Jinan, China


Jinan, China
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Yang L.,ShandongUniversity | Bovet P.,University of Lausanne | Liu Y.,Shandong University | Zhao M.,ShandongUniversity | And 3 more authors.
American Journal of Public Health | Year: 2017

Objectives. To compare consumption of carbonated soft drinks among young adolescents in 53 low-and middle-income countries (LMICs). Methods. We used 2009 to 2013 Global School-based Student Health Survey data to assess 137 449 young adolescents aged 12 to 15 years with available data (via a standardized questionnaire) on frequency of carbonated soft drink consumption. Results. Overall, young adolescents reported having consumed carbonated soft drinks 1.39 times per day (95% confidence interval [CI] = 1.26, 1.51), and 54.3% of adolescents reported consuming a carbonated soft drink at least once per day. Frequency (times per day) varied greatly across countries, ranging from 0.52 (95% CI = 0.43, 0.60) in Kiribati to 2.39 (95% CI = 2.25, 2.53) in Suriname. Conclusions.Ourdata confirmthat consumption of carbonated soft drinks is frequentamong young adolescents in LMICs.Ourfindings highlight the need for interventions in these countries to reduce adolescents' carbonated soft drink consumption.

Chang W.,ShandongUniversity | Li Y.,ShandongUniversity | Zhang L.,ShandongUniversity | Cheng A.,ShandongUniversity | And 2 more authors.
Biological and Pharmaceutical Bulletin | Year: 2012

Candida albicans is one of the most prevalent human opportunistic pathogens. C. albicans undergoes a yeast-to-hyphal transition that has been identified as a virulence factor as well as a critical element for mature biofilm formation. A previous study in our lab showed retigeric acid B (RAB), a lichen derived pentacyclic triterpenoid, displayed synergistic antifungal activity with azoles. We now showed that this combination also proved to be adequate in combating the formation of hyphae in vitro. In vivo tests with mice demonstrated RAB could markedly enhance the efficacy of fluconazole to promote the host's longevity through inhibiting hyphae formation and adherence to host cells. It was also observed that RAB and azoles interacted synergistically to block the formation of biofilm. Our data suggested the attenuated yeast-to-hyphal switch contributed to the defect of mature biofilm formation. Moreover, quantitative real-time polymerase chain reaction (qPCR) analysis showed RAB could reduce the transcript level of MDR1, a multidrug efflux pump, and caused a slight transcriptional reduction for another drug pump related gene CDR1. Taken together, our work provides a potential application to combat candidiasis using the combination of RAB and azoles. © 2012 The Pharmaceutical Society of Japan.

Yuan J.,ShandongUniversity | Yuan J.,Shandong University of Science and Technology | Zhang X.,ShandongUniversity | Zhang C.,ShandongUniversity | And 2 more authors.
Ceramics International | Year: 2016

In this study, high density NiAl/WC composite was successfully fabricated by a novel in-situ synthesis thermal explosion reaction method using Ni, Al and WC commercial powders as starting materials. In-situ synthesis of NiAl/WC composites requires the thermal explosion(TE) reaction to be ignited and fully controlled to maintain the geometry of the compressed parts. The temperature profiles were measured to monitor the reaction process. The results show that increasing WC content can increase the ignition temperature and decrease the maximum temperature in the synthesis process. Single phase NiAl can be produced by this new process regardless of the addition of WC. Microhardness of the products were tested to evaluate the performance of the synthesized composites. This work offers a low cost approach to NiAl/WC composites due to the very low synthesis temperature and extremely short processing time. © 2016 Elsevier Ltd and Techna Group S.r.l.

Zhang H.,ShandongUniversity | Liu Z.,ShandongUniversity | Xin F.,ShandongUniversity | Hao A.,ShandongUniversity
Chinese Journal of Organic Chemistry | Year: 2012

The synthesis, development and application of the new supramolecular host - pillar[n]arene in recent four years are reviewed. Two main synthetic strategies were employed in the synthesis of pillar[n]arene and its derivatives: "firstly cyclization then modification" and "firstly modification then cyclization". Owing to its special conformational structures and physical and chemical properties, pillar[n]arene has been mainly applied to the fields such as host-guest complex and molecular recognition, construction of assembly and smart materials. © 2012 Chinese Chemical Society & SIOC, CAS.

Liu X.,ShandongUniversity | Jiao Y.,ShandongUniversity | Cui B.,ShandongUniversity | Gao X.,Yuhuangding Hospital | And 2 more authors.
Lupus | Year: 2016

Objective The objective of this study was to investigate whether hepatitis B virus (HBV) infection plays a role in the regulation of autoimmunity for systemic lupus erythematosus (SLE). Method A total of 21 female BALB/c mice and 21 female HBV transgenic BALB/c mice aged two months were randomly divided into four groups: BALB/c mice, HBVTg mice, pristane-injected BALB/c mice, and pristane-injected HBVTg mice. BALB/c mice and HBVTg mice were given an intraperitoneal injection of 0.5 ml normal saline, and the mice in the other two groups were given an intraperitoneal injection of 0.5 ml pristane. ANA and anti-dsDNA levels in serum were detected by indirect immunofluorescence. Interleukin 2 (IL-2), IL-4, IL-6, IL-17, and TNF-α were measured by Luminex technology. The serum BAFF level was measured using an Elisa kit. Twenty-four weeks after pristane administration, kidneys were removed, dissected, and stained with hematoxylin and eosin and periodic-acid Schiff. Result At six months after injecting, the ANA titers in pristane-injected HBVTg mice were significantly lower than pristane-injected BALB/c mice. IL-17, TNF-α, and BAFF levels were significantly higher in pristane-injected BALB/c mice than BALB/c mice and pristane-injected HBVTg mice. IL-2, IL-4, and IL-6 levels were much higher in pristane-injected HBVTg mice than pristane-injected BALB/c mice. In pristane-injected HBVTg mice and HBVTg mice, fewer glomerulonephritis changes were found in the kidneys. Conclusions Our results showed that the incidence of SLE was much lower in HBVTg mice, and that HBV infection helped the SLE mice survive high levels of inflammatory cytokines and severe renal damage. All these findings demonstrated the protective role of HBV in SLE patients via the immunoregulatory networks of the cytokines. © The Author(s), 2016.

Yu W.T.,ShandongUniversity | Li H.W.,ShandongUniversity | Liu S.Q.,ShandongUniversity | Zhang Y.P.,ShandongUniversity
Advanced Materials Research | Year: 2013

The maglev blower used in sewage treatment, which power is 115kW, speed up to 20000rpm, for plain bearing blower speed 6-8 times, volume is only 1/4 of the plain bearing and the noise is less than 80dB. The controller uses a DSP and FPGA dual-core controller to complete. DSP process the rotor suspension signal with digital bandstop filter program and improved PID program, FPGA complete the current signal amplification. Two chip via custom protocol to complete the data transfer. It is successful application of the controller that used in the magnetic bearing blower.

Yu W.,ShandongUniversity | Liu S.,ShandongUniversity | Li H.,ShandongUniversity
Applied Mechanics and Materials | Year: 2012

Three-level power amplifier with the characteristics of a small ripple, Aimed at existing situations of the three-level power amplifier without ASIC chips, a new three-level power amplifier circuit based on FPGA(Field Programmable Gate Array) is presented. Detailed analysis the principle of the three-level power amplifier, According to the principle, the FPGA internal composition and function of each module is designed, programmed using VHDL Language, functional simulated and validated by Modelsim which is specialized simulation software. The actual production of the three-level power amplifier is experimental testing for a step signal and sinusoidal signal. Test results show that the current response of AMB coil is fast and the current track is good. Finally, industrial successful applications in the Active magnetic bearing spindle. © (2012) Trans Tech Publications, Switzerland.

Liu X.,Shandong University | Huang X.,Shandong University | Chen L.,Shandong University | Zhang Y.,Shandong University | And 6 more authors.
International Journal of Biochemistry and Cell Biology | Year: 2015

Hypertension can increase mechanical stretch on the vessel wall, an important stimulus that induces collagen remodeling. Prolyl-4-hydroxylaseα1 (P4Hα1) and matrix metalloproteinases (MMPs) are essential for collagen synthesis and degradation. However, the effect of mechanical strain and collagen synthesis remains largely unknown. This study aimed to identify the effect of stretch on MMPs and P4Hα1 and the involved signaling pathways. Human aortic smooth muscle cells (HASMCs) were stimulated with mechanical stretch (0, 10% and 18% strain), and production of P4Hα1 as well as production and gelatinolytic activity of MMP-2 was force-dependently increased. Mechanical stretch at 18% also increased the expression of type I and III collagen and the phosphorylation of Akt, p38 mitogen-activated protein kinase (MAPK) and c-Jun N-terminal kinase (JNK). MMP-2 production and activity enhanced by 18% stretch were inhibited by the PI3K/Akt inhibitor LY294002. Blockade of p38 MAPK or JNK inhibited the promoting effect of stretch on P4Hα1. The in vivo model of aortic banding showed increased protein levels of MMP-2, P4Hα1 and collagen I and III in the aorta. Thus, mechanical stretch increased MMP-2 and P4Hα1 expression in HASMCs via AKT-P38 MAPK-JNK signaling, thereby inducing vascular remodeling. © 2015 Published by Elsevier Ltd.

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