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Ding F.-H.,Shanghai Institute of Hypertension | Li Y.,Shanghai Institute of Hypertension | Zhang R.-Y.,Shanghai JiaoTong University | Zhang Q.,Shanghai JiaoTong University | Wang J.-G.,Shanghai Institute of Hypertension
Journal of Hypertension | Year: 2013

Background: We previously tested the accuracy of the SphygmoCor and Omron HEM-9000AI devices in the estimation of central blood pressure. In the present study, we investigated these two devices in the estimation of central-to-brachial pressure amplification against the invasive catheter measurement. Methods: In 33 individuals undergoing cardiac catheterization, we measured central blood pressure simultaneously by the invasive catheter and each of the two noninvasive devices and brachial blood pressure by the invasive catheter and an automated oscillometric blood pressure monitor of the Omron device. Pressure amplification was calculated as central-to-brachial systolic pressure difference and pulse pressure difference and ratio. The agreement between each of these two noninvasive devices and the invasive catheter was evaluated using the Student's t-test, intraclass correlation analysis, and the Bland-Altman method. Results: The mean central-to-brachial systolic pressure difference and pulse pressure difference and ratio estimated by Omron were significantly lower than those measured by the catheter (P < 0.001), whereas no difference was observed for SphygmoCor (PâŠâ‰1 0.07). Nonetheless, the intraclass correlation coefficients for systolic pressure difference and pulse pressure difference and ratio between the noninvasive and invasive catheter measurements were similar for the two devices, being 0.11 (P = 0.56), 0.38 (P = 0.03), and 0.40 (P = 0.02), respectively, for SphygmoCor, and 0.15 (P = 0.41), 0.23 (P = 0.20), and 0.53 (P = 0.002), respectively, for Omron. Conclusion: If the invasive catheter measurement would be considered as standard, the two noninvasive devices have similar accuracy in the estimation of pressure amplification, but apparently require device-specific criteria for diagnosis. Pulse pressure ratio seems to be a more consistent measure of central-to-brachial pressure amplification. © 2012 Wolters Kluwer Health | Lippincott Williams & Wilkins.

Niu W.-Q.,Shanghai JiaoTong University | Niu W.-Q.,CAS Shanghai Institutes for Biological Sciences | Niu W.-Q.,Shanghai Institute of Hypertension | You Y.-G.,Capital Medical University | Qi Y.,Capital Medical University
Journal of Human Hypertension | Year: 2012

Attempts to associate methylenetetrahydrofolate reductase (MTHFR) gene C677T polymorphism with hypertension have been extensively evaluated, but mostly in Caucasians. We therefore meta-analysed this polymorphism in association with hypertension and hypertension-in-pregnancy (HIP) among Chinese subjects. A random-effects model was applied irrespective of between-study heterogeneity, which was evaluated by subgroup and meta-regression analyses. Study quality was assessed in duplicate. Publication bias was weighed using Egger's test and funnel plot. Data on 20 qualified studies totalling 4461 Chinese subjects were meta-analysed. In overall allelic/genotypic models, carriers of 677T or 677TT were consistently at significantly increased risk of developing hypertension and HIP. No between-study heterogeneity was identified for all genetic models, with the exception for contrast of allele 677T versus 677C in hypertension association studies (P=0.03), and the dominant contrast in HIP association studies (P=0.025). Both the subgroup and meta-regression analyses indicated that study design was a potential source of between-study heterogeneity. Funnel plot and Eggers test suggested no evidence of publication bias. Taken together, our results supported the notion that carriers of 677T or 677TT were at significantly increased risk of developing hypertension and HIP, but indicated caution in interpreting this result, because the study design made marginal significant contribution to the heterogeneity. © 2012 Macmillan Publishers Limited All rights reserved.

Niu W.,Shanghai JiaoTong University | Niu W.,Shanghai Institute of Hypertension | Qi Y.,Capital Medical University | Wu Z.,Shanghai JiaoTong University | And 4 more authors.
Molecular and Cellular Endocrinology | Year: 2012

Genetic association studies on the gene encoding receptor for advanced glycation end products (RAGE) and diabetes mellitus have reported conflicting results. To evaluate the association of RAGE gene four widely-evaluated polymorphisms (T-429C, T-374A, Gly82Ser and G1704T) and diabetes mellitus, a meta-analysis was conducted. A random-effects model was applied irrespective of between-study heterogeneity. There were a total of 5808/3742 (n=14) case-patients/controls (studies) for T-429C, 8259/6935 (n=19) for T-374A, 7029/5266 (n=19) for Gly82Ser, and 2843/3302 (n=13) for G1704T. Overall results detected no significant association of polymorphisms T-429C, T-374A and Gly82Ser with diabetes risk. There was a trend toward an increased risk for alleles 1704T relative to 1704G (odds ratio [OR]=1.09; 95% confidence interval [CI]: 0.98-1.22; I 2=0). Subgroup analysis by ethnicity indicated that allele 1704T conferred a significantly increased risk in East Asians (OR=1.21; 95% CI: 1.04-1.4; I 2=0) but not in Caucasians (OR=0.8; 95% CI: 0.6-1.07; I 2=0), and that by type of diabetes mellitus indicated that association was potentiated exclusively for G1704T with diabetic retinopathy (OR=1.24; 95% CI: 1.01-1.51; I 2=0). No publication bias was observed. Our results provide convincing evidence regarding the association of RAGE gene 1704T allele with an increased risk of diabetes mellitus, especially diabetic retinopathy. Notably, this effect was more pronounced in East Asians. © 2012 Elsevier Ireland Ltd.

Xue P.,Shanghai JiaoTong University | Niu W.-Q.,Shanghai Institute of Hypertension | Jiang Z.-Y.,Shanghai JiaoTong University | Jiang Z.-Y.,Shanghai Institute of Digestive Surgery | And 2 more authors.
PLoS ONE | Year: 2012

Background: Numerous studies have investigated the relationship between apolipoprotein (Apo) E gene polymorphisms and gallbladder stone disease (GSD) across ethnic populations; however, the results are often inconsistent. This meta-analysis aims to comprehensively evaluate the influence of a common ε2/ε3/ε4 polymorphism in Apo E gene on the risk of gallbladder stone disease. Method: Data were analyzed using the RevMan software (V5.1) and a random-effects model was applied irrespective of between-study heterogeneity. Publication bias was weighed using the fail-safe number. Results: There were 17 study populations totaling 1773 cases and 2751 controls for ε2/ε3/ε4 polymorphism of Apo E gene. Overall comparison of alleles ε2 with ε3 in all study populations yielded a 16% decreased risk for GSD (95% confidence interval [95% CI]: 0.68-1.05; P = 0.31; I2 = 13%), and comparison of alleles ε4 with ε3 yielded a 25% increased risk (95% confidence interval [95% CI]: 0.97-1.61; P = 0.0003; I2 = 63%). Subgroup analysis by study design indicated that the magnitude of association in hospital-based studies was largely significantly strengthened for ε4 allelic model (odds ratio [OR] = 1.46; 95% CI: 1.05-2.02; p = 0.0007; I2 = 65%). Subgroup analysis by age of controls indicated a remarkably significant elevation in the magnitude of association in age >50 subgroups in ε4 allelic model (OR = 1.50; 95% CI: 1.03-2.19; p = 0.0009; I2 = 72%). Moreover, subgroup analysis by cases gender indicated a reduction in the magnitude of association in male<30% studies for E2/2 genotypic model (OR = 0.32; 95% CI: 0.07-1.49; p = 0.16; I2 = 45%). Conclusions: Our results reveal that Apo E gene ε4 allele is a risk factor of gallbladder stone disease, especially in elder people and Chinese population. © 2012 Xue et al.

Niu W.,Shanghai JiaoTong University | Niu W.,CAS Shanghai Institutes for Biological Sciences | Niu W.,Shanghai Institute of Hypertension | Qi Y.,Capital Medical University
PLoS ONE | Year: 2011

Background: Mounting evidence has suggested that α-adducin and G-protein β3 (GNB3) genes are logical candidates for salt-sensitive hypertension. Some, but not all, studies have reported that α-adducin G460T and GNB3 C825T polymorphisms may influence the risk of the disease. To comprehensively address this issue, we performed a meta-analysis to evaluate the influence of these two polymorphisms on hypertension and potential biases in Chinese. Methods: Data were analyzed using Stata (v11.0) and random-effects model was applied irrespective of between-studies heterogeneity, which was evaluated via subgroup and meta-regression analyses. Study quality was assessed in duplicate. Publication bias was weighed using Egger's test and funnel plot. Results: 36 study populations totaling 9042 hypertensive patients and 8399 controls were finally identified. Overall, in allelic/genotypic/dominant/recessive models, no significant association was identified for both G460T and C825T polymorphisms (P>0.05) and there was possible heterogeneity (I2>25%). Subgroup analyses by study design indicated that the magnitude of association in population-based studies was marginally significantly strengthened for α-adducin G460T allelic model (OR = 1.12; 95% CI: 1:00-1.25; P = 0.043). Moreover, subgroup analyses by geographic distribution indicated comparison of 825T with 825C yielded a marginally significant increased risk in southern Chinese only (OR = 1.48; 95% CI: 1.01-2.16; P = 0.045). Further meta-regression analyses showed that geographic regions were a significant source of between-study heterogeneity for both polymorphisms. There was a possibility of publication bias for G460T, but not for C825T. Conclusions: Our overall results suggest null association of α-adducin G460T and GNB3 C825T polymorphisms with hypertension in Chinese but indicate local marginal significance of C825T, as a putative salt-sensitive switch, in southern Chinese. © 2011 Niu, Qi.

Niu W.,Shanghai JiaoTong University | Niu W.,Shanghai Institute of Hypertension | Qi Y.,Capital Medical University
Heart | Year: 2012

Context and Objective: The association between matrix metalloproteinase (MMP) family gene polymorphisms and coronary artery disease (CAD) has been widely evaluated; however, the studies have yielded contradictory results. The authors sought to investigate this inconsistency by performing a comprehensive metaanalysis on MMP family genes. Data Sources: Articles were identified by searches of PubMed, HuGE Navigator, EMBASE, Wanfang, and China Biological Medicine databases before January 2012, and by hand searches of bibliographies of retrieved articles and reviews. Study Selection: Qualified articles were retrospective or nested case-control studies of MMP family gene polymorphisms and CAD. A total of 11 polymorphisms from five MMP family genes were meta-analysed. Forty-eight articles encompassing 59 studies fulfilled the predefined criteria. Data Extraction: Data were independently extracted from qualified articles by two reviewers using a standardized Excel template and were verified. Any disagreement was adjudicated by discussion and a consensus was reached. Results: Overall significant associations were observed for Glu45Lys in MMP3 gene under both allelic (OR: 1.52; 95% CI 1.3 to 1.76; p<0.001) and dominant (1.37; 1.23 to 1.54; <0.001) models, and for -1562C/T in MMP9 gene under allelic model (1.11; 1.02 to 1.2; 0.012). Subgroup analyses demonstrated that sources of study heterogeneity stemmed from the CAD endpoint for -519A/G, -1612 6A/5A, Glu45Lys, from the descent of study populations for -1607GG/G, -1612 6A/5A, -790T/G, -1562C/T, from the study design for -1607GG/G, -1612 6A/5A, -1562C/T, and from the selection of controls for -1306C/T, -1562C/T, Arg279Gln. In meta-regression analyses, effect of -1612 6A/5A on CAD was ethnicity-specific (coefficient: 0.21; p=0.048), and this effect was more prominent for myocardial infarction patients or East Asians. Conclusions: The results provided strong evidence regarding the susceptibility of MMP3 and MMP9 genes to the development of CAD. Future studies incorporating gene-gene and gene-environment interactions are encouraged.

Agency: Cordis | Branch: FP7 | Program: CP-IP | Phase: HEALTH-2007-2.1.1-2 | Award Amount: 14.61M | Year: 2008

The project is focused on the definition of a comprehensive genetic epidemiological model of complex traits like Essential Hypertension (EH) and intermediate phenotypes of hypertension dependent/associated Target Organ Damages (TOD). To identify the common genetic variants relevant for the pathogenesis of EH and TODs, we will perform a Whole Genome Association (WGA) study of 4.000 subjects recruited from historical well-characterized European cohorts. Genotyping will be done with the Illumina Human 1M BeadChip. Well-established multi-variate techniques and innovative genomic analyses through machine learning techniques will be used for the WGA investigations. Using machine learning approach we aim at developing a disease model of EH integrating the available information on EH and TOD with relevant validated pathways and genetic/environmental information to mimic the clinicians recognition pattern of EH/TOD and their causes in an individual patient. Our statistical design is with two samples run in parallel, each with 1,000 cases and 1,000 controls, followed by a replication/joint analysis. This design is more powerful than replication alone and allows also a formal testing of the potential heterogeneity of findings compared to a single step (one large sample) design. The results represent the source to build a customized and inexpensive genetic diagnostic chip that can be validated in our existing cohorts (n=12,000 subjects). HYPERGENES is in the unique position to propose a ground-breaking project, improving the methodology of genetic epidemiology of chronic complex diseases that have a high prevalence among EU populations. Designing a comprehensive genetic epidemiological model of complex traits will also help us to translate genetic findings into improved diagnostic accuracy and new strategies for early detection, prevention and eventually personalised treatment of a complex trait. The ultimate goal will be to promote the quality of life of EU populations.

Patel V.B.,University of Alberta | Zhong J.-C.,Shanghai JiaoTong University | Zhong J.-C.,Shanghai Institute of Hypertension | Fan D.,University of Alberta | And 7 more authors.
Hypertension | Year: 2014

Angiotensin-converting enzyme (ACE) 2 is a key negative regulator of the renin-angiotensin system and metabolizes angiotensin II (Ang II) into Ang 1 to 7. Ang II is a vasoactive peptide, which plays an important role in vascular disease. The objective of the present study was to define the role of ACE2 in pathological vascular remodeling. We found upregulation of ACE2 in dilated human aorta with bicuspid aortic valve and in murine aorta in response to Ang II. Ex vivo pressure myography showed increased vascular stiffness in ACE2 knockout (KO) mesenteric arteries in response to Ang II (1.5 mg/kg per day) and with aging. Histological analyses revealed reduced media-to-lumen ratio in ACE2KO mesenteric arteries with loss of vascular smooth muscle cells. Aortic vascular smooth muscle cells from ACE2KO mice showed markedly increased reactive oxygen species and apoptosis in response to Ang II along with increased cleaved caspase-3 and cleaved caspase-8 levels in the ACE2KO aorta. Ang II type 1 receptor blockade and Ang 1 to 7 supplementation prevented the increase in Ang II-induced reactive oxygen species and apoptotic cell death. In the aorta, Ang II resulted in thoracic and abdominal aortic dilation with loss of vascular smooth muscle cell density in ACE2KO aorta as revealed by α-smooth muscle actin, calponin staining, and electron microscopy with increased promatrix metalloproteinase 2, matrix metalloproteinase 2, and matrix metalloproteinase 9 levels. ACE2 is upregulated in vascular diseases, and ACE2 deficiency exacerbates Ang II-mediated vascular remodeling driven by increased reactive oxygen species and vascular smooth muscle cell apoptosis. In conclusion, the key counter-regulatory role of ACE2 against an activated renin-angiotensin system provides novel insights into the role of ACE2 in vascular diseases. © 2014 American Heart Association, Inc.

News Article | December 6, 2016
Site: www.24-7pressrelease.com

SAN FRANCISCO, CA, December 06, 2016 /24-7PressRelease/ -- This is a series of simple yet highly effective qigong exercises that enhance people's immune system, fills the body up with energy so that it can start the self-healing process. The ancient qigong moves were studied, used and perfected by Elizabeth Hovirag who has practiced several types of qigong for more than 15 years. Thus she was able to put together a highly effective series that anybody can do with ease and which brings quick results. As she has more than 25 years' experience teaching a wide range of age groups from 5 up to 85, she is a highly experienced teacher whose instructions can be easily followed and performed by anyone - be it a slow or a fast learner. Due to her expertise her teaching is highly successful and people attend her courses from all over the world - from Australia to Europe and America. In a PBS documentary, Dr. Wang Chong Xing from the Shanghai Institute of Hypertension said that after 30 years of study, "We think Chi Kong can cure every kind of disease, some responding better than others." Also, Richard medical doctor and author says the following about the qigong exercises: "...by moving Chi through the body, you can heal yourself of many ailments." The DVD is shipped world-wide and can be ordered throughhttp://chikongmadeeasy.weebly.com where one can also read testimonials from those who already purchased either the course or the DVD. Elizabeth points out that this qigong method is effective on all areas of life. It helps people bring balance into their lives, clean the clutter in their minds, thus start creating the life they really want, clean the emotional garbage from their body, thus they feel relieved and joyful besides helping their body heal itself from any kind of diseases. With the system having helped so many people from so many different countries from around the world, Elizabeth suggests the best way for people to make use of the Chikong Made Easy exercises is to follow the instructions word by word. They need to do the exercises in order to experience the change in their lives. So for example if one simply practices one part of the system, one will be successful in the long run, while if one does the whole system, they will see results within the first week of their practice. „The reason why there are several exercises put into a series is to guarantee both a quick change, and a long-term one. My typical customer is on their 3rd time with the process, with many over 10 times, and most of them are now on their 30th+ time through. So this is not something you are just aiming to buy, and then read through to just add more information into your mind. One of the key parts of the process is in fact repetition - that is continuous practice". Anyone who wishes to buy the qigong DVD or for more information visit: http://chikongmadeeasy.weebly.com

Liu M.,Shanghai Institute of Hypertension | Li Y.,Shanghai Institute of Hypertension | Wei F.-F.,Shanghai Institute of Hypertension | Zhang L.,Shanghai Institute of Hypertension | And 2 more authors.
Journal of Hypertension | Year: 2013

Objective: Blood pressure (BP) load, defined as the percentage of abnormally elevated BP readings, is usually provided on the report of ambulatory BP monitoring. However, the usefulness of BP load is still uncertain. In the present study, we examined whether BP load would be associated, independently of BP level, with target organ damage. Methods: We recruited 869 individuals (430 men, mean age 51 years) who were referred for 24-h ambulatory BP monitoring and were off antihypertensive medication for at least 2 weeks. BP load was defined as the percentage of daytime and nighttime SBP/DBP readings at least 135/85 and at least 120/70 mmHg, respectively. Brachial-ankle pulse wave velocity (baPWV) and carotid-femoral pulse wave velocity (cfPWV), left ventricular mass index (LVMI) and urinary albumin-to-creatinine ratio (ACR) were determined as measures of target organ damage. Results: SBP and DBP load had a skewed distribution (P< 0.001). In multivariate-adjusted categorical analyses, baPWV(13.8, 14.6 and 15.6 m/s), cfPWV (7.4, 7.7 and 8.4m/s), LVMI (90.1, 94.8 and 100.7g/m 2) and ACR (0.47, 0.58 and 0.77mg/mmol) all increased from tertiles 1-3 of SBP load (P< 0.001). However, these differences became nonsignificant (P≥0.16) after additionally adjusted for 24-h SBP level. In a continuous analysis in individuals with a BP load greater than zero (n = 838), adding the logarithmically transformed SBP load did not improve the fit of models relating measures of target organ damage to SBP level (P≥0.14), except for cfPWV (P = 0.01) that was however negatively associated with BP load. Analyses on DBP load produced similar results. Conclusion: BP load was associated with target organ damage, but not independently of BP level. © 2013 Wolters Kluwer Health Lippincott Williams & Wilkins.

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