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Ni Y.,Shandong UniversityShandong | Le K.,Shandong UniversityShandong | Du W.,Shandong University | Fang W.,Shandong UniversityShandong | And 4 more authors.
Sensors and Actuators, B: Chemical | Year: 2017

The Sb2O5 modified SnO2 porous nanocomposites serving as NO2 gas sensing material have been successfully synthesized through a facile hydrothermal method followed by a calcination process. The porous Sb2O5/SnO2 nanocomposites display a dominant pore size of ca. 20 nm and specific surface area of 37.2 m2 g−1, which can provide large contact area for the chemical adsorption of NO2 molecules and abundant channels for the import and export of NO2 gas. Gas sensing tests demonstrated that the as-prepared porous Sb2O5/SnO2 nanocomposites (1 mol% Sb2O5) achieved superior sensing performances including high selectivity to NO2, low optimal operating temperature (ca. 100 °C), high response (800–5 ppm NO2), and short response and recovery times (20 s and 70 s to 5 ppm NO2, respectively). Comparing with pure SnO2 porous structure, the enhanced gas sensing performances of the porous Sb2O5/SnO2 nanocomposites are mainly ascribed to the p-n junctions generated from the hybrid of n-type SnO2 with p-type Sb2O5, which not only improved the response and selectivity to NO2 gas, but also reduced the operating temperature. © 2017 Elsevier B.V.


Long M.,Arizona Cancer Center | Long M.,Chongqing Medical University | Tao S.,Arizona Cancer Center | De La Vega M.R.,Arizona Cancer Center | And 6 more authors.
Cancer Prevention Research | Year: 2015

The progressive nature of colorectal cancer and poor prognosis associated with the metastatic phase of the disease create an urgent need for the development of more efficacious strategies targeting colorectal carcinogenesis. Cumulative evidence suggests that the redox-sensitive transcription factor Nrf2 (nuclear factor-E2-related factor 2), a master regulator of the cellular antioxidant defence, represents a promising molecular target for colorectal cancer chemoprevention. Recently, we have identified cinnamon, the ground bark of Cinnamomum aromaticum (cassia cinnamon) and Cinnamomum verum (Ceylon cinnamon), as a rich dietary source of the Nrf2 inducer cinnamaldehyde (CA) eliciting the Nrf2-regulated antioxidant response in human epithelial colon cells, conferring cytoprotection against electrophilic and genotoxic insult. Here, we have explored the molecular mechanism underlying CA-induced Nrf2 activation in colorectal epithelial cells and have examined the chemopreventive potential of CA in a murine colorectal cancer model comparing Nrf2+/+ with Nrf2-/- mice. In HCT116 cells, CA caused a Keap1-C151-dependent increase in Nrf2 protein half-life via blockage of ubiquitination with upregulation of cytoprotective Nrf2 target genes and elevation of cellular glutathione. After optimizing colorectal Nrf2 activation and target gene expression by dietary CA-supplementation regimens, we demonstrated that CA suppresses AOM/DSS-induced inflammatory colon carcinogenesis with modulation of molecular markers of colorectal carcinogenesis. Dietary suppression of colorectal cancer using CA supplementation was achieved in Nrf2+/+ but not in Nrf2-/- mice confirming the Nrf2 dependence of CA-induced chemopreventive effects. Taken together, our data suggest feasibility of colorectal cancer suppression by dietary CA, an FDA-approved food additive derived from the third most consumed spice in the world. ©2015 AACR.


Wang Y.,University of Chinese Academy of Sciences | Zhang Y.,University of Chinese Academy of Sciences | Schauer J.J.,University of Wisconsin - Madison | de Foy B.,Saint Louis University | And 2 more authors.
Science of the Total Environment | Year: 2016

The Beijing government and its surrounding provinces implemented a series of measures to ensure haze-free skies during the 22nd Asia-Pacific Economic Cooperation (APEC) conference (November 10th–11th, 2014). These measures included restrictions on traffic, construction, and industrial activity. Twelve hour measurements of the concentration and composition of ambient fine particulate matter (PM2.5) were performed for 5 consecutive months near the APEC conference site before (September 11th–November 2nd, 2014), during (November 3rd–12th, 2014) and after (November 13th, 2014–January 31st, 2015). The measurements are used in a positive matrix factorization model to determine the contributions from seven sources of PM2.5: secondary aerosols, traffic exhaust, industrial emission, road dust, soil dust, biomass burning and residual oil combustion. The source apportionment results are integrated with backward trajectory analysis using Weather Research and Forecast (WRF) meteorological simulations, which determine the relative influence of new regulation and meteorology upon improved air quality during the APEC conference. Data show that controls are very effective, but meteorology must be taken into account to determine the actual influence of the controls on pollution reduction. The industry source control is the most effective for reducing concentrations, followed by secondary aerosol and biomass controls, while the least effective control is for the residual oil combustion source. The largest reductions in concentrations occur when air mass transport is from the west-northwest (Ulanqab). Secondary aerosol and traffic exhaust reductions are most significant for air mass transport from the north-northwest (Xilingele League) origin, and least significant for northeast transport (Chifeng via Tangshan conditions). The largest reductions of soil dust, biomass burning, and industrial source are distinctly seen for Ulanqab conditions and least distinct for Xilingele League. © 2016 Elsevier B.V.


Wang S.,Shandong University | Wang X.,Shandong UniversityShandong | Guo Q.,Shandong University | Wang G.,Shandong University | And 4 more authors.
Technology in Cancer Research and Treatment | Year: 2016

This study investigated the biological effects of microRNA-126 overexpression in human MG63 osteosarcoma cells. A recombinant plasmid expressing microRNA-126, pcDNA6.2-microRNA-126, was constructed and transfected into MG63 cells. Using real-time fluorogenic quantitative polymerase chain reaction, the microRNA-126 expression was measured in microRNA-126-MG63 group, Ctrl-MG63 group, and blank group. Cell proliferation, cell cycle distribution, cell migration, and invasion were analyzed using methyl thiazolyl tetrazolium assay, flow cytometer, wound-healing assay, and transwell assay, respectively. As expected, microRNA-126 expression was higher in microRNA-126-MG63 group than in Ctrl-MG63 group and blank group (both P <.05). After 48/72 hours of transfection, cell proliferation in microRNA-126-MG63 group was significantly reduced compared to blank group (both P <.05). Compared to blank group, cell population in G0/G1 stage was significantly higher in microRNA-126-MG63 group, accompanied by lower cell numbers in the S and G2/M phases and decreased proliferation index (all P <.05). Wound-healing assay showed a wider scratch width in microRNA-126-MG63 group and reduced cell migration than blank group (both P <.05). Cells overexpressing microRNA-126 exhibited reduced ADAM9 expression levels compared to other 2 groups (all P <.05), suggesting ADAM9 is a target of microRNA-126. Cell proliferation, migration, and invasion rates were reduced in microRNA-126 group after 48/72 hours of transfection, compared with blank group (all P <.05). Cotransfection of pcDNA6.2-microRNA-126 and pMIR-ADAM9 into MG63 cells led to higher cell proliferation, invasion, and migration rates, compared with transfection of pcDNA6.2-microRNA-126 alone (all P <.05). In summary, our data show that microRNA-126 inhibits cell proliferation, migration, and invasion in human osteosarcoma cells by targeting ADAM9. © 2015, © The Author(s) 2015.


Li J.,Shandong UniversityShandong | Li J.,Taian Central Hospital | Han T.,Shandong University | Xu L.,Taian Central Hospital | Luan X.,Taian Central Hospital
Przeglad Gastroenterologiczny | Year: 2015

Introduction: A number of studies have shown that diabetes mellitus is implicated in susceptibility to several cancers. However, the relationship between diabetes and cholangiocarcinoma remain unclear. Aim: To quantitatively assess the relationship between diabetes and incidence of cholangiocarcinoma in cohort and case-control studies. Material and methods: A literature search was performed for entries from 1996 to 2014 using the PubMed and EMBASE databases. Studies were included if they reported odds ratios (OR) and corresponding 95% CI of cholangiocarcinoma with respect to diabetes mellitus. Results: Twenty studies met the inclusion criteria, which included fifteen case-control studies and five cohort studies from Asia (n = 11), the United States (n = 5), and Europe (n = 4). Compared with individuals without diabetes, the pooled OR of cholangiocarcinoma was 1.74 (95% CI: 1.62-1.87, p = 0.568 for heterogeneity) for patients with diabetes, ICC (summary RR, 1.93; 95% CI: 1.65-2.25; p = 0.037 for heterogeneity), and ECC (summary RR, 1.66; 95% CI: 1.39-1.98; p = 0.001 for heterogeneity). The funnel plot revealed no evidence for publication bias concerning diabetes and the risk of CC (including ICC and ECC). Conclusions: The findings from this meta-analysis suggest that diabetes may increase the risk of cholangiocarcinoma. This relationship needs to be confirmed by further follow-up studies. © 2015, Termedia Publishing House Ltd. All rights reserved.


Qiu G.-Z.,Shandong UniversityShandong | Tian W.,Linyi Oncosurgical HospitalShandong | Fu H.-T.,Shandong UniversityShandong | Li C.-P.,Eye Institute of XuzhouJiangsu | Liu B.,Tongji University
Biochemical and Biophysical Research Communications | Year: 2016

Microvascular dysfunction is an important characteristic of diabetic retinopathy. Long non-coding RNAs (lncRNAs) play important roles in diverse biological processes. In this study, we investigated the role of lncRNA-MEG3 in diabetes-related microvascular dysfunction. We show that MEG3 expression level is significantly down-regulated in the retinas of STZ-induced diabetic mice, and endothelial cells upon high glucose and oxidative stress. MEG3 knockdown aggravates retinal vessel dysfunction in vivo, as shown by serious capillary degeneration, and increased microvascular leakage and inflammation. MEG3 knockdown also regulates retinal endothelial cell proliferation, migration, and tube formation in vitro. The role of MEG3 in endothelial cell function is mainly mediated by the activation of PI3k/Akt signaling. MEG3 up-regulation may serve as a therapeutic strategy for treating diabetes-related microvascular complications. © 2016 Elsevier Inc. All rights reserved.


Wang D.,Linyi UniversityShandong | Wang D.,Shandong UniversityShandong | Chen L.,Linyi UniversityShandong | Chen L.,Shandong UniversityShandong | And 3 more authors.
Physical Chemistry Chemical Physics | Year: 2015

From first-principles calculations, the effects of h-BN and AlN substrates on the topological nontrivial properties of stanene are studied with different strains. We find that the quantum spin Hall phase can be induced in stanene film on a h-BN substrate under a tensile strain of between 6.0% and 9.3% with a stable state confirmed by the phonon spectrum, while for stanene on 5 × 5 h-BN, the quantum spin Hall phase can be preserved without strain. However, for stanene on a AlN substrate, the quantum spin Hall phase cannot be found under compressive or tensile strains less than 10%, while for 2 × 2 stanene on 3 × 3 AlN, the compressive strain needed to induce the quantum spin Hall phase is just 2%. These theoretical results will be helpful in understanding the effect of substrate and strain on stanene and in further realizing the quantum spin Hall effect in stanene on semiconductor substrates. This journal is © the Owner Societies.


Li G.,Shandong UniversityShandong | Kong L.,Shandong UniversityShandong | Zhou H.,Peoples Hospital of LiaochengShandong | Kang X.,Shandong UniversityShandong | And 2 more authors.
Sleep Medicine | Year: 2016

Objective To examine the relationship between prenatal maternal stress, resilience, and sleep quality, and to determine whether resilience plays a mediating role in the relationship between prenatal maternal stress and sleep quality among pregnant women. Methods Two hundred and thirty-one pregnant women in their second trimester participated in the study. They completed questionnaires, including: the Pittsburgh Sleep Quality Index (PSQI), the Pregnancy Stress Rating Scale (PSRS), and the 10-item Connor-Davidson Resilience Scale (CD-RISC-10). A structural equation model was used to analyze the relationships among prenatal maternal stress, resilience, and sleep quality, with resilience as a mediator. Results Prenatal maternal stress was negatively associated with sleep quality in pregnant women (p < 0.01), whereas resilience was positively associated with sleep quality (p < 0.01). Furthermore, resilience mediated the relationship between prenatal maternal stress and sleep quality, and the mediation effect ratio was 22.0% (p < 0.01). Conclusions The risk factor for disturbed sleep was pregnancy-specific stress; however, the protective factor for sleep quality was resilience. This finding could provide scientific evidence for the development of intervention strategies with which to improve sleep quality in pregnant women. © 2016 Elsevier B.V.


Yang Y.,Saarland University | Shrestha Y.R.,ETH Zurich | Li W.,Changsha University | Guo J.,Shandong UniversityShandong
Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) | Year: 2016

In the k-Vertex-Disjoint Paths problem, we are given a graph G and k terminal pairs of vertices, and are asked whether there is a set of k vertex-disjoint paths linking these terminal pairs, respectively. In the k-Path problem, we are given a graph and are asked whether there is a path of length k. It is known that both problems are NP-hard even in split graphs, which are the graphs whose vertices can be partitioned into a clique and an independent set. We study kernelization for the two problems in split graphs. In particular, we derive a 4k vertex-kernel for the k-Vertex-Disjoint Paths problem and a 3/2k2+ ½k vertex-kernel for the k-Path problem. © Springer International Publishing Switzerland 2016.


Xu C.,Qingdao University | Yin X.,Shandong UniversityShandong | Sun X.,Qingdao University | Xing J.,Qingdao University | Sun Y.,Qingdao University
International Journal of Clinical and Experimental Medicine | Year: 2016

Baicalein is a medicinal herb and has various biological activities. Our present work aimed to evaluate the protective effect of baicalein on sepsis-associated encephalopathy (SAE) and further probe the potential mechanisms. SAE model was prepared using cecal ligation and puncture in mice. Animals were treated with saline or baicalein by doses of 10, 20 and 40 mg/kg for seven consecutive days. Neuronal function was assessed with the Open Field tests, Morris Water Maze task and Y Maze tests. The serum ammonia levels were measured after SAE. Besides, malondialdehyde (MDA) contents and the activities of catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GSH-PX) and inducible nitric oxide synthase (iNOS) activities were also detected using respective commercial kits. Detection of NO production was conducted using Griess reagent. No significance was found in Open Field test. However, the cognitive deficits were remarkably improved in SAE-induced mice after baicalein treatment based on the results of Morris Water Maze and Y Maze tests. Meanwhile, baicalein didn’t alter the serum ammonia levels in SAE-induced mice. But baicalein significantly suppressed oxidative stress, the protein levels of iNOS and NO production while the protein expressions of BDNF was found to be markedly enhanced in mice with SAE after baicalein treatment. It was concluded that baicalein reversed cognitive deficits in a mouse model of SAE via suppressing oxidative stress and iNOS-mediated NO production and activating BDNF/TrkB signaling. © 2016, E-Century Publishing Corporation. All rights reserved.

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