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Jin W.-R.,Liaocheng Peoples Hospital | Zhang F.-E.,Shandong Liaocheng Peoples Hospital | Diao B.-Z.,Liaocheng Peoples Hospital | Zhang Y.-Y.,Shandong Academy of Sciences
Evidence-based Complementary and Alternative Medicine | Year: 2016

Objective. To evaluate the efficacy of Wulingsan subtraction ( WLSS) decoction in the treatment of postoperative brain edema and fever as a complication of glioma neurosurgery. Methods. This retrospective study was conducted at the Department of Neurosurgery of Liaocheng People's Hospital. Patients hospitalized between March 2011 and December 2014 were divided into three groups: Group A received WLSS oral liquid (50 mL), twice a day; Group B received an intravenous infusion of mannitol; and Group C received WLSS combined with mannitol (n = 30 patients per group). All patients were treated for 10 days continuously. Therapeutic efficacy was evaluated by measuring body temperature and indicators of renal function before and 3, 5, and 10 days after treatment. Results. Compared to the other two groups, significantly greater clinical efficacy was observed in the patients treated with mannitol (Group B; P < 0.05), although marked clinical efficacy was also observed over time in patients treated with WLSS (Group A). After 5 days, the quantifiable effects of the WLSS and mannitol combination group (Group C) were substantial (P < 0.05). The renal damage in Group B was more obvious after 5 days and 10 days. Conclusion. Compared with mannitol treatment alone, WLSS combined with mannitol induced a more rapid reduction in body temperature. Our findings suggest that patients should be started on mannitol for 3 days and then switched to WLSS to achieve obvious antipyretic effects and protect renal function. This method of treatment should be considered for clinical applications. © 2016 Wei-rong Jin et al.

Zhang D.-F.,Shandong Liaocheng Peoples Hospital | Zhang F.,Binzhou Medical University | Zhang J.,Shandong Liaocheng Peoples Hospital | Zhang R.-M.,Shandong Liaocheng Peoples Hospital | Li R.,Liaocheng University
Asian Pacific Journal of Tropical Medicine | Year: 2015

Objective: To study the effect of trigonelline on the change of indicators of serum transaminase, lipoprotein and liver lipid of model rats with non-alcoholic fatty liver diseases and on the expression level of Bcl-2 and Bax proteins. Methods: A total of 45 SD rats were randomly divided into the control group, model group and trigonelline intervention group. Rats in the control group were fed with the common diet, while rats in the model group and intervention group were fed with the high fat diet. 8 weeks later, the intervention group received the intragastric administration of trigonellin e (with the dosage of 40 mg/kg/d) for 8 weeks; while control group and model group received the intragastric administration of saline with the equal dosage. Blood was taken from the abdominal aorta of rats 8 weeks later, detecting the level of a series of indicators of ALT, AST, TG, TC, HDL-C and LDL-C in the serum. After the rats were sacrificed, detect the indicators of TG, TC, SOD and MDA in the liver tissue of rats, as well as the expression of Bcl-2 and Bax in the liver tissue. Results: Results of histopathologic examination showed that the damage degree of liver for rats in the trigonelline intervention group was smaller than the one in the model group, with significantly reduced hepatic steatosis and the partially visible hepatic lobule. The levels of ALT, AST, TC and LDL-C in the serum of rats in the trigonelline group were significantly reduced, while the change in the levels of TG and HDL-C was not significantly different. The levels of TG, TC and MDA in the liver tissues were significantly decreased, while the level of SOD significantly increased; the expression of Bcl-2 protein in the liver tissues of rats in the trigonelline intervention group was significantly increased, while the expression of Bax protein significantly decreased. Conclusions: The trigonelline contributes to the therapeutic effect of non-alcoholic fatty liver diseases. It can also increase the expression of Bcl-2 protein and decrease the expression of Bax protein in the liver tissues, which can protect the liver. © 2015 Hainan Medical College.

Wang X.,Shandong Liaocheng Peoples Hospital | Zhou M.,Shandong Liaocheng Peoples Hospital | Yang L.,Shandong Liaocheng Peoples Hospital | Wang Y.,Shandong Liaocheng Peoples Hospital | Jin Y.,Shandong Liaocheng Peoples Hospital
Experimental and Clinical Cardiology | Year: 2014

BACKGROUND: The aim of this study was to explore the cardioprotective effects of intensive atorvastatin therapy in patients with non ST-elevation acute coronary syndrome (NSTEACS) undergoing intervention. METHODS: Eighty NSTEACS patients undergoing intervention in the Department of Cardiology were selected and randomized into test and control groups; 40 patients in test group orally took 40 mg/d atorvastatin before and 30 days after operation, followed by 20 mg/d atorvastatin for 30 days; patients in control group orally took 20 mg/d atorvastatin before and after operation; myocardial injury biomarkers were compared between two groups. RESULTS: CTnI and CK-MB levels in both groups significantly increased after operation (P<0.05), while postoperative CTnI and CK-MB levels were distinctly higher in control group than that of test group ( P<0.05). CRP level elevated in both groups one day after operation but their difference did not reach statistical significance (P>0.05), while CRP level was markedly lower in test group than that of control group (P<0.05). CONCLUSIONS: Intensive atorvastatin therapy ameliorates myocardial injury and inflammation in NSTEACS patients.

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