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Chen X.,Shanghai Institute of Digestive Disease
Chinese Journal of Gastroenterology | Year: 2012

Recently endoscopic biopsy and operative specimens are sharply increasing, however, standardized pathological examination formulation is still lacking. This article detailed the pathological examination highlights of gastrointestinal biopsy specimens, endoscopic mucosal resection (EMR), endoscopic submucosal dissection (ESD) and surgical operation, with the aim of standardizing the digestive system pathological diagnosis. Source


Yanming Y.,Shanghai Institute of Digestive Disease
Zhongguo yi liao qi xie za zhi = Chinese journal of medical instrumentation | Year: 2010

The mechanism and principles of autofluorescence imaging based on autofluorescence technique are reported. The threshold value of fluorescence spectrum ratio applied can be quantitative and objective and the reliable measurement method that may provide intuitive method of autofluorescence imaging in the gut mucosa. The suspected lesion may be found rapidly according to the imaging color difference, therefore the results of clinical study of the digestive tract cancer diagnosis indicated that the sensitivity, specificity, and diagnostic accuracy were 94%, 95.5% and 94.8% respectively, and it has very high value in clinical application. Source


Xu J.,State Key Laboratory for Oncogenes and Related Genes | Li Z.,Vrije Universiteit Brussel | Wang J.,Shanghai Institute of Digestive Disease | Chen H.,State Key Laboratory for Oncogenes and Related Genes | And 3 more authors.
Translational Oncology | Year: 2014

Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) is a tumor suppressor commonly inactivated in glioblastoma multiforme (GBM), but the prognostic significance of PTEN remains controversial. Here, we demon- strate significant prognostic value of combined PTEN mutation and expression for the survival of patients with GBM on the basis of analysis of large-scale cancer genomic data. PTEN nonsense mutations associated with significantly shorter disease-free survival and overexpression of PTEN protein linked to shorter disease-free and overall survival of patients with GBM. PTEN nonsense mutations correlated with decreased p53 and Gata3 protein levels and increased genomic instability in human GBM tissues. Expression of nonsense PTEN mutant decreased p53 and Gata3 levels, producing increased DNA damage both in vitro and in vivo. Mice carrying xenograft tumors with nonsense PTEN mutant displayed significantly shorter survival. Our data demonstrated the prognostic value of combined PTEN mutation and protein expression for patients with GBM and highlighted distinct biologic effects of nonsense and missense mutations of PTEN. © 2014 Neoplasia Press. All rights reserved. Source


Liu W.,Shanghai Institute of Digestive Disease
Chinese Journal of Gastroenterology | Year: 2013

Gastroesophageal reflux disease (GERD) is a common, significantly affecting the life quality of patients. Rational diagnosis and management is very important to improve the life quality of patients and reduce the medical costs. Relevant professional societies of many countries already issued guidelines or consensus of GERD diagnosis and management, but most of them were publicized a long time ago, except American College of Gastroenterology (ACG). This paper presented the understanding of this new guidelines of ACG in coordination with situation in China. Source


Li H.,Shanghai Institute of Digestive Disease
Chinese Journal of Gastroenterology | Year: 2013

There are two defined diagnostic criteria for acute-on-chronic liver failure (ACLF): Asia-Pacific Association for the Study of Liver (APASL) and European Association for the Study of the Liver-Chronic Liver Failure (EASL-CLIF) consortium criteria. APASL criteria emphasized on hepatic function failure patient with involvement of extrahepatic organs. EASL-CLIF criteria placed emphasis on multi-organ failure of ACLF patient. Neither of them can distinguish ACLF from decompensated cirrhotic patients completely. Future perspective studying of ACLF should include identifying the disease's pathological features, making a comprehensive definition of ACLF and the mechanisms how hepatic insults triggering acute deterioration of liver function. Source

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