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Yan X.,Shandong Provincial Medical Center for Dermatovenereology Shandong | Yu C.,Shandong Provincial Medical Center for Dermatovenereology Shandong | Yu C.,Shandong Provincial Institute of Dermatology and Venereology | Shi Z.,Shandong Provincial Medical Center for Dermatovenereology Shandong | And 4 more authors.
Pediatric Dermatology | Year: 2013

A healthy 10-year-old Chinese boy developed verrucous plaques on the nose. The fungus was identified as Fusarium moniliforme via culture of biopsy fragments. The patient had normal immune status and was successfully treated with oral itraconazole (100 mg/day) for 2 months and application of oral itraconazole and topical sertaconazole nitrate cream. Fusarium is a ubiquitous hyalohyphomycete isolated from food that is also widespread in the environment and is present at all latitudes. Infections due to this mold may be disseminated or localized. Fusarium species have been known to colonize the cornea, nails, and burn eschars in otherwise healthy patients. Cutaneous and disseminated infections have been reported mostly in immunocompromised hosts. Here we describe an unusual case of localized infection caused by Fusarium moniliforme in an otherwise healthy child, with significant improvement after 2 months of oral itraconazole and topical sertaconazole nitrate cream therapy. © 2013 Wiley Periodicals, Inc. Source


Yang B.,Shandong Academy of Sciences | Yang B.,Shandong Provincial Key Laboratory for Dermatovenereology | Wang C.,Shandong Academy of Sciences | Wang C.,Shandong Provincial Key Laboratory for Dermatovenereology | And 11 more authors.
Australasian Journal of Dermatology | Year: 2014

A 22-year-old primigravida had a pruritic, erythematous, bullous eruption on the skin during the 26th week of gestation. After delivery the eruption flared up. The diagnosis of pemphigoid gestationis was confirmed based on histopathological and immunofluorescence findings. The result of immunoblotting showed IgG autoantibodies which reacted against BP230 in epidermal extracts and 290 kDa type VII collagen in dermal extracts. The BP180 antibodies were also detected by an enzyme-linked immunosorbent assay BP180NC16a diagnosis kit. Pulsed corticosteroid and cyclophosphamide resulted in a favourable response at the acute stage. The patient was cured in 2 years. The analysis of the patient's autoantibodies provides strong evidence for the involvement of epitope spreading in her autoimmune disease. © 2012 The Australasian College of Dermatologists. Source

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