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Zhang P.,Shanghai University | Zhang P.,Zhejiang University | Zhang P.,Shanghai Allist Pharmaceuticals Inc. | Han H.,Shanghai University
Colloids and Surfaces A: Physicochemical and Engineering Aspects | Year: 2012

Compact PEGylated polymer-caged quantum dots were prepared by covalently cross-linking the surface ligands using bifunctional poly(ethylene glycol). CdSe/ZnSe/ZnS quantum dots prepared in organic solvent via conventional synthesis method were firstly transferred to water phase by surface ligands exchange with glutathione molecules, and then cross-linked by bifunctional PEG through the carboxyl-amine coupling by carbodiimide method. Compared with small molecules capped QDs, polymer-caged QDs using PEG crosslinker have shown improved colloidal and pH stability, lower cell toxicity and non-specific binding, and still maintain compact hydrodynamic diameters (<15. nm) and monodispersity. This surface crosslinking strategy can also be used to improve the stability of other similar nanoparticles. © 2012 Elsevier B.V.

Shanghai Allist Pharmaceuticals Inc. | Date: 2013-01-17

The present invention refers to aminoheteroaryl compounds of the following formula (I) as well as the preparation method and use thereof, wherein R

Shanghai Allist Pharmaceuticals Inc. | Date: 2011-10-27

The present invention relates to a C-aryl glucoside derivative of Formula (I) below, a preparation method therefor and a use thereof, wherein X, R

The present invention relates to polymorphic forms of N-{4-[3-chloro-4-(3-fluoro-benzyloxy)phenylamino]-quinazolin-6-yl}-acrylamide p-toluenesulfonate with the characteristic X-ray powder diffraction data as stated in the description, preparation methods thereof, pharmaceutical compositions comprising the same and the use thereof.

Shanghai Allist Pharmaceuticals Inc. | Date: 2011-06-14

he present invention has disclosed a compound of formula I and a pharmaceutically acceptable salt or a solvate thereof, wherein the substituents are as defined in the description. The invention has also disclosed a method for preparing the compound of formula I, the pharmaceutical compositions comprising the same and their uses in the preparation of an anti-tumor medicament.

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