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Song H.-Z.,Hefei University of Technology | Bi L.,Shandong Drug and Food Vocational College | Lv S.,Hefei University of Technology | Lu J.-F.,Hefei University of Technology | And 3 more authors.
Modern Food Science and Technology | Year: 2014

Fish skin is the main byproduct in channel catfish filet processing industrial. Preparation antihypertensive peptides using channel catfish skin gelatin can promote its utility value. Spontaneously hypertensive rats (SHR) and normal SD rats were used to assess the antihypertensive effects of the ACE inhibitory peptides under optimized condition in vivo. The ACE activity and Ang II contents in the serum and lung tissue of SHR were measured. The blood pressure of SHR was decreased significantly after one-time dosing experiment and long-term dosing study (28 days), and the antihypertensive effects were dose-dependent. The blood pressure of SHR in high dose group decreased from 206 mmHg to 159 mmHg after 2 h oral administration and remained around 155 mmHg after long-term oral administration for 10 days. Moreover, the ACE inhibitory peptides had no significant effect on normal SD rats. The ACE inhibitory peptide from channel catfish skin gelatin inhibited the ACE activity, and decreased the Ang II contents in serum and lung tissue of SHR. While there was no significant effect on ACE activity and Ang II content in serum and hung tissue for normal SD rats. Source


Zhao J.F.,Shandong Drug and Food Vocational College
Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials | Year: 2012

To identify consistency of the composition and efficacy of Porcellio scaber and Armadillidium vulgare and provide reference for the safe and scientific use of the medicinal material. Identified the Porcellio scaber and the Armadillidium vulgare with the method of characteristics; Compared the two chemical composition by thin layer method; Determined the extract by water and ethanol using the pharmacopoeia extract method. Porcellio scaber and Armadillidium vulgare were two varieties, they had similar chemical composition, the water and ethanol extract were the same. The compostion and efficary of Porcellio scaber and Armadillidium vulgare are the same, and these two varieties can be mixed or used alone. Source


Tan W.,CAS Yantai Institute of Coastal Zone Research | Tan W.,University of Chinese Academy of Sciences | Li Q.,CAS Yantai Institute of Coastal Zone Research | Wang H.,Shandong Drug and Food Vocational College | And 5 more authors.
Carbohydrate Polymers | Year: 2016

Four novel starch-linked-1,2,3-triazole derivatives were synthesized including 6-hydroxymethyltriazole-6-deoxy starch (HMTST), 6-bromomethyltriazole-6-deoxy starch (BMTST), 6-chloromethyltriazole-6-deoxy starch (CMTST), and 6-carboxyltriazole-6-deoxy starch (CBTST). Their antibacterial properties against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) were evaluated in vitro, respectively. The inhibitory property of the obtained amphiprotic starch derivatives exhibited a remarkable improvement over starch. And the antibacterial indices of most of the products were higher than 60% and 40% at 1.0 mg/mL when the culture time was 8 h and 16 h, respectively. Moreover, the inhibitory index of CBTST attained 97% above at 1.0 mg/mL. Generally, the inhibitory activity decreased in the order: CBTST > CMTST > BMTST > HMTST > starch. Furthermore, the order of their antibacterial activity was consistent with the electron-withdrawing property of different substituted groups of the 1,2,3-triazole groups. The substituted groups with stronger electron withdrawing ability relatively possessed greater antibacterial activity. © 2016 Elsevier Ltd. All rights reserved. Source


Wan M.,Shandong University | Xu L.,Shandong University | Hua L.,Shandong Drug and Food Vocational College | Li A.,Shandong Drug and Food Vocational College | And 6 more authors.
Bioorganic Chemistry | Year: 2014

A series of novel isoxazolyl chalcones were synthesized and evaluated for their activities in vitro against four types of human non-small cell lung cancer cells, including H1792, H157, A549 and Calu-1 cells. The preliminary biological screening showed that compounds 5d and 5f-i exhibited significant cytotoxicity, particularly, compounds 5f and 5h were identified as the most potent anticancer agents with IC50 values 1.35-2.07 μM and 7.27-11.07 μM against H175, A549 and Calu-1 cell lines, respectively. Compounds 5f-i could induce apoptosis in A549 cells by death receptor 5 (DR5) mediated extrinsic pathways. The preliminary structure-activity relationship study showed that compounds bearing electron withdrawing groups (EWG) at the 2-position of the phenyl ring in Ar group were more effective than those with EWG at 4-position. These results further demonstrated that the scaffolds designed in this work might lead to the discovery of novel anti-lung cancer agents. © 2014 Elsevier Inc. All rights reserved. Source


Li S.-M.,Shandong Drug and Food Vocational College | Yang J.-L.,Shandong Drug and Food Vocational College | Liu Y.-P.,Shandong Drug and Food Vocational College | Liu Y.-P.,Hainan Normal University | Fu Y.-H.,Hainan Normal University
Chinese Traditional and Herbal Drugs | Year: 2015

Objective: To study the non-alkaloid constituents from the stems and leaves of Alstonia mairei. Methods: The chemical constituents were separated and purified by silica gel, ODS, Sephadex LH-20 gel column chromatographies, and preparative HPLC. Their structures were determined by physicochemical properties, spectral data, as well as comparisons with the data in literature. Results: Eighteen compounds were isolated from the petroleum ether fraction of 90% ethanol extract from the stems and leaves of A. mairei, and identified as lupeol (1), 30-oxo-lupeol (2), lupenyl acetate (3), α-amyrin (4), α-amyrenone (5), 23-hydroxyursolic acid (6), β-amyrin (7), β-amyrenone (8), maslinic acid (9), friedelinol (10), friedelin (11), tectochrysin (12), 5,6-dihydroxy-7,4'- dimethoxyflavone (13), 5,3'-dihydroxy-7,4'-dimethoxyflavone (14), 7-hydroxy-7,5,3',4'-trimethoxyflavone (15), 5,7,3',4'- tetramethoxyflavone (16), 5-hydroxy-6,7,8,4-tetramethoxyflavone (17), and 5-hydroxy-6,7,8,3',4'-pentamethoxyflavone (18). Conclusion: All compounds are isolated from A. mairei for the first time. In addition to compound 1, the other compounds are isolated from the plants of Alstonia R. Br. for the first time. © 2015, Editorial Office of Chinese Traditional and Herbal Drugs. All right reserved. Source

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