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Shanghai, China

Zhang Y.,Chinese Academy of Sciences | Jia X.,Shanghai University | Yang J.,Chinese Academy of Sciences | Li Q.,Chinese Academy of Sciences | And 3 more authors.
BioMed Research International | Year: 2016

The mechanisms by which Shaoyao-Gancao decoction (SGD) inhibits the production of inflammatory cytokines in serum and brain tissue after cerebral ischemia-reperfusion (CI-RP) in rats were investigated. A right middle cerebral artery occlusion was used to induce CI-RP after which the rats were divided into model (n = 39), SGD (n = 28), clopidogrel (n = 25) and sham operated (n = 34) groups. The Bederson scale was used to evaluate changes in behavioral indices. The levels of IL-1β, TNF-α, MCP-1, IL-10, RANTES, VEGF, and TGF-β1 in the serum and infarcted brain tissues were measured. Nissl body and immunohistochemical staining methods were used to detect biochemical changes in neurons, microglial cells, and astrocytes. Serum levels of VEGF, TNF-α, MCP-1, IL-1β, and IL-10 increased significantly 24 h after CI-RP. In brain tissue, levels of TNF-α and IL-1β significantly increased 24 h after CI-RP, whereas levels of TGF-β1 and MCP-1 were significantly higher 96 h after CI-RP (P < 0.05). SGD or clopidogrel after CI-RP reduced TNF-α and IL-1β levels in brain tissue and serum levels of MCP-1, IL-1β, and IL-10. SGD increased the number of NeuN-positive cells in infarcted brain tissue and reduced the number of IBA1-positive and GFAP-positive cells. The efficacy of SGD was significantly higher than that of clopidogrel. © 2016 Ying Zhang et al.

Yingmin L.,Shanghai JiaoTong University | Nengcai Y.,Shanghai JiaoTong University | Cunfang D.,Shanghai JiaoTong University | Laixin S.,Shanghai JiaoTong University | And 8 more authors.
Scientific Research and Essays | Year: 2011

The aim of this study is to investigate the impact of exercise-training on restenosis rate within six months after drug-elution stent (DES) (≥ 3.0 mm) implantation. A total of 90 hospitalized patients with coronary artery disease underwent DES (≥ 3.0 mm) implantation were retrospectively analyzed. Acute myocardial infarction, chronic total occlusion lesions, restenosis lesions and bypass graft lesions were excluded. Patients were randomly divided into exercise-training group (n = 42) and non-exercisetraining group (n = 48). Patients in the exercise-training group underwent the rehabilitation exercise program for patients after percutaneous transluminal coronary angioplasty and stent implantation. The restenosis rate during the six-month follow-up was compared. The restenosis rate in exercise-training group was significantly lower than that in non- exercise-training group (9.5% vs.18.8%, P < 0.05). The exercise-training is an effective method for reducing the restenosis rate in patients with DES (≥ 3.0 mm) implantation. © 2011 Academic Journals.

Bai X.,Shanghai JiaoTong University | Zhu Y.,Shanghai JiaoTong University | Zhu Y.,Fudan University | Jin Y.,Shanghai JiaoTong University | And 8 more authors.
Carcinogenesis | Year: 2011

To investigate the roles of mutations in enhancer II (Enh II) and basal core promoter (BCP) of hepatitis B virus (HBV) in hepatocellular carcinoma (HCC), we determined the sequence of Enh II/BCP in 152 HCC and 136 non-HCC patients from a highincidence area of East China. A longitudinal study was conducted on 21 cases in which serial plasma samples were available before HCC. In total, six point mutations, including T1653, V1753, T1762, A1764, T1766 and A1768, were found to occur more frequently in HCC patients. Multivariate analysis showed that the T1653 [odds ratio (OR), 2.07; 95% confidence interval (CI), 1.114-3.845] and V1753 (OR, 3.099; 95% CI, 1.520-6.317) were independent factors that were associated with HCC. Although a T1762/A1764 double mutation was found in 73.0% of the HCC patients and 66.9% of the non-HCC patients, if the combined pattern with other adjacent mutations was not taken into account, it alone showed a lower frequency in HCC patients compared with non-HCC patients (19.7 versus 34.6%, P 5 0.005). Interestingly, while the OR of HCC patients with a double mutation was only 0.393 (95% CI, 0.234-0.660), it increased to 1.861 (95% CI, 1.161-2.984) with a triple mutation and to 4.434 (95% CI, 1.630-12.063) with a quadruple mutation. The longitudinal study demonstrated that the mutations in Enh II/BCP accumulated during the development of HCC. In conclusion, the T1653 and V1753 mutations were independent risk factors for HCC in East China. The T1762/A1764 double mutation was necessary but not sufficient to produce an association between Enh II/BCP mutations and HCC. © The Author 2010. Published by Oxford University Press. All rights reserved.

Wang Z.,Soochow University of China | Huang X.,Shanghai Ruijin Hospital Luwan Branch | Cao J.,Shanghai Dahua Hospital | Huang G.,Shanghai JiaoTong University | And 3 more authors.
CardioVascular and Interventional Radiology | Year: 2012

Objective This study was designed to compare the clinical effectiveness of intraluminal radioactive stent loaded with iodine-125 seeds implantation versus covered stent alone insertion in patients with malignant esophageal stricture. Methods We studied two groups of patients with malignant esophageal stricture. Group A comprised 28 patients (19 men and 9 women) who underwent intraluminal radioactive stent loaded with iodine-125 seeds implantation and were followed prospectively. Group B comprised 30 patients (18 men and 12 women) who had previously received covered stent alone insertion; these patients were evaluated retrospectively. There was no crossover between the two groups during follow-up. Informed consent was obtained from each patient, and our institutional review board approved the study. The dysphagia score, overall survival rates, complication rates, and reintervention rates were compared in the two groups. Results There were no significant differences between the two groups in terms of baseline characteristics. Stent placement was technically successful and well tolerated in all patients. The dysphagia score was improved in both groups after stent placement. The median survival was significantly longer in group A than in group B: 11 versus 4.9 months, respectively (P<0.001). The complications of chest pain, esophageal reflux, and stent migration was more frequent in group B, but this difference did not reach statistical significance. There was no statistical difference in reintervention between two groups. Conclusions Intraluminal radioactive stent loaded with iodine-125 seeds implantation was a feasible and practical management in treating malignant esophageal stricture and was superior to covered stent alone insertion, as measured by survival. © 2011 Springer Science+Business Media, LLC and the Cardiovascular and Interventional Radiological Society of Europe (CIRSE).

Xiao J.,Shanghai Normal University | Zhao Y.,Shanghai Normal University | Wang H.,Shanghai Dahua Hospital | Yuan Y.,Shanghai Dahua Hospital | And 3 more authors.
Integrative Biology | Year: 2011

The molecular structure/property-affinity relationships of dietary polyphenols non-covalently binding to total plasma proteins of type II diabetes (IIDTPP) were investigated by comparing the binding constants obtained from the fluorescence titration method. An additional methoxy group in flavonoids increased their binding affinities for IIDTPP by 1.38 to 15.85 times. The hydroxylation at the 4′ position (Ring B) of flavonols and the 5 position (Ring A) of isoflavones weakened the binding affinities; however, hydroxylation at other positions on flavonoids slightly enhanced or little affected the binding affinities for IIDTPP. The glycosylation of flavonoids slightly decreased or little affected the affinities for IIDTPP by less than 1 order of magnitude. The hydrogenation of the C2C3 double bond of flavone, 6-hydroxyflavone, 6-methoxyflavone and myricetin decreased the binding affinities. The galloylation of catechins significantly improved the binding affinities with IIDTPP approximately 10 to 1000 times. The esterification of gallic acid increased its binding affinity. The hydrophobic force played an important role in the binding interaction between polyphenols and IIDTPP. © 2011 The Royal Society of Chemistry.

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