Shandong Mental Health Center

China

Shandong Mental Health Center

China
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Guo W.-B.,University Institute of Mental Health | Liu F.,University of Electronic Science and Technology of China | Xun G.-L.,Shandong Mental Health Center | Hu M.-R.,University Institute of Mental Health | And 6 more authors.
Progress in Neuro-Psychopharmacology and Biological Psychiatry | Year: 2013

Background: It is unclear how patients with early onset depression (EOD) and late onset depression (LOD) differ at the neural level. Using amplitude of low-frequency fluctuations (ALFF) approach, we are to test the hypothesis of the different abnormal neural activities between patients with EOD and LOD. Methods: Fifteen patients with EOD, 15 patients with LOD, 15 young healthy subjects (HS) and 15 old HS were enrolled in the study. ALFF approach was employed to analyze the images. Results: ANOVA analysis revealed widespread differences in ALFF values among the four groups throughout frontal, parietal, temporal, occipital cortex, cerebellum and limbic regions. Compared to LOD group, EOD group had higher ALFF in bilateral precuneus, superior medial frontal gyrus and superior frontal gyrus, and lower ALFF in left brainstem and left superior temporal gyrus. Compared to young HS, lower ALFF in left superior/inferior temporal gyrus, left lingual gyrus and right middle occipital gyrus and higher ALFF in left medial frontal gyrus and bilateral superior frontal gyrus were seen in the EOD group; in contrast, in the LOD group, lower ALFF in bilateral superior frontal gyrus and higher ALFF in left superior temporal gyrus were observed. Further ROC analysis suggested that the mean ALFF values in the bilateral superior frontal gyrus and left superior temporal gyrus could serve as markers to separate patients with EOD from individuals with LOD. Conclusions: Patients with EOD and LOD exhibit reversal pattern of abnormal ALFF in bilateral superior frontal gyrus and left superior temporal gyrus. © 2012 Elsevier Inc.


He Y.,Guangxi Medical University | Han C.,Shandong Mental Health Center | Chang K.-F.,U.S. Center for Disease Control and Prevention | Wang M.-S.,Shandong Provincial Chest Hospital | Huang T.-R.,Guangxi Medical University
BMC Infectious Diseases | Year: 2017

Background: Currently, there is limited data on the risk factors associated with treatment delay in tuberculous meningitis (TBM). This study aimed to assess the duration of delay in the treatment TBM and to investigate its determinants. Methods: During the period from September 2009 to February 2016, a retrospective cohort study of consecutive TBM patients admitted to our hospital was conducted to determine the risk factors associated with treatment delay in TBM. Treatment delay duration was defined as the time interval from onset of symptoms (by patient recall) to initiation of treatment and was stratified into two categories: ≤ 20 days, >20 days (median delay day is 20 days). Data collected included demography, comorbidity, cerebrospinal fluid (CSF) examinations and others. Univariable and multivariable logistic regression analysis was used to evaluate the determinants of treatment delay. Results: A total of 161 TBM patients were included in our study, all were confirmed by CSF mycobacterial culture. The median treatment delay for all patients included in the study was 20 days [interquartile range, 14-60 days]. Multivariate analysis revealed that age (≤21 years old, OR = 0.202, 95% CI: 0.079, 0.521), fever (OR = 0.414, 95% CI: 0.180, 0.952), and headache (OR = 0.204, 95% CI: 0.095, 0.442) had significantly lower risk for treatment delay, while multiple healthcare contact (>3 times) (OR = 3.938, 95% CI: 1.326, 11.691) as well as CSF chloride (>111 mmol/L) (OR = 2.479, 95% CI: 1.143, 5.377) had significantly higher risk of the delay. Conclusions: Our findings indicate that multiple healthcare contact and high CSF chloride predict the risk of long delay, while young age, fever and headache are associated with short delay. Maintained focus on awareness of TBM in the population and in healthcare systems, and continuous implementation of diagnostic methods for TBM to detect the disease early, may reduce the mortality and morbidity. © 2017 The Author(s).


He Y.,Guangxi Medical University | Han C.,Shandong Mental Health Center | Chang K.-F.,U.S. Center for Disease Control and Prevention | Wang M.-S.,Shandong Provincial Chest Hospital | Huang T.-R.,Guangxi Medical University
International Journal of Clinical and Experimental Pathology | Year: 2017

Background: The diagnostic value of GenoType MTBDRplus assay hasn't been validated in smear-negative retreated tuberculosis (TB) patients. Therefore, a retrospective study was conducted to evaluate it. Methods: Between Jun, 2013 and Sep, 2016, 35 retreatment TB patients were enrolled in the study. The phenotypic drug susceptibility test (DST) was evaluated using indirect proportion method with L-J medium. The GenoType MTBDRplus assay was done on culture specimens according to the manufacturer's instructions. The sensitivity, specificity, positive likelihood ratio and negative likelihood ratio of GenoType MTBDRplus assay in detection of isoniazid (INH)- and rifampicin (RIF)-resistance were calculated using the phenotypic DST assay as the gold standard. Results: The average age was 28.9 ± 11.3 years (range 5 to 61 years), 57.1% (21/35) were male. For detecting INH-resistance, the sensitivity, specificity, positive likelihood ratio and negative likelihood ratio of GenoType MTBDRplus assay were 94.1% (73.0%, 99.0%), 55.6% (33.7%, 75.4%), 2.12 (1.25, 3.60) and 0.106 (0.02, 0.74), respectively; For detecting RIF-resistance, the sensitivity, specificity, positive likelihood ratio and negative likelihood ratio were 100% (85.1%, 100.0%), 91.7% (64.6%, 98.5%), 12.00 (1.84, 78.37) and 0, respectively; For detecting MDR-TB, the sensitivity, specificity, positive likelihood ratio and negative likelihood ratio were 93.3% (70.2%, 98.8%), 65.0% (43.3%, 81.9%), 2.67 (1.45, 4.92) and 0.10 (0.02, 0.70), respectively. Conclusion: The GenoType MTBDRplus assay has high sensitivity for detection of INH- and RIF-resistance in retreatment TB patients. However, the specificity is moderate, this should be taken into account when interpreting the test results.


Liu Z.,Shandong University | Liu Z.,Shandong Mental Health Center | Shi Z.,Shandong Mental Health Center | Liu J.,Shandong University | Wang Y.,Shandong University
NeuroReport | Year: 2014

Abuse of methamphetamine (MA) increases the risk of infection of HIV-1, induces considerable neurotoxicity in several brain regions, and impairs the motor and cognitive function in individuals. HIV-1 transactivator of transcription (Tat) has also shown the potent capability to induce neuronal death and impaired brain function. The present study aims to study the synergistic effect of MA and Tat on cytokine synthesis in substantia nigra, striatal dopamine content, and behavioral performance in the rats. Although increased expression of cytokines (interleukin-1β and tumor necrosis factor-α) was observed in the substantia nigra in the rats receiving either MA or Tat alone, a combination of MA and Tat induced a larger and more sustained upregulation of cytokines. In the rats receiving either MA or Tat alone, significant loss in striatal dopamine content was found, which was further exacerbated in the rats receiving both MA and Tat. In the rats receiving either MA or Tat alone, significantly lower performance in the rotarod test and open-field test was observed, whereas the rats receiving both MA and Tat showed more sustained behavioral impairments. These results suggested that Tat protein synergized with MA to induce central neuroinflammation and impair the dopaminergic transmission, thus leading to sustained Parkinson's-like behavior. © 2014 Wolters Kluwer Health | Lippincott Williams & Wilkins.


Chen J.-D.,Central South University | Liu F.,Central South University | Xun G.-L.,Shandong Mental Health Center | Chen H.-F.,University of Electronic Science and Technology of China | And 7 more authors.
Journal of Affective Disorders | Year: 2012

Background: Patients with early onset depression (EOD) and late onset depression (LOD) have distinctive risk factors and clinical pictures. Using regional homogeneity (ReHo) approach, we were to test the hypothesis of the different abnormal neural activity between patients with EOD or LOD. Methods: Fifteen patients with EOD, 15 patients with LOD, 15 young healthy subjects (HS) and 15 old HS participated in the study. ReHo approach was employed to analyze the scans. Results: ANOVA analysis revealed widespread differences in ReHo values among the four groups throughout frontal, parietal, temporal, occipital cortex, cerebellum and limbic regions. Compared to LOD group, EOD group had higher ReHo in right precuneus (PCu) and bilateral superior frontal gyrus, and lower ReHo in left superior temporal gyrus. Compared to young HS, lower ReHo in left parahippocampal gyrus and higher ReHo in left fusiform gyrus and bilateral superior frontal gyrus were seen in EOD group; in contrast, in LOD group, lower ReHo in right PCu and higher ReHo in left superior temporal gyrus and left Crus I of the cerebellum were observed. Further ROC analysis suggested that the mean ReHo values in right PCu and bilateral superior frontal gyrus could serve as markers to identify patients with EOD from individuals with LOD. Limitation: The large age gap may limit the translational value of our findings. Conclusions: Patients with EOD and those with LOD have abnormal neural activities in different brain regions, although the two groups share the same symptoms. © 2012 Elsevier B.V.


Guo W.,Central South University | Guo W.,Guangxi Medical University | Liu F.,University of Electronic Science and Technology of China | Xun G.,Shandong Mental Health Center | And 6 more authors.
Journal of Affective Disorders | Year: 2014

Background Abnormalities of white matter integrity in frontal and limbic regions have been postulated to play a key role in the pathophysiology of geriatric depression. However, there is no diffusion tensor imaging (DTI) study in patients with first-episode, drug-naive, late-onset depression (LOD). The aim of this study was to investigate whole-brain fractional anisotropy (FA) difference between patients with LOD and healthy controls without a previously determined region of interest. Methods The sample included 15 patients with first-episode, drug-naive LOD and 15 age-, sex-, and education-matched healthy controls. The tract-based spatial statistics (TBSS) method was employed to analyze the DTI data. Results Lower FA in the white matter of bilateral parahippocampal gyrus was observed in patients with LOD relative to healthy controls by voxel-wise statistics with the TBSS method. Patients did not have higher FA values in any brain regions compared to healthy controls. There was no correlation between the abnormal FA value in bilateral parahippocampal gyrus and depression severity or related factors. Limitations The present study should be considered preliminary due to relatively small sample size. Conclusions Our findings suggest that loss of white matter integrity in parahippocampal gyrus may be associated with the pathophysiology of LOD, and thus highlight the limbic contribution to the pathophysiology of LOD. © 2014 Elsevier B.V.


Chen J.,Virginia Commonwealth University | Cao F.,Huazhong University of Science and Technology | Liu L.,Shandong Mental Health Center | Wang L.,Shandong Mental Health Center | Chen X.,Virginia Commonwealth University
Neuroscience Bulletin | Year: 2015

Schizophrenia (SCZ) is a complex and heterogeneous mental disorder that affects about 1% of global population. In recent years, considerable progress has been made in genetic studies of SCZ. A number of common variants with small effects and rare variants with relatively larger effects have been identified. These variants include risk loci identified by genome-wide association studies, rare copy-number variants identified by comparative genomic analyses, and de novo mutations identified by high-throughput DNA sequencing. Collectively, they contribute to the heterogeneity of the disease. In this review, we update recent discoveries in the field of SCZ genetics, and outline the perspectives of future directions. © 2015, Shanghai Institutes for Biological Sciences, CAS and Springer-Verlag Berlin Heidelberg.


Zhang H.,Shandong Mental Health Center | Zhang Z.,Shandong Mental Health Center | Zhang D.,Shandong Mental Health Center
International Journal of Clinical and Experimental Medicine | Year: 2016

Objective: To evaluate the psychological status of patients with somatization disorders by using questionnaire survey and professional mental scale, aiming to provide effective coping strategies for psychological and physical recovery. Methods: Fifty patients diagnosed with somatization disorder and 50 corresponding family members were assigned into the study group. Fifty healthy subjects and 50 their family members were allocated into the control group. All participants received comprensive evaluation by using SCL-90, SSRS and CSQ. Results: In the study group, the average scores of a majority of items in the SAS and SDS were significantly higher than those in the control group (all P<0.05). The mean scores of overall social and subjective support in patients with somatization disorder were considerably lower than those in their counterparts (all P<0.05). In the study group, the average score of negative factor was significantly higher whereas that of the positive factor was apparently lower compared with the values obtained in the control group (all P<0.05). Conclusion: Patients diagnosed with somatization disorder and their family members present with evident psychological symptoms, lack of social support and effective strategy against the symptoms of somatization disorder. © 2016, E-Century Publishing Corporation. All rights reserved.


Chang X.-R.,Shandong Mental Health Center | Wang L.,Shandong University | Li J.,Blood Group Reference Laboratory | Wu D.-S.,Shandong University
Brain Research | Year: 2016

The present study investigated the antidepressant potential of curcumin in olfactory bulbectomy and forced swimming test models of depression in male albino rats under chronic treatment. The experimental animals were divided into four groups, and curcumin was administered for 45 days. Our results showed that the curcumin significantly reduced olfactory bulbectomy-induced behavioral abnormalities including deficits in step-down passive avoidance, increased activity in the open area and immobility time. Chronic administration of curcumin significantly reversed levels of 3, 4-dihydroxyphenylacetic acid, noradrenaline, serotonin and 5-hydroxyindoleacetic acid in the hippocampus region of male albino rats. Also, curcumin normalizes the levels of dopamine, noradrenaline, and 5-hydroxyindoleacetic acid in the frontal cortex of rats. Taking all these results together, it may suggest that curcumin is potent compound acting against the depression in the male albino rats. © 2016, Elsevier B.V. All rights reserved.


Wang M.,Shandong University | Hou R.,University of Southampton | Jian J.,Shandong Mental Health Center | Mi G.,Shandong Mental Health Center | And 3 more authors.
Human Psychopharmacology | Year: 2014

Objective Effects of conventional and atypical antipsychotics on bone mineral density (BMD) and serum prolactin levels (PRL) were examined in patients with schizophrenia. Methods One hundred and sixty-three first-episode inpatients with schizophrenia were recruited, to whom one of three conventional antipsychotics (perphenazine, sulpiride, and chlorpromazine) or one of three atypical antipsychotics (clozapine, quetiapine, and aripiprazole) was prescribed for 12 months as appropriate. BMD and PRL were tested before and after treatment. Same measures were conducted in 90 matched healthy controls. Results Baseline BMD of postero-anterior L1-L4 range from 1.04 ± 0.17 to 1.42 ± 1.23, and there was no significant difference between the patients group and healthy control group. However, post-treatment BMD values in patients (ranging from 1.02 ± 0.15 to 1.23 ± 0.10) were significantly lower than that in healthy controls (ranging from 1.15 ± 0.12 to 1.42 ± 1.36). The BMD values after conventional antipsychotics were significantly lower than that after atypical antipsychotics. The PRL level after conventional antipsychotics (53.05 ± 30.25 ng/ml) was significantly higher than that after atypical antipsychotics (32.81 ± 17.42 ng/ml). Conditioned relevance analysis revealed significant negative correlations between the PRL level and the BMD values after conventional antipsychotics. Conclusion The increase of PRL might be an important risk factor leading to a high prevalence of osteoporosis in patients with schizophrenia on long-term conventional antipsychotic medication. Copyright © 2014 John Wiley & Sons, Ltd. Copyright © 2014 John Wiley & Sons, Ltd.

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