Bi Y.,Shandong University |
Huan Y.,Shandong Provincial Jiaotong Hospital |
Cai W.,Shandong University |
Wang X.,Shandong University |
And 3 more authors.
Experimental and Therapeutic Medicine | Year: 2014
The aim of this study was to investigate the effects of mild hypothermia and minimally invasive evacuation of hematoma on the brain function of patients with cerebral hemorrhage. Seventy-six patients with acute cerebral hemorrhage were divided into the minimally invasive evacuation of hematoma (MIHE) and mild hypothermia and minimally invasive evacuation of hematoma (MHMIHE) groups. National Institutes of Health Stroke Scale (NIHSS) scores on the day of admission of the patient and one, three and seven days after the procedure were recorded. Perihematoma brain tissue morphology was observed using hematoxylin and eosin staining. Nuclear factor-κB (NF-κB) expression was determined by immunohistochemistry. The tumor necrosis factor-α (TNF-α) level was detected by ELISA. NIHSS scores in the MHMIHE group were significantly lower than those in the MIHE group on days three and seven. TNF-α and NF-κB levels peaked on day three, and the MHMIHE group had significantly lower levels of TNF-α and NF-κB than the MIHE group. In conclusion, the present study demonstrated that mild hypothermia and minimally invasive evacuation of hematoma. © 2014, Spandidos Publications. All right reserved.
Gao H.,Shandong Provincial Jiaotong Hospital |
Ge R.C.,Shandong Provincial Jiaotong Hospital |
Liu H.Y.,Affilated Hospital of Tai Shan Medical College |
Wang Y.,The Fourth Peoples Hospital of Jinan |
Yan S.,The Fourth Peoples Hospital of Jinan
Genetics and Molecular Research | Year: 2014
We conducted a cohort study to investigate the role of 3 single-nucleotide polymorphisms of the excision repair cross-complementation group 1 (ERCC1) gene on the response to chemotherapy and clinical outcomes of non-small cell lung cancer (NSCLC). A total of 163 patients with newly diagnosed and histopathologically confirmed primary NSCLC were examined in our study and were followed up until December 2012. ERCC1 rs11615, rs3212986, and rs2298881 were selected and genotyped. Of the 163 patients, 86 patients showed a complete response and partial response to chemotherapy (52.76%), while 91 patients (55.83%) died from NSCLC during the follow-up period with a median survival time of 19.3 months (range, 2-60 months). Multivariate regression analysis showed that individuals carrying the rs11615 TT genotype and T allele had a significantly lower response rate to chemotherapy using the rs11615 CC genotype as the reference. For rs3212986, carriers of the rs3212986 AA genotype and A allele had a significantly lower response rate to chemotherapy when compared with the CC genotype. In the Cox proportional hazards model, patients carrying the rs11615 TT genotype and T allele and the rs3212986 AA genotype and A allele were significantly associated with increased risk of death from NSCLC. We found that polymorphisms in ERCC1 rs11615 and rs3212986 were associated with poor response to chemotherapy and shorter survival time of advanced NSCLC. © FUNPEC-RP.