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Wei Y.-C.,Shandong Cancer Hospital and Institute | Wei Y.-C.,Shandong University | Hu X.,Shandong Cancer Hospital and Institute | Gao Y.,Shandong Cancer Hospital and Institute | And 8 more authors.
PLoS ONE | Year: 2015

Purpose: To explore the value of a new simple lyophilized kit for labeling PRGD2 2peptide (18F-ALF-NOTA-PRGD2, denoted as 18F-alfatide) in the determination of metabolic tumor volume (MTV) with micro-PET in lewis lung carcinoma (LLC) tumor-bearing C57BL/6 mice verified by pathologic examination and compared with those using 18F-fluorodeoxyglucose (FDG) PET. Methods: All LLC tumor-bearing C57BL/6 mice underwent two attenuation-corrected whole-body micro-PET scans with the radiotracers 18F-alfatide and 18F-FDG within two days. 18F-alfa-tide metabolic tumor volume (VRGD) and 18F-FDG metabolic tumor volume (VFDG) were manually delineated slice by slice on PET images. Pathologic tumor volume (VPath) was measured in vitro after the xenografts were removed. Results: A total of 37 mice with NSCLC xenografts were enrolled and 33 of them underwent 18F-alfa-tide PET, and 35 of them underwent 18F-FDG PET and all underwent pathological examination. The mean ± standard deviation of VPath, VRGD, and VFDGwere 0.59±0.32 cm3(range, 0.13∼1.64 cm3), 0.61 ±0.37 cm3(range, 0.15∼1.86 cm3), and 1.24±0.53 cm3(range, 0.17∼2.20 cm3), respectively. VPathvs. VRGD, VPathvs. VFDG, and VRGDvs. VFDGcomparisons were t = -0.145, P = 0.885, t = -6.239, P<0.001, and t = -5.661, P<0.001, respectively. No significant difference was found between VPathand VRGD.VFDGwas muchlarger than VRGDand VPath. VRGDseemed more approximate to the pathologic gross tumor volume. Furthermore, VPathwas more strongly correlated with VRGD(R = 0.964, P<0.001) than with VFDG(R = 0.584, P<0.001). Conclusions: 18F-alfatide PET provided a better estimation of gross tumor volume than 18F-FDG PET in LLC tumor-bearing C57BL/6 mice. Copyright: © 2015 Wei et al. Source

Zhao B.,Shandong University | Abdelmoudjib G.,Shandong University | Li J.,Shandong University | Li H.,Shandong Province Hospital | And 3 more authors.
International Journal of Immunogenetics | Year: 2011

The gene family of the T cell immunoglobulin and mucin domain (TIM) proteins encodes cell surface receptors that are involved in the regulation of Th1- and Th2-cell-mediated immunity. TIM-1 gene has been found to be associated with asthma in several populations. TIM-4, the natural ligand for TIM-1, may influence the susceptility to asthma.To investigate the association of the TIM-4 gene polymorphisms with asthma in a Chinese Han population. Three single nucleotide polymorphisms (SNPs) in TIM-4 gene, rs6882076, rs12658558 and rs4702747, were genotyped in 551 unrelated asthma patients and 549 healthy controls. We found that two SNPs of the TIM-4 gene, rs6882076 and rs4702747, were associated with asthma susceptibility in our study population (with P-values = 0.009 and 0.005 respectively). No association was observed between asthma and rs12658558. Our results suggest that TIM-4 gene polymorphisms are associated with asthma in a Chinese Han population. © 2010 Blackwell Publishing Ltd. Source

Zhong H.,Shandong University | Gan J.,Shandong University | Zhao Y.,Shandong University of Traditional Chinese Medicine | Xu Z.,Shandong Medical Imaging Research Institute | And 3 more authors.
American Journal of Roentgenology | Year: 2011

OBJECTIVE. Popliteal vascular entrapment syndrome is an uncommon congenital abnormality of the anatomic relations between the popliteal vessels and the neighboring musculotendinous structures. The purpose of this essay is to describe the CT angiographic findings in the diagnosis and treatment of this syndrome. CONCLUSION. Digital subtraction angiography is of limited value in the evaluation of popliteal vascular entrapment syndrome and has been replaced by noninvasive imaging techniques, such as Doppler sonography, CT angiography, MRI, and MR angiography. © American Roentgen Ray Society. Source

Li Q.,Shandong University | Li W.-W.,Tokyo Medical University | Yang X.,Shandong Province Hospital | Fan W.-B.,Unit of Digestive Disease | And 6 more authors.
International Journal of Cancer | Year: 2012

Type 2 diabetes has been suggested as an independent risk factor for the development of hepatocellular carcinoma (HCC). However, the role of Type 2 diabetes on the development of HCC in the presence of chronic hepatitis B (CHB) remains inconclusive. We conducted this hospital-based case - control study to evaluate the roles of Type 2 diabetes in HCC development in patients with CHB. From January 2004 to December 2008, a total of 6,275 eligible consecutive patients with chronic hepatitis B virus (HBV) infection were recruited. A total of 1,105 of them were patients with HBV-related HCC and 5,170 patients were CHB but without HCC. We used multivariate logistic regression models to investigate the association between Type 2 diabetes and HCC risk. The prevalence of Type 2 diabetes is higher among HCC patients without cirrhosis than among those with cirrhosis (12.1% vs. 6.7%, p = 0.003). Type 2 diabetes was associated with a significantly high risk of HCC in female patients after adjusting for age, family history of HCC, city of residence, hepatitis B e antigen and cirrhosis with an odds ratio (95% confidence interval, CI) of 1.9 (1.1-3.4). Restricted analyses among female patients without cirrhosis indicated that Type 2 diabetes was strongly associated with HCC risk with adjusted odds ratio (95% CI) of 5.6 (2.2-14.1). In conclusion, Type 2 diabetes is independently associated with the increased risk of HCC in female CHB patients. Female CHB patients with Type 2 diabetes are of a high HCC risk population and should be considered for HCC close surveillance program. © 2011 UICC. Source

Sun M.,Shandong University | Su X.,Shandong University | Ding B.,Shandong University | He X.,Affiliated Hospital of Shandong Medical Institution | And 4 more authors.
Nanomedicine | Year: 2012

Curcumin (CUR), a bioactive component of turmeric, which is a commonly used spice and nutritional supplement, is isolated from the rhizomes of Curcuma longa Linn. (Zingiberaceae). In recent years, the potential pharmacological actions of CUR in inflammatory disorders, cardiovascular disease, cancer, Alzheimers disease and neurological disorders have been shown. However, the clinical application of CUR is severely limited by its main drawbacks such as instability, low solubility, poor bioavailability and rapid metabolism. Multifarious nanotechnology-based delivery approaches have been used to enhance the oral bioavailability, biological activity or tissue-targeting ability of CUR. This article reviews potential novel drug delivery systems for CUR including liposomes, polymeric nanoparticles, solid lipid nanoparticles, micelles, nanogels, nanosuspensions, nanoemulsions, complexes and dendrimer/dimer, which provide promising results for CUR to improve its biological activities. © 2012 Future Medicine Ltd. Source

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