Shandong Polytechnic Technician College

Liaocheng, China

Shandong Polytechnic Technician College

Liaocheng, China

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Guo Q.,Liaocheng University | Li L.,Liaocheng University | Dong J.,Liaocheng University | Dong J.,Shandong Polytechnic Technician College | And 3 more authors.
Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy | Year: 2013

A divanadium(V) complex, [V2O3(o-van-val) 2] (o-van-val = Schiff base derived from o-vanillin and l-valine), has been synthesized and structurally characterized. The crystal structure shows that both of the vanadium centers in the complex have a distorted octahedral coordination environment composed of tridentate Schiff base ligand. A V 2O3 core in molecular structure adopts intermediate between cis and trans configuration with the O1V1⋯V1AO1A torsion angle 115.22 (28)° and the V1⋯V1A distance 3.455 Å. The binding properties of the complex with calf thymus DNA (CT-DNA) have been investigated by UV-vis absorption, fluorescence, CD spectra and viscosity measurement. The results indicate that the complex binds to CT-DNA in non-classical intercalative mode. Meanwhile, the interaction of the complex with bovine serum albumin (BSA) has been studied by UV-vis absorption, fluorescence and CD spectra. Results indicated that the complex can markedly quench the intrinsic fluorescence of BSA via a static quenching process, and cause its conformational change. The calculated apparent binding constant Kb was 1.05 × 10 6 M-1 and the binding site number n was 1.18. © 2013 Elsevier B.V. All rights reserved.


Dong J.,Liaocheng University | Dong J.,Shandong Polytechnic Technician College | Li L.,Liaocheng University | Xu T.,Liaocheng University | Wang D.,Liaocheng University
Chinese Journal of Chemistry | Year: 2011

A new copper(II) complex, [Cu(naph-leu)phen]CH3OH·0. 5H2O, in which naph-leu is the tridentate Schiff base ligand derived from the condensation of 2-hydroxy-1-naphthaldehyde and L-leucine, phen is phenanthroline, has been synthesized and characterized by elemental analyses, IR spectra and single crystal X-ray diffraction. The DNA-binding properties of this complex have been investigated by absorption spectra, fluorescence spectra and circular dichroism (CD) spectra, as well as viscosity measurement. Results show that this copper(II) complex binds to calf thymus DNA (CT-DNA) in an intercalative mode and its intrinsic binding constant Kb is 4.87×103 L·mol-1. Furthermore, the DNA cleavage activity of this copper(II) complex has also been investigated by submarine gel electrophoresis. Interestingly, it was found that this complex can cleave the supercoiled plasmid pBR322 DNA to both nicked and linear forms. Copyright © 2011 SIOC, CAS, Shanghai & WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.


Liu H.,Liaocheng University | Li L.,Liaocheng University | Guo Q.,Liaocheng University | Dong J.,Shandong Polytechnic Technician College | Li J.,Liaocheng University
Transition Metal Chemistry | Year: 2013

A new Cr(III) complex, [CrCl(sal-gly)phen]·0.5H2O (sal-gly = Schiff base derived from salicylaldehyde and l-glycine), has been synthesized and characterized by physicochemical methods. There are two independent complex molecules and a water molecule in each asymmetric unit. Each Cr(III) atom is six-coordinated in a distorted octahedral coordination environment. In the crystal, a 3D network is formed via intermolecular hydrogen bonds. The interactions between the Cr(III) complex and calf thymus DNA (CT-DNA) and Bovine serum albumin (BSA) have been studied by spectroscopic methods. The results show that the complex binds to CT-DNA in an intercalative mode, and it can also bind to BSA and produce conformational changes in the protein. © 2013 Springer Science+Business Media Dordrecht.


Dong J.,Liaocheng University | Dong J.,Shandong Polytechnic Technician College | Li L.,Liaocheng University | Liu G.,Liaocheng University | And 2 more authors.
Journal of Molecular Structure | Year: 2011

A new copper(II) complex, [Cu(sal-l-val)phen] (sal-l-val = a Schiff base derived from salicylaldehyde and l-valine, phen = 1,10-phenanthroline), has been synthesized and characterized by elemental analysis, IR spectra and X-ray single crystal diffraction. Results show that this crystal structure of the copper(II) complex belongs to triclinic crystal system, P1 space group with crystallographic data: a = 10.3710(16) , b = 13.9350(19) , c = 16.670(2) , α = 79.970(2)°, β = 75.623(2)°, γ = 84.160(3)° and Z = 4. The copper(II) complex has four independent structures in the crystallographic asymmetric unit, three of them show distorted square-pyramidal and the fourth displays distorted trigonal bipyramid CuN3O 2 coordination geometry. In the crystal, π-π stacking and the intermolecular hydrogen bonds form two-dimensional network. The interactions between the copper(II) complex and calf thymus DNA(CT-DNA) have been studied by using UV, fluorescence and CD spectra, as well as viscosity and thermal denaturation measurements. Experiment results confirm that the copper(II) complex binds to CT-DNA in an intercalative mode. © 2010 Elsevier B.V. All rights reserved.


Dong J.F.,Shandong Polytechnic Technician College | Dong J.F.,Liaocheng University | Li L.Z.,Liaocheng University
Advanced Materials Research | Year: 2014

A new oxovanadium(IV) complex, [VO(o-van-phe)(phen)] (1) (o-van-phe = Schiff base derived from o-vanillin and L-phenylalanine, phen =1,10-phenanthroline), has been synthesized and characterized by elemental analysis, IR spectra and single crystal X-ray diffraction. The results show that complex 1 belongs to triclinic crystal system, with P-1 space group, a=10.646(2) Å, b=11.089(3) Å, c=14.143(4) Å, α=67.374(4)°, β=79.685(4)°, γ=89.711(4)°, Z=2, V=1512.5(7) Å3, Dc =1.195 mg·m–3, μ=0.366 mm–1, F(000)=562. In the molecular structure, the V(IV) ion is six coordinated to form a distorted octahedral geometry. In the crystal, a dimer is formed by intermolecular hydrogen bonding and π–π stacking interactions. © (2014) Trans Tech Publications, Switzerland.


Li L.,Liaocheng University | Guo Q.,Liaocheng University | Dong J.,Liaocheng University | Dong J.,Shandong Polytechnic Technician College | And 2 more authors.
Journal of Photochemistry and Photobiology B: Biology | Year: 2013

The DNA-binding properties and DNA-cleavage activities of a Cu(II) complex, [Cu(sal-tau(phen)]·1.5H2O (sal-tau = a Schiff base derived from salicylaldehyde and taurine, phen = 1,10-phenanthroline), have been investigated by using UV-Vis absorption, fluorescence, circular dichroism (CD) spectra and agarose gel electrophoresis. Results indicated that this Cu(II) complex can bind to calf thymus DNA (CT-DNA) via an intercalative mode and shows efficient cleavage activity in the absence and presence of reducer. Its intrinsic binding constant Kb (1.66 × 104 M -1) was calculated by absorption spectra and its linear Stern-Volmer quenching constant Ksq (3.05) was obtained from florescence spectroscopy, as well as the cleaving reaction rate constant k1 (2.0 × 10-4 s-1) was acquired from agarose gel electrophoresis. Meanwhile, the interactions of the complex with BSA have also been studied by spectroscopy. Results showed that the complex could quench the intrinsic fluorescence of bovine serum albumin (BSA) remarkably through a static quenching process, and induce a conformational change with the loss of helical stability of protein. © 2013 Elsevier B.V.


Li L.,Liaocheng University | Dong J.,Liaocheng University | Dong J.,Shandong Polytechnic Technician College | Li J.,Liaocheng University | And 2 more authors.
Transition Metal Chemistry | Year: 2011

A ternary Cu(II) complex, [Cu(naph-ser)(bipy)]·0.125CH 2Cl2 (naph-ser = a Schiff base derived from 2-hydroxy-1-naphthaldehyde and L-serine, bipy = 2,2-bipyridine), has been synthesized and structurally characterized. In the crystal structure, a supramolecular assembly with left-handed double helices is formed by O-H·O hydrogen bonding interactions. The DNA-binding properties and DNA-cleavage activity of the Cu(II) complex have been investigated by spectroscopic methods and agarose gel electrophoresis. The results indicate that the Cu(II) complex can bind to CT-DNA via an intercalative mode and shows efficient cleavage activity in the absence and presence of reducer. © Springer Science+Business Media B.V. 2011.


Jing B.,Shanxi Datong University | Jing B.,Liaocheng University | Li L.,Liaocheng University | Dong J.,Liaocheng University | And 3 more authors.
Transition Metal Chemistry | Year: 2011

A mixed-ligand Cu(II) complex, [Cu(o-van-ile)(phen)]•1.5H2O (o-van-ile = Schiff base derived from o-vanillin and l-isoleucine, phen = 1,10-phenanthroline), has been synthesized and structurally characterized. The crystal structure shows 1-D linear chains formed by C-H.O hydrogen bond interactions. The DNA-binding interactions of the Cu(II) complex with calf thymus DNA (CT-DNA) have been investigated by spectroscopic methods and agarose gel electrophoresis. The results indicate that the complex can bind to CT-DNA via an intercalative mode and show efficient cleavage activity in both the absence and presence of reducing agents. © 2011 Springer Science+Business Media B.V.


Bian L.,Liaocheng University | Li L.,Liaocheng University | Zhang Q.,Liaocheng University | Dong J.,Shandong Polytechnic Technician College | And 3 more authors.
Transition Metal Chemistry | Year: 2012

Two new V(IV) complexes, [VO(Naph- trp)(phen)].CH 3OH (1) and [VO(o-Van-trp)(phen)]- CH 3OH.H 2O (2) (Naph-Trp = Schiff base derived from 2-hydroxy-1-naphthaldehyde and L-tryptophan, o-Van- trp = Schiff base derived from o-vanillin and L-tryptophan, phen = 1,10-phenanthroline), have been synthesized and characterized by physicochemical methods. The V(IV) atoms in both complexes are six-coordinated in a distorted octahedral environment. In the crystals of complex 1, the C-H⋯p and p-p stacking interactions form a 1D chain structure, whereas for complex 2, hydrogen bonds connect the molecular units into a 2D plane structure. The DNA binding properties and cleavage efficiencies of the complexes have been investigated by spectroscopic methods, viscosity measurements and agarose gel electrophoresis. The results suggest that both complexes can bind to CTDNA in an intercalative mode and can also cleave pBR322 DNA. © Springer Science+Business Media Dordrecht 2012.


Li J.,Liaocheng University | Dong J.,Liaocheng University | Dong J.,Shandong Polytechnic Technician College | Cui H.,Liaocheng University | And 2 more authors.
Transition Metal Chemistry | Year: 2012

A new Cu(II) complex, [Cu(naph-val)phen] (naph-val = Schiff base derived from 2-hydroxy-1-naphthaldehyde and L-valine, phen = 1,10-phenanthroline), has been synthesized and characterized by physicochemical methods. The crystal structure of the complex showed that there are four independent molecular structures in the crystallographic asymmetric unit, and each of them shows a distorted square-pyramidal CuN 3O 2 coordination geometry. In the crystal, the π - π stacking and intermolecular hydrogen bonds form a 2D network. The interactions between the Cu(II) complex and calf thymus DNA (CT-DNA) have been studied by spectroscopic methods, as well as viscosity and thermal denaturation measurements. The results indicate that the Cu(II) complex binds to CT-DNA in an intercalative mode. The cleavage reaction on pBR322 plasmid DNA has been investigated by agarose gel electrophoresis in the absence and presence of mercaptopropionic acid. The Cu(II) complex exhibits an efficient DNA cleavage activity. © Springer Science+Business Media B.V. 2012.

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