Shanghai Dongyue Biochemical Ltd.

Shanghai, China

Shanghai Dongyue Biochemical Ltd.

Shanghai, China

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Wu F.,East China University of Science and Technology | Long Z.,Shanghai Dongyue Biochemical Ltd. | Zhang P.,East China University of Science and Technology | Cai S.,Shanghai Dongyue Biochemical Ltd. | Zhao H.,East China University of Science and Technology
Huagong Xuebao/CIESC Journal | Year: 2010

4, 1′, 6′-Trichloro-2, 3, 6, 3′, 4′-sucrose pentaacetate(TOSPA), as the key intermediate of sucralose, was synthesized by chlorination which treated with thionyl chloride and catalyst TEBA. The yield was up to 90% by applying the optimized conditions [SOCl2 150% (mol), toluene, 90°C, 6 h]which was explored by the two important factors including amount of thionyl chloride and reaction temperature. The TOSPA complex was formed by mono-TOSPA and mono-toluene which was characterized by X-ray, 1H NMR, IR and EA. The TOSPA with high purity was obtained by separation utilizing the complex physical characteristic. The process is of potential for industrial application. © All Rights Reserved.


Long Z.-Z.,Shanghai Dongyue Biochemical Co. | Cai S.-H.,Shanghai Dongyue Biochemical Co. | Zhang P.,East China University of Science and Technology | Wu F.-Z.,East China University of Science and Technology | Song G.-H.,East China University of Science and Technology
Huadong Ligong Daxue Xuebao/Journal of East China University of Science and Technology | Year: 2010

The trace impurity in (3aS,6aR)-9-cis-tetrahydrogen-4-methoxyfuran[3, 4b]furan-2(3H)-one(MFO) is enriched and purified. The impurity was identified by high resolution MS, elemental analysis, NMR, and monocrystal X-ray diffraction, and its structrue is a new dimer of MFO(β-IMFO), which is an epimer of known impurity, α-DIMFO. Formation mechanism of the impurity is discussed.

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