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Song F.-Y.,Fudan University | Song F.-Y.,Shanghai Institute of Cardiovascular Disease | Song F.-Y.,Shanghai Institute of Medical Imaging | Cheng L.-L.,Fudan University | And 2 more authors.
Fudan University Journal of Medical Sciences | Year: 2016

Anthracycline provides considerable therapeutic benefit in most patients with lymphoma. However, the cardiotoxicity of anthracycline in these patients cannot be ignored. In recent years, with the right ventricular function being given attention gradually, subclinical dysfunction of right ventricle induced by anthracycline has attracted worldwide attention. This review was concentrated on various methods of detecting the subclinical cardiotoxicity of anthracycline on right ventricle in patients with lymphoma, such as biological markers, electrocardiogram, cardiac magnetic resonance, endocardial biopsy and echocardiography. The novel echocardiographic technique including tissue Doppler imaging, strain and strain rate imaging, speckle tracking echocardiography and real-time 3-dimensional echocardiography were involved in detail. © 2016, Editorial Department of Fudan University Journal of Medical Sciences. All right reserved. Source


Burgess S.,University of Cambridge | Thompson S.G.,University of Cambridge | Andrews G.,University of North Carolina | Samani N.J.,University of Leicester | And 75 more authors.
Statistics in Medicine | Year: 2010

Genetic markers can be used as instrumental variables, in an analogous way to randomization in a clinical trial, to estimate the causal relationship between a phenotype and an outcome variable. Our purpose is to extend the existing methods for such Mendelian randomization studies to the context of multiple genetic markers measured in multiple studies, based on the analysis of individual participant data. First, for a single genetic marker in one study, we show that the usual ratio of coefficients approach can be reformulated as a regression with heterogeneous error in the explanatory variable. This can be implemented using a Bayesian approach, which is next extended to include multiple genetic markers. We then propose a hierarchical model for undertaking a meta-analysis of multiple studies, in which it is not necessary that the same genetic markers are measured in each study. This provides an overall estimate of the causal relationship between the phenotype and the outcome, and an assessment of its heterogeneity across studies. As an example, we estimate the causal relationship of blood concentrations of C-reactive protein on fibrinogen levels using data from 11 studies. These methods provide a flexible framework for efficient estimation of causal relationships derived from multiple studies. Issues discussed include weak instrument bias, analysis of binary outcome data such as disease risk, missing genetic data, and the use of haplotypes. Copyright © 2010 John Wiley & Sons, Ltd. Source


Hu K.,Fudan University | Hu K.,Shanghai Institute of Cardiovascular Disease | Hong T.,Fudan University | Hong T.,Shanghai Institute of Cardiovascular Disease | Hong T.,Shanghai Key Laboratory of Organ Transplantation
Fudan University Journal of Medical Sciences | Year: 2013

Endothelial progenitor cells (EPCs) have the ability to differentiate into mature endothelial cells (ECs). They can facilitate the repair of damaged blood vessels or augment development of new vessels. Recent data indicate that EPCs play a significant role in the occurrence and development of cardiac allograft vasculopathy (CAV). The injury of endothelium of donor heart post-transplantation triggers the process of neoendothelialization. This paper reviews homing and differentiation of EPCs in the occurrence and development of allograft vasculopathy, and explore the prediction, diagnosis and therapeutic value of EPCs on CAV. Source


Zhou N.-W.,Institute of Medical Imaging | Zhou N.-W.,Shanghai Institute of Cardiovascular Disease | Pan C.-Z.,Institute of Medical Imaging | Pan C.-Z.,Shanghai Institute of Cardiovascular Disease | And 8 more authors.
Fudan University Journal of Medical Sciences | Year: 2016

To assess early left heart functional alteration in patients with heart transplantaion by three-dimensional speckle-tracking echocardiography. Three-dimensional images of 55 patients with heart transplantaion were analyzed using post-processing software to evaluate and compare the left ventricular systolic function, volume and other indicators at 1 and 12 months after surgery. Fifty-five patients with heart transplantaion, with 2 cases lost to follow-up, were divided into the rejection group (n=10) and the no-rejection group (n=43). Intragroup comparison showed no difference for left ventricular function between 1 month and 12 months after transplantation in the no-rejection group while in the rejection group, left ventricular end diastolic volume (LVEDV), left ventricular end-stolic volume (LVESV), left ventricular stroke volume (LVSV), MASS at 12 months after transplantation were smaller than that at 1 month. Compared with the no-rejection group, the rejection group had similar left ventricular function at 1 month after heart transplantation, while at 12 months after surgery, their LVEDV, LVSV, MASS, and global principal longitudinal strain (GPSL) were significantly decreased (P<0.05). The left ventricular function had changed early after heart transplantation. Three-dimensional speckle-tracking echocardiography can accurately determine the alteration of left ventricular function in patients with heart transplantaion. © 2016, Fudan University. All right reserved. Source


Xia Y.,Fudan University | Xia Y.,Shanghai Institute of Cardiovascular Disease | Xia Y.,Affiliated Hospital of Zunyi Medical College | Zhu K.,Fudan University | And 10 more authors.
Experimental Biology and Medicine | Year: 2015

Mesenchymal stem cell (MSC) transplantation by intramyocardial injection has been proposed as a promising therapy strategy for cardiac repair after myocardium infarction. However, low retention and survival of grafted MSCs hinder its further application. In this study, copolymer with N-isopropylacrylamide/acrylic acid/2-hydroxylethyl methacrylate-poly(ɛ-caprolactone) ratio of 88:9.6:2.4 was bioconjugated with type I collagen to construct a novel injectable thermosensitive hydrogel. The injectable and biocompatible hydrogel-mediated MSC transplantation could enhance the grafted cell survival in the myocardium, which contributed to the increased neovascularization, decreased interstitial fibrosis, and ultimately improved heart function to a significantly greater degree than regular MSC transplantation. We suggest that this novel hydrogel has the potential for future stem cell transplantation. © 2014 by the Society for Experimental Biology and Medicine Source

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