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Gao Q.,Shanghai University | Zhang Z.-H.,Shandong Provincial Institute for Food and Drug Control | Lu F.,Shanghai University
Guang Pu Xue Yu Guang Pu Fen Xi/Spectroscopy and Spectral Analysis | Year: 2012

In the present paper, four kinds of cluster analysis methods were used in rapid, non-destructive discrimination of hypoglycemic tablets by the Raman spectroscopy technology. Nine kinds of hypoglycemic tablets, including 48 samples, were determined using a Raman spectrometer. The sample data were pretreated with the methods of frequency range cutting, baseline correction, smoothing and vector normalization, then were analyzed by K-means, hierachical cluster, self-organizing maps(SOM) and PCA-SOM respectively. The results demonstrated that SOM was better than K-means and hierachical cluster, and it provided the best discrimination when combined with PCA. The research offers a new approach to the rapid discrimination of different kinds of hypoglycemic tablets.


Wang W.-J.,Shandong Provincial Institute for Food and Drug Control | Li T.,Shandong Provincial Institute for Food and Drug Control | Li J.,Shandong Provincial Institute for Food and Drug Control | Liu Q.,Shandong Provincial Institute for Food and Drug Control | Xie Y.-C.,Shandong Provincial Institute for Food and Drug Control
Yaoxue Xuebao | Year: 2012

The study aims to identify the degradation products of levofloxacin by HPLC-MS. The degradation products of levofloxacin were chromatographed on Agilent Zorbax Extend-C18 column (250 mm x 4.6 mm, 5 μm). The mobile phase was 0.1% ammonium acetate solution (using methanoic acid to adjust to pH 3.5)-acetonitrile at the flow rate of 0.5 mL·min-1 (gradient elution), the column temperature was 40°C. Descarboxyl levofloxacin, desmethyl levofloxacin and levofloxacin N-oxide were identified through comparing with the standard spectrum and the results of mass spectrometry, i.e. m/z 318.2 was descarboxyl levofloxacin, m/z 348.2 was desmethyl levofloxacin, m/z 378.1 was levofloxacin-N-oxide. This method is simple, fast, accurate and suitable for the identification of degradation products of levofloxacin.

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