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Zhang K.,Shandong Academy of Sciences | Song L.,Shandong Cancer Hospital and Institute
PLoS ONE | Year: 2014

Background: The associations between vitamin D receptor (VDR) gene polymorphisms and breast cancer risk were comprehensively investigated to clarify issues that remain controversial. Methodology/Principal Findings: An electronic search was conducted of several databases, including PubMed, the Cochrane library, Web of Science, EMBASE, CBM and CNKI, for papers that describe the association between Fok1, poly-A repeat, Bsm1, Taq1 or Apa1 polymorphisms of the VDR gene and breast cancer risk. Summary odds ratios and 95% confidence intervals (CI) were estimated based on a fixed-effect model (FEM) or random-effect model (REM), depending on the absence or presence of significant heterogeneity. A total of 39 studies met the inclusion criteria. A meta-analysis of high-quality studies showed that the Fok1 polymorphism of the VDR gene was associated with an increased risk of breast cancer (ff vs. Ff+FF, OR: 1.09, 95%CI: 1.02 to 1.16, p = 0.007). No significant associations were observed between the other polymorphisms and breast cancer risk. No positive results were detected by pooling the results of all relevant studies. Conclusion: A meta-analysis of high-quality studies demonstrated that the Fok1 polymorphism of the VDR gene was closely associated with breast cancer risk. © 2014 Zhang, Song.

An electromagnetic radiation field within a biological organism is characterized by non-local interference. The interfering beams form a unitary tridimensional network with beams of varying intensity, also called striae, which are distributed on the organism surface. These striae are equivalent to semi-reflectors. The striae carry bio-information of corresponding organs and, thus, integrate all tissues, and organs of the organism. The longitudinal striae are classified as channels, while the transverse striae are collaterals. The acupoints are seen as the points where electromagnetic interfering striae intersect or converge. This hypothesis builds a foundation to understand the traditional Chinese medicine, including acupuncture, from the perspective of scientific knowledge. © 2011 Springer Science+Business Media, LLC.

Zhao Y.,Shandong Academy of Sciences | Song Z.,Liaocheng Peoples Hospital
Materials Letters | Year: 2014

Previously reported silver sulfide (Ag2S) quantum dots (QDs) emitting in the second near-infrared window (NIR-II, 1000-1400 nm) showed the capacity of in vitro and in vivo bioimaging. Herein, we reported a facile phase transfer- based synthesis to achieve water-dispersed NIR-II-emitting Ag 2S QDs. After undergoing phase transfer of Ag+ ions from water to toluene, and the synthesis of Ag2S in toluene followed by ligand exchange, Ag2S QDs were favorably prepared. A series of characterizations confirmed that the prepared products were monoclinic α-Ag2S, showing an average size of 3.7 nm. The Ag2S QDs exhibited the maximum emission located at 1045 nm, high PL stability and low cytotoxicity, indicating the feasibility of Ag2S QDs for effective bioimaging in NIR-II biological window. © 2014 Elsevier B.V. All rights reserved.

Yang Y.,Shandong Academy of Sciences
Materials Science and Engineering B: Solid-State Materials for Advanced Technology | Year: 2013

LaPO4:Eu3+ microspheres were synthesized, using LaCl3, EuCl3 and (NH4)2HPO 4 as starting materials. The morphology, formation mechanism, and luminescent property of samples were systemically studied. X-ray diffraction (XRD) and infrared spectroscopy (IR) show that LaPO4:Eu3+ microspheres have a pure monoclinic phase. Cetyltrimethyl ammonium bromide (CTAB) usually forms spherical micelles above a critical micelle concentration, which plays an important role in the formation of LaPO4:Eu 3+ microspheres. The excitation spectrum of LaPO4:Eu 3+ microspheres consists of several sharp lines due to the direct excitation of the Eu3+ cations from the ground state to higher levels of the 4f-manifold. The emission intensity of microspheres is higher than irregular particles because of the lowlier surface area. The lifetimes of Eu3+ ions in the LaPO4:Eu3+ microspheres are determined to be 2.41 ms. © 2013 Elsevier B.V. All rights reserved.

Li Z.J.,Shandong Academy of Sciences
Zhonghua zhong liu za zhi [Chinese journal of oncology] | Year: 2013

To investigate the effect of high mobility group box-1 (high mobility group box B 1, HMGB1) on the invasive and metastatic abilities of gastric cancer cell line MGC-803 and analyze the possible mechanisms. HMGB1 gene targeting siRNA was designed and synthesized, and HMGB1 siRNA oligonucleotides were transfected into the MGC-803 cells with Lipofectamine 2000. The invasive and migratory abilities were detected by transwell assay and scratch assay. The Matrigel matrix glue adhesive ability of MGC-803 cells was evaluated by MTT assay. NF-κB activity was detected by electrophoretic mobility shift assay. The mRNA and protein levels of HMGB1 and MMP-9 were determined by RT-PCR and Western blot, respectively. The siRNA down-regulated the levels of HMGB1 mRNA and protein. Compared with that of the control group, the number of invasive (142.7 ± 3.4 /view vs. 303.5 ± 4.3/view) and migratory (293.7 ± 4.4/view vs. 445.5 ± 5.6/view) cells was significantly increased (P < 0.05) and the adhesive ability of MGC-803 cells to Matrigel was significantly elevated (33.4 ± 0.03% vs. 57.4 ± 4.2%, P < 0.05). In addition, silencing of HMGB1 gene significantly inhibited the activity of NF-κB and the relative expression folds of mRNA (0.2 ± 0.1 vs. 1.4 ± 0.4, P < 0.05)and protein (0.4 ± 0.1 vs. 2.3 ± 0.7, P < 0.05) of MMP-9. Silencing of HMGB1 can effectively inhibit the invasion and migration of gastric cancer cells and this effect of HMGB1 may be partly due to its regulation of NF-κB and MMP-9 expressions.

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