Shanghai Institute of Mental Health

Shanghai, China

Shanghai Institute of Mental Health

Shanghai, China
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Li T.,Shanghai JiaoTong University | Li Z.,Shanghai JiaoTong University | Chen P.,Shanghai JiaoTong University | Zhao Q.,Shanghai JiaoTong University | And 11 more authors.
Biological Psychiatry | Year: 2010

Background: Schizophrenia is a complex major psychiatric disorder affecting ∼1% of the world population. Recently, in a genome-wide association study and a follow-up in Caucasians, Stefansson et al. examined 7662 schizophrenic cases and 29053 normal control subjects and reported seven common single nucleotide polymorphisms (SNPs) that were significantly (>10-8) associated with schizophrenia. Methods: To investigate whether these risk SNPs were significantly associated in Han Chinese, we analyzed the seven SNPs in 2496 schizophrenia patients and 5184 normal control subjects. Because only three of the seven SNPs were polymorphic in Han Chinese, we genotyped two additional common SNPs from the same risk regions. Results: Three SNPs, rs6932590 (p = .00096), rs3131296 (p = 1.29 × 10-6), and rs3130375 (p = 1.76 × 10-5), mapping to the major histocompatibility complex region and one SNP rs2958182 (p = 3.64 × 10-6) located in the TCF4 gene were significant in our sample set. A meta-analysis using published genome-wide association study results also supported our findings. Conclusions: Our results confirm that common risk factors in the major histocompatibility complex region and TCF4 gene are associated with schizophrenia in Han Chinese, but our results fail to show an association with SNP rs12807809 in the NRGN gene. © 2010 Society of Biological Psychiatry.


Zhang S.,Tongji University | Edwards H.,Queensland University of Technology | Yates P.,Queensland University of Technology | Li C.,Shanghai Institute of Mental Health | And 2 more authors.
Dementia and Geriatric Cognitive Disorders | Year: 2014

Background: There is a paucity of research assessing health-related quality of life (HRQoL) and self-efficacy in caregivers of relatives with dementia in mainland China. Aims: To compare the level of HRQoL between caregivers and the general population in mainland China and to assess the role of caregiver self-efficacy in the relationship between caregiver social support and HRQoL. Methods: A cross-sectional study was conducted in Shanghai, China. The caregivers were recruited from the outpatient department of a teaching hospital. A total of 195 participants were interviewed, using a survey package including the Chinese version of the 36-Item Short-Form Health Survey (SF-36), demographic data, the variables associated with the impairments of care recipients, perceived social support and caregiver self-efficacy. The caregivers' SF-36 scores were compared with those of the general population in China. Results: The results indicated that the HRQoL of the caregivers was poorer compared with that of the general population when matched for age and gender. Multiple regression analyses revealed that caregiver self-efficacy is a partial mediator between social support and HRQoL, and a partial mediator between behavioral and psychological symptoms of dementia (BPSD) and caregiver mental health. Conclusion: Assisting with managing BPSD and enhancing caregiver self-efficacy can be considered integral parts of interventions to improve caregiver HRQoL. © 2013 S. Karger AG, Basel.


Li J.,Shanghai JiaoTong University | Zhou G.,Shanghai JiaoTong University | Ji W.,Shanghai JiaoTong University | Feng G.,Shanghai Institute of Mental Health | And 14 more authors.
Archives of General Psychiatry | Year: 2011

Context: Recent genome-wide association studies have revealed that common variations and rare copy-number variations contribute to the risk of mental disorders. Rare recurrent microdeletions at 1q21.1 were reported to be associated with schizophrenia, and the BCL9 gene at 1q21.1 was also a functional candidate gene for mental disorders. Objectives: To investigate and validate whether common variations exist in a functional candidate gene in the copy-number variation region, and, if so, to determine whether these variations confer risk of schizophrenia or other mental disorders. Design: A 3-stage case-control study. Setting: Shanghai, China. Participants: A total of 12 229 subjects were included: 5772 normal controls, 4187 patients with schizophrenia, 1135 patients with bipolar disorder patients, and 1135 patients with major depressive disorder. Main Outcome Measure: During the first and second stages of our study, we genotyped 10 singlenucleotide polymorphisms using the ligation detection reaction method. During the third stage of our study, all single-nucleotide polymorphisms were genotyped using TaqMan technology (Applied Biosystems, Foster City, California). Results: During the first stage of our study, we found that rs672607 was significantly associated with schizophrenia (P = 2.69 × 10-5). During the second stage, rs672607 was successfully replicated (P = 1.33 × 10-5), and rs9326555 (P = .002), rs1240083 (P = 1.7 × 10-4), and rs688325 (P = .006) were newly identified to be significant. During the third stage, we genotyped all singlenucleotide polymorphisms in 1135 patients with schizophrenia, 1135 patients with bipolar disorder, 1135 patients with major depressive disorder, and 1135 normal controls for further validation. Finally, when we combined all the data from the 3 stages of our schizophrenia study, we found that rs9326555 (P = 1.53 × 10-5), rs10494251 (P = .02), rs1240083 (P = 1.52 × 10-4), rs672607 (P = 1.23 × 10-11), rs688325 (P = 2.54 × 10-4), and rs3766512 (P = .01) were significant. Moreover, we found that rs672607 was significant in major depressive disorder (P = .001) and bipolar disorder (P = .03), and rs10494251 (P = .04), rs1541187 (P = .04), rs688325 (P = .02), and rs946903 (P = .006) were significant in major depressive disorder. Conclusion: These findings indicate that common variations in the BCL9 gene confer risk of schizophrenia and may also be associated with bipolar disorder and major depressive disorder in the Chinese Han population. ©2011 American Medical Association. All rights reserved.


Li J.,Shanghai JiaoTong University | Wu X.,East China Normal University | Li X.,Shanghai JiaoTong University | Feng G.,Shanghai Institute of Mental Health | And 4 more authors.
Cardiology | Year: 2010

Introduction: Previous case-control studies have suggested that the endothelial nitric oxide synthase (eNOS) gene polymorphisms (G894T, 4b/a, T-786C) are associated with coronary artery disease (CAD). However, other studies do not confirm these relationships. The objective was to assess these relationships using meta-analysis. Methods: Databases, including Pubmed and Embase, were searched to access the relevant genetic association studies up to July 2009. Results: The meta-analysis included 56 studies, consisting of 23 studies for G894T, 19 for 4b/a and 14 for T-786C. For the allelic analysis of the G894T variant, all studies showed a positively significant association (OR = 0.83, p = 0.004). For the genotypic analysis, the combined studies of the T allele showed significance (OR = 1.57, p = 0.003). For the allelic analysis of the T-786C variant, all studies showed an obviously significant association (OR = 0.79, p = 0.0007), reflected in both non-Asian and Asian studies. For the genotype analysis, combined studies of the C allele showed significance (OR = 0.72, p = 0.0001). Moreover, non-Asian studies showed significant results. For the analysis of the 4b/a variant, none of the studies showed significant results. No publication bias was found in the meta-analysis. Conclusion: The synthesis of available evidence supports the fact that eNOS G894T andT-786C are associated with CAD. Copyright © 2010 S. Karger AG, Basel.


Zhao Q.,Shanghai JiaoTong University | Li T.,Shanghai JiaoTong University | Zhao X.,Fudan University | Huang K.,Shanghai JiaoTong University | And 12 more authors.
Schizophrenia Bulletin | Year: 2013

Background: Rare copy number variations (CNVs) were involved in the etiology of neuropsychiatric disorders, and some of them appeared to be shared risk factors for several different diseases. One of those promising loci is the CNV at 15q11.2, including 4 genes, TUBGCP5, CYFIP1, NIPA2, and NIPA1. Several studies showed that microdeletions at this locus were significant associated with schizophrenia. In the current study, we investigated the role of both rare CNVs and common single nucleotide polymorphisms (SNPs) at 15q11.2 in schizophrenia in the Chinese Han population.Methods:We screened deletions at 15q11.2 in 2058 schizophrenia patients and 3275 normal controls in Chinese Han population by Affymetrix 500K/6.0 SNP arrays and SYBR green real-time polymerase chain reaction and then validated deletions by multiplex ligation-dependent probe amplification and Taqman real-time assays. We successfully genotyped 27 tag SNPs in total and tested associations in 1144 schizophrenia cases and 1144 normal controls.Results:We found a triple increase of deletions in cases over controls, with OR = 4.45 (95% CI = 1.36-14.60) and P =. 014. In the analysis of common SNPs, we found that the most significant SNP in schizophrenia was rs4778334 (OR =. 72, 95% CI = 0.60-0.87, allelic P =. 0056 after permutation, genotypic P =. 015 after permutation). We also found SNP rs1009153 in CYFIP1 was associated with schizophrenia (OR = 0.82, 95% CI = 0.73-0.93, allelic P =. 044 after permutation).Conclusion:We found that both rare deletions and common variants at 15q11.2 were associated with schizophrenia in the Chinese Han population. © 2012 The Author.


Ma J.,Taishan Medical University | Ma J.,Shanghai JiaoTong University | Hou L.-N.,Shanghai JiaoTong University | Rong Z.-X.,Shanghai JiaoTong University | And 5 more authors.
Anti-Cancer Agents in Medicinal Chemistry | Year: 2013

Depression is the most common psychiatric syndrome in cancer patients and adversely affects anti-cancer immune system and life quality of patients. Antidepressant desipramine (DMI) is clinically prescribed in the auxiliary treatment of cancer patients. Increasing evidences suggest that DMI has a broad spectrum of target-off biological effects, such as anticancer properties. Our previous study revealed that DMI at the clinical relevant concentrations could induce CHOP-dependent apoptotic death in C6 glioma cells. In this study, we further explored the pro-autophagic effect of DMI in C6 glioma cells and its underlying mechanism. Treatment with DMI could induce autophagic cell death characterized by the formation of autophagosome and the elevated level of autophagic protein Beclin-1 and cellular redistribution of marker LC3. Meanwhile, DMI inhibited the activation of PI3K-AKT-mTOR pathway which is considered as a negative regulator of autophagy. Furthermore, DMI activated PERK-eIF2α and ATF6 of endoplasmic reticulum (ER) stress pathway, while knockdown of PERK with the PERK-specific short interfering RNA (siRNA) could obviously attenuate the autophagy. The results strongly suggested that DMI could induce autophagy through the PERK-ER stress pathway in C6 glioma cells. Our findings provided new insights into another beneficial potential of antidepressant DMI in the adjuvant therapy of cancer. © 2013 Bentham Science Publishers.


Zhang S.,Tongji University | Edwards H.,Queensland University of Technology | Yates P.,Queensland University of Technology | Guo Q.,Fudan University | Li C.,Shanghai Institute of Mental Health
PLoS ONE | Year: 2013

We explored the mediation effect of caregiver self-efficacy on the influences of behavioral and psychological symptoms (BPSD) of dementia care recipients (CRs) or family caregivers' (CGs) social supports (informational, tangible and affectionate support and positive social interaction) on CGs' mental health. We interviewed 196 CGs, using a battery of measures including demographic data of the dyads, CRs' dementia-related impairments, and CGs' social support, self-efficacy and the Medical Outcome Study (MOS) Short-Form (SF-36) Health Survey. Multiple regression analyses showed that gathering information on self-efficacy and managing CG distress self-efficacy were the partial mediators of the relationship between positive social interaction and CG mental health. Managing caregiving distress self-efficacy also partial mediated the impact of BPSD on CG mental health. We discuss implications of the results for improving mental health of the target population in mainland China. © 2013 Zhang et al.


Tan Y.,Southwest University | Zhang Q.,Southwest University | Li W.,Shanghai Institute of Mental Health | Wei D.,Southwest University | And 4 more authors.
Brain and Cognition | Year: 2014

A number of recent studies have investigated the neurological substrates of Emotional Intelligence (EI), but none of them have considered the neural correlates of EI that are measured using the Schutte Self-Report Emotional Intelligence Scale (SSREIS). This scale was developed based on the EI model of Salovey and Mayer (1990). In the present study, SSREIS was adopted to estimate EI. Meanwhile, magnetic resonance imaging (MRI) and voxel-based morphometry (VBM) were used to evaluate the gray matter volume (GMV) of 328 university students. Results found positive correlations between Monitor of Emotions and VBM measurements in the insula and orbitofrontal cortex. In addition, Utilization of Emotions was positively correlated with the GMV in the parahippocampal gyrus, but was negatively correlated with the VBM measurements in the fusiform gyrus and middle temporal gyrus. Furthermore, Social Ability had volume correlates in the vermis. These findings indicate that the neural correlates of the EI model, which primarily focuses on the abilities of individuals to appraise and express emotions, can also regulate and utilize emotions to solve problems. © 2014 Elsevier Inc.

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