Yang R.-y.,Research Station of Sport Science of Shanghai Huangpu District |
Lou S.-j.,Shanghai University of Sport |
Chen X.-e.,Shanghai Huadong Hospital
Journal of Clinical Rehabilitative Tissue Engineering Research | Year: 2011
BACKGROUND: Several studies have demonstrated that treadmill running can promote hippocampal neurogenesis in healthy rats. OBJECTIVE: To investigate the effects of treadmill running on hippocampal neurogenesis and mRNA expression in vascular endothelial growth factors (VEGF) in a rat model of ischemia and reperfusion injury. METHODS: The method of reversible middle cerebral artery occlusion (MCAO) was used to obtain rat models of ischemia and reperfusion injury. MCAO rat models were randomly divided into exercise group and control group. A sham-operated group was used. Rats in the control and sham-operated groups were fed without exercise. The exercise group rats were subjected to 7-day treadmill running. The exercise and control group rats were intraperitoneally injected with 5-bromodeoxyuridine (BrdU) solution. RESULTS AND CONCLUSION: Immunohistochemical staining results showed that BrdU-positive cells in the bilateral hippocampus and dentate gyrus were significantly more in the exercise group than in the control group (P < 0.01). Real time quantitative PCR results showed that mRNA expression in VEGF was significantly greater in the exercise group than in the control and sham-operated groups (P < 0.05). The results suggest that appropriate treadmill running can promote hippocampal neurogenesis and further enhance the mRNA expression in hippocampal VEGF in ischemia and reperfusion adult rats.
Jiang Y.,Peking Union Medical College |
Zhang Z.-L.,Shanghai JiaoTong University |
Zhang Z.-L.,General Hospital of the Peoples Liberation Army |
Zhu H.-M.,Shanghai Huadong Hospital |
And 7 more authors.
Clinical Interventions in Aging | Year: 2014
Objective: To evaluate whether the efficacy and safety of menatetrenone for the treatment of osteoporosis is noninferior to alfacalcidol in Chinese postmenopausal women. Method: This multicenter, randomized, double-blinded, double-dummy, noninferiority, positive drug-controlled clinical trial was conducted in five Chinese sites. Eligible Chinese women with postmenopausal osteoporosis (N=236) were randomized to Group M or Group A and received menatetrenone 45 mg/day or alfacalcidol 0.5 μg/day, respectively, for 1 year. Additionally, all patients received calcium 500 mg/day. Posttreatment bone mineral density (BMD), new fracture onsets, and serum osteocalcin (OC) and undercarboxylated OC (ucOC) levels were compared with the baseline value in patients of both groups. Results: A total of 213 patients (90.3%) completed the study. After 1 year of treatment, BMD among patients in Group M significantly increased from baseline by 1.2% and 2.7% at the lumbar spine and trochanter, respectively (P,0.001); and the percentage increase of BMD in Group A was 2.2% and 1.8%, respectively (P,0.001). No difference was observed between groups. There were no changes in femoral neck BMD in both groups. Two patients (1.9%, 2/108) in Group M and four patients (3.8%, 4/105) in Group A had new fracture onsets (P.0.05). In Group M, OC and ucOC decreased from baseline by 38.7% and 82.3%, respectively (P,0.001). In Group A, OC and ucOC decreased by 25.8% and 34.8%, respectively (P,0.001). Decreases in serum OC and ucOC were more obvious in Group M than in Group A (P,0.001). The safety profile of menatetrenone was similar to alfacalcidol. Conclusion: Menatetrenone is an effective and safe choice in the treatment of postmenopausal osteoporosis in Chinese women. © 2014 Jiang et al.
Zhang F.,Fudan University |
Ge J.,Fudan University |
Qian J.,Fudan University |
Ge L.,Fudan University |
And 95 more authors.
EuroIntervention | Year: 2012
Aims: The FOCUS registry is a prospective, multicentre, web-based programme designed to collect clinical outcome data from real-world patients receiving the second-generation cobalt-chromium sirolimus-eluting stent (CoCr-SES). Methods and results: From March 2009 to February 2010, a total of 5,084 patients from 83 centres who were eligible to receive CoCr-SES were enrolled in the FOCUS registry. The primary endpoint was 12-month major adverse cardiac events (MACE, defined as the composite of cardiac death, myocardial infarction [MI], and target vessel revascularisation [TVR]). One-year data were available for 5,013 (98.6%) of the 5,084 patients enrolled. The primary endpoint occurred in 174 (3.47%) of 5,013 patients, consisting of 43 (0.86%) cardiac deaths, 132 (2.63%) MI, and 46 (0.92%) TVR. According to the Academic Research Consortium definition, definite and probable stent thrombosis (ST) occurred in 0.52% (26/5,013) of patients, including 19 cases of early ST and 7 of late ST. The 12-month MACE rates were 3.73% and 2.60% for extended-use and standard-use patients, respectively (p=0.065). Conclusions: The second-generation CoCr-SES was associated with low rates of 12-month MACE and ST in a broad spectrum of patients, thereby confirming the clinical safety and efficacy of this stent in a real-world setting. © Europa Digital & Publishing 2012. All rights reserved.
Liang C.,Shanghai Huadong Hospital |
Yang F.,Shanghai Huadong Hospital |
Lin W.,Shanghai Huadong Hospital |
Fan Y.,Shanghai Huadong Hospital
International Journal of Clinical and Experimental Medicine | Year: 2015
Aim: To compare the efficacies of four surgical treatments, i.e., total hip arthroplasty (THA), internal fixation (IF), hemiarthroplasty (HA), and artificial femoral head replacement (artificial FHR), by performing a network meta-analysis based on Harris hip score (HHS) in elderly patients with femoral neck fracture. Methods: In strict accordance with specific inclusion and exclusion criteria, randomized controlled trails (RCTs) were screened and selected from a larger group of studies that were retrieved through a comprehensive search of scientific literature databases, further complimented by manual search. The resultant high-quality data from final selected studies were analyzed using Stata 12.0 software. Results: A total of 3680 studies were initially retrieved from database search, and 15 RCTs were eventually incorporated into this meta-analysis, containing 1781 elderly patients who had undergone various surgical treatments for femoral neck fracture (THA group = 604; HA group = 604; IF group = 495; artificial FHR group = 78). Our major result revealed a statistically significant difference in HHS of femoral neck fracture when HA and IF groups were compared with THA. No differences were detected in the HHS of femoral neck fracture undergoing artificial FHR and THA. The surface under the cumulative ranking curves (SUCRA) value of HHS, in elderly patients with femoral neck fracture after surgery, revealed that IF has the highest value. Conclusions: The current network meta-analysis results suggest that IF is the superlative surgical procedure for femoral neck fracture patients, and IF significantly improves the HHS in femoral neck fracture patients. © 2015 E-Century Publishing Corporation. All rights reserved.