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He T.-X.,Shanghai University of Traditional Chinese Medicine | Cheng Y.-W.,Shanghai Academy of Traditional Chinese Medicine
Journal of Acupuncture and Tuina Science | Year: 2013

In order to understand clinical research advance on palpation for cervical 'vertebral subluxation', we have retrieved, sorted and analyzed relevant literature on 'vertebral subluxation' palpation from database both home and abroad. The study has suggested that static palpation is the major method for cervical 'vertebral subluxation' palpation and motion palpation for cervical segmental mobility has great clinical significance. However, there is no sufficient evidence or 'gold standard' regarding motion palpation. As a result, the future research priority should be put on rigorous clinical studies according to evidence-based diagnostic trial design. This can help to assess palpation method for 'vertebral subluxation' objectively, scientifically and practically, thus providing standardized palpation procedures for spinal manipulation. © 2013 Shanghai Research Institute of Acupuncture and Meridian and Springer-Verlag Berlin Heidelberg. Source


Li X.,Shanghai University of Traditional Chinese Medicine | Li X.,Boston University | Kong L.,Shanghai Academy of Traditional Chinese Medicine | Li F.,Shanghai University of Traditional Chinese Medicine | And 6 more authors.
PLoS ONE | Year: 2015

Psoriasis is considered a systemic inflammatory disorder. Previous studies have reported conflicting positive or negative correlations between psoriasis and chronic obstructive pulmonary disease. We performed a meta-analysis to determine whether there is an associated risk between psoriasis and chronic obstructive pulmonary disease. We performed a complete 30-year literature search of MEDLINE, Embase, and Cochrane Central Register databases on this topic. Four observational studies with a total of 13,418 subjects were identified. The odds ratios of chronic obstructive pulmonary disease in subjects with psoriasis/ mild-to-moderate psoriasis were analyzed using the random-effects model, while the odds ratios of chronic obstructive pulmonary disease in subjects with severe psoriasis and current smoking in subjects with psoriasis were analyzed using the fixed-effect model. We found that psoriasis patients were at a greater risk of developing chronic obstructive pulmonary disease than the general population (odds ratio, 1.90; 95% confidence interval, 1.36- 2.65) and that the association between of psoriasis and with chronic obstructive pulmonary disease was stronger among patients with severe psoriasis (odds ratio, 2.15; 95% confidence interval, 1.26-3.67). Psoriasis patients should be advised to cease smoking to reduce their risk of COPD. Moreover, identification of this potential risk may enable earlier implementation of preventive measures for reduction comorbidity and mortality rates. ©2015 Li et al.This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Source


Guo H.-L.,Shanghai University of Traditional Chinese Medicine | Wang X.,Shanghai Academy of Traditional Chinese Medicine | Xu Y.,Shanghai Academy of Traditional Chinese Medicine | Zhan H.-S.,Shanghai Academy of Traditional Chinese Medicine | Zhao Y.-F.,Shanghai Academy of Traditional Chinese Medicine
Journal of Clinical Rehabilitative Tissue Engineering Research | Year: 2010

BACKGROUND: Type I collagen is a specific collagen secreted by in vitro cultured osteoblast, and the formed network is the basis of bone mineralization, which also reflects the ability of osteoblast bone formation. Studies have shown astragalus root increased osteoblast proliferation. However, the effect of astragalus root on improving type I collagen expression of osteoblast remains poorly understood. OBJECTIVE: To evaluate the effect of astragalus root injection on the abilities of rat cranium-derived osteoblast proliferation and type I collagen expression. METHODS: Rat osteoblast was cultured in vitro and divided into control group (MEM culture solution containing calf serum) and astragalus root groups (different concentrations). The effect on osteoblast proliferation was evaluated on days 1, 3, 5, 7, and 9 by MTT method. Moreover, the expression of type I collagen protein was observed after 6 hours of treatment with astragalus root injection using in cell western-blot method. In addition, the gene expression of COLLa1 was investigated by real-time PCR method. RESULTS AND CONCLUSION: From days 3 to 9, the different concentrations of astragalus root injection improved osteoblast proliferation, respectively compared with control group (P < 0.05), and this ascending trend peaked on day 7. Different concentrations of astragalus root injection improved COLLa1mRNA expression, especially 15% astragalus root injection was the most effective. The type I collagen protein expression of 15% and 10% astragalus root injection were significantly greater compared with the control group (P < 0.05). Astragalus root injection improved in vitro cultured osteoblast proliferation and type I collagen secretion in a certain dose-effect manner. Source


Kong L.J.,Shanghai University of Traditional Chinese Medicine | Kong L.J.,Shanghai Academy of Traditional Chinese Medicine | Fang M.,Shanghai University of Traditional Chinese Medicine | Zhan H.S.,Shanghai University of Traditional Chinese Medicine | And 4 more authors.
Evidence-based Complementary and Alternative Medicine | Year: 2012

Non-specific low back pain (NLBP) is an increasing health problem for athletes. This randomized controlled trial was designed to investigate the effects of Chinese massage combined with herbal ointment for NLBP. 110 athletes with NLBP were randomly assigned to experimental group with Chinese massage combined with herbal ointment or control group with simple massage therapy. The primary outcome was pain by Chinese Short Form McGill Pain Questionnaire (C-SFMPQ). The secondary outcome was local muscle stiffness by Myotonometer. After 4 weeks, the experimental group experienced significant improvements in C-SFMPQ and in local muscle stiffness compared with control group (between-group difference in mean change from baseline, -1.24 points, P=0.005 in sensory scores; -3.14 points, P<0.001 in affective scores; -4.39 points, P<0.001 in total scores; -0.64 points, P=0.002 in VAS; -1.04 points, P=0.005 in local muscle stiffness during relaxation state). The difference remained at one month followup, but it was only significant in affective scores (-2.83 points, P<0.001) at three months followup. No adverse events were observed. These findings suggest that Chinese massage combined with herbal ointment may be a beneficial complementary and alternative therapy for athletes with NLBP. © 2012 Ling Jun Kong et al. Source


Pang J.,Shanghai University of Traditional Chinese Medicine | Pang J.,Shanghai Academy of Traditional Chinese Medicine | Ye M.,Shanghai University of Traditional Chinese Medicine | Gu X.,Shanghai Academy of Traditional Chinese Medicine | And 6 more authors.
Rejuvenation Research | Year: 2015

Objective: It is known that bone healing is delayed in the presence of osteoporosis in humans. However, due to the complexities of the healing of osteoporotic fractures, animal models may be more appropriate for studying the effects of osteoporosis in more detail and for testing drugs on the fracture repair process. The purpose of this study was to investigate the influence of ovariectomy-induced osteopenia in bone healing in an open femoral osteotomy model, and to test the feasibility of this model for evaluating the healing process under osteopenic conditions. Methods: Ovariectomized (OVX) mouse models were employed to assess the effects of osteopenia on fracture healing, A mid-shaft femur osteotomy model was also established 3 weeks after ovariectomy as an osteopenic fracture group (OVX group). Femurs were then harvested at 2 weeks and 6 weeks after fracture for X-ray radiography, micro-computed tomography (micro-CT), histology, and biomechanical analysis. A sham-operated group (sham group) was used for comparison. Results: The OVX mice had significantly lower bone volume density (BVF), volumetric bone mineral density (vBMD), and tissue mineral density (TMD) in the fracture calluses at 6 weeks (p<0.05), and similar trend was observed in 2 weeks. Additionally, larger calluses in OVX animals were observed via micro-CT and X-ray, but these did not result in better healing outcomes, as determined by biomechanical test at 6 weeks. Histological images of the healing fractures in the OVX mice found hastening of broken end resorption and delay of hard callus remodeling. The impaired biomechanical measurements in the OVX group (p<0.05) were consistent with micro-CT measurements and radiographic scoring, which also indicated delay in fracture healing of the OVX group. Conclusions: This study provided evidence that ovariectomy-induced osteopenia impair the middle and late bone healing process. These data also supported the validity of the mouse femoral osteotomy model in evaluating the process of bone healing under osteopenic conditions. © 2015, Mary Ann Liebert, Inc. Source

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