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Shi H.,Shanghai Hospital of Traditional Chinese Medicine | Yang X.,Shanghai University
Advances in Intelligent Systems and Computing | Year: 2013

Parkinson's disease is a high incidence of neurodegenerative diseases. This study was based on previous studies, using data mining methods, from dopamine (DA) Metabolic pathway, the use of artificial neural network algorithms and association algorithms to dig and forecast zhichan soup, only Chinese drug group, On the role of neural stem cells (NSC) transplantation Parkinson's disease (PD) in the rat substantia nigra DA and its metabolites in the meaning of content changes, to determine the soup, only directed differentiation of NSC transplantation is non-linear effects of changes in real, and NSC transplantation for the treatment of PD to solve difficult problems in medicine to provide an effective solution to the experimental data. © 2013 Springer-Verlag. Source

Yang X.,Shanghai University | Dong H.,National Marine Information Center | Xu L.,Shanghai Institute of Computer Science and Engineering | Zhong F.,Shanghai Institute of Computer Science and Engineering | Zhu Y.,Shanghai Hospital of Traditional Chinese Medicine
Advanced Materials Research | Year: 2012

In view of the high incidence of myopia in young people, by multiple regression analysis algorithm applied to acupuncture treatment of young patients with myopia in all the quantitative analysis of influencing factors, we found that patients get the best return for each The equation is not the same, indicating that a variety of reasons of visual acuity, and analyzes the various factors in the equation and the proportion appears in all equations, in the hope of in-depth study through a more comprehensive vision to grasp the changes caused by the substance of meaning. © (2012) Trans Tech Publications, Switzerland. Source

Yu X.,Jiashan No.1 Peoples Hospital | Liang G.,Shanghai Hospital of Traditional Chinese Medicine | Wu M.,Shanghai JiaoTong University | Zheng J.,Jiashan No.1 Peoples Hospital | And 7 more authors.
Chinese Journal of Andrology | Year: 2015

Objective To investigate the prevalence of benign prostatic hyperplasia (BPH) among old and middle-aged males in community inhabitants. Methods A cross-sectional randomized study of 2 000 men aged between 40 to 70 years was performed in Shanghai and Zhejiang community. The lower urinary tract symptoms (LUTS) was investigated by International Prostate Symptom Score (IPSS). The length, width, height of prostate zone were measured by transrectal ultrasonography (TRUS) in each volunteer for calculating the prostate volume (PV). The data were processed by one-way analysis of variance. Results Totally 1,982 cases meeting the study criteria were included in the investigation. The mean age was (57.85±8.33) years old. The mean IPSS and PV were (5.43±3.21) and (29.86±20.32)mL respectively. The prevalence of moderate and severe LUTS was 50.61%(1 003/1 982). The PV was over 20mL in 68.92%(1 366/1 982). The incidence rate of BPH was 29.97%. Of three groups with different ages, the BPH prevalence was 2.03%, 24.89% and 54.18% respectively. It showed a trend of increase with age (P<0.01). The prevalence of BPH was 36.58% in Shanghai community, while 23.42% in Zhejiang area. Conclusion The BPH prevalence was serious among old and middle-aged males in community inhabitants, especially in urban and should be given much more attention. © 2015, Shanghai Jiaotong University School of Medicine. All rights reserved. Source

Pan W.,Shanghai University of Traditional Chinese Medicine | Chen X.,Fudan University | Bao J.,Shanghai University of Traditional Chinese Medicine | Bai Y.,Shanghai University of Traditional Chinese Medicine | And 12 more authors.
Evidence-based Complementary and Alternative Medicine | Year: 2013

Objective. To investigate the current use of integrative therapies (IT) in the treatment of patients with amyotrophic lateral sclerosis (ALS). Methods. A cross-sectional, multicenter clinical epidemiological survey was conducted in 12 hospitals in Shanghai. We investigated the type and frequency of IT use and determined whether the use of IT correlated with demographic, social, or disease-specific characteristics in our patient population. Results. A total of 231 (89.5%) of 258 patients with ALS were eligible for the study and 229 (99% of all) of 231 reported the use of at least one IT for the treatment of ALS. Vitamins and Chinese herb decoctions, Chinese herb compounds, massage therapy, and acupuncture were the 5 most commonly used therapies. There was a strong association between education level, income, and use of IT. A household income of more than 75,000 RMB ($49,995) correlated with multiple IT use, and married patients used IT more often than single individuals. The main reasons for using IT were to treat weakness and fatigue, muscle atrophy, the development of ALS, depression, insomnia, limb pain or numbness, and side effects associated with Riluzole. Conclusion. The use of IT is common in patients with ALS in Shanghai. Vitamins and TCM are the most used additional therapies and the widespread and largely unexamined use of IT for ALS requires more attention. © 2013 Weidong Pan et al. Source

Shi H.-F.,Shanghai Hospital of Traditional Chinese Medicine | Lu Y.,Shanghai Hospital of Traditional Chinese Medicine | Song J.,Shanghai University of Traditional Chinese Medicine | Li W.-T.,Shanghai Hospital of Traditional Chinese Medicine
Journal of Clinical Rehabilitative Tissue Engineering Research | Year: 2011

Background: How to make the transplanted neural stem cells differentiated into more dopaminergic neurons, so as to accomplish the plerosis of injured dopaminergic neuron. This problem solving will be the breakthrough progress for the treatment of Parkinson disease (PD). Objective: To study the effects of Zhichan Decoction on substantia nigra dopamine (DA) and metabolites, and the survival and directional differentiation after neural stem cells were transplanted from metabolic pathway in PD rats. Methods: PD rats models were established by 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine. The contents of DA, homovanillic acid (HVA) and 3, 4-dihydroxy phenyl acetic acid (DOPAC) were measured with high-performance liquid chromatography (HPLC). Results and Conclusion: Zhichan Decoction could increase the content of DA and DOPAC. But there were no effects on HVA. The Zhichan Decoction has the effect to promote the neural stem cells differentiating into dopaminergic neurons in PD rats; At the same time, it could inhibit DA breaks down, so that the therapeutic effect was achieved. Source

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