Shandong Qidu Pharmaceutical Co.

China

Shandong Qidu Pharmaceutical Co.

China
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Zhai H.-M.,Shandong Qidu Pharmaceutical Co. | Feng L.,Occupational Disease Prevention Hospital in the City of Zibo | Yu C.-A.,Shandong Qidu Pharmaceutical Co. | Wu H.-J.,Shandong Qidu Pharmaceutical Co. | Wang X.,Shandong Qidu Pharmaceutical Co.
Chinese Journal of Pharmaceutical Biotechnology | Year: 2014

The colon-specific drug delivery system (OCDDS) is defined as a drug delivery system that could make the orally administered drug not release in the gastrointestinal tract segment, but in the cecum in response to some physiological factors in the colon. Novel OCDDS has the advantages of the targeted, controlled-release, realizating the treatment of colorectal localized disease and avoiding hepatic first-pass effect. OCDDS can be divided into four categories, including the pH-dependent, the time-dependent, the pressure-controlled and the enzymatic-type, base on the mechanism. At present, those formulations are able to realize oral colon-specific delivery mainly including pellets, tablets, capsules, hydrogels and microspheres. In this review, the mechanisms for colon-specific drug delivery and the commonly used support materials for colon-specific delivery were addressed. Besides, the main formulations for colon-specific drug delivery were fully discussed in detail with an expectation to contribute to the clinical research and development of OCDDS. © 2014, Editorial Board of Pharmaceutical Biotechnology. All right reserved.


Zhang T.,Shandong University | Zhang T.,Shandong Qidu Pharmaceutical Co. | Zhai M.,Shandong Qidu Pharmaceutical Co. | Ji J.,Shandong University | And 3 more authors.
Bioorganic and Medicinal Chemistry Letters | Year: 2017

Ebola virus is one of the most threatening pathogens with the mortality rate as high as 90% in the world. There are no licensed therapeutic drugs or preventive vaccines for Ebola hemorrhagic fever up to date. Favipiravir, a novel antiviral drug which was mainly used for the treatment of influenza, now has been demonstrated to have a curative effect in treating Ebola virus infection. In this review, we present an overview of recent progress on the treatment of Ebola virus disease with Favipiravir and describe its possible mechanism. Moreover, we give a brief summary of other related treatment strategies against Ebola. © 2017 Elsevier Ltd.


Ye Y.,Shandong University | Zhang T.,Shandong University | Zhang T.,Shandong Qidu Pharmaceutical Co. | Yuan H.,Shandong University | And 3 more authors.
Journal of Medicinal Chemistry | Year: 2017

Betulin and betulinic acid have been widely studied for their anticancer activities. However, their further development is limited due to low bioavailability, poor aqueous solubility, and limited intracellular accumulation. In the present study, a triphenylphosphonium cation moiety was linked to betulin and betulinic acid to specifically target them to cancer cell mitochondria. Biological characterization established that uptake of mitochondria-targeted compound 1a in the mitochondria of cancer cells was increased compared to betulin. The mitochondria-targeted derivatives of betulin and betulinic acid showed stronger cytotoxicity than their parent drugs and exhibited more cytotoxic effects in cancer cells than normal cells. The mechanisms may involve the mitochondrial apoptotic pathway, probably caused by the induction of reactive oxygen species production and reducing mitochondrial membrane potential. More importantly, 1a significantly inhibited cancer cell proliferation and migration in an in vivo zebrafish xenograft model. Collectively, these results encourage further study of 1a analogs as anticancer agents. © 2017 American Chemical Society.


Fan P.,Shandong University | Zhang T.,Shandong Qidu Pharmaceutical Co. | Hostettmann K.,University of Geneva
Journal of Traditional and Complementary Medicine | Year: 2013

Polygonum cuspidatum Sieb. and Zucc. has been traditionally used as a member of many anti-inflammatory polyherbal formulations, but is now a widespread invasive neophyte in Europe and America. To discuss if the invasive variety is chemically identical to the native one in traditional medicine, the different constituents of the invasive variety compared to the native variety were isolated and their anti-inflammatory activity was tested. Resveratroloside and catechin-(4α→8)-catechin, the newly found constituents in the invasive variety, have similar nitric oxide (NO) inhibition potency as that of piceid (the major constituent of P. cuspidatum), but the newly found major constituent, i.e., piceatannol glucoside, showed no apparent effect. On the other hand, as a marker, the total content of resveratrol in the methanol root extract after glucosidase hydrolysis was measured and compared between the invasive and native varieties. The total content of resveratrol measured in the root extracts of the Swiss sample was about 2.5 times less than that of the Chinese one. This study brings attention to the point that when the invasive variety of P. cuspidatum is used in traditional medicine, the chemical difference should be kept in mind. Copyright © 2013 Committee on Chinese Medicine and Pharmacy, Taiwan.


Wang X.-J.,Weifang Medical University | Duan Y.,Weifang Medical University | Li Z.-T.,Shandong Qidu Pharmaceutical Co. | Feng J.-H.,Shandong Academy of Sciences | And 4 more authors.
Asian Pacific Journal of Cancer Prevention | Year: 2014

Multi-target drug design, in which drugs are designed as single molecules to simultaneously modulate multiple physiological targets, is an important strategy in the field of drug discovery. QT-011, a tamibarotene-furoxan derivative, was here prepared and proposed to exert synergistic effects on antileukemia by releasing nitric oxide and tamibarotene. Compared with tamibarotene itself, QT-011 displayed stronger antiproliferative effects on U937 and HL-60 cells and was more effective evaluated in a nude mice U937 xenograft model in vivo. In addition, QT-011 could release nitric oxide which might contribute to the antiproliferative activity. Autodocking assays showed that QT-011 fits well with the hydrophobic pocket of retinoic acid receptors. Taken together, these results suggest that QT-011 might be a highly effective derivative of tamibarotene and a potential candidate compound as antileukemia agent.


Fu H.,Shandong University | Han L.,Shandong University | Hou X.,Shandong University | Dun Y.,Shandong University | And 3 more authors.
Bioorganic and Medicinal Chemistry | Year: 2015

We report the development of a novel series of saccharin-based N-hydroxybenzamides as histone deacetylases inhibitors. Among them, 6j exhibited potent HDACs inhibitory activity against Hela nuclear extract. Further biological evaluation found 6i showed similar antiproliferative activities in vitro compared with the approved SAHA. © 2015 Elsevier Ltd.


PubMed | Shandong Qidu Pharmaceutical Co. and Shandong University
Type: Journal Article | Journal: Bioorganic & medicinal chemistry | Year: 2015

We report the development of a novel series of saccharin-based N-hydroxybenzamides as histone deacetylases inhibitors. Among them, 6 j exhibited potent HDACs inhibitory activity against Hela nuclear extract. Further biological evaluation found 6 i showed similar antiproliferative activities in vitro compared with the approved SAHA.

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