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Jinan, China

Liu X.,Shandong University | Huang X.,Shandong University | Chen L.,Shandong University | Zhang Y.,Shandong University | And 6 more authors.
International Journal of Biochemistry and Cell Biology | Year: 2015

Hypertension can increase mechanical stretch on the vessel wall, an important stimulus that induces collagen remodeling. Prolyl-4-hydroxylaseα1 (P4Hα1) and matrix metalloproteinases (MMPs) are essential for collagen synthesis and degradation. However, the effect of mechanical strain and collagen synthesis remains largely unknown. This study aimed to identify the effect of stretch on MMPs and P4Hα1 and the involved signaling pathways. Human aortic smooth muscle cells (HASMCs) were stimulated with mechanical stretch (0, 10% and 18% strain), and production of P4Hα1 as well as production and gelatinolytic activity of MMP-2 was force-dependently increased. Mechanical stretch at 18% also increased the expression of type I and III collagen and the phosphorylation of Akt, p38 mitogen-activated protein kinase (MAPK) and c-Jun N-terminal kinase (JNK). MMP-2 production and activity enhanced by 18% stretch were inhibited by the PI3K/Akt inhibitor LY294002. Blockade of p38 MAPK or JNK inhibited the promoting effect of stretch on P4Hα1. The in vivo model of aortic banding showed increased protein levels of MMP-2, P4Hα1 and collagen I and III in the aorta. Thus, mechanical stretch increased MMP-2 and P4Hα1 expression in HASMCs via AKT-P38 MAPK-JNK signaling, thereby inducing vascular remodeling. © 2015 Published by Elsevier Ltd. Source

Yu W.,ShandongUniversity | Liu S.,ShandongUniversity | Li H.,ShandongUniversity
Applied Mechanics and Materials | Year: 2012

Three-level power amplifier with the characteristics of a small ripple, Aimed at existing situations of the three-level power amplifier without ASIC chips, a new three-level power amplifier circuit based on FPGA(Field Programmable Gate Array) is presented. Detailed analysis the principle of the three-level power amplifier, According to the principle, the FPGA internal composition and function of each module is designed, programmed using VHDL Language, functional simulated and validated by Modelsim which is specialized simulation software. The actual production of the three-level power amplifier is experimental testing for a step signal and sinusoidal signal. Test results show that the current response of AMB coil is fast and the current track is good. Finally, industrial successful applications in the Active magnetic bearing spindle. © (2012) Trans Tech Publications, Switzerland. Source

Zhang H.,ShandongUniversity | Liu Z.,ShandongUniversity | Xin F.,ShandongUniversity | Hao A.,ShandongUniversity
Chinese Journal of Organic Chemistry | Year: 2012

The synthesis, development and application of the new supramolecular host - pillar[n]arene in recent four years are reviewed. Two main synthetic strategies were employed in the synthesis of pillar[n]arene and its derivatives: "firstly cyclization then modification" and "firstly modification then cyclization". Owing to its special conformational structures and physical and chemical properties, pillar[n]arene has been mainly applied to the fields such as host-guest complex and molecular recognition, construction of assembly and smart materials. © 2012 Chinese Chemical Society & SIOC, CAS. Source

Yu W.T.,ShandongUniversity | Li H.W.,ShandongUniversity | Liu S.Q.,ShandongUniversity | Zhang Y.P.,ShandongUniversity
Advanced Materials Research | Year: 2013

The maglev blower used in sewage treatment, which power is 115kW, speed up to 20000rpm, for plain bearing blower speed 6-8 times, volume is only 1/4 of the plain bearing and the noise is less than 80dB. The controller uses a DSP and FPGA dual-core controller to complete. DSP process the rotor suspension signal with digital bandstop filter program and improved PID program, FPGA complete the current signal amplification. Two chip via custom protocol to complete the data transfer. It is successful application of the controller that used in the magnetic bearing blower. Source

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