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Ma L.,Fudan University | Xiang L.-H.,Fudan University | Yu B.,Peking University | Yin R.,Chongqing Medical University | And 12 more authors.
Photodiagnosis and Photodynamic Therapy | Year: 2013

Objectives: To investigate the efficacy and safety of low-concentration 5-aminolevulinic acid photodynamic therapy (ALA-PDT) in the treatment of different severity of acne vulgaris and optimize the treatment regimen. Methods: A self-controlled multicenter clinical trial was carried out in 15 centers throughout China. A total of 397 acne patients of grade II-IV received 3- or 4-session PDT treatment. 5% ALA gel was applied topically to acne lesions for 1h incubation. The lesions were irradiated by a LED light of 633nm at dose levels of 96-120J/cm2. Clinical assessment was conducted before and after every treatment up to 8 weeks. Results: The effective rate overall and of grade II, III and IV are 82.1%, 71.6%, 79.6% and 88.2%, respectively. The effective rate rises significantly proportionally to the severity of acne (P<. 0.01). No significant differences are found in the efficacy between patients received 3-session and 4-session PDT treatments (P>. 0.05). The count of inflammatory and non-inflammatory acne lesions gradually decrease after each treatment (P<. 0.01) and during the 8-week follow up (P<. 0.01 or P<. 0.05). Maximum efficacy is obtained at 8 weeks after the treatment completion. Conclusions: A low-dose topical ALA-PDT regimen using 5% ALA, 1. h incubation and red light source of 3 treatment sessions is suggested as optimal scheme for the treatment of different severity of acne vulgaris in Chinese patients. Superior efficacy is found in severe cystic acne of grade IV with mild side effects. © 2013 Elsevier B.V.. Source


Yang B.,Shandong Academy of Sciences | Yang B.,Shandong Provincial Key Laboratory for Dermatovenereology | Wang C.,Shandong Academy of Sciences | Wang C.,Shandong Provincial Key Laboratory for Dermatovenereology | And 11 more authors.
Australasian Journal of Dermatology | Year: 2014

A 22-year-old primigravida had a pruritic, erythematous, bullous eruption on the skin during the 26th week of gestation. After delivery the eruption flared up. The diagnosis of pemphigoid gestationis was confirmed based on histopathological and immunofluorescence findings. The result of immunoblotting showed IgG autoantibodies which reacted against BP230 in epidermal extracts and 290 kDa type VII collagen in dermal extracts. The BP180 antibodies were also detected by an enzyme-linked immunosorbent assay BP180NC16a diagnosis kit. Pulsed corticosteroid and cyclophosphamide resulted in a favourable response at the acute stage. The patient was cured in 2 years. The analysis of the patient's autoantibodies provides strong evidence for the involvement of epitope spreading in her autoimmune disease. © 2012 The Australasian College of Dermatologists. Source


Liu H.,Shandong Provincial Institute of Dermatology and Venereology | Liu H.,Shandong Provincial Key Laboratory for Dermatovenereology | Fu X.-A.,Shandong Provincial Institute of Dermatology and Venereology | Fu X.-A.,Shandong Provincial Key Laboratory for Dermatovenereology | And 13 more authors.
Clinical and Experimental Dermatology | Year: 2011

Dyschromatosis symmetrica hereditaria (DSH) is a rare, autosomal dominant dermatosis, characterized by a mixture of hyperpigmented and hypopigmented macules on the dorsa of the hands and feet. The DSH locus has been mapped to chromosome 1q21, and in 2003, pathogenic mutations were identified in the ADAR1 (adenosine deaminase acting on RNA1) gene. In this study, we performed mutation detection of the ADAR1 gene in two Chinese families with DSH. PCR and direct sequencing of the ADAR1 gene were used to identify and confirm the mutations in the two families. Furthermore, we analysed the RNA transcripts by reverse transcriptase (RT)-PCR. Two aberrant splice products were confirmed with RT-PCR and DNA direct sequence analysis. These novel findings further extend our understanding of the role of ADAR1 in DSH. © 2011 British Association of Dermatologists. Source


Yang B.,Shandong Academy of Sciences | Yang B.,Shandong Provincial Key Laboratory for Dermatovenereology | Wang C.,Shandong Academy of Sciences | Wang C.,Shandong Provincial Key Laboratory for Dermatovenereology | And 13 more authors.
Pediatric Dermatology | Year: 2012

Epidermolysis bullosa acquisita (EBA) is a rare, acquired, subepidermal blistering disease characterized by autoantibodies directed against type VII collagen, the major component of anchoring fibrils. We report a 5-year-old Chinese boy who presented with extensive lesions consisting of disseminated pruritic vesicles and tense blisters. The diagnosis of EBA was confirmed by histopathology, immunofluorescence, and immunoblotting analysis. The disease was controlled with a combination of prednisone and dapsone. © 2012 Wiley Periodicals, Inc. Source


Jiang H.-W.,Shandong Academy of Sciences | Jiang H.-W.,Shandong Provincial Key Laboratory for Dermatovenereology | Tian H.-Q.,Shandong Provincial Hospital for Skin Diseases | Tian H.-Q.,Shandong Provincial Medical Center for Dermatovenereology | And 9 more authors.
International Journal of Infectious Diseases | Year: 2011

Background: Syphilis is a sexually transmitted infection (STI) caused by the Treponema pallidum subspecies pallidum spirochete bacterium. The association of human leukocyte antigen (HLA) with syphilis has been reported in several populations, but not in the Chinese population. Furthermore, serology methods have mostly been used in previous studies investigating the association between STIs and HLA alleles. The objective of this study was to analyze the association of the HLA-DRB1 alleles and susceptibility to syphilis in the Chinese population. Methods: A polymerase chain reaction with sequence-specific primers (PCR-SSP) method was used to genotype HLA-DRB1 alleles in 196 syphilis patients and 500 healthy controls. Results: The HLA-DRB1z.ast;14 allele was more prevalent in syphilis patients than in the healthy controls (p= 0.013; corrected p< 0.05). Conclusions: The allele HLA-DRB1*14 was found to be associated with susceptibility to syphilis in the Chinese population. © 2011 International Society for Infectious Diseases. Source

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