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Zhong W.-G.,Shanghai Changning District Maternity and Infant Health Hospital | Ge X.-Y.,Hebei North University | Ge X.-Y.,Shanghai University | Zhu H.,Shanghai Putuo District Maternity and Children Healthcare Hospital | And 5 more authors.
International Journal of Clinical and Experimental Medicine | Year: 2015

Purpose: Postoperative nausea and vomiting (PONV) is a common complication after gynecological surgeries. This meta-analysis was conducted to evaluate the efficacy of dexmedetomidine on PONV after gynecological surgeries. Methods: Three main electronic databases including Pub Med, Embase and Cochrane Central Register of Controlled Trials for randomized controlled trials (RCTs) were searched by two researchers independently. The metaanalysis was completed using Review Manager. Results: Eleven RCTs with 692 patients were included in this metaanalysis. Dexmedetomidine a bridged postoperative nausea [Risk Ratio (RR)=0.59, 95% confidence interval (CI): 0.44 to 0.79] and vomiting [RR=0.48, 95% CI: 0.36 to 0.64] compared with placebo. Despite of higher incidence of intra operative bradycardia [RR 2.87, 95% CI 1.08 to 7.58] and hypotension [RR 4.26, 95% CI 1.43 to 12.69], we found significant decrease in postoperative shivering [RR 0.23, 95% CI 0.13 to 0.40] and pruritus [RR 0.40, 95% CI 0.17 to 0.93] in dexmedetomidine group, as well as the pain scores [standard mean difference (SMD)-0.96, 95% CI-1.37 to-0.54]. Significant reductions in the need for intraoperative fentanyl (RR 0.10, 95% CI 0.01-0.76, I2 0%), antiemetic (RR 0.62, 95% CI 0.39-0.99, I2 0%) and postoperative analgesic (RR 0.18, 95% CI 0.08-0.42, I2 0%) were also elicited. Conclusions: The current meta-analysis exhibits that dexmedetomidine is superiority to placebo in attenuating the incidence of PONV, postoperative shivering, pruritus, as well as the pain scores in patients undergoing gynecological surgeries. Still, the potential cardiovascular complications should be taken seriously. © 2015, E-Century Publishing Corporation. All rights reserved. Source


Bing L.,Shanghai Changning District Maternity and Infant Health Hospital | Jinping X.,Shanghai Changning District Maternity and Infant Health Hospital | Xuejun Z.,Shanghai Changning District Maternity and Infant Health Hospital | Zhongying W.,Shanghai Changning District Maternity and Infant Health Hospital | Haiyun Z.,Shanghai Changning District Maternity and Infant Health Hospital
Cancer Research and Clinic | Year: 2014

Objective: To investigate the expression of heat shock protein 5 (HSPA5) in breast carcinoma and to study its relationship with clinical and pathological factors. Methods: HSPA5 from 97 cases of breast carcinoma and 40 cases of adjacent tissues of breast carcinoma were examined by immunohistochemical method. Results: The overall positive rate of HSPA5 in 97 cases of breast cancer was 81.4 % (79/97). The positive rates of HSPA5 in cancer tissues and paired normal tissues were 32.5 % (13/40) and 7.5 % (3/40), respectively. The expression rate of HSPA5 in tumor tissues was significantly higher than that in normal tissues (χ2 = 7.813, P = 0.038). The expression of HSPA5 in breast carcinoma was correlated with histologic grade and lymph node metastasis (χ2 = 22.233, P = 0.007; χ2 = 5.342, P = 0.024). Conclusion: The occurrence of breast carcinoma and the formation of invasion may be related with overexperssion of HSPA5. Source


Zhao X.-J.,Shanghai Changning District Maternity and Infant Health Hospital | Xu J.-P.,Shanghai Changning District Maternity and Infant Health Hospital | Li B.,Shanghai Changning District Maternity and Infant Health Hospital | Qi J.-L.,Shanghai Changning District Maternity and Infant Health Hospital | And 3 more authors.
Chinese Journal of Pathology | Year: 2012

Objective To investigate the relationship between pathological abnormalities of placenta and small-for-gestational-age neonates.Methods One hundred placentas of small-for-gestational-age (SGA group) and 200 appropriate-for-gestational-age (AGA group) with single living birth in third trimester were investigated by gross and microscopic examination.The AGA placentas were collected from 2 cases following every SGA placenta.All cases were collected from Shanghai Changning District Maternity and Infant Health Hospital from January 2010 to December 2011.Results The gestational week, neonatal birth weight, full-term neonatal birth weight, the preterm birth rate and vaginal spontaneous delivery rate were significantly lower in SGA group than that in AGA group (P<0.002).Full-term placental volume, placental weight and fetal placental weight ratio were lower in SGA group than that in AGA group ( P<0.05).Unusual insertion and torsion of umbilical cord were more common in SGA group ( P <0.05).Syncytial knots increase, avascular villi and villous infarcts were significantly higher in SGA group ( P<0.005), but there were no significant difference between SGA group and AGA group in intervillous thrombi, chronic villitis and chorangiosis ( P > 0.05).Gestational hypertension disease and abnormality of fetal monitoring were more common in SGA group ( P<0.05).Conclusions Gestational hypertension disease is the main clinical cause of SGA.Some placental abnormality can affect the growth and development of intrauterine fetus. Source

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