Gai L.,China Institute of Technology |
Zhang J.,Shandong University |
Zhang H.,China Institute of Technology |
Gai P.,Shandong Provincial Hospital |
And 2 more authors.
Contraception | Year: 2011
Background: Depot medroxyprogesterone acetate (DMPA) as a hormonal contraceptive is highly effective and widely used, but it may reduce bone mineral density (BMD) and increase the risk of osteoporosis. We compared BMD between users of intramuscular DMPA and nonhormonal subjects and evaluated the changes in BMD after discontinuation of DMPA. Study Design: The study included 68 women aged between 25 and 40 years using DMPA for 24 months and 59 women aged between 25 and 40 years using nonhormonal contraception as nonusers of hormonal contraception. Sixty-one women in the DMPA group and 52 women in the nonusers of hormonal contraception group completed the 2-year post-treatment periods. BMD of the lumbar spine and femoral neck was measured every 12 months for 48 months using dual-energy X-ray absorptiometry, comparing mean BMD changes in DMPA users and discontinuers with nonusers. Results: At 24 months of treatment, as compared to baseline, the mean BMD of DMPA users in lumbar spine and femoral neck decreased by 5.52% and 6.35%, respectively. Lumbar spine and femoral neck BMD in women who used DMPA significantly decreased compared to the nonusers (p<.001). At 24 months after DMPA discontinuation, the mean BMD values in DMPA users increased significantly. Although the values of the lumbar spine and femoral neck BMD in DMPA users were still 1.08% and 2.30%, respectively, below their baseline values, there were no significant difference when compared to nonusers (p>.05). Conclusion: These results show that BMD declined during use of DMPA in women aged 25 to 40 years. Bone loss occurring with DMPA use is reversible after DMPA discontinuation. © 2011 Elsevier Inc. All rights reserved.
Zhang Y.,Shandong Medical Imaging Research Institute
Magnetic Resonance Imaging Clinics of North America | Year: 2014
Assessment of tumor response is crucial in determining the effectiveness of loco-regional and systemic therapy, and for determining the need for subsequent treatment. The ultimate goal is to improve patient's survival. Changes in tumor size and enhancement after therapy may not be detected early by the traditional response criteria. Tumor response is better assessed in the entire tumor volume rather than in a single axial plane. The purpose of this article is to familiarize the reader with early treatment response assessed by anatomic and volumetric functional magnetic resonance imaging metrics of the liver after loco-regional and systemic therapy. © 2014 Elsevier Inc.
Zhang M.,Shandong Medical Imaging Research Institute |
Chu C.,Taishan Medical College
Journal of Digital Imaging | Year: 2012
Because of a much higher dynamic range of flat panel detectors, patient dose can vary without change of image quality being perceived by radiologists. This condition makes optimization (OT) of radiation protection undergoing digital radiography (DR) more complex, while a chance to reduced patient dose also exists. In this study, we evaluated the difference of patient radiation and image rejection before and after OT to identify if it is necessary to carry out an OT procedure in a routine task with DR. The study consisted of a measurement of the dose area product (DAP) and entrance surface dose (ESD) received by a reference group of patients for eight common radiographic procedures using the DR system before and after OT. Meanwhile image rejection data during two 2-month periods were collected and sorted according to reason. For every radiographic procedure, t tests showed significant difference in average ESD and DAP before and after OT (p<0.005). The ESDs from most examinations before OT were three times higher than that after OT. For DAPs, the difference is more significant. Image rejection rate after OT is significantly lower than that before OT (χ 2=36.5, p<0.005). The substantial reductions of dose after OT resulted from appropriate mAs and exposure field. For DR patient dose, less than recommended diagnostic reference level can meet quality criteria and clinic diagnosis. © Society for Imaging Informatics in Medicine 2011.
Zhang Z.,Shandong University |
Liu S.,Shandong University |
Lin X.,Shandong Medical Imaging Research Institute |
Teng G.,Nanjing Southeast University |
And 3 more authors.
Neuroradiology | Year: 2011
Introduction: The purpose of this study is to show the condition of laminar organization on 3.0T and 7.0T postmortem magnetic resonance imaging (MRI) and analyze developmental changes. Methods: Heads of 131 fetal specimens of 14-40 weeks gestational age (GA) were scanned by 3.0T MRI. Eleven fetal specimens of 14-27 weeks GA were scanned by 7.0T MRI. Clear images were chosen for analysis. Results: On T1-weighted 3.0T MRI, layers could be visualized at 14 weeks GA and appeared clearer after 18 weeks GA. On 7.0T MRI, four zones could be recognized at 14 weeks GA. During 15-22 weeks GA, when laminar organization appeared typical, seven layers including the periventricular zone and external capsule fibers could be differentiated, which corresponded to seven zones in histological stained sections. At 23-28 weeks GA, laminar organization appeared less typical, and borderlines among them appeared obscured. After 30 weeks GA, it disappeared and turned into mature-like structures. The developing lamination appeared the most distinguishable at the parieto-occipital part of brain and peripheral regions of the hippocampus. The migrating thalamocortical afferents were probably delineated as a high signal layer located at the lower, middle, and upper part of the subplate zone at 16-28 weeks GA on T1-weighted 3.0T MRI. Conclusions: T1-weighted 3.0T MRI and T2- weighted 7.0T MRI can well demonstrate the laminar organization. Development of the lamination follows a specific spatio-temporal regularity, and postmortem MRI of the parieto-occipital part of brain obtained with 3.0T or 7.0T is an effective way to show developmental changes. © 2010 Springer-Verlag.
Joshi S.H.,University of California at Los Angeles |
Cabeen R.P.,Brown University |
Joshi A.A.,University of Southern California |
Sun B.,Shandong Medical Imaging Research Institute |
And 4 more authors.
IEEE Transactions on Medical Imaging | Year: 2012
We present a diffeomorphic approach for constructing intrinsic shape atlases of sulci on the human cortex. Sulci are represented as square-root velocity functions of continuous open curves in R 3, and their shapes are studied as functional representations of an infinite-dimensional sphere. This spherical manifold has some advantageous propertiesit is equipped with a Riemannian L 2 metric on the tangent space and facilitates computational analyses and correspondences between sulcal shapes. Sulcal shape mapping is achieved by computing geodesics in the quotient space of shapes modulo scales, translations, rigid rotations, and reparameterizations. The resulting sulcal shape atlas preserves important local geometry inherently present in the sample population. The sulcal shape atlas is integrated in a cortical registration framework and exhibits better geometric matching compared to the conventional euclidean method. We demonstrate experimental results for sulcal shape mapping, cortical surface registration, and sulcal classification for two different surface extraction protocols for separate subject populations. © 2012 IEEE.
Zhang M.,Shandong Medical Imaging Research Institute |
Liu K.,Shandong Medical Imaging Research Institute |
Niu X.,Fourth Hospital of Jinan |
Liu X.,Fourth Hospital of Jinan
Pediatric Radiology | Year: 2013
Background: Little information exists concerning appropriate exposure and measuring overall patient dose in pediatric digital radiography. Objective: To establish a convenient method of appropriate exposure from target exposure index (EI) and thickness in pediatric digital radiography and estimate patient entrance-surface dose (ESD) and dose-area product (DAP) associated with chest, abdomen and pelvis radiography. Materials and methods: A formula was deduced to calculate appropriate mAs changed with children's weight and height. EI was used to control image quality. With this formula, dose-optimized procedures were carried out. Data were collected from 180 pediatric examinations, including chest, abdomen and pelvis anterior-posterior (AP) projections. The children were divided into the following age bands: newborns (0-28 days), infants (28 days-2 years) and older children (2-7 years). In each age band, ten children were exposed with the calculated appropriate mAs and EI values were kept steady in appropriate range (referred as target group) and ten children were exposed to the factors routinely used in practice (referred to as the routine group). DAP to children was measured with a DAP meter, and ESD was calculated using measured DAP and data from the National Radiological Protection Board. Data were compared between groups. Results: ESD ranges in the target group were 32-202 μGy (chest AP), 57-333 μGy (abdomen AP) and 52-372 μGy (pelvis AP). For every radiographic procedure, chi-square Student's t tests showed a significant difference in average ESD and DAP between the two groups (P < 0.005). Most ESD values from the routine group were two times higher than those from the target group. Conclusions: The study established a convenient method to set appropriate exposure parameters (mAs) to reach a target EI using the child's weight and height in pediatric radiography. By this method, ESD and DAP can be significantly reduced in children. © 2012 Springer-Verlag Berlin Heidelberg.
Li C.,Shandong Medical Imaging Research Institute |
Ai B.,Shandong Medical Imaging Research Institute |
Li Y.,Shandong Medical Imaging Research Institute |
Qi H.,Shandong Medical Imaging Research Institute |
Wu L.,Shandong Medical Imaging Research Institute
European Journal of Radiology | Year: 2010
Objective: To evaluate the value of intratumoral vessels and micro-hemorrhage shown in susceptibility weighted imaging (SWI) for grading brain astrocytomas and to analyze the difference between SWI and conventional imaging techniques. Methods: 22 patients with astrocytomas were diagnosed with surgical specimens, 9 of which were grades I-II, and 13 were grades III-IV. All examinations were performed on Signa DEx 3.0 T MRI scanner. Conventional imaging techniques (T1WI, T2WI, T2FLAIR, CE-T1WI) and SWI sequence were used. The parameters of SWI sequence were the following: TR = 35 ms, TE = 20 ms, FA = 15°, slice thickness = 2 mm. The small vessels and blood products of the tumors in SW images were analyzed. The differences between the two groups in SW images were analyzed statistically. Results: The findings in SW images of brain astrocytomas were correlated strongly with pathology. SWI was more sensitive compared to conventional imaging techniques for showing small vessels and micro-hemorrhage in brain astrocytomas. Statistical comparison showed that the small vessels and micro-hemorrhage of two groups of brain astrocytomas in SW images differed significantly. Conclusion: SWI is superior to conventional imaging techniques at showing the small vessels and micro-hemorrhage in brain astrocytomas, which plays an important role in the tumor grading. © 2009 Elsevier Ireland Ltd. All rights reserved.
He X.M.,Shandong Medical Imaging Research Institute
Zhongguo shi yan xue ye xue za zhi / Zhongguo bing li sheng li xue hui = Journal of experimental hematology / Chinese Association of Pathophysiology | Year: 2012
This study was aimed to investigate the therapeutic effect of two molecular targeted therapeutic drugs, tyrosine kinase inhibitors gefitinib and lapatinib, on JAK2 V617F positive myeloproliferative disorders (MPD). The human leukemia cell line (HEL cell line) carrying JAK2 V617F mutation was treated with gefitinib (0.5, 1, 5, 10, 25 μmol/L) and lapatinib (0.5, 1, 2, 4, 8, 16 μmol/L) respectively. MTT method was used to detect HEL cell proliferation. The apoptotic rate and cell cycle were measured by flow cytometry. The results showed that gefitinib could significantly inhibit the proliferation of HEL cells in a dose-dependent manner, it's correlation coefficients for 24 and 48 h were 0.991 and 0.895 respectively. IC(50) at 48 h was 5.4 μmol/L. Gefitinib could effectively induce apoptosis of HEL cells in a dose-dependent manner (r = 0.896). Otherwise, gefitinib could arrest HEL cells at G(0)/G(1) phase. The inhibitory effect of lapatinib was less than gefitinib, it's IC(50) of inhibiting proliferation of HEL cells was 19.6 μmol/L. It is concluded that both gefitinib and lapatinib can inhibit the proliferation of HEL cells. These two tyrosine kinase inhibitors can be used for researching of targeted therapy of JAK2 V617 positive MPD.
Zhang Z.,Shandong University |
Hou Z.,Shandong University |
Lin X.,Shandong University |
Lin X.,Shandong Medical Imaging Research Institute |
And 5 more authors.
American Journal of Neuroradiology | Year: 2013
BACKGROUNDANDPURPOSE: Few investigators have analyzed the fetal cerebral cortex withMRimaging of high magnetic strength. Our purpose was to document the sulcal development and obtain quantitative measurements of the fetal brain in the second trimester. MATERIALS AND METHODS: The brains of 69 fetal specimens, with GA 12-22 weeks, were first scanned on a 7TMR imaging scanner. Then the sequential development of the different fissures and sulci was analyzed, and quantitative measurements of the cerebral cortex were obtained. RESULTS: A new chronology of sulcal development during 12-22 weeks GA was summarized. Before 12 weeks, few sulci were present; by 16 weeks, many sulci were present. The 16th week could be considered the most intensive time point for sulcal emergence. Most sulci, except for the postcentral sulcus and intraparietal sulcus, were present by 22 weeks GA. Measurements of the fetal brains, each with different growth rates, linearly increased with GA, but no sexual dimorphisms or cerebral asymmetries were detected. CONCLUSIONS: The second trimester is the most important phase, during which most sulci are present and can be clearly shown on 7T postmortem MR imaging. It is apparent that the specific time during which neuropathologic features of sulci appear, previously thought to be well understood, should be redefined. Quantitative data provide assistance in the precise understanding of the immature brain. The present results are valuable in anatomic education, research, and assessment of normal brain development in the uterus.
Hu P.,Shandong University |
Liu W.,Shandong Medical Imaging Research Institute |
Wang L.,Shandong University |
Yang M.,Shandong University |
Du J.,Shandong University
Journal of Cancer Research and Clinical Oncology | Year: 2013
Purpose: Vascular endothelial growth factor (VEGF) is considered as the best-validated key regulator of angiogenesis, while the prognostic role of circulating VEGF in lung cancer remains controversial. We conducted a meta-analysis to evaluate the prognostic role of circulating VEGF. Methods: Nineteen studies with a total number of 2,890 patients were analyzed in our meta-analysis. Hazard ratios (HRs) and their 95 % confidence intervals (CIs) were used to quantify the predictive ability of circulating VEGF on survival. Results: The pooled HR of all 17 studies evaluating overall survival (OS) was 1.29 (95 % CI 1.19-1.40, p < 0.001), indicating high circulating VEGF predicted poor OS. When grouped by disease stages, the pooled HRs were 0.97 (95 % CI 0.47-1.47, p < 0.001) for operable stage and 1.34 (95 % CI 1.18-1.49, p < 0.001) for inoperable stage. The pooled HRs were 1.28 (95 % CI 1.15-1.42, p < 0.001) for serum and 1.31 (95 % CI 1.13-1.49, p < 0.001) for plasma, when categorized by blood sample. Meta-analysis of circulating VEGF related to progression-free survival (PFS) was performed in 7 studies, and the pooled HR was 1.03 (95 % CI 0.96-1.09). Conclusions: Our results indicate that high level of circulating VEGF predicts poor OS in lung cancer, yet it does not predict poor PFS. © 2013 Springer-Verlag Berlin Heidelberg.