Shandong Hospital of Communication

Jinan, China

Shandong Hospital of Communication

Jinan, China

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Li Q.,Shandong Hospital of Communication | Lu Y.-t.,Shandong Hospital of Communication | Huan Y.,Shandong Hospital of Communication | Liu M.,Shandong Hospital of Communication | And 6 more authors.
Chinese Journal of Tissue Engineering Research | Year: 2012

BACKGROUND: Studies have demonstrated that umbilical cord blood mononuclear cells exhibit some effects in treatment of autism. OBJECTIVE: To detect levels of nerve growth factor (NGF), vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) in cerebrospinal fluid of autism patients treated with umbilical cord blood mononuclear cells. METHODS: A total of 30 autism children received treatment by injection of human umbilical cord blood mononuclear cells via lumbar puncture subarachnoid cavity, once a week, for three times totally. RESULTS AND CONCLUSION: The levels of nerve growth factors were significantly greater at 1 week after the second treatment than pretreatment and 1 week after the first treatment (P < 0.05). The levels of vascular endothelial growth factors and basic fibroblast growth factors were slightly, but not significantly, higher at 1 week after the second treatment than pretreatment and at 1 week after the first treatment (P > 0.05). Results suggest that the levels of nerve growth factors in cerebrospinal fluid were significantly increased in autism children who received treatment of umbilical cord blood mononuclear cells, however, the levels of vascular endothelial growth factors and basic fibroblast growth factors were not influenced significantly.

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