JiaoTong University | Zhang W.,Shanghai JiaoTong University
Angewandte Chemie - International Edition | Year: 2012

It's all in the solvent: An enantioselective variant of an aza-Wacker-type cyclization that gives isoindolinones containing tetrasubstituted carbon centers α to the nitrogen atom has been developed (see scheme; tfa=trifluoroacetate). The use of a highly coordinating solvent is crucial for the activity of the catalyst and the stereoselectivity the reaction (up to 99 % ee). Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.


Liu B.,Shanghai JiaoTong University | Han L.,Shanghai JiaoTong University | Che S.,Shanghai JiaoTong University
Angewandte Chemie - International Edition | Year: 2012

Impeller-like helical DNA-silica complexes (see picture; green: silica) were synthesized in the presence of magnesium ions (a). DNA chiral packing and corresponding macroscopic helical morphologies are tuned by the change of reaction temperature, pH value, and molar ratio (b) of the quaternary ammonium (yellow)/phosphate group. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.


Huang Y.,Shanghai JiaoTong University | Dong R.,Shanghai JiaoTong University | Zhu X.,Shanghai JiaoTong University | Yan D.,Shanghai JiaoTong University
Soft Matter | Year: 2014

Photo-responsive polymeric micelles have received increasing attention in both academic and industrial fields due to their efficient photo-sensitive nature and unique nanostructure. In view of the photo-reaction mechanism, photo-responsive polymeric micelles can be divided into five major types: (1) photoisomerization polymeric micelles, (2) photo-induced rearrangement polymeric micelles, (3) photocleavage polymeric micelles, (4) photo-induced crosslinkable polymeric micelles, and (5) photo-induced energy conversion polymeric micelles. This review highlights the recent advances of photo-responsive polymeric micelles, including the design, synthesis and applications in various biomedical fields. Especially, the influence of different photo-reaction mechanisms on the morphology, structure and properties of the polymeric micelles is emphasized. Finally, the possible future directions and perspectives in this emerging area are briefly discussed. This journal is © the Partner Organisations 2014.


Guo X.-X.,Shanghai JiaoTong University
Journal of Organic Chemistry | Year: 2013

The addition of o-halobenzoic acids to active internal alkynes proceeds efficiently in the presence of CuCl2 as a catalyst to give the corresponding isocoumarin derivatives in moderate to good yields. This strategy offers a simple, efficient route to synthesis of the isocoumarin derivatives. © 2013 American Chemical Society.


Yu R.,Renmin University of China | Yu R.,Shanghai JiaoTong University | Si Q.,Rice University
Physical Review Letters | Year: 2015

Motivated by the properties of the iron chalcogenides, we study the phase diagram of a generalized Heisenberg model with frustrated bilinear-biquadratic interactions on a square lattice. We identify zero-temperature phases with antiferroquadrupolar and Ising-nematic orders. The effects of quantum fluctuations and interlayer couplings are analyzed. We propose the Ising-nematic order as underlying the structural phase transition observed in the normal state of FeSe, and discuss the role of the Goldstone modes of the antiferroquadrupolar order for the dipolar magnetic fluctuations in this system. Our results provide a considerably broadened perspective on the overall magnetic phase diagram of the iron chalcogenides and pnictides, and are amenable to tests by new experiments. © 2015 American Physical Society.


Yimei J.,Shanghai JiaoTong University
European review for medical and pharmacological sciences | Year: 2012

For these patients with colorectal cancers, improving their quality of life is just as important as clearing them of their tumor burden. To assess the reference value to surgeons of magnetic resonance imaging (MRI) and endorectal ultrasound (EUS) in local staging of rectal cancer. According to the criteria we set, 69 patients received MRI and 60 patients received EUS, all by senior doctors. We compared two groups in staging accuracy of depth of penetration (T), lymph nodes positive (N) and combined T and N (TN) result. Strategy one (Str1.) was chosen based on MRI or EUS staging. Strategy two (Str2.) took into account clinical parameters, such as computed tomography (CT) and colonoscopy. Strategy three (Str3.) was the best treatment strategy; this was, in part, based on analysis of patients' specimen pathological results. Compared to Str.1 and Str.2, the use of Str.3 as the reference standard separately reflected the reference values of MRI and EUS for surgeons and actual treatment accuracy. EUS had higher sensitivity in T1 (p = 0.044 < 0.05) and specificity in T2 (p = 0.039 < 0.05) than MRI. MRI had higher sensitivity in N staging (p = 0.046 < 0.05) and was more accurate in pT1~4N1~2 (p < 0.05) than EUS. Reference values for surgery (comparing appropriate rates of Str.1 with Str.3) of MRI and EUS were 79.7% vs. 76. 7%, respectively (p > 0.05). The actual treatment accuracy (comparing appropriate rates of Str.2 with Str.3) was increased up to 94.2% vs. 91.7%, respectively (p > 0.05). EUS is good for early-stage patients but MRI for local advanced ones. Strategies both could be improved by combining clinical factors that lead to similar reference values for surgery.


Xiong H.,Brookhaven National Laboratory | Xiong H.,Shanghai JiaoTong University | Sfeir M.Y.,Brookhaven National Laboratory | Gang O.,Brookhaven National Laboratory
Nano Letters | Year: 2010

We report the successful fabrication of optically active three-dimensional (3D) superlattices that incorporate DNA-encoded components, metallic nanoparticles, and molecular chromophores in well-defined positions. A DNA linker with three distinct binding sites serves as an assembly agent and dynamically tunable structural element for the superlattice. Using small angle X-ray scattering we have revealed the organization of particle-chromophore 3D arrays and monitored their reversible contractions and expansions that were modulated by ionic strength changes. As the distance between the molecular chromophores and plasmonic nanoparticles in the superlattice was regulated in situ, we were able to uncover the relationship between experimentally determined structure and optical response of the system. This dynamical tunability of superlattice results in a dramatic optical response: nearly a three times change of emission rate of the chromophore. The evolution of lifetime with structural changes reasonably agrees with the calculations based on a cumulitative coupling of chromophores with metallic nanoparticles in different coordination shells. © 2010 American Chemical Society.


Pan J.,Shanghai JiaoTong University
Current Opinion in Infectious Diseases | Year: 2016

PURPOSE OF REVIEW: Although available therapies can effectively inhibit hepatitis B virus (HBV) replication in patients with active chronic hepatitis B (CHB) infection, therapeutic efficacy is limited because of potential drug resistance, and an inability to mediate viral clearance and to rectify immune impairment in CHB patients. This review will summarize the state-of-the-art for anti-HBV drugs and focus on potential drugs and targets under development and evaluation. RECENT FINDINGS: New developing drugs are evaluated for their antiviral effects in the areas of interference with the viral replication cycle, elimination of closed circular DNA, modulation of host immunity and identification of the La protein and its regulator casein kinase as possible targets for the development of anti-HBV therapies. SUMMARY: These novel compounds and targets have showed great inhibitory effects on HBV replication in vitro and in animal models. Several novel therapies are promising in early clinical trials. Potentially, combination of newly developing and current antiviral drugs may cure CHB in the clinic. Copyright © 2016 Wolters Kluwer Health, Inc. All rights reserved.


Shen H.-S.,Shanghai JiaoTong University | Xiang Y.,University of Western Sydney
Engineering Structures | Year: 2014

Nonlinear bending analysis is presented for nanocomposite cylindrical panels subjected to a transverse uniform or sinusoidal load resting on elastic foundations in thermal environments. Carbon nanotubes are used to reinforce the cylindrical panels in two distinguished patterns, namely, uniformly distributed (UD) and functionally graded (FG) reinforcements. The material properties of CNTRCs are assumed to be temperature-dependent and are estimated by a micromechanical model. The governing equations of the panel are derived based on a higher-order shear deformation theory with a von Kármán-type of kinematic nonlinearity and are solved by a two-step perturbation technique. The nonlinear bending behaviors of the CNTRC panels with different CNT volume fraction distributions, foundation stiffnesses, temperature rise, and the character of in-plane boundary conditions are studied in details. © 2014 Elsevier Ltd.


Ying X.,Shanghai JiaoTong University
Hypertension | Year: 2016

Ubiquitin-specific protease 18 (USP18), a USP family member, is involved in antiviral activity and cancer inhibition. Although USP18 is expressed in heart, the role of USP18 in the heart and in cardiac diseases remains unknown. Here, we show that USP18 expression is elevated in both human dilated hearts and hypertrophic murine models. Cardiomyocyte-specific overexpression of USP18 in mice significantly blunted cardiac remodeling as evidenced by mitigated myocardial hypertrophy, fibrosis, ventricular dilation, and preserved ejection function, whereas USP18-deficient mice displayed exacerbated cardiac remodeling under the same pathological stimuli. Similar results were observed for in vitro angiotensin II–induced neonatal rat cardiomyocyte hypertrophy. The antihypertrophic effects of USP18 under hypertrophic stimuli were associated with the blockage of the transforming growth factor-β–activated kinase 1-p38/c-Jun N-terminal kinase 1/2 signaling cascade. Blocking transforming growth factor-β–activated kinase 1-p38/c-Jun N-terminal kinase 1/2 signaling with a pharmacological inhibitor (5Z-7-oxozeaenol) greatly reversed the detrimental effects observed in USP18-knockout mice subjected to aortic banding. Our data indicate that USP18 inhibits cardiac hypertrophy and postpones cardiac dysfunction during the remodeling process, which is dependent on its modulation of the transforming growth factor-β–activated kinase 1-p38/c-Jun N-terminal kinase 1/2 signaling axis. Thus, USP18 is a potent therapeutic target for heart failure treatment. © 2016 American Heart Association, Inc


Wang Y.,Shanghai JiaoTong University
ISA transactions | Year: 2012

This paper is concerned with the guaranteed cost control for continuous-time singular Markovian jump systems with time-varying delay. Without using the free weighting matrices method, a delay-range-dependent condition is derived in terms of strict linear matrix inequality (LMI), which guarantees that the singular system is regular, impulse free and mean-square exponentially stable with an H(∞) performance. Based on this, the existence condition of the guaranteed cost state feedback controller is proposed. A numerical example is given to illustrate the effectiveness and less conservatism of the proposed design method. Copyright © 2012 ISA. Published by Elsevier Ltd. All rights reserved.


Deng Y.,Southwest University | Deng Y.,Shanghai JiaoTong University | Chan F.T.S.,Hong Kong Polytechnic University
Expert Systems with Applications | Year: 2011

Supplier selection is a multi-criterion decision making problem under uncertain environments. Hence, it is reasonable to hand the problem in fuzzy sets theory (FST) and Dempster Shafer theory of evidence (DST). In this paper, a new MCDM methodology, using FST and DST, based on the main idea of the technique for order preference by similarity to an ideal solution (TOPSIS), is developed to deal with supplier selection problem. The basic probability assignments (BPA) can be determined by the distance to the ideal solution and the distance to the negative ideal solution. Dempster combination rule is used to combine all the criterion data to get the final scores of the alternatives in the systems. The final decision results can be drawn through the pignistic probability transformation. In traditional fuzzy TOPSIS method, the quantitative performance of criterion, such as crisp numbers, should be transformed into fuzzy numbers. The proposed method is more flexible due to the reason that the BPA can be determined without the transformation step in traditional fuzzy TOPSIS method. The performance of criterion can be represented as crisp number or fuzzy number according to the real situation in our proposed method. The numerical example about supplier selection is used to illustrate the efficiency of the proposed method. © 2011 Published by Elsevier Ltd.


Lin C.,Shanghai JiaoTong University | Liu Y.,Shanghai JiaoTong University | Tao M.,Shanghai JiaoTong University
IEEE Journal on Selected Areas in Communications | Year: 2013

Two-way relaying promises considerable improvements on spectral efficiency in wireless relay networks. While most existing works focus on physical layer approaches to exploit its capacity gain, the benefits of two-way relaying on upper layers are much less investigated. In this paper, we study the cross-layer design and optimization for delay quality-of-service (QoS) provisioning in two-way relay systems. Our goal is to find the optimal transmission policy to maximize the weighted sum throughput of the two users in the physical layer while guaranteeing the individual statistical delay-QoS requirement for each user in the datalink layer. This statistical delay-QoS requirement is characterized by the QoS exponent. By integrating the concept of effective capacity, the cross-layer optimization problem is equivalent to a weighted sum effective capacity maximization problem. We derive the jointly optimal power and rate adaptation policies for both three-phase and two-phase two-way relay protocols. Numerical results show that the proposed adaptive transmission policies can efficiently provide QoS guarantees and improve the performance. In addition, the throughput gain obtained by the considered three-phase and two-phase protocols over direct transmission is significant when the delay-QoS requirements are loose, but the gain diminishes at tight delay requirements. It is also found that, in the two-phase protocol, the relay node should be placed closer to the source with more stringent delay requirement. © 1983-2012 IEEE.


Guan N.,National University of Defense Technology | Tao D.,Intelligent Systems Technology, Inc. | Luo Z.,National University of Defense Technology | Yuan B.,Shanghai JiaoTong University
IEEE Transactions on Signal Processing | Year: 2012

Nonnegative matrix factorization (NMF) is a powerful matrix decomposition technique that approximates a nonnegative matrix by the product of two low-rank nonnegative matrix factors. It has been widely applied to signal processing, computer vision, and data mining. Traditional NMF solvers include the multiplicative update rule (MUR), the projected gradient method (PG), the projected nonnegative least squares (PNLS), and the active set method (AS). However, they suffer from one or some of the following three problems: slow convergence rate, numerical instability and nonconvergence. In this paper, we present a new efficient NeNMF solver to simultaneously overcome the aforementioned problems. It applies Nesterov's optimal gradient method to alternatively optimize one factor with another fixed. In particular, at each iteration round, the matrix factor is updated by using the PG method performed on a smartly chosen search point, where the step size is determined by the Lipschitz constant. Since NeNMF does not use the time consuming line search and converges optimally at rate O(1/k2) in optimizing each matrix factor, it is superior to MUR and PG in terms of efficiency as well as approximation accuracy. Compared to PNLS and AS that suffer from numerical instability problem in the worst case, NeNMF overcomes this deficiency. In addition, NeNMF can be used to solve L 1-norm, L 2-norm and manifold regularized NMF with the optimal convergence rate. Numerical experiments on both synthetic and real-world datasets show the efficiency of NeNMF for NMF and its variants comparing to representative NMF solvers. Extensive experiments on document clustering suggest the effectiveness of NeNMF. © 2012 IEEE.


Wang X.,Shanghai JiaoTong University | Fu L.,Shanghai JiaoTong University | Hu C.,Shanghai JiaoTong University
IEEE/ACM Transactions on Networking | Year: 2012

It has been shown in a previous version of this paper that hierarchical cooperation achieves a linear throughput scaling for unicast traffic, which is due to the advantage of long-range concurrent transmissions and the technique of distributed multiple-input-multiple-output (MIMO). In this paper, we investigate the scaling law for multicast traffic with hierarchical cooperation, where each of the n nodes communicates with k randomly chosen destination nodes. Specifically, we propose a new class of scheduling policies for multicast traffic. By utilizing the hierarchical cooperative MIMO transmission, our new policies can obtain an aggregate throughput of Ω ((n/k) 1-ε)for any ε > This achieves a gain of nearly n/k compared to the noncooperative scheme in Li 's work (Proc. ACM MobiCom, 2007, pp. 266-277). Among all four cooperative strategies proposed in our paper, one is superior in terms of the three performance metrics: throughput, delay, and energy consumption. Two factors contribute to the optimal performance: multihop MIMO transmission and converge-based scheduling. Compared to the single-hop MIMO transmission strategy, the multihop strategy achieves a throughput gain of (n/k) h-1/h(2h-1) and meanwhile reduces the energy consumption by k α-2/2 times approximately, where h is the number of the hierarchical layers, α and 2 is the path-loss exponent. Moreover, to schedule the traffic with the converge multicast instead of the pure multicast strategy, we can dramatically reduce the delay by a factor of about (n/k) h/2 Our optimal cooperative strategy achieves an approximate delay-throughput tradeoff D(n,k)/T(n,k)=θ (k) when h → ∞ This tradeoff ratio is identical to that of noncooperative scheme, while the throughput is greatly improved. © 2012 IEEE.


Chen H.,Shanghai JiaoTong University
International journal of nanomedicine | Year: 2011

A promising therapy for retinal diseases is to employ biodegradable scaffolds to deliver retinal progenitor cells (RPCs) for repairing damaged or diseased retinal tissue. In the present study, cationic chitosan-graft-poly(e-caprolactone)/polycaprolactone (CS-PCL/PCL) hybrid scaffolds were successfully prepared by electrospinning. Characterization of the obtained nanofibrous scaffolds indicated that zeta-potential, fiber diameter, and the content of amino groups on their surface were closely correlated with the amount of CS-PCL in CS-PCL/PCL scaffolds. To assess the cell-scaffold interaction, mice RPCs (mRPCs) were cultured on the electrospun scaffolds for 7 days. In-vitro proliferation assays revealed that mRPCs proliferated faster on the CS-PCL/PCL (20/80) scaffolds than the other electrospun scaffolds. Scanning electron microscopy and the real-time quantitative polymerase chain reaction results showed that mRPCs grown on CS-PCL/PCL (20/80) scaffolds were more likely to differentiate towards retinal neurons than those on PCL scaffolds. Taken together, these results suggest that CS-PCL/PCL(20/80) scaffolds have potential application in retinal tissue engineering.


Dong L.Y.,Shanghai JiaoTong University
European review for medical and pharmacological sciences | Year: 2013

Ischemic preconditioning (IP) has been used to reduce ischemia-reperfusion injury in several models. It remains unknown whether IP is sufficient to prevent deep hypothermic circulatory arrest (DHCA) cardiopulmonary bypass (CPB) induced lung injury. Twenty-four piglets were randomly divided into four groups: routine CPB (CPB), CPB + DHCA (DHCA), CPB + IP + DHCA (IP-1) and CPB + hypoxia-ischemia preconditioning + DHCA (IP-2). Lung static compliance (Cstat) and pulmonary vascular resistance (PVR) were measured as indicators of lung function at three points during CPB. TNF-α, IL-8 and IL-10 expressions were detected by radioimmunoassay. CD18 expression was determined by flow cytometer. Some lung tissues were excised to measure the wet/dry weight ratio (W/D) and some were fixed to observe pathological changes. Cstat significantly decreased whereas PVR increased in DHCA group. IP prevented DHCA-induced lung functional impairment, especially IP-2 treatment. More cytokines were produced after CPB in all groups, but with varying level. Left atrium/pulmonary artery ratio of CD18 expression on monocytes decreased only in DHCA group, whereas which on polymorphonuclear neutrophils decreased in DHCA group, IP-1 group at 1h post-CPB and IP-2 group. Although lung W/D was increased in IP-2 group compared with pre-CPB, but significantly lower than that in DHCA group. Histological findings showed less lung injuries in IP groups than DHCA group. DHCA aggravates lung inflammatory injury and IP may reverse this injury. Maintaining ventilation with pulmonary artery perfusion in the lung IP process during CPB seems to be more superior to single pulmonary artery perfusion.


Gong S.,Shanghai JiaoTong University | Cheng P.,Shanghai JiaoTong University
Computers and Fluids | Year: 2012

An improved model for simulation of phase transitions and single-component multiphase flows by lattice Boltzmann method is proposed and developed in this paper. It is shown that both the scheme for the interparticle interaction force term and the method of incorporating the force term are important for obtaining accurate and stable numerical results for simulations of single-component multiphase flows. A new scheme for the force term is proposed and simulation results of several non-ideal equation of state suggest that the proposed scheme can greatly improve the coexistence curves. Among several methods of incorporating the force term, the exact difference method is shown to have better accuracy and stability. Furthermore, it avoids the unphysical phenomenon of relaxation time dependence. Compared with existing models, the proposed model, consisting of the new force term scheme together with the exact different method to incorporate the force term, can give more accurate and stable numerical results in a wider temperature range with the spurious currents greatly reduced. Droplet motion and coalescence processes on surfaces with wettability gradients are numerically investigated based on the newly proposed model. The velocity field and mechanism of droplet motion are illustrated in details. © 2011 Elsevier Ltd.


Zhang Z.,Shanghai JiaoTong University | Chu X.,Shanghai JiaoTong University
Expert Systems with Applications | Year: 2011

Failure mode and effects analysis (FMEA) is a powerful tool for identifying and assessing potential failures. The tool has become increasingly important in new product development, manufacture or engineering applications. Generally, risk assessment in FMEA is carried out by using risk priority numbers (RPNs) which can be determined by evaluating three factors: occurrence (O), severity (S) and detection (D). Due to the vagueness and uncertainty existing in the evaluating process, crisp numbers representing RPNs in the traditional FMEA might be improper or insufficient in contrast to fuzzy numbers. Currently, the fuzzy methods and linear programming method have been proposed as an effective solution for the calculations of fuzzy RPNs. However, considering the fact that fuzzy RPNs are determined on a multidimensional scale spanning O, S and D along with their interactions under a fuzzy environment, several gaps should be bridged in the evaluation, calculation, and ranking of fuzzy RPNs. First, decision makers tend to use multi-granularity linguistic term sets for expressing their assessments because of their different backgrounds and preferences. Second, numerical compensation may be existed among O, S and D that can derive different RPNs in the engineering applications. Third, the complete ranking results for fuzzy RPNs may be easily changed by the effects of uncertain factors. In this study, a fuzzy-RPNs-based method integrating weighted least square method, the method of imprecision and partial ranking method is proposed to generate more accurate fuzzy RPNs and ensure to be robust against the uncertainty. A design example of new horizontal directional drilling machine is used for illustrating the application of the proposed approach. © 2010 Elsevier Ltd. All rights reserved.


The association between the NAD(P)H: quinone oxidoreductase 1 (NQO1) gene C609T polymorphism and gastric cancer has been widely evaluated, yet with conflicting results. Data were available from seven study populations involving 2600 subjects. Overall, comparison of alleles 609T and 609C indicated a significantly increased risk (46%) for gastric cancer (95% confidence interval (95%CI) for odds ratio (OR) = 1.20-1.79) in individuals with the T allele. The tendency was increased in the homozygous comparison (609TT versus 609CC), with an OR = 2.04 (95%CI = 1.37-3.05). Stratified analysis by study design demonstrated stronger associations in population-based studies than in hospital-based studies, based on OR. Ethnicity-based analysis demonstrated a significant association in Asians but not in Caucasians. Additionally, in the subgroup analyses by the type of gastric cancer, a significantly increased risk was found with all genetic models in the gastric adenocarcinoma subgroup compared to the others. We conclude that the NQO1 gene C609T polymorphism increases the risk for gastric cancer, especially in Asian populations.


Gao L.,Shanghai JiaoTong University | Wang X.,Shanghai JiaoTong University | Xu Y.,Shanghai JiaoTong University | Zhang Q.,Hong Kong University of Science and Technology
IEEE Journal on Selected Areas in Communications | Year: 2011

Cognitive radio is a promising paradigm to achieve efficient utilization of spectrum resource by allowing the unlicensed users (i.e., secondary users, SUs) to access the licensed spectrum. Market-driven spectrum trading is an efficient way to achieve dynamic spectrum accessing/sharing. In this paper, we consider the problem of spectrum trading with single primary spectrum owner (or primary user, PO) selling his idle spectrum to multiple SUs. We model the trading process as a monopoly market, in which the PO acts as monopolist who sets the qualities and prices for the spectrum he sells, and the SUs act as consumers who choose the spectrum with appropriate quality and price for purchasing. We design a monopolist-dominated quality-price contract, which is offered by the PO and contains a set of quality-price combinations each intended for a consumer type. A contract is feasible if it is incentive compatible (IC) and individually rational (IR) for each SU to purchase the spectrum with the quality-price intended for his type. We propose the necessary and sufficient conditions for the contract to be feasible. We further derive the optimal contract, which is feasible and maximizes the utility of the PO, for both discrete-consumer-type model and continuous-consumer-type model. Moreover, we analyze the social surplus, i.e., the aggregate utility of both PO and SUs, and we find that, depending on the distribution of consumer types, the social surplus under the optimal contract may be less than or close to the maximum social surplus. © 2006 IEEE.


Gu G.-Y.,Shanghai JiaoTong University | Yang M.-J.,Shanghai JiaoTong University | Zhu L.-M.,Shanghai JiaoTong University
Review of Scientific Instruments | Year: 2012

This paper presents a novel real-time inverse hysteresis compensation method for piezoelectric actuators exhibiting asymmetric hysteresis effect. The proposed method directly utilizes a modified Prandtl-Ishlinskii hysteresis model to characterize the inverse hysteresis effect of piezoelectric actuators. The hysteresis model is then cascaded in the feedforward path for hysteresis cancellation. It avoids the complex and difficult mathematical procedure for constructing an inversion of the hysteresis model. For the purpose of validation, an experimental platform is established. To identify the model parameters, an adaptive particle swarm optimization algorithm is adopted. Based on the identified model parameters, a real-time feedforward controller is implemented for fast hysteresis compensation. Finally, tests are conducted with various kinds of trajectories. The experimental results show that the tracking errors caused by the hysteresis effect are reduced by about 90, which clearly demonstrates the effectiveness of the proposed inverse compensation method with the modified Prandtl-Ishlinskii model. © 2012 American Institute of Physics.


Li G.,Shanghai JiaoTong University
Journal of Coatings Technology Research | Year: 2010

Hafnium carbide coatings with different carbon contents were synthesized in Ar-C 2H 2 mixture by reactive magnetron sputtering. Energy-dispersive X-ray, X-ray diffraction, scanning electron microscopy, atomic force microscopy, and nanoindentation were employed to characterize their microstructure and mechanical properties. The effects of C 2H 2 partial pressure on the composition, phase, microstructure, and mechanical properties of the coatings were investigated. The results show that hafnium carbide coatings can be synthesized at a low partial pressure of C 2H 2. The single-phase HfC coating with columnar crystal and favorable mechanical properties is obtained when the proportion of C 2H 2 partial pressure is only about 3.0% in the mixture, and the highest hardness and modulus are 27.9 and 255 GPa, respectively. The coating contains metal Hf and HfC phases and obtains low hardness under lower C 2H 2 partial pressure. When the C 2H 2 partial pressure is higher, the hardness and elastic moduli of acquired amorphous coatings decrease significantly. © FSCT and OCCA 2009.


Kou Y.,Shanghai JiaoTong University | Chen X.,Shanghai JiaoTong University
Optics Express | Year: 2011

Multimode interference (MMI) effect in metal-insulator-metal (MIM) waveguides is studied in this paper. Theoretical calculation based on the self-imaging principle and the finite element method (FEM) simulation are used to analyze the effect and further guide the design of plasmonic MMI devices. We show that wavelength-selective routing and splitting with high extinction ratios can be realized in the multimode waveguides, and active control by refractive index modulation is also demonstrated. © 2011 Optical Society of America.


Zhu K.,Shanghai JiaoTong University
Cancer Research and Clinic | Year: 2015

Long non-coding RNA (IncRNA) is a group of length more than 200 nucleotides without coding protein RNA. It plays an important role in cell proliferation, differentiation, senescence, death, tumor occurrence and development. This article reviews the main characteristics of IncRNA and its role in tumor drug resistance.


Su H.,Huazhong University of Science and Technology | Chen M.Z.Q.,University of Hong Kong | Wang X.,Shanghai JiaoTong University | Lam J.,University of Hong Kong
IEEE Transactions on Industrial Electronics | Year: 2014

This paper studies the observer-based leader-following consensus of a linear multiagent system on switching networks, in which the input of each agent is subject to saturation. Based on a low-gain output feedback method, distributed consensus protocols are developed. Under the assumptions that the networks are connected or jointly connected and that each agent is asymptotically null controllable with bounded controls and detectable, semiglobal observer-based leader-following consensus of the multiagent system can be reached on switching networks. A numerical example is presented to illustrate the theoretical results. © 1982-2012 IEEE.


Li H.,Shanghai JiaoTong University | Wan A.,Shanghai JiaoTong University
Mediators of Inflammation | Year: 2013

Rheumatoid arthritis is a chronic inflammatory disease characterized by synovial hyperplasia and progressive joint destruction. The impaired apoptosis of rheumatoid arthritis fibroblast-like synoviocytes (RA-FLS) is pivotal in this process. However, the molecular mechanisms responsible for the reduced apoptosis are not fully understood. Both nitric oxide and thioredoxin 1 as two important mediators are widely investigated in the pathogenesis of rheumatoid arthritis. Interestingly, studies have showed that thioredoxin 1 may serve as a master regulator of S-nitrosylation of caspase-3 to fine-tune apoptosis in vivo. Thus, it is anticipated that further investigations on the role of thioredoxin 1 in the S-nitrosylation and denitrosylation of caspase-3 in RA-FLS will likely provide a novel understanding of mechanisms implicated in the impaired apoptosis of RA-FLS. In this paper, we will provide an overview on pathways involved in the reduced apoptosis of RA-FLS and then discuss specially the possible roles of nitric oxide and the thioredoxin 1 redox system associated with apoptosis of RA-FLS. © 2013 Huili Li and Ajun Wan.


Sanetuntikul J.,Daegu Gyeongbuk Institute of Science and Technology | Hang T.,Shanghai JiaoTong University | Shanmugam S.,Daegu Gyeongbuk Institute of Science and Technology
Chemical Communications | Year: 2014

Hollow nitrogen-doped carbon spheres (HNCSs) were prepared by a facile method as non-precious catalysts for the oxygen reduction reaction (ORR). The HNCS catalysts exhibited ORR activity comparable with a commercial Pt/C catalyst and superior stability in alkaline electrolyte medium. This journal is © the Partner Organisations 2014.


Zhang Z.,Shanghai JiaoTong University
Machine Learning | Year: 2014

We are concerned with an approximation problem for a symmetric positive semidefinite matrix due to motivation from a class of nonlinear machine learning methods. We discuss an approximation approach that we call matrix ridge approximation. In particular, we define the matrix ridge approximation as an incomplete matrix factorization plus a ridge term. Moreover, we present probabilistic interpretations using a normal latent variable model and a Wishart model for this approximation approach. The idea behind the latent variable model in turn leads us to an efficient EM iterative method for handling the matrix ridge approximation problem. Finally, we illustrate the applications of the approximation approach in multivariate data analysis. Empirical studies in spectral clustering and Gaussian process regression show that the matrix ridge approximation with the EM iteration is potentially useful. © 2014, The Author(s).


Zhao J.,Shanghai JiaoTong University | Ye J.,Shanghai JiaoTong University | Zhang Y.J.,Shanghai JiaoTong University
Advanced Synthesis and Catalysis | Year: 2013

A practical process for the stereospecific cross-coupling of secondary allylic carbonates with arylboronic acids has been developed. The reaction is catalyzed by in situ generated palladium nanoparticles (PdNPs) without any ligands and additional stabilizers in water under ambient conditions and furnishes the allyl-aryl coupling products in high isolated yields with high stereospecificities as well as excellent chemo-, regio- and E/Z-selectivities. The in situ generated PdNPs showed extraordinary catalytic activity (S/C up to 5000) even for the allyl-aryl coupling reactions of easily eliminated allylic carbonates under aqueous ambient conditions. The mechanism of the process has also been investigated. © 2013 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.


He J.-H.,National institute for astrophysics | Wang B.,Shanghai JiaoTong University
Physical Review D - Particles, Fields, Gravitation and Cosmology | Year: 2013

We reconstruct an f(R) gravity model that gives rise to the particular ΛCDM background evolution of the Universe. We find well-defined, real-valued analytical forms for the f(R) model to describe the Universe both in the early epoch from the radiation to matter dominated eras and the late time acceleration period. We further examine the viability of the derived f(R) model and find that it is viable to describe the evolution of the Universe in the past and the future singularity does not exist in the Lagrangian. © 2013 American Physical Society.


One of the most significant findings in recent stem cell research is the establishment of the induced pluripotent stem (iPS) cells, because they could have critical implications in both regenerative and reproductive medicine. Male gametes play a crucial role in transmitting genetic information to subsequent generations, and notably there are more and more patients with azoospermia, due to genetic and environmental factors. Recent advancements on generation of male gametes from human iPS cells would bring great promise to produce patient own male gametes for treating male infertility and provide an excellent platform for unveiling molecular mechanisms of male germ cell development. © 2012 AJA, SIMM & SJTU. All rights reserved.


Zhang S.-J.,Shanghai JiaoTong University | Wang B.,Shanghai JiaoTong University
Physical Review D - Particles, Fields, Gravitation and Cosmology | Year: 2013

Recently, in the Einstein gravity, Majhi and Padmanabhan proposed a straightforward and transparent way of obtaining the Bekenstein-Hawking entropy by using an approach based on the Virasoro algebra and central charge. In this work, we generalize their approach to the modified gravity with higher-curvature corrections and show that their approach can successfully lead to the corresponding Wald entropy in the higher-curvature gravity. Our result shows that the approach is physically general. © 2013 American Physical Society.


Hao Y.,Shanghai JiaoTong University | Asundi A.,Nanyang Technological University
Optics Letters | Year: 2013

Digital holography (DH) is a 3D measurement technique with a theoretical axial resolution of better than 1-2 nm. However, practically, the axial resolution has been quoted to be in the range 10-20 nm. One possible reason is that the axial measurement error is much larger so that the theoretical axial resolution cannot be achieved. Until now the axial measurement errors of the DH system have not been thoroughly discussed. In this Letter, the impact of CCD chip size on the axial measurement error is investigated through both simulation and experiment. The results show that a larger CCD size reduces the axial measurement error and improves the measurement accuracy of edges. © 2013 Optical Society of America.


Kou Y.,Shanghai JiaoTong University | Ye F.,Shanghai JiaoTong University | Chen X.,Shanghai JiaoTong University
Optics Letters | Year: 2013

We predict multiband vector plasmonic lattice solitons (PLSs) in metal-dielectric waveguide arrays, in both focusing and defocusing nonlinearities. Such vector solitons consist of two components originating from different transmission bands. By simulating the full nonlinear Maxwell's equations, we demonstrate the diffractionless propagation of vector PLSs and their discrete diffraction when only one component is present. Their subwavelength size characteristics and the influences of metallic losses are also studied. © 2013 Optical Society of America.


Yuan X.-Z.,Shanghai JiaoTong University
Physical Review A - Atomic, Molecular, and Optical Physics | Year: 2013

The stationary continuous-variable entanglement between an optical cavity and a nanomechanical resonator beam is generated by their common interaction with a quantum dot. To deal with the quantum dot which is modeled as a two-level system, we do not use the low excitation limit approximation to bosonize the spin operators, but we keep them in the quantum Langevin equations. We linearize the quantum Langevin equations reasonably and investigate the stationary continuous-variable entanglement in detail, and finally we show that a high degree of entanglement can be achieved for experimentally feasible parameters. © 2013 American Physical Society.


Leung J.Y.-T.,New Jersey Institute of Technology | Pinedo M.,New York University | Wan G.,Shanghai JiaoTong University
Operations Research | Year: 2010

We consider a scheduling environment with m (m≥ 1) identical machines in parallel and two agents. Agent A is responsible for n1 jobs and has a given objective function with regard to these jobs; agent B is responsible for n 2 jobs and has an objective function that may be either the same or different from the one of agent A. The problem is to find a schedule for the n1 + n2 jobs that minimizes the objective of agent A (with regard to his n 1 jobs) while keeping the objective of agent B (with regard to his n2 jobs) below or at a fixed level Q. The special case with a single machine has recently been considered in the literature, and a variety of results have been obtained for two-agent models with objectives such as f max, ∑wjCj , and ∑Uj . In this paper, we generalize these results and solve one of the problems that had remained open. Furthermore, we enlarge the framework for the two-agent scheduling problem by including the total tardiness objective, allowing for preemptions, and considering jobs with different release dates; we consider also identical machines in parallel. We furthermore establish the relationships between two-agent scheduling problems and other areas within the scheduling field, namely rescheduling and scheduling subject to availability constraints. ©2010 INFORMS.


Wei W.,Shanghai JiaoTong University | Yi L.,Shanghai JiaoTong University | Jaouen Y.,Telecom ParisTech | Hu W.,Shanghai JiaoTong University
Optics Express | Year: 2014

We propose a rectangular optical filter based on stimulated Brillouin scattering (SBS) in optical fiber with bandwidth tuning from 50 MHz to 4 GHz at less than 15-MHz resolution. The rectangular shape of the filter is precisely achieved utilizing digital feedback control of the comb-like pump spectral lines. The passband ripple is suppressed to ∼1 dB by mitigating the nonlinearity influences of the comb-like pump lines generated in electrical and optical components and fibers. Moreover a fiber with a single Brillouin peak is employed to further reduce the in-band ripple and the out-of-band SBS gain at the same time. Finally, we analyze the noise performance of the filter at different bandwidth cases and demonstrate the system performance of the proposed filter with 2.1-GHz bandwidth and 19-dB gain by amplifying a 2-GHz orthogonal frequency-division-multiplexing (OFDM) signal with quadrature-phase-shift-keying (QPSK) and 16-quadrature-amplitude-modulation (16-QAM) on each subscriber. ©2014 Optical Society of America.


Li Y.,Shanghai JiaoTong University | Weng Y.,Shanghai JiaoTong University
Journal of Power Sources | Year: 2011

This paper presents an analysis of the fuel flexibility of a methane-based solid oxide fuel cell-gas turbine (SOFC-GT) hybrid system. The simulation models of the system are mathematically defined. Special attention is paid to the development of an SOFC thermodynamic model that allows for the calculation of radial temperature gradients. Based on the simulation model, the new design point of system for new fuels is defined first; the steady-state performance of the system fed by different fuels is then discussed. When the hybrid system operates with hydrogen, the net power output at the new design point will decrease to 70% of the methane, while the design net efficiency will decrease to 55%. Similar to hydrogen, the net output power of the ethanol-fueled system will decrease to 88% of the methane value due to the lower cooling effect of steam reforming. However, the net efficiency can remain at 61% at high level due to increased heat recuperation from exhaust gas. To increase the power output of the hybrid system operating with non-design fuels without changing the system configuration, three different measures are introduced and investigated in this paper. The introduced measures can increase the system net power output operating with hydrogen to 94% of the original value at the cost of a lower efficiency of 45%. © 2011 Elsevier B.V. All rights reserved.


Mi J.,Shanghai JiaoTong University
Frontiers of Medicine in China | Year: 2011

Acute promyelocytic leukemia (APL) is a unique subtype of acute myeloid leukemia (AML). The prognosis of APL has changed from the worst among the AMLs to currently the best. The application of all-trans retinoic acid (ATRA) in the induction therapy of APL decreases the high mortality of newly diagnosed patients, thereby significantly improving the response rate. ATRA combined with anthracycline-based chemotherapy is the current standard treatment, and for high-risk patients, high doses cytarabine have a beneficial effect on relapse prevention. In recent years, the indications of arsenic trioxide (ATO) therapy for APL have been extended from the salvage therapy for relapse patients to the first-line treatment of de novo APL. The introduction of both ATRA and ATO represents great achievements in translational medicine. In this review article, we discuss the therapeutic strategies for this disease, including the initial approaches to newly diagnosed patients, prevention, and treatment of side effects and relapse to ensure the best and timely treatment for each newly diagnosed APL patient. © 2011 Higher Education Press and Springer-Verlag Berlin Heidelberg.


Shi C.,Shanghai JiaoTong University | Parker R.G.,Virginia Polytechnic Institute and State University
Journal of Sound and Vibration | Year: 2013

This work studies the symmetry breaking effects on the vibration mode structure of centrifugal pendulum vibration absorber (CPVA) systems when multiple groups of absorbers are used. An absorber group is a set of equally spaced, identical absorbers. Absorbers within a group are cyclically symmetric while the entire system is asymmetric because the groups have no pre-defined relative angular spacing. One rotational and two translational degrees of freedom for the rotor and a single arclength degree of freedom for each absorber are considered in the planar model. The well-defined structure of the vibration modes is obtained by analytical and numerical investigations of the associated eigenvalue problem. This vibration mode structure is similar to that for CPVA systems with equally spaced, identical absorbers. Thus, the disrupted symmetry from multiple absorber groups does not destroy the vibration mode structure resulting from the cyclic symmetry within each group. The critical speeds and flutter instability of the system are investigated. © 2013 Elsevier B.V. All rights reserved.


Bai X.,Shanghai JiaoTong University | Zhai Y.,Shanghai JiaoTong University | Zhang Y.,Shanghai JiaoTong University
Journal of Physical Chemistry C | Year: 2011

Chemically reduced graphene (CR-G)/poly-(ethylene oxide) (PEO) composites are prepared by a simple aqueous mixing method. Graphite oxide (GO) is prepared by a modified Hummers method and further dispersed in water to form graphene oxide (G-O). The as prepared G-O is mixed with PEO and in situ reduced by L-ascorbic acid. CR-G monolayers are ∼1 nm in thickness and ∼1.5 μm in both length and width as confirmed by AFM, indicating their large aspect ratio of about 1500. G-O is dispersed in PEO at the molecular level due to hydrogen bonding, and PEO acts as a barrier for CR-G layers to prevent agglomeration during the process of reduction. CR-G/PEO composites have high permittivity, resulting from the uniform dispersion of electrically conductive CR-G with high aspect ratio. CR-G/PEO composite (2.6 vol %) shows high microwave absorbing capacity as its minimum reflection loss is-38.8 dB. CR-G sheets form a huge number of electrical pathways which can dissipate microwave energy into heat effectively as well as dielectric relaxation and interface scattering induced by large CR-G/PEO interfaces. © 2011 American Chemical Society.


We previously demonstrated that fermitin family member 1 (FERMT1) was significantly overexpressed in colon cancer (CC) and associated with poor metastasis-free survival. This study aimed to investigate the precise role of FERMT1 in CC metastasis and the mechanism by which FERMT1 is involved in the epithelial–mesenchymal transition (EMT). Correlations between FERMT1 and EMT markers (E-cadherin, Slug, N-cadherin and β-catenin) were examined via immunohistochemistry in a cohort of CC tissues and adjacent normal colon mucosae. A series of in vitro and in vivo assays were performed to elucidate the function of FERMT1 in CC metastasis and underlying mechanisms. The upregulated expression of FERMT1 in CC tissues correlated positively with that of Slug, N-cadherin and β-catenin, but correlated inversely with E-cadherin expression. Altered FERMT1 expression led to marked changes in the proliferation, migration, invasion and EMT markers of CC cells both in vitro and in vivo. Investigations of underlying mechanisms found that FERMT1 interacted directly with β-catenin and activated the Wnt/β-catenin signaling pathway by decreasing the phosphorylation level of β-catenin, enhancing β-catenin nuclear translocation and increasing the transcriptional activity of β-catenin/TCF/LEF. Activation of the Wnt/β-catenin pathway by CHIR99021 reversed the effect of FERMT1 knockdown, whereas inhibition of the Wnt/β-catenin pathway by XAV939 impaired the effect of FERMT1 overexpression on EMT and cell motility. In conclusion, findings of this study suggest that FERMT1 activates the β-catenin transcriptional activity to promote EMT in CC metastasis.Oncogene advance online publication, 19 September 2016; doi:10.1038/onc.2016.339. © 2016 Macmillan Publishers Limited, part of Springer Nature.


Shuai X.M.,Shanghai JiaoTong University | Shen W.Z.,Shanghai JiaoTong University
Journal of Physical Chemistry C | Year: 2011

We report a simple chemical conversion approach to fabricate ZnO/ZnS core/shell nanorods and various metal sulfide nanotubes such as ZnS, Ag 2S, CuS, PbS, and Bi2S3. The formation mechanisms of the ZnO/ZnS core/shell nanorods and ZnS nanotubes are due to the sulfidation conversion and the Kirkendall effect, respectively, in a low-temperature hydrothermal growth through the reaction of ZnO nanowires and thioacetamide. The successful chemical conversion of the ZnS nanotubes into the other metal sulfide nanotubes is to utilize the large difference in solubility between ZnS and the other metal sulfides for the effective transformation. In addition to the perfect maintenance of the morphology after conversion, we have shown that the yielded metal sulfide nanostructures possess good crystalline qualities with high optical and sensing performances. The present chemical conversion technique is expected to be employed in a broad range of applications to fabricate innovative semiconductor core/shell and hollow structures with various compositions and shapes for unique properties. © 2011 American Chemical Society.


Zhang C.,Shanghai JiaoTong University
Cell Death and Differentiation | Year: 2016

Cerebellar granule neuronal progenitors (GNPs) are the precursors of cerebellar granule cells (CGCs) and are believed to be the cell of origin for medulloblastoma (MB), yet the molecular mechanisms governing GNP neurogenesis are poorly elucidated. Here, we demonstrate that storkhead box 1 (Stox1), a forkhead transcriptional factor, has a pivotal role in cerebellar granule neurogenesis and MB suppression. Expression of Stox1 is upregulated along with GNP differentiation and repressed by activation of sonic hedgehog (SHH) signaling. Stox1 exerts its neurogenic and oncosuppressing effect via direct transcriptional repression of Math1, a basic helix-loop-helix transcription activator essential for CGC genesis. This study illustrates a SHH-Stox1-Math1 regulatory axis in normal cerebellar development and MB formation.Cell Death and Differentiation advance online publication, 26 August 2016; doi:10.1038/cdd.2016.85. © 2016 Macmillan Publishers Limited


Xia L.,Shanghai JiaoTong University | Zhang P.,Shanghai JiaoTong University
Solar Energy Materials and Solar Cells | Year: 2011

As a phase change material (PCM), acetamide (AC) can be a potential candidate for energy storage application in the active solar systems. Its utilization is however hampered by poor thermal conductivity. In this work, AC/expanded graphite (EG) composite PCM with 10 wt% (mass fraction) EG as the effective heat transfer promoter was prepared; its thermal properties were studied and compared with those of pure AC. Transient hot-wire tests showed that the addition of 10 wt% EG led to about five-fold increase in thermal conductivity. Investigations using a differential scanning calorimeter revealed that the melting/freezing points shifted from 66.95/42.46 °C for pure AC to 65.91/65.52 °C for AC/EG composite, and the latent heat decreased from 194.92 to 163.71 kJ kg-1. In addition, heat storage and retrieval tests in a latent thermal energy storage unit showed that the heat storage and retrieval durations were reduced by 45% and 78%, respectively. Further numerical investigations demonstrated that the less improvement in heat transfer rate during the storage process could be attributed to the weakened natural convection in liquid (melted) AC because of the presence of EG. © 2011 Elsevier B.V.


Zheng H.,Shanghai JiaoTong University | Wang Y.,Shanghai JiaoTong University | Che S.,Shanghai JiaoTong University
Journal of Physical Chemistry C | Year: 2011

On the basis of amino group-functionalized mesoporous materials, a pH-responsive system by constructing a designable coordination bonding-based "NH2-metal-DOX" architecture in mesopores has been investigated. The DOX can be released by the cleavage of either the "NH2-metal" or the "metal-DOX" coordinate bonding in response to pH variations. Here, the strengths of coordination bondings on both sides have been designed and fabricated from the aspects of NH2 loading amount, metal ion, and the counteranion accompanying the metal ion. It has been found that (i) the increase of amino group loading led to increased release percentage of the DOX under physiological condition due to a small number of "metal-DOX" bondings resulted from too many "NH 2-metal" bondings, and this tendency finally resulted in a decrease in its stability; (ii) the pH-sensitivity can be controlled by choosing the type of metal ion; and (iii) the physiological stabilities of "NH 2-metal-DOX" architectures formed by various metal sources are in the decreasing order of CH3COO- > NO 3 2- > SO4 2- > Cl-, indicating that different counteranions gave rise to different coordination bonding strengths of the architectures. Amino group loading amount of 2.4 mmol/g and CH3COO- counterion were suitable for "NH 2-Zn-DOX" pH-responsive delivery system, which was stable under physiological condition, while it was unstable with the DOX release triggered by the slight decrease to pH 6.0-5.0. The efficient cellular uptake of this pH-responsive system for cancer cells has been confirmed by cell assay. This coordination bonding-based pH-responsive system provides a new insight into the molecular factors governing the strength of chemical bonds in restrictive domain, which would open up new possibilities of porous materials for advanced applications in adsorption and desorption of biological and paramedical materials for antitumor therapy. © 2011 American Chemical Society.


Xu Y.,Shanghai JiaoTong University | Zhang F.,Shanghai JiaoTong University | Feng X.,Shanghai JiaoTong University | Feng X.,Max Planck Institute for Polymer Research
Small | Year: 2011

Conjugated polymers have been attracting more and more attention because they possess various novel electrical, magnetical, and optical properties, which render them useful in modern organic optoelectronic devices. Due to their organic nature, conjugated polymers are light-weight and can be fabricated into flexible appliances. Significant research efforts have been devoted to developing new organic materials to make them competitive with their conventional inorganic counterparts. It is foreseeable that when large-scale industrial manufacture of the devices made from organic conjugated polymers is feasible, they would be much cheaper and have more functions. On one hand, in order to improve the performance of organic optoelectronic devices, it is essential to tune their surface morphologies by techniques such as patterning. On the other hand, patterning is the routine requirement for device processing. In this review, the recent progress in the patterning of conjugated polymers for high-performance optoelectronic devices is summarized. Patterning based on the bottom-up and top-down methods are introduced. Emerging new patterning strategies and future trends for conventional patterning techniques are discussed. Recent progress in the patterning of conjugated polymers for high-performance optoelectronic devices is summarized in this review. Various patterning techniques based on bottom-up and top-down strategies are introduced. Future trends for conventional patterning techniques and emerging new techniques and trends in this field are also discussed. © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.


Xu K.,Shanghai JiaoTong University | Simaan N.,Columbia University
IEEE Transactions on Robotics | Year: 2010

This paper presents the intrinsic capability of full-wrench estimation of multisegment continuum robots with multiple flexible backbones. Intrinsic-full-wrench estimation refers to the ability of continuum robots to also serve as force and moment sensors by using measurements of axial loads on their backbones. This end-effector-as-sensor approach fulfills the rapidly increasing needs for miniature-robotic-surgical tools with haptic sensing ability subject to various limitations, such as size, magnetic resonance imaging (MRI) compatibility, sterilizability, etc. A performance index for the intrinsic wrench-sensing capability is introduced and evaluated to show how this index can serve as a design guide for continuum robots that provide force sensing. © 2010 IEEE.


Luo X.-G.,Shenyang University | Chen S.-D.,Shanghai JiaoTong University
Translational Neurodegeneration | Year: 2012

It has been nearly a century since the early description of microglia by Rio-Hortega; since then many more biological and pathological features of microglia have been recognized. Today, microglia are generally considered to be beneficial to homeostasis at the resting state through their abilities to survey the environment and phagocytose debris. However, when activated microglia assume diverse phenotypes ranging from fully inflamed, which involves the release of many pro-inflammatory cytokines, to alternatively activated, releasing anti-inflammatory cytokines or neurotrophins, the consequences to neurons can range from detrimental to supportive. Due to the different experimental sets and conditions, contradictory results have been obtained regarding the controversial question of whether microglia are " good" or " bad." While it is well understood that the dual roles of activated microglia depend on specific situations, the underlying mechanisms have remained largely unclear, and the interpretation of certain findings related to diverse microglial phenotypes continues to be problematic. In this review we discuss the functions of microglia in neuronal survival and neurogenesis, the crosstalk between microglia and surrounding cells, and the potential factors that could influence the eventual manifestation of microglia. © 2012 Luo and Chen; licensee BioMed Central Ltd.


Xie J.,Shanghai JiaoTong University | Duan Y.,Shanghai JiaoTong University | Che S.,Shanghai JiaoTong University
Advanced Functional Materials | Year: 2012

Chiroptical properties of pure inorganic material have been achieved by dispersing small amounts of achiral Ag nanoparticles into highly ordered chiral mesoporous silica. There are three types of chirality in chiral mesoporous silica: i) the helical hexagonal surface, ii) the helical pore orientation, and iii) the helical arrangement of aminopropyl groups on the surface of the mesopores, all of which impart plasmonic circular dichroism and have been investigated by introducing Ag nanoparticles into the as-made, calcined and extracted chiral mesoporous silica, respectively. The three types of optical response originate from asymmetric plasmon-plasmon interactions of achiral Ag nanoparticles in three types of chiral environments. Among the three sources of chirality, the helical pore orientation was considered to be predominantly responsible for the optical response owing to the high efficiency of nanoscale chirality. Interestingly, large Ag nanoparticles aggregation as a result of calcination still resulted in a strong optical activity, even the chiral mesostructure was destroyed completely. Rather than the pitch length, the length of helical channel was more effective for increasing the intensity of plasmonic circular dichroism due to longitudinal propagation of Ag nanoparticles along helical channel. Such novel chiral inorganic material will bring new opportunities in non-linear optics, biosensors and chiral recognition. Chiroptical properties of pure inorganic material are investigated in detail by dispersing achiral Ag nanoparticles into chiral mesoporous silica, due to collectively asymmetric plasmon interactions of Ag nanoparticles arranged along helical pore orientation. © 2012 WILEY-VCH Verlag erlag GmbH & Co. KGaA, Weinheim.


Wang R.,Shanghai JiaoTong University | Yu B.,Shanghai JiaoTong University | Jiang X.,Shanghai JiaoTong University | Yin J.,Shanghai JiaoTong University
Advanced Functional Materials | Year: 2012

The host-guest interaction between polymer nanoparticles and guest molecules plays a key role in fields such as controlled drug delivery, separation, and nanosensors. To understand this host-guest interaction, a series of hybrid polymer nanoparticles (SiO 1.5-hPEA NPs) are designed and prepared based on hyperbranched poly(ether amine) (hPEA) with the different hydrophobicity and functional groups. Their adsorption behavior to twelve hydrophilic dyes in aqueous solution is studied. The core-crosslinked hybrid nanoparticles (SiO 1.5-hPEA NPs) are prepared by direct dispersion of hPEA containing trimethoxysilyl moieties (TMS-hPEA) in aqueous solution, which exhibit sharp multiresponse to temperature, pH, and ionic strength in aqueous solution. The effect of molecular structure of TMS-hPEA on the host-guest interaction between SiO 1.5-hPEA NPs and hydrophilic dyes is investigated in detail. The obtained SiO 1.5-hPEA NPs interact selectively with different hydrophilic dyes in aqueous solution. The distribution coefficient (K) for partitioning of dyes between SiO 1.5-hPEA NPs and water is proposed to define the strength of the host-guest interaction between the nanoparticles and dyes. K increases with the increasing hydrophobicity of the hPEA backbone regardless of their charge states of SiO 1.5-hPEA NPs and dyes. A methodology is demonstrated for the smart separation of a mixture of dyes in water using SiO 1.5-hPEA NPs. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.


Wang J.,Shanghai JiaoTong University | Waas A.M.,University of Michigan | Wang H.,Shanghai JiaoTong University
Composite Structures | Year: 2013

This paper presents the results of an experimental and numerical study on the low-velocity impact behavior of foam-core sandwich panels. Panels with polyurethane foam core and plain weave carbon fabric laminated face-sheets were subjected to low-velocity impact with hemispherical steel impactors of different diameters at various energy levels. Digital image correlation technique (a non-contact measuring system) was used to measure the real-time displacement and velocity of the impactor, and the back surface out-of-plane panel deflection time-history. A load sensor was used to record the contact force time-history. Non-destructive inspection and destructive sectioning methods were used to evaluate the internal and external damage on the sandwich panels after impact. The effects of impact variables such as impactor diameter, impact energy, and sandwich panel configuration parameters, such as face-sheet thickness and foam core thickness on the impact behavior and resulting impact damage states were studied. Based on the generalized Schapery theory, a progressive damage model is developed to describe the nonlinear behavior of plain weave carbon laminates during impact. The foam core was modeled as a crushable foam material. Coupon tests were conducted to determine the input parameters for the progressive damage model and the foam crushing properties. Three-dimensional finite element models were implemented to analyze the impact response incorporating the progressive damage model. Results from the numerical models were found to agree well with experimental observations. © 2012 Elsevier Ltd.


Jia Z.,Shanghai JiaoTong University
Journal of medical engineering & technology | Year: 2012

Multipurpose active capsule endoscopes (ACE) have drawn considerable attention in recent years, but these devices continue to suffer from energy limitations. In order to deliver stable and sufficient energy safely, a wireless power transmission system based on inductive coupling is presented. The system consists of a double-layer solenoid pair primary coil outside and a multiple secondary coils inside the body. At least 500 mW usable power can be transmitted under the worst geometrical conditions and the safety restraints in a volume of Φ13 × 13 mm. The wireless power transmission system is integrated to an ACE and applied in animal experiments. The designed wireless power transmission is proved to be feasible and potentially safe in a future application.


Yong Y.-C.,Jiangsu University | Zhong J.-J.,Shanghai JiaoTong University
Bioresource Technology | Year: 2013

The mechanism for quorum sensing (QS) regulation on aromatics degradation was investigated. Deletion of rhl QS system resulted in a significant decrease in aromatics biodegradation as well as the activity of catechol 2,3-dioxygenase (C23O, key enzyme for catechol meta-cleavage pathway) in Pseudomonas aeruginosa CGMCC1.860. Interestingly, this repression could be relieved by N-butyryl homoserine lactone (the signaling molecule of rhl QS system) addition. In accordance, the transcription level of nahH (the gene encoding C23O) and nahR (transcriptional activator) also responded to rhl perturbation in a similar way. The results indicated that rhl QS system positively controlled the catechol meta-cleavage pathway, and hence improved aromatics biodegradation. It suggested manipulation of QS system could be a promising strategy to tune the catechol cleavage pathway and to control aromatics biodegradation. © 2013 Elsevier Ltd.


Chen X.,Shanghai JiaoTong University | Anstey A.V.,Royal Gwent Hospital | Anstey A.V.,University of Cardiff | Bugert J.J.,University of Cardiff
The Lancet Infectious Diseases | Year: 2013

Molluscum contagiosum virus is an important human skin pathogen: it can cause disfigurement and suffering in children, in adults it is less common and often sexually transmitted. Extensive and persistent skin infection with the virus can indicate underlying immunodeficiency. Traditional ablative therapies have not been compared directly with newer immune-modulating and specific antiviral therapies. Advances in research raise the prospect of new approaches to treatment informed by the biology of the virus; in human skin, the infection is localised in the epidermal layers, where it induces a typical, complex hyperproliferative lesion with an abundance of virus particles but a conspicuous absence of immune effectors. Functional studies of the viral genome have revealed effects on cellular pathways involved in the cell cycle, innate immunity, inflammation, and cell death. Extensive lesions caused by molluscum contagiosum can occur in patients with DOCK8 deficiency-a genetic disorder affecting migration of dendritic and specialised T cells in skin. Sudden disappearance of lesions is the consequence of a vigorous immune response in healthy people. Further study of the unique features of infection with molluscum contagiosum virus could give fundamental insight into the nature of skin immunity. © 2013 Elsevier Ltd.


To develop a liposome formulation incorporating antigen-presenting cells (APCs) membrane microdomains with enriched epitope/MHC complexes to evaluate the activities of these liposomes (RAFTsomes) to activate T cells and prime immune responses. We isolated membrane microdomain structures that contained the epitope/MHC complexes from ovalbumin (OVA) primed dendritic cells (DCs), and reconstituted them on liposomes surface by detergent dialysis. The resulted RAFTsomes were purified by density gradient centrifugation. Their T cell activation functions were evaluated by IL-2 secreting and proliferation assays in vitro. In vivo immune responses and the protective effect against OVA expressing EG.7 tumor challenge were also examined. Membrane microdomains containing enriched epitope/MHC complexes can be reconstituted into liposomes with defined size and composition. The integrity and activities of these complexes after reconstitution were confirmed by in vitro T cell assays. OVA epitope loaded RAFTsomes injected in vivo resulted in high anti-OVA IgG production (predominantly IgG1). The immunized mice were protected from EG.7 tumor cell inoculation challenge. Based on these findings, we propose that RAFTsomes can be prepared with unique properties that may be used as an antigen delivery system for immunotherapeutic applications.


Zhao C.Y.,Shanghai JiaoTong University
International Journal of Heat and Mass Transfer | Year: 2012

Thermal transport in metal foams has received growing attention in both academic research and industrial applications. In this paper the recent research progress of thermal transport in metal foams has been reviewed. This paper aims to provide the comprehensive state-of-the-art knowledge and research results of thermal transport in open celled cellular metal foams, which covers the effective thermal conductivity, forced convection, natural convection, thermal radiation, pool boiling and flow boiling heat transfer, solid/liquid phase change heat transfer and catalytic reactor. The forced convection and thermal conductivity have been extensively investigated, while less research were performed on two-phase (boiling and solid/liquid phase change heat transfer) and thermal radiation in metal foams. Also most research still treats the metal foam as one type of effective continuous porous media, very few researchers investigated the detailed thermal behaviours at the pore level either by numerical or experimental approaches. © 2012 Elsevier Ltd. All rights reserved.


Fei P.,Shanghai JiaoTong University
Retina | Year: 2016

PURPOSE:: To report the management of complicated advanced familial exudative vitreoretinopathy in a predominantly young population. METHODS:: This retrospective study was performed on 34 eyes of 25 patients with severe complications of advanced familial exudative vitreoretinopathy, including retinal detachment, corneal opacity, shallow or flat anterior chamber, cataract, posterior pupillary adhesion, secondary glaucoma, vitreous hemorrhage, and preretinal hemorrhage. Preoperative and postoperative clinical information was reviewed. RESULTS:: The average age of the patients was 3.52 ± 5.94 years. Of the 34 eyes, 22 underwent lensectomy, 9 underwent lensectomy combined with vitrectomy, 2 underwent staged lensectomy and vitrectomy, and 1 underwent lens-sparing vitrectomy. After surgery, the shallow or flat anterior chamber became normal in 26/28 eyes; corneal opacity disappeared or improved in 10/22 eyes; and secondary glaucoma was controlled in 22/24 eyes. Among the 12 eyes operated by vitrectomy, the retina was attached in 5 eyes and partly attached in 7. Final visual acuity ranged from no light perception to 30/200 (n = 17). All 5 eyes with preoperative and postoperative visual acuity records showed improvement. CONCLUSION:: Surgical intervention is recommended to resolve complications of advanced familial exudative vitreoretinopathy and to preserve visual function. Staged lensectomy and vitrectomy is an alternative for advanced familial exudative vitreoretinopathy with corneal complications and/or vascularly active fibrovascular proliferation. © 2016 by Ophthalmic Communications Society, Inc.


Thermal post-buckling and nonlinear vibration behaviors of FGM beams are analyzed by using concept of physical neutral surface, von Kármán strain-displacement relationships and high order shear deformation theory. Material properties are assumed to be temperature dependent and vary along the thickness. The prominent character of physical neutral surface higher-order shear deformation beam theory is that stretching-bending couplings are eliminated in constitutive equations, and governing equations have the similar forms as homogeneous isotropic beams. Approximate solutions are given out by Ritz method, and influences played by different supported boundaries, thermal environmental conditions and volume fraction index are discussed in detail. © 2013 Springer Science+Business Media Dordrecht.


Pan Z.,Shanghai JiaoTong University | Zhao C.Y.,Shanghai JiaoTong University
Energy | Year: 2015

Thermal energy storage systems improve the inefficiency of industrial processes and renewable energy systems (supply versus demand). Chemical reaction is a promising way to store thermal energy because of its high energy storage density, long-term energy storage, etc. This study investigated an MgO/H2O chemical thermal storage system that stores thermal energy by decomposing Mg(OH)2 (endothermic reaction), and supplies thermal energy by combining water vapor with MgO (exothermic reaction). Heat supply is greatly influenced by MgO properties, particularly dehydration temperature. Therefore, the equilibrium hydration fractions of MgO prepared at various dehydration temperatures were measured. Then, the relation between dehydration temperature and the equilibrium hydration fractions of MgO was determined. The equilibrium hydration fractions of MgO at various hydration temperatures and pressures were also measured. The chemical thermal storage system was inefficient at dehydration temperatures lower than 350°C or higher than 500°C. The efficiency of this system can be improved by increasing the hydration temperature while keeping the relative vapor pressure unchanged. © 2015 Elsevier Ltd.


In this paper, model of the FGM plates resting on two-parameter elastic foundations is put forward by using on physical neutral surface and high-order shear deformation theory. Material properties are assumed to be temperature dependent and vary along the thickness, while Poisson's ratio depends weakly on temperature change and position and is assumed to be a constant. It is worth noting that physical neutral surface will be changed with temperature. The character of physical neutral surface higher-order shear deformation plate theory is that the displacements have special forms, stretching-bending couplings are eliminated in constitutive equations, and governing equations have the simple and similar forms as homogeneous isotropic plates. The validity of physical neutral surface higher-order shear deformation plate theory can be confirmed by comparing with related researchers' results. Nonlinear bending approximate solutions of FGM rectangular plates with six cases of boundary conditions are given out using Ritz method, and influences played by different supported boundaries, foundation stiffnesses, thermal environmental conditions, and volume fraction index are discussed in detail. © 2013 Springer-Verlag Berlin Heidelberg.


Yun J.N.,Shanghai JiaoTong University | Su J.-B.,Shanghai JiaoTong University
IEEE Transactions on Control Systems Technology | Year: 2014

This brief proposes a method for designing a disturbance observer (DOB) to decouple joint interactions in robot dynamics with nonlinearity. The traditional DOB based on filter design theory has limited performance since the cut-off frequency of its Q-filter is the only tunable parameter to deal with disturbance suppression and model uncertainty. In this brief, a robust optimal design method is developed for the DOB, which can achieve optimal performance of suppressing disturbance by systematically shaping its $Q$-filter. Simulation results of application to a two-link manipulator with flexible joints show the improvements in disturbance suppression, which illustrates the validity of the proposed method. © 1993-2012 IEEE.


Sukmak P.,Suranaree University of Technology | Horpibulsuk S.,Suranaree University of Technology | Shen S.-L.,Shanghai JiaoTong University
Construction and Building Materials | Year: 2013

This paper presents the role of influential factors on the strength development in a clay-fly ash geopolymer that a silty clay is used as fine aggregates and fly ash, FA is used as a pozzolanic material. A liquid alkaline activator, L is a mixture of sodium silicate solution (Na2SiO 3) and sodium hydroxide solution (NaOH). The studied influential factors are Na2SiO3/NaOH ratio, L/FA ratio and heat conditions. The optimum ingredient for the clay-FA geopolymer is the Na 2SiO3/NaOH ratio of 0.7 and the L/FA ratio of 0.6. The Na2SiO3/NaOH ratio required for the clay-FA geopolymer is less than that of the FA geopolymer because the clay has high cation absorption ability and then absorbs some of the input NaOH. For a given Na 2SiO3/NaOH content, the strength increases with increasing the liquid alkaline activator. The excess input alkaline activator causes the precipitation at very early stage before the condensation process in geopolymerization and results in the cracks on the FA particles. The overheating (very high temperature) and excess heat duration cause the micro-cracks on the specimens. The relationship between the strength and heat energy is proposed to integrate the role of heat temperature and duration on the geopolymerization. The compressive strength increases with increasing heat energy up to a certain level. Beyond this level, the specimens shrink and crack due to the reduction in pore fluid, which results in the strength reduction. The relationship between strength and heat energy can be used as fundamental for further study on the strength development and the mix design method for the clay-FA geopolymer with different specimen dimensions, clay minerals, liquid alkaline activators, pozzolanic materials and clay:FA ratios. © 2012 Elsevier Ltd. All rights reserved.


Zhang P.,Shanghai JiaoTong University | Ma Z.W.,Shanghai JiaoTong University
Renewable and Sustainable Energy Reviews | Year: 2012

Phase change material slurries (PCS) can be employed in the refrigeration and air conditioning systems as both secondary refrigerant and cold energy storage media simultaneously, which benefits not only the system efficiency improvement by the high cold carry capacity but also the reduction of the environment-negative-impact gas emission. This paper reviews the previous researches and developments on the applications of PCS, including ice slurry, microencapsulated phase change material slurry (MPCS) as well as clathrate hydrate slurry (CHS), to the secondary loop refrigeration and air conditioning systems. The paper mainly focuses on the generation approaches and storage strategies of these slurries which are considered as the most important issues relevant to the application of PCS, while the flow and heat transfer characteristics of PCS in both tubes and heat exchangers are also summarized. Moreover, several application cases of PCS and the corresponding operation performances are presented. © 2012 Elsevier Ltd. All rights reserved.


Ling Y.,Shanghai JiaoTong University | Ling Y.,Shanxi Datong University | Cai X.,Shanghai JiaoTong University
Renewable and Sustainable Energy Reviews | Year: 2012

Wind energy, as a reliable, natural and renewable electrical power supply, produces no emissions and so it is an excellent alternative to conventional, more heavily polluting fuels in the long term based on the worldwide concern about the environment and energy supply. Wind energy resources in China are affluent, but its distribution are uneven, centralized, and far from both the utility and the high electricity demand markets. This made China's onshore wind power development have such characteristics as large scale, high centralization and far transmission, which is different with that in Europe, where the characteristics are even distribution, decentralized. In past two decades, considering the economic, technical and environmental benefits of wind power, China has given priority to its development. Besides the dramatic growth of large scale grid-connected wind power, household-scale wind power has been used most successfully in remote rural regions in China. Therefore, the development of wind power will be of great importance to alleviate the energy crisis and environmental pollution resulting from the rapid economic growth of China in the future. In this paper, the current development of wind energy utilization in China is investigated, and some critical barriers are discussed. Finally, the perspective of wind energy utilization is presented, where focuses are placed on seven wind power bases. © 2012 Elsevier Ltd. All rights reserved.


Liu J.,Shanghai JiaoTong University | Zhang H.-X.,Shanghai JiaoTong University
American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics | Year: 2014

This comprehensive meta-analysis was applied to case-control studies of the association between PD and GBA to assess the joint evidence for the association, the influence of individual studies, and evidence for publication bias. We searched PubMed, Medline, Cochrane Library, reference lists of relevant studies to June 2012, and email contact with authors. For the case-control studies, the authors found 1) support for the association between PD and GBA, both in total group analysis [fixed: OR and 95%CI: 4.825 (3.901-5.968), P<0.001; random: OR and 95%CI: 4.791 (3.520-6.520), P<0.001] and in Asia, Europe, Americas, and Israel subgroups analysis [Asia: fixed: OR and 95%CI: 7.495 (4.490-12.511), P<0.001, random: OR and 95%CI: 7.989 (4.060-15.723), P<0.001; Americas: fixed: OR and 95%CI: 4.036 (2.460-6.622), P<0.001, random: OR and 95%CI: 4.065 (2.464-6.707), P<0.001; Europe: fixed: OR and 95%CI: 3.353 (2.287-4.917), P<0.001, random: OR and 95%CI: 3.559 (2.148-5.894), P<0.001; Israel: fixed/random: OR and 95%CI: 6.430 (4.430-9.333), P<0.001], 2) no evidence that this association was accounted for by any one study, and 3) no evidence for publication bias. In conclusion, GBA mutation status may be significantly associated with PD. © 2013 Wiley Periodicals, Inc.


Peng M.,Shanghai JiaoTong University | Liu L.,Shanghai JiaoTong University | Jiang C.,Shanghai JiaoTong University
Renewable and Sustainable Energy Reviews | Year: 2012

Nowadays, the deterioration of ecological environment and the ever rising gas price make green transportation our relentless pursuit. Energy-saving, low-emission even zero-emission electric vehicles (EVs) have been considered as one solution to the problem. With the rapid development of plug-in electric vehicle (PHEV) and forceful support and incentives from the government, PHEV and its supporting facilities are being gradually popularized. When randomly being connected to the power grid in large scale, PHEVs will bring new challenges to power grid in operation and management. This paper presents an overall review on historical research on power system integrated with electric vehicles and especially focuses on economic dispatch of PHEV in the electricity market. The paper also discusses the joint scheduling problem considering other renewable energy resources and risk management of PHEV-penetrated power systems. © 2011 Elsevier Ltd. All rights reserved.


Xuan W.,Shanghai JiaoTong University | Zhu C.,Shanghai JiaoTong University | Liu Y.,Shanghai JiaoTong University | Cui Y.,Shanghai JiaoTong University
Chemical Society Reviews | Year: 2012

Metal-organic frameworks (MOFs) have emerged as a new type of porous materials for diverse applications. Most open MOFs reported to date are microporous (pore sizes <2 nm), and only a small fraction of MOFs with ordered mesoscale domains (2-50 nm) is reported. This tutorial review covers recent advances in the field of mesoporous MOFs (mesoMOFs), including their design and synthesis, porosity activation and surface modification, and potential applications in storage and separation, catalysis, drug delivery and imaging. Their specificities are dependent on the pore shape, size, and chemical environments of the cages or channels. The relationship between the structures and functions is discussed. The future outlook for the field is discussed in the context of current challenges in applications of mesoporous materials. © 2012 The Royal Society of Chemistry.


Wang X.-Z.,Shanghai JiaoTong University
Journal of Physics A: Mathematical and Theoretical | Year: 2010

The reversible Carnot cycle in reversible thermodynamics is composed of two reversible heat exchange processes and two reversible adiabatic processes. We construct an irreversible cycle in linear irreversible thermodynamics by analogy with the reversible Carnot cycle. The irreversible cycle is composed of two linear irreversible heat exchange processes and two linear irreversible adiabatic processes. It is found that the Curzon-Alhborn efficiency can be attained if the power for each of the four linear irreversible processes reaches its maximum. The maximum efficiency is the Carnot efficiency. The strong coupling condition is prerequisite for the respective attainment of the Curzon-Alhborn efficiency and the Carnot efficiency. © 2010 IOP Publishing Ltd.


Liu Y.,Shanghai JiaoTong University | Tan L.,Shanghai JiaoTong University | Li L.,Shanghai JiaoTong University
Chemical Communications | Year: 2012

A LiMn 2O 4 cathode lithium-ion battery using lithiated ion exchange membranes swollen with organic non-aqueous solvent as the electrolyte to overcome capacity fading at high temperature is first demonstrated, and shows very good capacity retention compared with conventional lithium-ion batteries using liquid electrolyte. © The Royal Society of Chemistry 2012.


Shi L.-C.,Shanghai JiaoTong University | Lu B.-L.,Shanghai JiaoTong University
Neurocomputing | Year: 2013

For many human machine interaction systems, techniques for continuously estimating the vigilance of operators are highly desirable to ensure work safety. Up to now, various signals are studied for vigilance analysis. Among them, electroencephalogram (EEG) is the most commonly used signal. In this paper, extreme learning machine (ELM) and its modifications with L1 norm and L2 norm penalties are adopted for EEG-based vigilance estimation. A comparative study on system performance is conducted among ordinary ELM, its modifications, and support vector machines (SVMs). Experimental results show that, compared with SVMs, the ordinary ELM and its modifications can all dramatically speed up the training process while still achieving similar or better vigilance estimation accuracy. In addition, the following three observations have been made from the experiment results: (a) the ordinary ELM and the ELM with L1 norm penalty (LARS-ELM) are sensitive on the number of hidden nodes; (b) the ELM with L2 norm penalty (regularized-ELM) and the ELMs with both L1 norm and L2 norm penalties (LARS-EN-ELM, TROP-ELM) are stable and insensitive on the number of hidden nodes; and (c) regularized-ELM has a much faster training speed, while LARS-EN-ELM can achieve better vigilance estimation accuracy. © 2012 Elsevier B.V.


Wang R.,Shanghai JiaoTong University | Tao M.,Shanghai JiaoTong University | Huang Y.,Hong Kong Baptist University
IEEE Transactions on Wireless Communications | Year: 2012

Two-way relaying can improve spectral efficiency in two-user cooperative communications. It also has great potential in multiuser systems. A major problem of designing a multiuser two-way relay system (MU-TWRS) is transceiver or precoding design to suppress co-channel interference. This paper aims to study linear precoding designs for a cellular MU-TWRS where a multi-antenna base station (BS) conducts bi-directional communications with multiple mobile stations (MSs) via a multi-antenna relay station (RS) with amplify-and-forward relay strategy. The design goal is to optimize uplink performance, including total mean-square error (Total-MSE) and sum rate, while maintaining individual signal-to-interference-plus-noise ratio (SINR) requirement for downlink signals. We show that the BS precoding design with the RS precoder fixed can be converted to a standard second order cone programming (SOCP) and the optimal solution is obtained efficiently. The RS precoding design with the BS precoder fixed, on the other hand, is non-convex and we present an iterative algorithm to find a local optimal solution. Then, the joint BS-RS precoding is obtained by solving the BS precoding and the RS precoding alternately. Comprehensive simulation is conducted to demonstrate the effectiveness of the proposed precoding designs. © 2012 IEEE.


Fei S.-W.,Shanghai JiaoTong University
Expert Systems with Applications | Year: 2010

Diagnosis of arrhythmia cordis is very significant to ensure human health and save human lives. Support vector machine (SVM) is a new machine learning method based on statistical learning theory, which can solve the classification problem with small sampling, non-linear and high dimension. However, the practicability of SVM is affected due to the difficulty of selecting appropriate SVM parameters. Particle swarm optimization (PSO) is a new optimization method, which is motivated by social behavior of bird flocking or fish schooling. The optimization method not only has strong global search capability, but also is very easy to implement. Thus, in the study, the proposed PSO-SVM model is applied to diagnosis of arrhythmia cordis, in which PSO is used to determine free parameters of support vector machine. The experimental data from MIT-BIH ECG database are used to illustrate the performance of proposed PSO-SVM model. The experimental results indicate that the PSO-SVM method can achieve higher diagnostic accuracy than artificial neural network in diagnosis of arrhythmia cordis. © 2010 Published by Elsevier Ltd.


PURPOSE:: To investigate the choroidal thickness in unilateral idiopathic macular hole (IMH) eyes and compare them with normal control eyes using enhanced depth imaging optical coherence tomography (EDI-OCT). METHODS:: In this cross-sectional study, the subfoveal choroidal thickness (SFCT) and choroidal thickness at 1 mm and 3 mm nasal, temporal, superior, and inferior to the fovea of IMH eyes and normal control eyes were measured using EDI-OCT. Univariate and multivariate linear regression analyses were performed to evaluate the correlation between choroidal thickness at various locations and clinical factors. A meta-analysis was conducted using the Stata software package to calculate the summary of weighted mean differences (WMDs). RESULTS:: Thirty-two unilateral IMH patients and 32 controls were enrolled in this study. The IMH eyes had a thinner choroid than the control eyes at all macular locations (all P < 0.001). Multivariate linear regression analysis further showed that the choroidal thickness at any of the nine points was significantly thinner in association with the IMH diagnosis, as well as being somewhat thinner in association with age and axial length. The result of our cross-sectional study was consistent with the meta-analysis with a pooled WMD of −56.99 (95% confidence interval [CI]: −68.58 to −45.41) for subfoveal choroidal thickness. CONCLUSION:: The study of Chinese unilateral IMH patients, along with the comprehensive meta-analysis, suggested that the choroidal thickness at all macular locations in unilateral IMH eyes significantly decreased relative to the control group. © 2016 by Ophthalmic Communications Society, Inc.


Li C.,Shanghai JiaoTong University | Wang R.Z.,Shanghai JiaoTong University
Renewable and Sustainable Energy Reviews | Year: 2012

China has a big population and all countryside are being urbanized recently, more and more buildings are being built with careful considerations of energy saving. Building integrated energy systems are thought to be of priority importance. There are extended energy storage researches and developments for buildings, such as building materials for stabilization of room temperature using the daily and night temperature difference in north China, desiccant materials integrated with buildings used for constant relative humidity control in south China. Solar thermal energy storage using specialized design of hot water tank, phase change materials (PCMs) or pebble stones have been well studied and demonstrated, whereas chemical energy storage capability had been also considered with potential applications. The development of electric battery storage for Photovoltaic (PV) is also highlighted as it is a good opportunity for smart grid development. In modern commercial building, uninterruptible power supplies using rechargeable battery packs and thermal energy storage are currently two of the most common applications for energy storage, while other storage technologies are still at the research stage. The above development of building integrated energy storage opportunities in China are described and analyzed, some demonstration projects are shown in this paper. © 2012 Elsevier Ltd.


Wang J.,Chinese University of Hong Kong | Wang J.,Shanghai JiaoTong University
IEEE Transactions on Neural Networks | Year: 2010

This paper presents a k-winners-take-all (kWTA) neural network with a single state variable and a hard-limiting activation function. First, following several kWTA problem formulations, related existing kWTA networks are reviewed. Then, the kWTA model model with a single state variable and a Heaviside step activation function is described and its global stability and finite-time convergence are proven with derived upper and lower bounds. In addition, the initial state estimation and a discrete-time version of the kWTA model are discussed. Furthermore, two selected applications to parallel sorting and rank-order filtering based on the kWTA model are discussed. Finally, simulation results show the effectiveness and performance of the kWTA model. © 2006 IEEE.


Lou S.,Shanghai JiaoTong University | Guo X.,Shanghai JiaoTong University | Fan T.,Shanghai JiaoTong University | Zhang D.,Shanghai JiaoTong University
Energy and Environmental Science | Year: 2012

Solar cells and photocatalysts to yield hydrogen are two significant strategies for taking advantage of clean and sustainable solar energy, and their light manipulation and harvesting ability will play a dominant role in their conversion efficiencies. Butterflies demonstrate their brilliant colors due to their wonderful skills of light manipulation, originating intrinsically from their elaborate architectures. We review the inspiration of butterflies for solar cells and sunlight water-splitting catalysts, focusing on the nipple arrays in butterfly compound eyes, as well as ridge and hole arrays, and the photonic crystal structures in butterfly wing scales. After giving a brief introduction to the typical architectures, we reveal the physical principles lying behind antireflection of compound eyes and black scales and iridescence of wing scales, respective prototypes are extracted and highlighted for the design and fabrication of solar cells and sunlight water-splitting catalysts. We conclude by reviewing the prospects for the integration of these prototypes and the appropriate materials for solar energy, which is the product of an intimate conversation between humanity and nature, as well as close cooperation between scientists from diverse fields. © 2012 The Royal Society of Chemistry.


Liang L.,Shanghai JiaoTong University
Respirology (Carlton, Vic.) | Year: 2013

Ozone exposure worsens the development of allergen-induced asthma. The p38 mitogen-activated protein kinase (MAPK) pathway plays an important role in the development of the inflammatory response, airway hyperresponsiveness (AHR) and airway remodelling. In this study, the role of the p38 MAPK pathway on the effects of chronic ozone exposure in ovalbumin (OVA)-sensitized and -challenged mice was investigated. Mice were sensitized and challenged with OVA followed by ozone exposure. Dexamethasone (Dex) and SB239063, a p38 MAPK inhibitor, were used as preventive treatment. Compared with OVA-challenged mice, ozone exposure of OVA-challenged mice led to enhanced recruitment of inflammatory cells in bronchoalveolar lavage fluid, increases in inflammation scores, collagen accumulation, bronchial wall thickness and messenger RNA levels of inflammatory cytokines, along with activation of p38 MAPK/HSP27 and downregulation of MAPK phosphatase-1 (MKP-1) in the lung tissue. Dex treatment partially attenuated lung inflammation, while the cotreatment of Dex and SB239063 effectively reduced lung inflammation, inhibited airway remodelling, inactivated p38 MAPK/HSP27 and upregulated MKP-1 in the lung tissue. Ozone exposure aggravated airway inflammation, airway remodelling, activation of p38 MAPK and downregulation of MKP-1 in OVA-sensitized and -challenged mice, which was ineffectively controlled by corticosteroids. p38 MAPK activation is a likely pathway involved in corticosteroid insensitivity. © 2013 The Authors. Respirology © 2013 Asian Pacific Society of Respirology.


We investigated a novel application of phrenic nerve stimulation (PNS) in diaphragm dysfunction induced by mechanical ventilation (MV). Twenty-one Sprague-Dawley rats were assigned randomly to 3 groups: spontaneous breathing, 18-h controlled MV, and 18-h controlled MV with PNS. Upon completion of the experimental protocol, diaphragm contractility, gene expression of insulin-like growth factor-1 (IGF-1) and ubiquitin ligases, and serum IGF-1 levels were analyzed. Compared with the spontaneously breathing rats, impaired diaphragm contractile function, including force-related properties and force-frequency responses, were pronounced with MV. Furthermore, MV suppressed IGF-1 and induced muscle ring finger 1 mRNA expression in the diaphragm. In contrast, PNS counteracted MV-induced gene expression changes in the diaphragm and restored diaphragm function. PNS exerted a protective effect against MV-induced diaphragm dysfunction by counteracting altered expression of IGF-1 and ubiquitin ligase in the diaphragm. Copyright © 2013 Wiley Periodicals, Inc.


Zhang Z.,Shanghai JiaoTong University
International Journal of Solids and Structures | Year: 2013

The virtual internal bond (VIB) is a micro-macro constitutive model. Although this model is based on a postulated discrete microstructure, it ultimately returns to a continuum constitutive relation through a homogenization process. The homogenization process can reduce the internal degrees of freedom, but it omits the effect of the individual micro bond that may play an important role in the fracture process. The present research develops a discrete system to represent the nonlinear elasticity by discretizing the continuous VIB. This discrete system is composed of unit cells, which can adopt any geometry with any number of bonds. The system is characterized by the force-displacement, not the stress-strain constitutive relationship. The nonlinear properties of this discrete system are governed by the micro-bond potential. The micro bond properties are related to Young's modulus of the material, the volume and the bond number of the unit cell. For a given material, the unit cell has a certain topological structure and configuration. A discussion of two specific cases (the 2D triangular and 3D tetrahedral unit cells) suggests that the discrete system converges with decreasing unit cell size. In the unstructured unit cell scheme, the discrete system can almost precisely represent the initial Young's modulus and the Poisson ratio of a nonlinear continuum. A mixed fracture example demonstrates that the present method can efficiently simulate the fracture propagation. The present paper provides a theory for developing a lattice-type mechanical model for nonlinear elasticity and provides new method for the fracture simulation of a nonlinear elastic material. © 2013 Elsevier Ltd. All rights reserved.


Li D.,Shanghai JiaoTong University | Xi Y.,Shanghai JiaoTong University
IEEE Transactions on Automatic Control | Year: 2010

This note addresses the feedback robust model predictive control (FRMPC) for a category of linear parameter varying (LPV) systems with bounded rates of parameter changes. Based on the bounded rates of parameter changes and the detected current system parameters, future model variations can be described by a sequence of polytopic families with the same number of vertices. Then a FRMPC algorithm is developed. Since both the future model variations and the corresponding sequence of feedback control laws are adopted, the FRMPC can achieve high control performance. By transferring main design work to offline design, an efficient FRMPC is also developed. The recursive feasibility and closed-loop stability of the FRMPCs are proved to be guaranteed. © 2010 IEEE.


Wang R.,Shanghai JiaoTong University | Tao M.,Shanghai JiaoTong University
IEEE Transactions on Signal Processing | Year: 2012

Properly designed precoders can significantly improve the spectral efficiency of multiple-input multiple-output (MIMO) relay systems. In this paper, we investigate joint source and relay precoding design based on the mean-square-error (MSE) criterion in MIMO two-way relay systems, where two multiantenna source nodes exchange information via a multiantenna amplify-and-forward relay node. This problem is non-convex and its optimal solution remains unsolved. Aiming to find an efficient way to solve the problem, we first decouple the primal problem into three tractable subproblems, and then propose an iterative precoding design algorithm based on alternating optimization. The solution to each subproblem is optimal and unique, thus the convergence of the iterative algorithm is guaranteed. Second, we propose a structured precoding design to lower the computational complexity. The proposed precoding structure is able to parallelize the channels in the multiple access (MAC) phase and broadcast (BC) phase. It thus reduces the precoding design to a simple power allocation problem. Last, for the special case where only a single data stream is transmitted from each source node, we present a source-antenna-selection (SAS)-based precoding design algorithm. This algorithm selects only one antenna for transmission from each source and thus requires lower signalling overhead. Comprehensive simulation is conducted to evaluate the effectiveness of all the proposed precoding designs. © 2011 IEEE.


Tao M.,Shanghai JiaoTong University | Liu Y.,Shanghai JiaoTong University
IEEE Transactions on Wireless Communications | Year: 2013

In wireless cooperative orthogonal frequency-division multiple-access (OFDMA) networks, it is important to adapt the transmission strategies for each user according to the network channel dynamics in order to optimize the overall system performance. The adaption involves transmission mode selection (a user can choose from direct or cooperative transmission), subcarrier assignment, subcarrier pairing (the incoming and outgoing subcarriers at the relay for cooperative transmission need to be matched), relay selection, as well as power allocation and hence is highly challenging. Many previous works only consider a subset of the adaptation. In this paper, we tackle the joint optimization problem using a network flow approach. Specifically, we first show that for given power allocation, the combinatorial optimization problem of transmission mode selection, subcarrier assignment, relay selection and subcarrier pairing for the system total throughput maximization can be transformed into a minimum cost network flow (MCNF) problem with integer solutions. The linear optimal distribution (LOD) algorithm is applied to find the optimal solution in polynomial time. We then solve the mixed integer programming problem of the joint assignment and power allocation in an asymptotically optimal way in the dual domain. Simulation results show that the proposed algorithms can significantly enhance the overall system throughput. © 2002-2012 IEEE.


Wang L.,Shanghai JiaoTong University | Jia H.,Northeast Forestry University
Asian Journal of Control | Year: 2014

This paper deals with the trajectory tracking problem of a six-degree of freedom (6-DOF) quadrotor unmanned aerial vehicle (UAV). The problem of simplified kinematics based on Euler angles is analyzed and the modified Rodrigues parameters (MRPs) technique is introduced to model the rotational dynamics of the rigid body. A nonlinear system error model is established based on the trajectory tracking problem, and, due to the coupling property between the translational and rotational dynamics, we divide the complete closed-loop system into two reduced-order subsystems and a coupling term. The Rodrigues theorem is applied to analyze the internal connections between the coupling term and MRPs. Therefore, the global stability conclusions, by which the trajectory tracking controller of the quadrotor UAV could be designed based on the subsystem directly in future works, are proved based on several assumptions of the subsystems. Thereafter, the controllers, using the backstepping approach and nonlinear disturbance observer/sliding mode control approach, which stabilize the quadrotor UAV globally & #55349;& #56486; -exponentially and globally uniformly bounded, are proposed based on the stability theorem proofs mentioned above. Numerical simulations are provided to show that the theoretical conclusions and the controller proposed are effective. © 2013 Chinese Automatic Control Society and Wiley Publishing Asia Pty Ltd.


Xiao G.,Shanghai JiaoTong University
International Journal of Antennas and Propagation | Year: 2014

This paper discusses the application of loop-flower basis functions for solving surface integral equations involved in electromagnetic scattering problems on perfectly electrically conducting surfaces. Flower-shaped basis functions are proposed to replace the conventional star basis functions. The flower basis functions are defined based on mesh nodes instead of surface triangles. It is shown that the loop-flower basis functions not only can be used to handle the electromagnetic scattering problems at very low frequencies, but also can be directly used to implement Calderon preconditioners for EFIEs. © 2014 Gaobiao Xiao.


Xu Y.-D.,Shanghai JiaoTong University
Astrophysical Journal | Year: 2011

We explore thermal X-ray iron line emission from the galactic X-ray binary GX 339?4 in the off state, using the models of the advection-dominated accretion flow (ADAF) without or with outflows. The equivalent widths of hydrogen-like and helium-like thermal iron lines are calculated with different model parameters including viscosity parameter α, mass accretion rate at the outer radius of the ADAF ṁout, and outflow strength parameter p. Our calculations show that the equivalent widths of thermal iron lines emitted from the pure ADAF, i.e., the ADAF without outflows, should be very small, assuming a solar metallicity for the accreting gas in the accretion flow. Strong thermal iron lines are expected to be emitted from the ADAF with relatively strong outflows. For a reasonable choice of parameters, the total equivalent width of the He-like and H-like thermal iron lines reaches to ≳500 eV for accreting gas with solar metallicity. The observation of strong thermal X-ray lines from GX 339?4 at the off state may give a clue to the accretion mode of the source and provide evidence for the presence of outflows/winds in the accretion flow around the black hole in GX 339?4. It is found that the values of ṁout and p are degenerate, i.e., the observed X-ray continuum spectrum can be fairly well reproduced with different sets of the parameters ṁoutand p. Such degeneracy can be broken when the thermal X-ray line emission data are available. We also compare our results with those in a previous similar work. © 2011. The American Astronomical Society. All rights reserved.


Zhuan R.,Shanghai JiaoTong University | Wang W.,Shanghai JiaoTong University
International Journal of Heat and Mass Transfer | Year: 2012

Boiling flows of R-134a and R-22 fluids in a 0.50 mm circular channel have been simulated to analyze bubbly flow, bubbly/slug flow, slug flow and slug/semi-annular flow depending on bubble evolution. The vapor-liquid interface was captured using VOF method. We studied the behavior of bubble growth and coalescence related to flow pattern transitions (bubbly/slug flow to slug flow, slug flow to slug/semi-annular flow) and analyzed the effect of fluid properties on transition lines. Some parameters, including heat flux, mass velocity, ONB point, vapor velocity, bubble lifting diameter, growth rate and generation frequency, have been analyzed in detail. The results show that bubble growth and coalescence are important factors for flow pattern transitions. The flow patterns at the micro-channel outlet predicted by simulation were in agreement with phenomena observed in experiments for bubbly/slug flow, slug flow and slug/semi-annular flow. In addition, the peak bubble frequency at the outlet was predicted and the general shape of the bubble frequency distribution at the outlet from simulation was found to be consistent with the achieved experimental results. © 2011 Elsevier Ltd. All rights reserved.


Liu T.,Shanghai JiaoTong University | Liu Y.,Shanghai JiaoTong University | Xuan W.,Shanghai JiaoTong University | Cui Y.,Shanghai JiaoTong University
Angewandte Chemie - International Edition | Year: 2010

(Figure Presented) Cage rage: Chiral tetrahedral cages are diastereoselectively self-assembled from enantiopure C2-symmetric biphenyl bis(β-diketonate) linkers and C3-symmetric octahedral Fe3+ or Ca3+ ions (see picture; Fe purple, C blue, O red; cavity shown as an orange sphere). The porous polyhedra exhibit metal-dependent chiroptical behavior and act as hosts for the crystallization separation of racemic alcohols with up to 99.5% ee. © 2010 Wiley-VCH Verlag GmbH & Co. KGaA.


Hao L.,Shanghai JiaoTong University | Cheng P.,Shanghai JiaoTong University
International Journal of Heat and Mass Transfer | Year: 2012

Capillary pressures in a carbon paper gas diffusion layer (GDL) having hydrophilic and hydrophobic pores of a polymer electrolyte membrane fuel cell (PEMFC) are investigated by both lattice Boltzmann simulations and experimental measurements. The simulated and measured capillary pressures as a function of water saturation for water drainage and imbibition processes in the GDL are presented and compared. It is shown that the pore-scale simulated drainage and imbibition capillary pressure curves are in good agreement with that obtained by experiment, both indicating the coexistence of hydrophilic and hydrophobic properties in the polytetrafluoroethylene (PTFE) treated carbon paper GDLs. The fitted capillary pressure curves, obtained from this paper, can provide more accurate predictions of the capillary pressure in carbon paper GDLs with non-uniform porosity and wettability than the standard Leverett-Udell relationship which was obtained for soil with more uniform porosity and wettability. © 2011 Elsevier Ltd. All rights reserved.


Li J.,Shanghai JiaoTong University
International Journal of Obesity | Year: 2016

Objective:Uniparental disomy (UPD) is an unusual situation wherein two homologous chromosomes are inherited from the same parent. UPDs can cause clinical abnormalities owing to the aberrant dosage of genes regulated by epigenetic imprinting or homozygosity of variants for recessive phenotypes. The aim of this study was to identify the genetic cause of the obesity and developmental delay phenotype in a 3-year-old Chinese boy.Study Design:Chromosomal microarray analysis (CMA) was used for detecting potential copy number variations (CNVs) and homozygous segments. Whole-exome sequencing (WES) identified sequence variants. Sanger sequencing further confirmed the variants in GPBAR1 and CAPN10 both in the patient and the parents.Results:No clinically significant CNVs were identified by CMA but a complete UPD of chromosome 2 (UPD2) was revealed in the patient. WES identified a total of 13 rare homozygous single-nucleotide variants (SNVs) on chromosome 2. Among the 13 SNVs, a nonsense variation in GPBAR1 (c.753T>G; p.Y251*) and a missense variation in CAPN10 (c.413C>T; p.S138F) were evaluated as candidate disease-causing variants based on their functional impacts to their respective protein and the biological relevance of the genes to the clinical presentation of our patient. Both GPBAR1 and CAPN10 variants were detected in the patient’s mother in a heterozygous state, indicating that the patient had maternal UPD2. No other clinically relevant variants were identified.Conclusions:Homozygosity of rare recessive variations caused by UPD2 likely contributed to the phenotypes of our patient. Based on emerging evidence, the nonsense variation in GPBAR1 and the missense variation in CAPN10 are considered as causally related to our patient’s phenotype, that is, obesity and delayed development, respectively. The present study further supports the role of GPBAR1 in obesity and the role of calpain-10 in neurological function.International Journal of Obesity advance online publication, 18 October 2016; doi:10.1038/ijo.2016.160. © 2016 Macmillan Publishers Limited, part of Springer Nature.


Zhang L.,University of Arizona | Chen J.-J.,Shanghai JiaoTong University
Canadian Geotechnical Journal | Year: 2012

In this paper, the effect of spatial correlation of standard penetration test (SPT) data on the bearing capacity of driven piles in sand is analyzed. First, the direct approach for using SPT data to determine the bearing capacity of piles in sand is used to derive the expressions for probabilistic prediction of pile bearing capacity by considering the spatial correlation of the SPT data. To analyze the relationship between the probability of failure and the factor of safety, a procedure based on the advanced first-order, second-moment (FOSM) method is used. Then parametric studies are conducted on the spatial correlation between the spatial average of SPT numbers over the pile length, NLV, and the spatial average of SPT numbers over an interval near the pile base, NbV, and its effect on the bearing capacity of piles. The results indicate that it is important to consider the spatial correlation between NLV and NbV in the probabilistic prediction of pile bearing capacity. Ignoring this spatial correlation will underestimate the probability of failure and lead to unsafe design. Finally, three tested piles are analyzed to demonstrate the probabilistic analysis of piles by considering the spatial correlation of SPT data and the procedure for probabilistic analysis of pile bearing capacity is summarized.


Wu T.X.,Shanghai JiaoTong University
Wear | Year: 2011

Rail corrugation growth is related to the wheel-track dynamics and uneven wear on the rail head. The so-called pinned-pinned resonance of track vibration is considered as the cause of short pitch rail corrugation that is associated with railway rolling noise generation. A promising measure for reducing railway rolling noise is by the use of rail vibration absorber/damper. Reduction of 5-6. dB in the rail radiated noise can be achieved using rail vibration absorber/damper. In addition a rail vibration absorber/damper is found to be able to suppress the pinned-pinned resonance, and thus, its use may lead to attenuate formation of short pitch rail corrugation. In this work the effects of rail vibration absorber on short pitch rail corrugation growth are studied by combining the wheel-track-absorber dynamics, rolling contact mechanics and wear. The evolution process of rail corrugation is simulated and the results show that short pitch rail corrugation, whose wavelength is associated with the pinned-pinned resonance, is effectively suppressed by a rail vibration absorber. The use of rail vibration absorber has both immediate and long term effect on the railway rolling noise control, i.e. reducing the rail radiation and attenuating growth of short pitch rail corrugation, respectively. © 2010 Elsevier B.V.


Shen H.-S.,Shanghai JiaoTong University
Current Applied Physics | Year: 2011

Large amplitude flexural vibration behavior is presented for microtubules (MTs) embedded in an elastic matrix of cytoplasm. The microtubule is modeled as a nonlocal shear deformable cylindrical shell which contains small scale effect. The surrounding elastic medium is modeled as a two-parameter elastic foundation. Formulations are based on higher order shear deformation shell theory with a von Kármán-Donnell-type of kinematic nonlinearity. The thermal effect is also included and the material properties are assumed to be temperature-dependent. The small scale parameter e 0a is estimated by matching the fundamental frequencies from existing results with the numerical results obtained from the nonlocal shear deformable shell model. The numerical results show that the fundamental frequencies of MTs are very sensitive to the small scale parameter e 0a. The results reveal that the small scale parameter e 0a reduces the natural frequencies of MTs, but the effect of the small scale parameter on the nonlinear vibration response is relatively weaker when compared to the effect of the small scale parameter on the postbuckling response of MTs. © 2010 Elsevier B.V. All rights reserved.


Chen J.,Shanghai JiaoTong University | Rentzepis P.M.,University of California at Irvine
Journal of Physical Chemistry Letters | Year: 2014

This Perspective article considers an experimental system that consists of ultrafast optical, electron, and X-ray time-resolved components. These techniques are used simultaneously on the same sample to study, in real time, the events that occur immediately upon disturbance with an ultrafast optical pulse. Excited states and metastable species are generated on the surface, and the electrical and mechanical waves propagating through the sample are recorded with subpicosecond and sub-Angstrom resolution. The characteristic of each technique is briefly described as a means of introducing the experimental system that intergrates these techniques. The processes evolved after femtosecond excitation of a Au single crystal have been monitored by these techniques. The data presented show changes with a resolution of 0.3 ± 0.1 ps in optical thermoreflectance, 1.0 ± 0.2 ps in electron Bragg diffraction, and 0.6 ± 0.1 ps in X-ray diffraction intensity accompanying shift and broadening. © 2013 American Chemical Society.


Bao H.,Shanghai JiaoTong University
Wuli Xuebao/Acta Physica Sinica | Year: 2013

Anharmonic lattice dynamics method is employed to investigate the phonon frequency and relaxation time without any fitting parameters. The phonon relaxation time is used in Boltzmann transport equation to predict the lattice thermal conductivity of solid argon between 10 K and 80 K, and the results agree very well with experimental data. The effects of calculation parameters on the prediction accuracy are also analyzed, including mesh size of the reciprocal lattice points, and the broadening factor of delta function. The contribution of each individual phonon mode to the thermal conductivity is investigated. It is found that higher frequency phonons contribute more to the thermal conductivity at higher temperature, which is consistent with previous theoretical results. © 2013 Chinese Physical Society.


Shull P.B.,Shanghai JiaoTong University | Damian D.D.,Harvard University
Journal of NeuroEngineering and Rehabilitation | Year: 2015

Sensory impairments decrease quality of life and can slow or hinder rehabilitation. Small, computationally powerful electronics have enabled the recent development of wearable systems aimed to improve function for individuals with sensory impairments. The purpose of this review is to synthesize current haptic wearable research for clinical applications involving sensory impairments. We define haptic wearables as untethered, ungrounded body worn devices that interact with skin directly or through clothing and can be used in natural environments outside a laboratory. Results of this review are categorized by degree of sensory impairment. Total impairment, such as in an amputee, blind, or deaf individual, involves haptics acting as sensory replacement; partial impairment, as is common in rehabilitation, involves haptics as sensory augmentation; and no impairment involves haptics as trainer. This review found that wearable haptic devices improved function for a variety of clinical applications including: rehabilitation, prosthetics, vestibular loss, osteoarthritis, vision loss and hearing loss. Future haptic wearables development should focus on clinical needs, intuitive and multimodal haptic displays, low energy demands, and biomechanical compliance for long-term usage. © 2015 Shull and Damian.


Optimization of extraction of Tremella fuciformis polysaccharides was investigated using response surface methodology in this paper. T. fuciformis polysaccharides were extracted using boiling water at different extraction temperatures (80-100 °C), times (3.5-4.5 h) and ratios of solvent to raw material (4-6). The effect of extraction conditions on the yield of T. fuciformis polysaccharides were studied using a three-level three-factor Box-Behnken design. The results showed that the highest yield (3.08%) of T. fuciformis polysaccharides was reached at extraction temperature 100 °C, extraction time 4.5 h and ratio of solvent to raw material 5 (v/v). In addition, T. fuciformis polysaccharides could scavenge superoxide anion and hydroxyl radicals. At last, it could still be found that antitumour activities of T. fuciformis polysaccharides increased from 73.4% to 92.1% with increasing concentration of polysaccharides. Pharmacology experiment indicated that T. fuciformis polysaccharides was useful to the therapy of free radical injury and cancer diseases. © 2010.


Xu Y.-D.,Shanghai JiaoTong University
Astrophysical Journal | Year: 2011

We study the relation of optical/UV and X-ray emission in the low luminosity active galactic nuclei (LLAGNs), using a sample of 49 sources including 28 local Seyfert galaxies and 21 low-ionization nuclear emission-line regions with optical/UV spectral luminosity at wavelength λ = 2500 , 23.0 ≤ log L ν(2500 )(erg s-1 Hz-1) ≤ 27.7, and X-ray spectral luminosity at 2keV, 20.5 ≤ log L ν(2 keV) ≤ 25.3. Strong correlations are found between the X-ray luminosity and the optical/UV-to-X-ray index, αox, with the optical/UV luminosity, with slopes very similar to the findings for the luminous AGNs in previous works. The correlation between αox and L ν(2 keV) is very weak, as is that found for the luminous AGNs in the majority of previous similar works. We also study the relation between αox and the Eddington ratio L bol/L Edd for our sample and find a significant anti-correlation for the sources with L bol/L Edd ≲ 10-3, which is opposite to the correlation between the two variables for the luminous AGNs. Using the advection-dominated accretion flow (ADAF) model, we roughly reproduce this anti-correlationship for the two variables for the LLAGNs. This result strongly supports the ADAF as a candidate for the accretion mode in LLAGNs. © 2011 The American Astronomical Society. All rights reserved.


Gu J.-Y.,Fudan University | Li L.-W.,Shanghai JiaoTong University
Archives of Medical Research | Year: 2014

Background and Aims: Emerging evidences have shown that the Glu504Lys variant in ALDH2 gene may greatly reduce the ability of ALDH2 to metabolize acetaldehyde, which could increase the risk of coronary artery disease (CAD) and myocardial infarction (MI). However, the reported results are still conflicting. To investigate the association between ALDH2 Glu504Lys polymorphism and the risk of CAD and MI in Asians, we analyzed all available studies in a meta-analysis. Methods: A literature search of PubMed, Embase, Web of Science and Chinese BioMedical (CBM) databases was conducted for articles published before March 1, 2013. The principal outcome measure was the crude odds ratios (ORs) with their corresponding confidence intervals (95% CIs) for evaluating the strength of the association. Results: Meta-analysis showed that carriers of ALDH2*504lys allele were associated with increased risks of both CAD and MI (CAD: OR= 1.28, 95% CI: 1.10-1.48, p= 0.001; MI: OR= 1.58, 95% CI: 1.15-2.19, p= 0.005). Subgroup analysis by country showed significant correlations between mutant genotypes (Glu/Lys+ Lys/Lys) and increased risk to MI among Chinese and Korean populations (Chinese: OR= 1.89, 95% CI: 1.16-3.09, p= 0.011; Korean: OR= 1.69, 95%CI: 1.12-2.55, p= 0.013), whereas similar associations were not observed among Japanese populations. Conclusions: The current meta-analysis provides strong evidence that ALDH2 Glu504Lys polymorphism may be associated with increased risk of CAD and MI in East Asians, especially among Chinese and Korean populations. However, more detailed and well-designed studies are still warranted to confirm these findings. © 2014 IMSS.


Guo X.-X.,Shanghai JiaoTong University | Gu D.-W.,Shanghai JiaoTong University | Wu Z.,Shanghai JiaoTong University | Zhang W.,Shanghai JiaoTong University
Chemical Reviews | Year: 2015

A study was conducted to investigate the use of copper (Cu)-catalyzed C-H functionalization reactions for efficient synthesis of heterocycles. Copper-catalyzed C-H functionalization reaction methods provided significant benefits toward the synthesis of a variety of heterocycles. The use of Cu-catalyzed C-H functionalization reactions had gained significant traction, and a range of these methodologies relating to the construction of heterocycles were successfully developed. A series of important structural motifs including N-heterocycles, N,Oheterocycles, O-heterocycles, and N,S-heterocycles were synthesized using a number of Cu-catalyzed C-H functionalization reactions.


Gong S.,Shanghai JiaoTong University | Cheng P.,Shanghai JiaoTong University
International Journal of Heat and Mass Transfer | Year: 2012

A lattice Boltzmann model for the liquid-vapor phase change heat transfer is proposed in this paper. Two particle distribution functions, namely the density distribution function and the temperature distribution function, are used in this model. A new form of the source term in the energy equation is derived and the modified pseudo-potential model is used in the proposed model to improve its numerical stability. The commonly used Peng-Robinson equation of state is incorporated into the proposed model. The problem of bubble growth and departure from a horizontal surface is solved numerically based on the proposed model. © 2012 Elsevier Ltd. All rights reserved.


Liu Z.-H.,Shanghai JiaoTong University | Li Y.-Y.,Shanghai JiaoTong University
International Journal of Heat and Mass Transfer | Year: 2012

Nanofluid is a new kind of working fluid with special properties to enhance the heat transfer of heat pipes. This paper reviews and summarizes the research done on heat pipes using nanofluids as working fluids in recent years. The effect of characteristics and mass concentrations of nanoparticles on the thermal performance in various kinds of heat pipes with different base fluids under various operating conditions have been discussed. The mechanism of enhancement or degradation of heat transfer utilizing nanofluids in the investigated heat pipes has been explained. The paper discusses the relative reduction of the total heat resistance for various heat pipes with nanofluids in comparison with the existing ones and also presents a perspective on possible future research applications. © 2012 Elsevier Ltd. All rights reserved.


Yang X.-F.,Shanghai JiaoTong University | Liu Z.-H.,Shanghai JiaoTong University
International Journal of Heat and Mass Transfer | Year: 2012

An experimental study was carried out to understand the flow boiling heat transfer of water based CuO nanofluids in the evaporator of a thermosyphon loop under steady sub-atmospheric pressures. Experimental results show that both the heat transfer coefficient (HTC) and the critical heat flux (CHF) of flow boiling in the evaporator of the thermosyphon loop could be enhanced by substituting nanofluids for water. The operating pressure has apparent impact on the HTC enhancement of nanofluids. However, the operating pressure has negligible effect on the CHF enhancement. There exists an optimal mass concentration of nanoparticles corresponding to the best enhancement effect. Experimental results show that the CHF enhancement results mainly from the existing of the coating layer on the heated surface formed by the sediment of nanoparticles. However, the HTC enhancement results from the effects of both the existing of the coating layer and the change of thermophysical properties of the working fluid. © 2012 Elsevier Ltd. All rights reserved.


Li Z.-M.,Shanghai JiaoTong University | Qiao P.,Washington State University
Composite Structures | Year: 2014

Geometrically nonlinear free vibration analysis of shear deformable anisotropic laminated composite beams resting on a two-parameter elastic foundation is presented. The material of each layer of the beam is assumed to be linearly elastic and fiber-reinforced. A new nonlinear beam model involving the exact expression of bending curvature is introduced, and the nonlinear vibration analysis with exact nonlinear characteristics of the work done by axial loading is accordingly performed. The governing equations are based on higher order shear deformation beam theory with a von Kármán-type of kinematic nonlinearity and including the bending-stretching, bending-twisting, and stretching-twisting couplings. Two kinds of end conditions, namely movable and immovable, are considered, and a perturbation technique is employed to determine the linear and nonlinear frequencies of a composite beam with or without initial stresses. The frequency response of laminated beams with different geometric and material parameters, end conditions and effect on elastic foundation is numerically illustrated. The results reveal that the geometric and physical properties, end conditions, and elastic foundation effect have a significant influence on large amplitude vibration behavior of anisotropic laminated composite beams. © 2013 Elsevier Ltd.


Shen Q.,Shanghai JiaoTong University
International journal of nanomedicine | Year: 2011

The effect of eugenol on colchicine transport across an isolated rat intestinal membrane was studied using an in vitro diffusion chamber system. We found that eugenol increased the absorptive transport of the drug efficiently. The effect of eugenol on intestinal absorption of colchicine in an oral administrative nanoemulsion formulation was also demonstrated in vivo. The colchicine nanoemulsion was prepared with isopropyl myristate, eugenol, Tween80, ethanol and water, and eugenol was used as an oil phase in the formulation; an average particle size of this nanoemulsion was 41.2 ± 7.2 nm. The permeation of colchicine in the nanoemulsion across the intestinal membrane was significantly different from that of the control group (0.2 mM colchicine). Finally, co-administration of eugenol in colchicine nanoemulsion to enhance the colchicine bioavailability was investigated by an oral administration method. After oral administration of colchicine (8 mg/kg) in the form of either the nanoemulsion or in free colchicine solution, the relative bioavailability of nanoemulsion and eugenol-nanoemulsion were enhanced by about 1.6- and 2.1-fold, respectively, compared with free colchicine solution. The procedure indicated that the intestinal absorption of colchicine was enhanced significantly by eugenol in the tested nanoemulsion. All the results suggested that eugenol is an efficient component in an oral administrative formulation for improving the intestinal absorption of colchicine.


Xu N.,Shanghai JiaoTong University
International journal of nanomedicine | Year: 2011

Amphotericin B deoxycholate (AmB), a classic antifungal drug, remains the initial treatment of choice for deep fungal infections, but it is not appropriate for treatment of cryptococcal meningitis due to its inability to pass through the blood-brain barrier (BBB). We examined the efficacy of amphotericin B-polybutylcyanoacrylate nanoparticles (AmB-PBCA-NPs) modified with polysorbate 80 that had a mean particle diameter less than 100 nanometers (69.0 ± 28.6 nm). AmB-PBCA-NPs were detected in the brain 30 minutes after systemic administration into BALB/c mice and had a higher concentration than systemically administered AmB liposome (AmB-L, P < 0.05); AmB was not detected in the brain. Following infection for 24 hours and then 7 days of treatment, the survival rate of mice in the AmB-PBCA-NP group (80%) was significantly higher than that of the AmB (0%) or AmB-L (60%) treatment groups. Fungal load was also lower when assessed by colony-forming unit counts obtained after plating infected brain tissue (P < 0.05). Our study indicates that AmB-PBCA-NPs with polysorbate 80 coating have the capacity to transport AmB across the BBB and is an efficient treatment against cryptococcal meningitis in a mouse model.


Yu G.-F.,Shanghai JiaoTong University
Journal of the Physical Society of Japan | Year: 2014

A multi-component derivative coupled integrable dispersionless equations is presented. The multisoliton solution to the system is expressed by the pfaffians. © 2014 The Physical Society of Japan The author is indebted to the referees for their careful reading and valuable suggestions. The author would also express his thanks to Professor Mikhail Tyaglov for his helpful discussion and language promotion. The work is supported by National Natural Science Foundation of China (Grant No. 11371251).


Xu Z.,PLA University of Science and Technology | Xu Z.,Shanghai JiaoTong University | Liao H.,Shanghai JiaoTong University
IEEE Transactions on Fuzzy Systems | Year: 2014

The intuitionistic fuzzy set has shown definite advantages in handling vagueness and uncertainty over a fuzzy set. Taking the powerfulness of the analytic hierarchy process (AHP) and the fuzzy AHP (FAHP) into account when tackling comprehensive multi-criteria decision-making problems, in this paper, we extend the classic AHP and the FAHP into the intuitionistic fuzzy AHP (IFAHP) in which the preferences are represented by intuitionistic fuzzy values. The IFAHP can be used to handle more complex problems, where the decision maker has some uncertainty in assigning preference values to the objects considered. The paper proposes a new way to check the consistency of an intuitionistic preference relation and then introduces an automatic procedure to repair the inconsistent one. It is worth pointing out that our proposed method can improve the inconsistent intuitionistic preference relation without the participation of the decision maker, and thus, it can save much time and show some advantages over the AHP and the FAHP. This paper also develops a novel normalizing rank summation method to derive the priority vector of an intuitionistic preference relation, on which the priorities of the hierarchy in the IFAHP are derived. The procedure of the IFAHP is given in detail, and an example concerning global supplier development is used to demonstrate our results. © 1993-2012 IEEE.


Liu M.,Shanghai JiaoTong University
Pattern Recognition | Year: 2010

Fingerprint classification is an important indexing scheme to narrow down the search of fingerprint database for efficient large-scale identification. It is still a challenging problem due to the intrinsic class ambiguity and the difficulty for poor quality fingerprints. In this paper, we presents a fingerprint classification algorithm that uses Adaboost learning method to model multiple types of singularity features. Firstly, complex filters are used to detect the singularities. For powerful representation, we compute the complex filter responses of the detected singularities at multiple scales and a feature vector is constructed for each scale that consists of the relative position and direction and the certainties of the singularities. Adaboost learning method is then applied on decision trees to design a classifier for fingerprint classification. Finally, fingerprint class is determined by the ensemble of the classification results at multiple scales. The experimental results and comparisons on NIST-4 database have shown the effectiveness and superiority of the fingerprint classification algorithm. © 2009 Elsevier Ltd. All rights reserved.


Gu P.-H.,Shanghai JiaoTong University
Journal of Cosmology and Astroparticle Physics | Year: 2014

We propose an SO(10)×SO(10)′ model to simultaneously realize a seesaw for Dirac neutrino masses and a leptogenesis for ordinary and dark matter-antimatter asymmetries. A (16 × 16′)H scalar crossing the SO(10) and SO(10)′ sectors plays an essential role in this seesaw-leptogenesis scenario. As a result of lepton number conservation, the lightest dark nucleon as the dark matter particle should have a determined mass around 15GeV to explain the comparable fractions of ordinary and dark matter in the present universe. The (16×16′)H scalar also mediates a U(1)em × U(1)′em kinetic mixing after the ordinary and dark left-right symmetry breaking so that we can expect a dark nucleon scattering in direct detection experiments and/or a dark nucleon decay in indirect detection experiments. Furthermore, we can impose a softly broken mirror symmetry to simplify the parameter choice.


The therapeutic strategies for malignant melanoma are still cancer chemotherapy, radiotherapy, and tumor resection. However, these therapeutic strategies often lead to a reduced neutrophilic granulocyte count or loss of more blood after surgical tumor resection. In this study, we developed a formulation of hemostatic gauze impregnated with sustained-release granulocyte colony-stimulating factor (G-CSF) with increasing of the neutrophilic granulocyte count in the blood following chemotherapy and decreasing blood loss after surgical tumor resection. We designed a formulation with both hemostatic properties and increased neutrophil content to be used in cancer chemotherapy, radiotherapy, and tumor resection, comprising a hemostatic gauze as a scaffold and (G-CSF)-loaded dextran nanoparticles coated with polylactic-co- glycolic acid (PLGA) solution fabricated by direct spray-painting onto the scaffold and then vacuum-dried at room temperature. The performance of this system was evaluated in vitro and in vivo. Nearly zero-order release of G-CSF was recorded for 12-14 days, and the cumulative release of G-CSF retained over 90% of its bioactivity in a NFS-60 cell line proliferation assay when the scaffold was incubated in phosphate-buffered saline (pH 7.4) at 37°C. The in vivo hemostatic efficacy of this formulation was greater than that of native G-CSF, the scaffold directly spray-painted with G-CSF solution or PLGA organic solution as a coating, or when a blank scaffold was covered with the coating. Our results suggest that this formulation has both hemostatic properties and increased neutrophil activity.


Li J.-J.,Shanghai JiaoTong University | Zhu K.-D.,Shanghai JiaoTong University
Physical Review B - Condensed Matter and Materials Physics | Year: 2011

Surface plasmons on nanoparticles provide numerous ways to alternate and manipulate light at nanoscale dimensions, which have the potential to perfect the novel electronic and optical devices. Here, we demonstrate that plasmon-assisted mass sensing can be achieved in a hybrid nanocrystal coupled to a nanomechanical resonator. Compared with the traditional mass measurements, we use an all-optical technique rather than electrical circuitry, which may avoid the heat effect, to realize an ultrasensitive mass detection. The plasmon-assisted mass measurement proposed here may eventually enable sensitive measurement applications such as on-chip detection and analysis as well as identification of compounds. © 2011 American Physical Society.